JP2004505990A5 - - Google Patents
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- JP2004505990A5 JP2004505990A5 JP2002518239A JP2002518239A JP2004505990A5 JP 2004505990 A5 JP2004505990 A5 JP 2004505990A5 JP 2002518239 A JP2002518239 A JP 2002518239A JP 2002518239 A JP2002518239 A JP 2002518239A JP 2004505990 A5 JP2004505990 A5 JP 2004505990A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- hydroxy
- oxy
- oxo
- androsta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 3-furanylcarbonyl Chemical group 0.000 description 43
- 239000002253 acid Substances 0.000 description 42
- 150000001875 compounds Chemical class 0.000 description 41
- 150000003839 salts Chemical class 0.000 description 13
- 239000012453 solvate Substances 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- 125000000623 heterocyclic group Chemical group 0.000 description 8
- 229910052731 fluorine Inorganic materials 0.000 description 7
- 239000011737 fluorine Substances 0.000 description 7
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000005842 heteroatom Chemical group 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000029936 alkylation Effects 0.000 description 2
- 238000005804 alkylation reaction Methods 0.000 description 2
- 238000010511 deprotection reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 1
- 206010027654 Allergic conditions Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 description 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 description 1
- 239000000048 adrenergic agonist Substances 0.000 description 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 125000005997 bromomethyl group Chemical group 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0019172.6A GB0019172D0 (en) | 2000-08-05 | 2000-08-05 | Novel compounds |
| GBGB0108800.4A GB0108800D0 (en) | 2001-04-07 | 2001-04-07 | Novel compounds |
| PCT/GB2001/003499 WO2002012266A1 (en) | 2000-08-05 | 2001-08-03 | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505990A JP2004505990A (ja) | 2004-02-26 |
| JP2004505990A5 true JP2004505990A5 (enExample) | 2006-09-14 |
Family
ID=26244792
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002518238A Expired - Lifetime JP4436041B2 (ja) | 2000-08-05 | 2001-08-03 | 抗炎症剤としての6α,9α−ジフルオロ−17α−[(2−フラニルカルボキシル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスト−1,4−ジエン−17−チオカルボン酸S−フルオロメチルエステル |
| JP2002518239A Pending JP2004505990A (ja) | 2000-08-05 | 2001-08-03 | 抗炎症剤としての17β−カルボチオエート−17α−アリールカルボニルオキシルオキシアンドロスタン誘導体 |
| JP2009265248A Expired - Lifetime JP5150607B2 (ja) | 2000-08-05 | 2009-11-20 | 抗炎症剤としての6α,9α−ジフルオロ−17α−[(2−フラニルカルボキシル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスト−1,4−ジエン−17−チオカルボン酸S−フルオロメチルエステル |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002518238A Expired - Lifetime JP4436041B2 (ja) | 2000-08-05 | 2001-08-03 | 抗炎症剤としての6α,9α−ジフルオロ−17α−[(2−フラニルカルボキシル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスト−1,4−ジエン−17−チオカルボン酸S−フルオロメチルエステル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009265248A Expired - Lifetime JP5150607B2 (ja) | 2000-08-05 | 2009-11-20 | 抗炎症剤としての6α,9α−ジフルオロ−17α−[(2−フラニルカルボキシル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスト−1,4−ジエン−17−チオカルボン酸S−フルオロメチルエステル |
Country Status (36)
Families Citing this family (220)
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- 2001-08-03 AU AU7649701A patent/AU7649701A/xx active Pending
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- 2001-08-03 EP EP08020059A patent/EP2067784A3/en not_active Withdrawn
- 2001-08-03 CZ CZ20030352A patent/CZ304043B6/cs not_active IP Right Cessation
- 2001-08-03 AT AT01953272T patent/ATE380194T1/de active
- 2001-08-03 PT PT101791044T patent/PT2348032E/pt unknown
- 2001-08-03 SK SK142-2003A patent/SK287576B6/sk not_active IP Right Cessation
- 2001-08-03 AU AU7576001A patent/AU7576001A/xx active Pending
- 2001-08-03 AR ARP010103733A patent/AR032361A1/es unknown
- 2001-08-03 EP EP01954149A patent/EP1305330B1/en not_active Revoked
-
2003
- 2003-01-27 IL IL154148A patent/IL154148A/en active IP Right Grant
- 2003-02-04 BG BG107518A patent/BG66241B1/bg unknown
- 2003-02-04 NO NO20030550A patent/NO20030550L/no unknown
- 2003-02-04 NO NO20030549A patent/NO324747B1/no not_active IP Right Cessation
- 2003-02-05 MA MA27028A patent/MA25899A1/fr unknown
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2007
- 2007-10-22 NO NO20075376A patent/NO333467B1/no not_active IP Right Cessation
- 2007-12-24 IL IL188364A patent/IL188364A/en active IP Right Grant
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2008
- 2008-02-29 CY CY20081100241T patent/CY1107899T1/el unknown
- 2008-04-15 NL NL300343C patent/NL300343I2/nl unknown
- 2008-04-16 LU LU91429C patent/LU91429I2/fr unknown
- 2008-04-17 FR FR08C0014C patent/FR08C0014I2/fr active Active
- 2008-04-23 CY CY200800009C patent/CY2008009I1/el unknown
- 2008-05-28 NO NO2008006C patent/NO2008006I2/no not_active IP Right Cessation
- 2008-07-07 AR ARP080102929A patent/AR063555A1/es not_active Application Discontinuation
- 2008-08-28 US US12/199,991 patent/US20080317833A1/en not_active Abandoned
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2009
- 2009-11-20 JP JP2009265248A patent/JP5150607B2/ja not_active Expired - Lifetime
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2014
- 2014-12-05 CY CY20141101012T patent/CY1116145T1/el unknown
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2015
- 2015-09-28 CY CY20151100853T patent/CY1116845T1/el unknown
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2016
- 2016-03-11 HU HUS1600012C patent/HUS1600012I1/hu unknown
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