HU220624B1 - Eljárás (+)-7-[4-(4-fluor-fenil)-6-izopropil-2-(N-metil-N-metilszulfonil-amino)-pirimidin-5-il]-(3R,5S)-dihidroxi-(E)-6-hepténsav-kalciumsó és ezt tartalmazó gyógyszerkészítmények előállítására - Google Patents

Eljárás (+)-7-[4-(4-fluor-fenil)-6-izopropil-2-(N-metil-N-metilszulfonil-amino)-pirimidin-5-il]-(3R,5S)-dihidroxi-(E)-6-hepténsav-kalciumsó és ezt tartalmazó gyógyszerkészítmények előállítására Download PDF

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Publication number
HU220624B1
HU220624B1 HU0004863A HU0004863A HU220624B1 HU 220624 B1 HU220624 B1 HU 220624B1 HU 0004863 A HU0004863 A HU 0004863A HU 0004863 A HU0004863 A HU 0004863A HU 220624 B1 HU220624 B1 HU 220624B1
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HU
Hungary
Prior art keywords
calcium salt
dihydroxy
isopropyl
methyl
pyrimidin
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HU0004863A
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English (en)
Hungarian (hu)
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HU0004863D0 (OSRAM
Inventor
Kentaro Hirai
Teruyuki Ishiba
Haruo Noike
Masamichi Watanabe
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Shionogi Seiyaku Kabushiki Kaisha
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Application filed by Shionogi Seiyaku Kabushiki Kaisha filed Critical Shionogi Seiyaku Kabushiki Kaisha
Publication of HU0004863D0 publication Critical patent/HU0004863D0/hu
Publication of HU220624B1 publication Critical patent/HU220624B1/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU0004863A 1991-07-01 1992-06-30 Eljárás (+)-7-[4-(4-fluor-fenil)-6-izopropil-2-(N-metil-N-metilszulfonil-amino)-pirimidin-5-il]-(3R,5S)-dihidroxi-(E)-6-hepténsav-kalciumsó és ezt tartalmazó gyógyszerkészítmények előállítására HU220624B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18801591 1991-07-01

Publications (2)

Publication Number Publication Date
HU0004863D0 HU0004863D0 (OSRAM) 2001-02-28
HU220624B1 true HU220624B1 (hu) 2002-03-28

Family

ID=16216169

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0004863A HU220624B1 (hu) 1991-07-01 1992-06-30 Eljárás (+)-7-[4-(4-fluor-fenil)-6-izopropil-2-(N-metil-N-metilszulfonil-amino)-pirimidin-5-il]-(3R,5S)-dihidroxi-(E)-6-hepténsav-kalciumsó és ezt tartalmazó gyógyszerkészítmények előállítására
HU9202179A HU219407B (hu) 1991-07-01 1992-06-30 Eljárás pirimidin-származékok és ezeket tartalmazó gyógyászati készítmények előállítására

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU9202179A HU219407B (hu) 1991-07-01 1992-06-30 Eljárás pirimidin-származékok és ezeket tartalmazó gyógyászati készítmények előállítására

Country Status (18)

Country Link
US (2) US5260440A (OSRAM)
EP (1) EP0521471B1 (OSRAM)
JP (1) JP2648897B2 (OSRAM)
KR (1) KR960005951B1 (OSRAM)
AT (1) ATE197149T1 (OSRAM)
CA (1) CA2072945C (OSRAM)
CL (1) CL2010000113A1 (OSRAM)
CY (2) CY2226B1 (OSRAM)
DE (2) DE122009000017I2 (OSRAM)
DK (1) DK0521471T3 (OSRAM)
ES (1) ES2153824T3 (OSRAM)
GE (1) GEP20022693B (OSRAM)
GR (1) GR3035189T3 (OSRAM)
HU (2) HU220624B1 (OSRAM)
LU (1) LU91042I2 (OSRAM)
NL (1) NL300125I2 (OSRAM)
PT (1) PT521471E (OSRAM)
TW (1) TW203044B (OSRAM)

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