BR0317521A - Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coa - Google Patents
Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coaInfo
- Publication number
- BR0317521A BR0317521A BR0317521-9A BR0317521A BR0317521A BR 0317521 A BR0317521 A BR 0317521A BR 0317521 A BR0317521 A BR 0317521A BR 0317521 A BR0317521 A BR 0317521A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitor
- hmg
- coa reductase
- dosage forms
- cetp
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"FORMAS DE DOSAGEM COMPREENDENDO UM INIBIDOR DA CETP E UM INIBIDOR DA REDUTASE HMG-COA". Esta invenção refere-se a uma forma de dosagem que compreende (1) uma dispersão sólida amorfa compreendendo um inibidor da proteina de transferência do éster da colesterila e um polímero neutro ou acídico neutralizado e (2) um inibidor da redutase HMG-CoA. A forma de dosagem proporciona um aumento da estabilidade química do inibidor da redutase HMG-CoA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43529802P | 2002-12-20 | 2002-12-20 | |
PCT/IB2003/005861 WO2004056358A1 (en) | 2002-12-20 | 2003-12-09 | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0317521A true BR0317521A (pt) | 2005-11-16 |
Family
ID=32682213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0317521-9A BR0317521A (pt) | 2002-12-20 | 2003-12-09 | Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coa |
Country Status (11)
Country | Link |
---|---|
US (1) | US20040185102A1 (pt) |
EP (2) | EP1578415B1 (pt) |
JP (1) | JP2006513186A (pt) |
AT (2) | ATE407670T1 (pt) |
AU (1) | AU2003283769A1 (pt) |
BR (1) | BR0317521A (pt) |
CA (1) | CA2508840A1 (pt) |
DE (2) | DE60323536D1 (pt) |
ES (1) | ES2310676T3 (pt) |
MX (1) | MXPA05005813A (pt) |
WO (1) | WO2004056358A1 (pt) |
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US7700774B2 (en) * | 2004-12-20 | 2010-04-20 | Dr. Reddy's Laboratories Ltd. | Heterocyclic compounds and their pharmaceutical compositions |
WO2006073973A2 (en) | 2004-12-31 | 2006-07-13 | Reddy Us Therapeutics, Inc. | Novel benzylamine derivatives as cetp inhibitors |
US8604055B2 (en) * | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
EP1844078B1 (en) * | 2005-02-03 | 2016-09-28 | Bend Research, Inc | Pharmaceutical compositions with enhanced performance |
US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
US8828438B2 (en) | 2005-05-31 | 2014-09-09 | Bend Research, Inc. | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors and HMG-CoA reductase |
CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
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WO2013178679A2 (de) | 2012-05-30 | 2013-12-05 | Clariant International Ltd. | N-methyl-n-acylglucamin enthaltende zusammensetzung |
CN104540494B (zh) | 2012-05-30 | 2017-10-24 | 科莱恩金融(Bvi)有限公司 | N‑甲基‑n‑酰基葡糖胺作为增溶剂的用途 |
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DE102012021647A1 (de) | 2012-11-03 | 2014-05-08 | Clariant International Ltd. | Wässrige Adjuvant-Zusammensetzungen |
TWI615157B (zh) * | 2013-02-06 | 2018-02-21 | 大塚製藥股份有限公司 | 包括不定形西洛他唑的固體分散劑 |
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DE102016207877A1 (de) | 2016-05-09 | 2017-11-09 | Clariant International Ltd | Stabilisatoren für Silikatfarben |
JP2019131472A (ja) * | 2016-05-31 | 2019-08-08 | 興和株式会社 | 医薬組成物 |
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DE60039377D1 (de) * | 1999-02-09 | 2008-08-21 | Pfizer Prod Inc | Zusammensetzungen basischer Arzneistoffe mit verbesserter Bioverfügbarkeit |
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WO2002100394A1 (en) * | 2001-06-12 | 2002-12-19 | Galephar M/F | Oral pharmaceutical composition containing a statin derivative |
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-
2003
- 2003-12-09 BR BR0317521-9A patent/BR0317521A/pt not_active IP Right Cessation
- 2003-12-09 DE DE60323536T patent/DE60323536D1/de not_active Expired - Fee Related
- 2003-12-09 CA CA002508840A patent/CA2508840A1/en not_active Abandoned
- 2003-12-09 DE DE60331873T patent/DE60331873D1/de not_active Expired - Fee Related
- 2003-12-09 JP JP2004561822A patent/JP2006513186A/ja active Pending
- 2003-12-09 ES ES03775750T patent/ES2310676T3/es not_active Expired - Lifetime
- 2003-12-09 EP EP03775750A patent/EP1578415B1/en not_active Expired - Lifetime
- 2003-12-09 AT AT03775750T patent/ATE407670T1/de not_active IP Right Cessation
- 2003-12-09 WO PCT/IB2003/005861 patent/WO2004056358A1/en active IP Right Grant
- 2003-12-09 AU AU2003283769A patent/AU2003283769A1/en not_active Abandoned
- 2003-12-09 MX MXPA05005813A patent/MXPA05005813A/es unknown
- 2003-12-09 AT AT08157637T patent/ATE461700T1/de not_active IP Right Cessation
- 2003-12-09 EP EP08157637A patent/EP1961419B1/en not_active Expired - Lifetime
- 2003-12-18 US US10/739,750 patent/US20040185102A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2006513186A (ja) | 2006-04-20 |
EP1961419B1 (en) | 2010-03-24 |
AU2003283769A1 (en) | 2004-07-14 |
ATE461700T1 (de) | 2010-04-15 |
EP1961419A1 (en) | 2008-08-27 |
MXPA05005813A (es) | 2005-12-12 |
US20040185102A1 (en) | 2004-09-23 |
DE60331873D1 (de) | 2010-05-06 |
WO2004056358A1 (en) | 2004-07-08 |
EP1578415B1 (en) | 2008-09-10 |
ES2310676T3 (es) | 2009-01-16 |
ATE407670T1 (de) | 2008-09-15 |
EP1578415A1 (en) | 2005-09-28 |
DE60323536D1 (de) | 2008-10-23 |
CA2508840A1 (en) | 2004-07-08 |
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