BR112014016154A8 - funcionalização de biomateriais para controlar respostas à regeneração e inflamação - Google Patents

funcionalização de biomateriais para controlar respostas à regeneração e inflamação

Info

Publication number
BR112014016154A8
BR112014016154A8 BR112014016154A BR112014016154A BR112014016154A8 BR 112014016154 A8 BR112014016154 A8 BR 112014016154A8 BR 112014016154 A BR112014016154 A BR 112014016154A BR 112014016154 A BR112014016154 A BR 112014016154A BR 112014016154 A8 BR112014016154 A8 BR 112014016154A8
Authority
BR
Brazil
Prior art keywords
macrophages
immune cell
compositions
biomaterials
functionalization
Prior art date
Application number
BR112014016154A
Other languages
English (en)
Other versions
BR112014016154A2 (pt
Inventor
Panilaitis Bruce
L Kaplan David
Gallego Llamas Jabier
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Publication of BR112014016154A2 publication Critical patent/BR112014016154A2/pt
Publication of BR112014016154A8 publication Critical patent/BR112014016154A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A61L2300/222—Steroids, e.g. corticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Abstract

resumo funcionalização de biomateriais para controlar respostas à regeneração e inflamação os inventores fornecidos aqui geralmente se referem a composições e métodos para controlar a resposta de células imunes a pelo menos um estímulo ou condição (por exemplo, mas não limitado a, dano ao tecido, um dispositivo implantável e/ou citocina) in vitro ou in vivo. as composições descritas aqui compreendem um biomaterial (por exemplo, uma matriz à base de fibroína da sede) compreendendo pelo menos um agente modulador de célula imune em uma quantidade eficaz para seletivamente alterar o estado de ativação de pelo menos um tipo de células imune (por exemplo, mas não limitados a macrófagos e células dendríticas). consequentemente, em algumas modalidades, as composições e métodos descritos aqui podem ser usados para seletivamente distorcer macrófagos em fenótipo m1 e/ou fenótipo m2 e assim controlar as respostas inflamatórias e/ou regenerativas dos macrófagos, por exemplo, reparar e/ou regenerar um tecido alvo.
BR112014016154A 2011-12-29 2012-12-31 funcionalização de biomateriais para controlar respostas à regeneração e inflamação BR112014016154A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161581364P 2011-12-29 2011-12-29
PCT/US2012/072275 WO2013102193A1 (en) 2011-12-29 2012-12-31 Functionalization of biomaterials to control regeneration and inflammation responses

Publications (2)

Publication Number Publication Date
BR112014016154A2 BR112014016154A2 (pt) 2017-06-13
BR112014016154A8 true BR112014016154A8 (pt) 2017-07-04

Family

ID=48698691

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016154A BR112014016154A8 (pt) 2011-12-29 2012-12-31 funcionalização de biomateriais para controlar respostas à regeneração e inflamação

Country Status (7)

Country Link
US (1) US20150010630A1 (pt)
EP (1) EP2797641B1 (pt)
KR (1) KR20140108705A (pt)
BR (1) BR112014016154A8 (pt)
CA (1) CA2865796A1 (pt)
HK (1) HK1201761A1 (pt)
WO (1) WO2013102193A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201113856D0 (en) * 2011-08-11 2011-09-28 Oxford Biomaterials Ltd Medical device
AU2014308724A1 (en) * 2013-08-22 2016-03-10 Allergan, Inc. Implantable medical devices
US20160199450A1 (en) * 2013-08-26 2016-07-14 The Trustees Of Columbia University In The City Of New York Scaffolds containing cytokines for tissue engineering
US10925999B2 (en) * 2013-10-08 2021-02-23 Trustees Of Tufts College Tunable covalently crosslinked hydrogels and methods of making the same
WO2015077401A1 (en) * 2013-11-20 2015-05-28 Drexel University Compositions and methods for macrophage conversion
US9833474B2 (en) 2013-11-26 2017-12-05 Biomet Biologies, LLC Methods of mediating macrophage phenotypes
GB201415681D0 (en) 2014-09-04 2014-10-22 Cambridge Entpr Ltd And President And Fellows Of Harvard College Protien Capsules
US20180326080A1 (en) * 2015-10-27 2018-11-15 Purdue Research Foundation Polymer-based therapeutics for inductive browning of fat
US11617815B2 (en) 2016-10-31 2023-04-04 Sofregen Medical, Inc. Compositions comprising silk fibroin particles and uses thereof
WO2018095264A1 (zh) * 2016-11-22 2018-05-31 陈艳丽 Notch信号通路调控剂调节骨生成
US20200054796A1 (en) * 2017-02-21 2020-02-20 Trustees Of Tufts College Silk Fibroin Tracheal Stent
US20210121606A1 (en) * 2017-05-26 2021-04-29 Association For The Advancement Of Tissue Engineering Cell Based Technologies & Theapies (A4Tec) Ionic-doped composition methods and uses thereof
WO2019094702A1 (en) 2017-11-10 2019-05-16 Cocoon Biotech Inc. Ocular applications of silk-based products
US11773533B2 (en) * 2017-12-05 2023-10-03 Università degli Studi di Roma “La Sapienza” Composition for use in the finishing, preservation, restoration of manufactures
CN112203690A (zh) * 2018-01-12 2021-01-08 哈佛大学校长及研究员协会 与具有粘附颗粒的巨噬细胞和/或单核细胞有关的组合物和方法
WO2021076798A1 (en) 2019-10-15 2021-04-22 Sofregen Medical, Inc. Delivery devices for delivering and methods of delivering compositions
CN111888522B (zh) * 2020-09-22 2022-12-20 中山大学附属口腔医院 一种具有免疫调控功能的牙周再生材料及其制备方法
CN112451732A (zh) * 2020-11-27 2021-03-09 山东大学 一种单侧负载银的丝素蛋白抗菌敷料及制备方法和应用
CN115487350B (zh) * 2021-06-17 2023-10-31 中国科学院苏州纳米技术与纳米仿生研究所 一种调节免疫炎症微环境水凝胶支架及其制备方法和应用
CN113813445A (zh) * 2021-10-08 2021-12-21 苏州大学 一种丝素蛋白复合多孔支架及其制备方法

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (pt) 1974-06-07 1981-03-18
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
AU548996B2 (en) 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
AU570021B2 (en) 1982-11-22 1988-03-03 Novartis Ag Analogs of mevalolactone
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
JP2569746B2 (ja) 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
US5753675A (en) 1989-03-03 1998-05-19 Novartis Pharmaceuticals Corporation Quinoline analogs of mevalonolactone and derivatives thereof
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5245012A (en) 1990-04-19 1993-09-14 The United States Of America As Represented By The Secretary Of The Army Method to achieve solubilization of spider silk proteins
US5177080A (en) 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
EP0617706B1 (en) 1991-11-25 2001-10-17 Enzon, Inc. Multivalent antigen-binding proteins
WO1996013275A1 (en) * 1994-10-31 1996-05-09 Tkb Associates Limited Partnership Methods and products for enhancing immune responses
CN1200145A (zh) 1995-08-22 1998-11-25 阿格里科拉技术有限公司 高强度蛛丝蛋白的克隆方法
US6841543B1 (en) * 1996-01-31 2005-01-11 President And Fellows Of Harvard College Methods of inhibiting production of T helper type 2 cytokines in human immune cells
JP2990239B2 (ja) 1997-06-18 1999-12-13 農林水産省蚕糸・昆虫農業技術研究所長 絹フィブロインおよび絹セリシンを主成分とする創傷被覆材並びにその製造方法
US6287340B1 (en) 1999-05-14 2001-09-11 Trustees Of Tufts College Bioengineered anterior cruciate ligament
JP2001163899A (ja) 1999-12-09 2001-06-19 Natl Inst Of Sericultural & Entomological Science 機能性絹フィブロインの製造方法とその利用
US20110009960A1 (en) 2001-11-16 2011-01-13 Allergan, Inc. Prosthetic fabric structure
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
WO2004001103A2 (en) 2002-06-24 2003-12-31 Tufts University Silk biomaterials and methods of use thereof
JP4638735B2 (ja) 2002-06-24 2011-02-23 タフツ ユニバーシティー 絹糸生体材料およびその使用方法
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
EP1613796B1 (en) 2003-04-10 2017-03-22 Tufts University Concentrated aqueous silk fibroin solution and use thereof
WO2005000483A1 (en) 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
WO2005123114A2 (en) 2004-06-11 2005-12-29 Trustees Of Tufts College Silk-based drug delivery system
US20080280360A1 (en) 2004-10-12 2008-11-13 Trustees Of Tufts College Method for Producing Biomaterial Scaffolds
WO2006076711A2 (en) 2005-01-14 2006-07-20 Trustees Of Tufts College Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials
US9290579B2 (en) 2005-04-20 2016-03-22 Trustees Of Tufts College Covalently immobilized protein gradients in three-dimensional porous scaffolds
CA2645934C (en) 2005-08-02 2014-04-29 Trustees Of Tufts College Methods for stepwise deposition of silk fibroin coatings
US20080038236A1 (en) 2006-03-06 2008-02-14 Artecel Sciences, Inc. Biocompatible scaffolds and adipose-derived stem cells
US20100028451A1 (en) * 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
WO2008140562A2 (en) 2006-11-03 2008-11-20 Trustees Of Tufts College Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same
US20100068740A1 (en) 2006-11-03 2010-03-18 Trustees Of Tufts College Microfluidic device with a cylindrical microchannel and a method for fabricating same
WO2008127402A2 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
US20100046902A1 (en) 2006-11-03 2010-02-25 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
JP2010509645A (ja) 2006-11-03 2010-03-25 トラスティーズ オブ タフツ カレッジ ナノパターンが形成されたバイオポリマー光学デバイスおよびその製造方法
WO2008108838A2 (en) 2006-11-21 2008-09-12 Charles Stark Draper Laboratory, Inc. Microfluidic devices and methods for fabricating the same
US20120223293A1 (en) 2007-01-05 2012-09-06 Borenstein Jeffrey T Biodegradable Electronic Devices
CA2678618C (en) * 2007-02-21 2019-03-12 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cd1d molecules
JP2010522583A (ja) 2007-02-27 2010-07-08 トラスティーズ オブ タフツ カレッジ 組織工学的に作製された絹製臓器
EP2211876B1 (en) 2007-05-29 2014-10-01 Trustees Of Tufts College Method for silk fibroin gelation using sonication
WO2009061823A1 (en) 2007-11-05 2009-05-14 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
US20110218143A1 (en) * 2007-11-20 2011-09-08 University Of Florida Research Foundation Compositions and methods for tissue repair
WO2009100280A2 (en) 2008-02-07 2009-08-13 Trustees Of Tufts College 3-dimensional silk hydroxyapatite compositions
US8206774B2 (en) 2008-03-13 2012-06-26 Trustees Of Tufts College Diazonium salt modification of silk polymer
WO2009126689A2 (en) 2008-04-08 2009-10-15 Trustees Of Tufts College System and method for making biomaterial structures
US20110135697A1 (en) 2008-06-18 2011-06-09 Trustees Of Tufts College Edible holographic silk products
US8976938B2 (en) * 2008-07-07 2015-03-10 Centurylink Intellectual Property Llc Deluxe emergency notification
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
BRPI0920453A2 (pt) 2008-10-09 2015-12-22 Tufts College pelicula de seda, construção para engenharia de tecido, metodos para preparar uma película de seda, para cobrir uma superfície de um substrato com uma composição de seda, e para embutir pelo menos um agente ativo em uma película de seda, e, substrato coberto com película de sedal
WO2010057142A2 (en) 2008-11-17 2010-05-20 Trustees Of Tufts College Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti adhesion barriers and anti thrombotic materials
JP5653931B2 (ja) 2008-12-15 2015-01-14 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 補綴デバイスおよびその製作方法
CA2791580C (en) * 2009-03-04 2017-12-05 Trustees Of Tufts College Silk fibroin systems for antibiotic delivery
US20110111031A1 (en) 2009-04-20 2011-05-12 Guang-Liang Jiang Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof
EP2421551B2 (en) 2009-04-20 2020-07-15 Allergan, Inc. Silk fibroin hydrogels and uses thereof
US20110052695A1 (en) 2009-04-20 2011-03-03 Allergan, Inc. Drug delivery platforms comprising silk fibroin hydrogels and uses thereof
US20120070427A1 (en) 2009-06-01 2012-03-22 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
CA2805403A1 (en) 2009-07-10 2011-01-13 Trustees Of Tufts College Bioengineered silk protein-based nucleic acid delivery systems
US8293486B2 (en) 2009-07-21 2012-10-23 Trustees Of Tufts College Functionalization of silk material by avidin-biotin interaction
NZ598691A (en) 2009-09-11 2014-05-30 Allergan Inc Prosthetic device and method of manufacturing the same
CN101891962B (zh) * 2010-07-22 2012-06-06 苏州大学 丝素蛋白多孔三维材料的制备方法
JP2013542181A (ja) 2010-09-03 2013-11-21 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ プラズモンナノ粒子ドープ絹材料
US20140378661A1 (en) 2011-04-20 2014-12-25 Trustees Of Tufts College Molded regenerated silk geometries using temperature control and mechanical processing

Also Published As

Publication number Publication date
CA2865796A1 (en) 2013-07-04
EP2797641B1 (en) 2019-07-10
HK1201761A1 (en) 2015-09-11
US20150010630A1 (en) 2015-01-08
EP2797641A4 (en) 2015-07-29
KR20140108705A (ko) 2014-09-12
EP2797641A1 (en) 2014-11-05
BR112014016154A2 (pt) 2017-06-13
WO2013102193A1 (en) 2013-07-04

Similar Documents

Publication Publication Date Title
BR112014016154A8 (pt) funcionalização de biomateriais para controlar respostas à regeneração e inflamação
Sridharan et al. Macrophage polarization in response to collagen scaffold stiffness is dependent on cross-linking agent used to modulate the stiffness
Philippou et al. Cytokines in muscle damage
BR112014026090A2 (pt) composição de matriz tecidual apta a fluir, estojo, método de fabricação de uma composição de matriz tecidual apta a fluir, método de tratamento, e uso da composição de matriz tecidual apta a fluir
AU2018256656A1 (en) Activation of the Endogenous Ileal Brake Hormone Pathway for Organ regeneration and related Compositions, Methods of Treatment, Diagnostics and Regulatory Systems
Diercke et al. IL-1β and compressive forces lead to a significant induction of RANKL-expression in primary human cementoblasts.
MX2021003552A (es) Dispositivos implantables para terapia celular y metodos relacionados.
BR112017010490A2 (pt) roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano.
WO2010039823A3 (en) Compositions and methods for tissue repair with extracellular matrices
CO2019011450A2 (es) Expresión transgénica selectiva de tejidos
WO2008116157A3 (en) Mesenchymal stem cells and uses therefor
BR112013002298A2 (pt) complexação de ácidos nucleicos com componentes catiônicos reticulados com dissulfeto para transfecção e estimulação imunológica.
BR112015017174A2 (pt) preparação de enxertos de nervo de tecido manipulado com matriz extracelular modificada para reparo de lesão de nervo periférico
EP2243826A3 (en) Mesenchymal stem cells and uses therefor
MX2019014912A (es) Composiciones de injerto tipo parche para injerto de células.
AR080219A1 (es) Productos de membranas corionicas inmunocompatibles
WO2012002986A3 (en) Decellularized and delipidized extracellular matrix and methods of use
WO2013188336A3 (en) Bioactive bone graft substitutes
Xing et al. Effects of various decellularization methods on histological and biomechanical properties of rabbit tendons
King et al. Interleukin-10 regulates fetal extracellular matrix hyaluronan production
BR112015008925A2 (pt) preservação de propriedades de biomaterial e métodos de armazenamento
WO2019113373A3 (en) Products and methods for assessing and increasing klotho protein levels
Gerhke et al. Potential of the use of an antioxidant compound to promote peripheral nerve regeneration after injury
Umashankar et al. Long‐term healing of mildly cross‐linked decellularized bovine pericardial aortic patch
Moura et al. Cytotoxicity of bovine and porcine collagen membranes in mononuclear cells

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2495 DE 30-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]