MX2019014912A - Composiciones de injerto tipo parche para injerto de células. - Google Patents

Composiciones de injerto tipo parche para injerto de células.

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Publication number
MX2019014912A
MX2019014912A MX2019014912A MX2019014912A MX2019014912A MX 2019014912 A MX2019014912 A MX 2019014912A MX 2019014912 A MX2019014912 A MX 2019014912A MX 2019014912 A MX2019014912 A MX 2019014912A MX 2019014912 A MX2019014912 A MX 2019014912A
Authority
MX
Mexico
Prior art keywords
cells
tissue
graft
compositions
organ
Prior art date
Application number
MX2019014912A
Other languages
English (en)
Inventor
Lola M Reid
Wencheng Zhang
Eliane Wauthier
Original Assignee
Univ North Carolina Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina Chapel Hill filed Critical Univ North Carolina Chapel Hill
Publication of MX2019014912A publication Critical patent/MX2019014912A/es

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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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  • Cardiology (AREA)

Abstract

Se proporcionan composiciones y metodos para trasplantar celulas mediante estrategias de injerto en órganos sólidos; estos metodos y composiciones pueden usarse para reparar órganos enfermos o para establecer modelos de estados de enfermedad en huéspedes experimentales. el metodo implica la unión en la superficie de un tejido u órgano, un injerto tipo parche, un revestimiento "similar a un vendaje", que contiene celulas epiteliales con celulas mesenquimales en etapa temprana de linaje; las celulas se incorporan en biomateriales formadores de gel preparados bajo condiciones definidas, libres de suero que colectivamente soportan el estado estaminal de las celulas donantes; el injerto está revestido con un soporte biodegradable, biocompatible, bioerosionable que se usa para fijar el injerto al sitio diana; las celulas en el injerto migran a y a lo largo del tejido de manera que dentro de las dos semanas estas se dispersan uniformemente dentro del tejido receptor (huésped); los mecanismos mediante los cuales el injerto e integración de las celulas donantes en el órgano o tejido implican múltiples formas de las MMP asociadas a membranas y secretadas.
MX2019014912A 2017-06-12 2018-06-11 Composiciones de injerto tipo parche para injerto de células. MX2019014912A (es)

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