BR112012017463A2 - constructos de tecido de bioengenharia e métodos para sua produção e uso - Google Patents

constructos de tecido de bioengenharia e métodos para sua produção e uso

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Publication number
BR112012017463A2
BR112012017463A2 BR112012017463A BR112012017463A BR112012017463A2 BR 112012017463 A2 BR112012017463 A2 BR 112012017463A2 BR 112012017463 A BR112012017463 A BR 112012017463A BR 112012017463 A BR112012017463 A BR 112012017463A BR 112012017463 A2 BR112012017463 A2 BR 112012017463A2
Authority
BR
Brazil
Prior art keywords
production
methods
bioengineered
extracellular matrix
constructs
Prior art date
Application number
BR112012017463A
Other languages
English (en)
Inventor
Dolores Baksh
Esin Yesilalan
Lan Cao
Matthew Quin-Men Wong
Parid Sava
Thomas Bollenbach
Vincent Ronfard
Xianyan Wang
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Publication of BR112012017463A2 publication Critical patent/BR112012017463A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
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    • C12N5/0602—Vertebrate cells
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  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
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  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
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Abstract

constructos de tecido de bioengenharia e métodos para sua produção e uso a presente invenção se refere a constructos de bioengenharia que são formados a partir de células cultivadas induzidas para sintetizar e secretar componentes da matriz extracelular endogenamente produzida sem o requisito de componentes da matriz exógena ou suporte de rede ou membros de estrutura. os constructos de bioengenharia da invenção podem ser produzidos com múltiplos tipos de célula que podem todos contribuir para produzir a matriz extracelular. adicionalmente ou alternativamente, um dos múltiplos tipos de células pode ser distribuído em um local no corpo através dos componentes da matriz extracelular endogenamente produzida para alcançar vários benefícios terapêuticos.
BR112012017463A 2010-01-14 2011-01-14 constructos de tecido de bioengenharia e métodos para sua produção e uso BR112012017463A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29507310P 2010-01-14 2010-01-14
US33793810P 2010-02-12 2010-02-12
US34772510P 2010-05-24 2010-05-24
PCT/US2011/021362 WO2011088365A1 (en) 2010-01-14 2011-01-14 Bioengineered tissue constructs and methods for producing and using thereof

Publications (1)

Publication Number Publication Date
BR112012017463A2 true BR112012017463A2 (pt) 2015-09-15

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BR112012017463A BR112012017463A2 (pt) 2010-01-14 2011-01-14 constructos de tecido de bioengenharia e métodos para sua produção e uso

Country Status (12)

Country Link
US (1) US20110293667A1 (pt)
EP (1) EP2524034A1 (pt)
JP (3) JP2013517292A (pt)
CN (2) CN107802890A (pt)
AU (1) AU2011205674A1 (pt)
BR (1) BR112012017463A2 (pt)
CA (1) CA2787050A1 (pt)
IL (1) IL220903A0 (pt)
MX (1) MX354068B (pt)
RU (1) RU2645473C2 (pt)
SG (1) SG182508A1 (pt)
WO (1) WO2011088365A1 (pt)

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