HK1212693A1 - 作為溴結構域抑制劑的新的雜環化合物 - Google Patents

作為溴結構域抑制劑的新的雜環化合物

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Publication number
HK1212693A1
HK1212693A1 HK16100603.1A HK16100603A HK1212693A1 HK 1212693 A1 HK1212693 A1 HK 1212693A1 HK 16100603 A HK16100603 A HK 16100603A HK 1212693 A1 HK1212693 A1 HK 1212693A1
Authority
HK
Hong Kong
Prior art keywords
heterocyclic compounds
novel heterocyclic
bromodomain inhibitors
bromodomain
inhibitors
Prior art date
Application number
HK16100603.1A
Other languages
English (en)
Inventor
Shuang Liu
Bryan Cordell Duffy
John Frederick Quinn
May Xiaowu Jiang
Ruifang Wang
Gregory Scott Martin
He Zhao
Bruce Francis Molino
Peter Ronald Young
Original Assignee
Zenith Epigenetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenith Epigenetics Corp filed Critical Zenith Epigenetics Corp
Publication of HK1212693A1 publication Critical patent/HK1212693A1/zh

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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US20140179648A1 (en) 2014-06-26
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