ATE445400T1 - Hydantion-derivate als hemmer von matrix- metalloproteinasen - Google Patents

Hydantion-derivate als hemmer von matrix- metalloproteinasen

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Publication number
ATE445400T1
ATE445400T1 AT02741724T AT02741724T ATE445400T1 AT E445400 T1 ATE445400 T1 AT E445400T1 AT 02741724 T AT02741724 T AT 02741724T AT 02741724 T AT02741724 T AT 02741724T AT E445400 T1 ATE445400 T1 AT E445400T1
Authority
AT
Austria
Prior art keywords
inhibitors
matrix metalloproteinases
derivatives
hydantion
aggrecanase
Prior art date
Application number
AT02741724T
Other languages
English (en)
Inventor
James Sheppeck
Jingwu Duan
Chu-Biao Xue
Zelda Wasserman
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23129620&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE445400(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE445400T1 publication Critical patent/ATE445400T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C—CHEMISTRY; METALLURGY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AT02741724T 2001-05-25 2002-05-23 Hydantion-derivate als hemmer von matrix- metalloproteinasen ATE445400T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29357101P 2001-05-25 2001-05-25
PCT/US2002/016381 WO2002096426A1 (en) 2001-05-25 2002-05-23 Hydantion derivatives as inhibitors of matrix metalloproteinases

Publications (1)

Publication Number Publication Date
ATE445400T1 true ATE445400T1 (de) 2009-10-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT02741724T ATE445400T1 (de) 2001-05-25 2002-05-23 Hydantion-derivate als hemmer von matrix- metalloproteinasen

Country Status (8)

Country Link
US (3) US6890915B2 (de)
EP (1) EP1397137B1 (de)
JP (1) JP2004535411A (de)
AT (1) ATE445400T1 (de)
CA (1) CA2447475A1 (de)
DE (1) DE60234028D1 (de)
ES (1) ES2333412T3 (de)
WO (1) WO2002096426A1 (de)

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AU2001288213B2 (en) * 2000-06-28 2005-04-14 Bristol-Myers Squibb Company Selective androgen receptor modulators and methods for their identification, design and use
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
CN1596253A (zh) 2001-10-01 2005-03-16 布里斯托尔-迈尔斯斯奎布公司 用作抗炎药的螺－乙内酰脲化合物
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
JP2006502113A (ja) * 2002-07-17 2006-01-19 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー マトリックス・メタロプロテイナーゼ−１３アロステリック阻害剤と、セレコキシブ又はバルデコキシブでないシクロオキシゲナーゼ−２選択的阻害剤との複合体
MXPA05000754A (es) * 2002-07-17 2005-04-19 Warner Lambert Co Combinacion de un inhibidor carboxilico alosterico de la metaloproteinasa de matriz-13 con celecoxib o valdecoxib.
EP1536786A1 (de) * 2002-07-17 2005-06-08 Warner-Lambert Company Llc Kombination eines allosterischen hemmers von matrix-metalloproteinase-13 mit celecoxib oder valdecoxib
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
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