BR9707425A - Composto processo terapêutico para inibir o crescimento de células cancerosas e processo para utilizar o composto - Google Patents
Composto processo terapêutico para inibir o crescimento de células cancerosas e processo para utilizar o compostoInfo
- Publication number
- BR9707425A BR9707425A BR9707425A BR9707425A BR9707425A BR 9707425 A BR9707425 A BR 9707425A BR 9707425 A BR9707425 A BR 9707425A BR 9707425 A BR9707425 A BR 9707425A BR 9707425 A BR9707425 A BR 9707425A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- inhibit
- growth
- cancer cells
- therapeutic process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1145296P | 1996-02-12 | 1996-02-12 | |
US3216196P | 1996-10-01 | 1996-10-01 | |
PCT/US1997/001676 WO1997029106A1 (en) | 1996-02-12 | 1997-02-11 | Coralyne analogs as topoisomerase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9707425A true BR9707425A (pt) | 1999-07-20 |
Family
ID=26682407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9707425A BR9707425A (pt) | 1996-02-12 | 1997-02-11 | Composto processo terapêutico para inibir o crescimento de células cancerosas e processo para utilizar o composto |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0888346B1 (pt) |
JP (1) | JP2000504687A (pt) |
KR (1) | KR19990082488A (pt) |
CN (1) | CN1067070C (pt) |
AU (1) | AU710070C (pt) |
BR (1) | BR9707425A (pt) |
CA (1) | CA2241551A1 (pt) |
CZ (1) | CZ254498A3 (pt) |
DE (1) | DE69705112T2 (pt) |
ES (1) | ES2161442T3 (pt) |
HU (1) | HUP9900413A3 (pt) |
IL (1) | IL124803A0 (pt) |
NO (1) | NO983669L (pt) |
NZ (1) | NZ330705A (pt) |
PL (1) | PL328402A1 (pt) |
PT (1) | PT888346E (pt) |
TR (1) | TR199801555T2 (pt) |
WO (1) | WO1997029106A1 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW460464B (en) * | 1996-11-25 | 2001-10-21 | Nippon Kayaku Kk | Novel phenanthridinium derivative having an anti-tumor activity and pharmaceutical composition containing the same |
US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
IL137351A0 (en) | 1998-02-12 | 2001-07-24 | Univ Rutgers | Heterocyclic topoisomerase poisons |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
CN1093129C (zh) * | 1999-08-19 | 2002-10-23 | 广州市海科生物技术有限公司 | 一种具有抗肿瘤生理活性的尖叶唐松草阿原碱及其提取方法 |
US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
WO2003047505A2 (en) | 2001-11-14 | 2003-06-12 | Rutgers, The State University | Topoisomerase poison agents |
KR20050044491A (ko) | 2001-11-14 | 2005-05-12 | 루트거스, 더 스테이트 유니버시티 | 가용화된 토포이소머라제 독 |
CA2467279A1 (en) | 2001-11-14 | 2003-06-26 | Edmond J. Lavoie | Solubilized topoisomerase poison agents |
AU2003268075A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
AU2003265406A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
WO2004014862A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
JP4774212B2 (ja) | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
US8410109B2 (en) | 2005-07-29 | 2013-04-02 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
NZ579355A (en) | 2007-02-01 | 2012-03-30 | Resverlogix Corp | 2-(Aryl)-4-oxo-quinazoline derivatives |
EP2014651A1 (en) * | 2007-07-12 | 2009-01-14 | Exonhit Therapeutics SA | Compounds and methods for modulating Rho GTPases |
ES2532402T3 (es) | 2008-06-26 | 2015-03-26 | Resverlogix Corporation | Métodos de preparación de derivados de quinazolinona |
ES2463097T3 (es) | 2009-01-08 | 2014-05-27 | Resverlogix Corp. | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
EP2403856B1 (en) | 2009-03-06 | 2012-12-19 | Rutgers, The State University of New Jersey | Methylenedioxybenzo [i]phenanthridine derivatives used to treat cancer |
CA2992231C (en) | 2009-03-18 | 2022-03-29 | Resverlogix Corp. | Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents |
PL2421533T3 (pl) | 2009-04-22 | 2019-05-31 | Resverlogix Corp | Nowe środki przeciwzapalne |
WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
US8188109B2 (en) * | 2009-07-20 | 2012-05-29 | Naxospharma S.R.L. | Benzoquinolizinium salt derivatives as anticancer agents |
CN102746292B (zh) * | 2011-04-18 | 2015-03-18 | 中国医学科学院医药生物技术研究所 | 环化的小檗碱衍生物及其制备方法和用途 |
KR102011641B1 (ko) | 2011-11-01 | 2019-08-19 | 리스버로직스 코퍼레이션 | 치환된 퀴나졸리논을 위한 경구 즉시 방출 제형 |
US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
EP2935253B1 (en) | 2012-12-21 | 2018-08-01 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
WO2014144097A1 (en) * | 2013-03-15 | 2014-09-18 | Georgetown University | Antifungal drugs |
JP6559132B2 (ja) | 2013-08-23 | 2019-08-14 | ニューファーマ, インコーポレイテッド | ある特定の化学的実体、組成物および方法 |
EP3270694A4 (en) * | 2015-02-17 | 2018-09-05 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
JP6903585B2 (ja) | 2015-03-13 | 2021-07-14 | レスバーロジックス コーポレイション | 補体関連疾患の治療のための組成物および治療方法 |
CN105541714A (zh) * | 2015-12-16 | 2016-05-04 | 浙江普洛康裕制药有限公司 | 一种罂粟碱及盐酸罂粟碱的制备方法 |
JP2019515025A (ja) | 2016-04-04 | 2019-06-06 | ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー | トポイソメラーゼ毒 |
CA3033370A1 (en) | 2016-08-15 | 2018-02-22 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
CN110759963A (zh) * | 2018-07-25 | 2020-02-07 | 中山大学 | 一种稠环类化合物及其制备方法和用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
-
1997
- 1997-02-11 AU AU21155/97A patent/AU710070C/en not_active Ceased
- 1997-02-11 IL IL12480397A patent/IL124803A0/xx unknown
- 1997-02-11 WO PCT/US1997/001676 patent/WO1997029106A1/en not_active Application Discontinuation
- 1997-02-11 BR BR9707425A patent/BR9707425A/pt unknown
- 1997-02-11 TR TR1998/01555T patent/TR199801555T2/xx unknown
- 1997-02-11 KR KR1019980706221A patent/KR19990082488A/ko not_active Application Discontinuation
- 1997-02-11 PT PT97906466T patent/PT888346E/pt unknown
- 1997-02-11 CN CN97192211A patent/CN1067070C/zh not_active Expired - Fee Related
- 1997-02-11 CA CA002241551A patent/CA2241551A1/en not_active Abandoned
- 1997-02-11 PL PL97328402A patent/PL328402A1/xx unknown
- 1997-02-11 CZ CZ982544A patent/CZ254498A3/cs unknown
- 1997-02-11 HU HU9900413A patent/HUP9900413A3/hu unknown
- 1997-02-11 EP EP97906466A patent/EP0888346B1/en not_active Expired - Lifetime
- 1997-02-11 JP JP9528606A patent/JP2000504687A/ja active Pending
- 1997-02-11 NZ NZ330705A patent/NZ330705A/en unknown
- 1997-02-11 ES ES97906466T patent/ES2161442T3/es not_active Expired - Lifetime
- 1997-02-11 DE DE69705112T patent/DE69705112T2/de not_active Expired - Fee Related
-
1998
- 1998-08-11 NO NO983669A patent/NO983669L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP9900413A2 (hu) | 1999-05-28 |
CA2241551A1 (en) | 1997-08-14 |
JP2000504687A (ja) | 2000-04-18 |
ES2161442T3 (es) | 2001-12-01 |
NO983669L (no) | 1998-09-23 |
AU2115597A (en) | 1997-08-28 |
DE69705112D1 (en) | 2001-07-12 |
WO1997029106A1 (en) | 1997-08-14 |
CN1067070C (zh) | 2001-06-13 |
NO983669D0 (no) | 1998-08-11 |
EP0888346A1 (en) | 1999-01-07 |
DE69705112T2 (de) | 2002-03-21 |
KR19990082488A (ko) | 1999-11-25 |
EP0888346B1 (en) | 2001-06-06 |
NZ330705A (en) | 2000-03-27 |
CZ254498A3 (cs) | 1998-12-16 |
PT888346E (pt) | 2001-10-31 |
AU710070B2 (en) | 1999-09-16 |
TR199801555T2 (xx) | 1998-11-23 |
AU710070C (en) | 2001-08-30 |
HUP9900413A3 (en) | 2002-02-28 |
PL328402A1 (en) | 1999-01-18 |
IL124803A0 (en) | 1999-01-26 |
CN1211252A (zh) | 1999-03-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |