ZA935111B
(en)
*
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
ZA935110B
(en)
*
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
GB9307491D0
(en)
*
|
1993-04-08 |
1993-06-02 |
Sandoz Ltd |
Organic compounds
|
USRE40596E1
(en)
*
|
1993-04-08 |
2008-12-02 |
Novartis Ag |
Rapamycin assay
|
US7279561B1
(en)
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
DE69435044T2
(de)
|
1993-04-23 |
2008-09-18 |
Wyeth |
Rapamycin - Konjugate und Antikörper
|
USRE37421E1
(en)
|
1993-07-16 |
2001-10-23 |
Smithkline Beecham Corporation |
Rapamycin derivatives
|
DK1033128T4
(da)
*
|
1993-09-28 |
2012-03-19 |
Scherer Gmbh R P |
Blød gelatinekapselfremstilling
|
WO1995014023A1
(en)
*
|
1993-11-19 |
1995-05-26 |
Abbott Laboratories |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
US5527907A
(en)
*
|
1993-11-19 |
1996-06-18 |
Abbott Laboratories |
Macrolide immunomodulators
|
JP3745772B2
(ja)
*
|
1993-12-17 |
2006-02-15 |
ノバルティス アクチエンゲゼルシャフト |
免疫抑制剤として有用なラパマイシン誘導体
|
GB9405350D0
(en)
*
|
1994-03-18 |
1994-05-04 |
Sandoz Ltd |
Organic compounds
|
IL115742A
(en)
|
1994-10-26 |
2000-06-01 |
Novartis Ag |
Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant
|
US7205279B2
(en)
*
|
1995-10-25 |
2007-04-17 |
Novartis Ag |
Pharmaceutical compositions
|
KR100434682B1
(ko)
*
|
1994-10-26 |
2004-08-18 |
노바티스 아게 |
약학조성물
|
US5561138A
(en)
*
|
1994-12-13 |
1996-10-01 |
American Home Products Corporation |
Method of treating anemia
|
GB9618952D0
(en)
*
|
1996-09-11 |
1996-10-23 |
Sandoz Ltd |
Process
|
US6187757B1
(en)
|
1995-06-07 |
2001-02-13 |
Ariad Pharmaceuticals, Inc. |
Regulation of biological events using novel compounds
|
DK0833828T3
(da)
*
|
1995-06-09 |
2003-03-17 |
Novartis Ag |
Rapamycinderivater
|
BE1009856A5
(fr)
*
|
1995-07-14 |
1997-10-07 |
Sandoz Sa |
Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
|
US5780462A
(en)
*
|
1995-12-27 |
1998-07-14 |
American Home Products Corporation |
Water soluble rapamycin esters
|
GB9601120D0
(en)
*
|
1996-01-19 |
1996-03-20 |
Sandoz Ltd |
Organic compounds
|
KR100616020B1
(ko)
*
|
1996-03-27 |
2007-01-31 |
노파르티스 아게 |
맥관장애및이종이식술에서의라파마이신유도체의용도
|
GB9606452D0
(en)
*
|
1996-03-27 |
1996-06-05 |
Sandoz Ltd |
Organic compounds
|
CA2261666C
(en)
|
1996-07-30 |
2010-09-14 |
Novartis Ag |
Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin
|
US5922730A
(en)
*
|
1996-09-09 |
1999-07-13 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
JP2001500126A
(ja)
*
|
1996-09-09 |
2001-01-09 |
アメリカン・ホーム・プロダクツ・コーポレイション |
アルキル化ラパマイシン誘導体
|
GB9624038D0
(en)
*
|
1996-11-19 |
1997-01-08 |
Sandoz Ltd |
Organic compounds
|
US6306166B1
(en)
*
|
1997-08-13 |
2001-10-23 |
Scimed Life Systems, Inc. |
Loading and release of water-insoluble drugs
|
RU2214244C9
(ru)
*
|
1998-03-26 |
2020-07-29 |
Астеллас Фарма Инк. |
Препараты с замедленным высвобождением
|
US20050031611A1
(en)
*
|
1998-05-08 |
2005-02-10 |
Beth Israel Deaconess Medical Center |
Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis
|
AU5487499A
(en)
*
|
1998-08-17 |
2000-03-06 |
American Home Products Corporation |
Photocyclized rapamycins
|
US6015809A
(en)
*
|
1998-08-17 |
2000-01-18 |
American Home Products Corporation |
Photocyclized rapamycin
|
GB9826882D0
(en)
|
1998-12-07 |
1999-01-27 |
Novartis Ag |
Organic compounds
|
US7276506B2
(en)
*
|
1998-12-28 |
2007-10-02 |
4 Aza Bioscience Nv |
Immunosuppressive effects of pteridine derivatives
|
US6946465B2
(en)
*
|
1999-02-02 |
2005-09-20 |
4 Aza Bioscience Nv |
Immunosuppressive effects of pteridine derivatives
|
US7063857B1
(en)
|
1999-04-30 |
2006-06-20 |
Sucampo Ag |
Use of macrolide compounds for the treatment of dry eye
|
AU4565000A
(en)
|
1999-05-10 |
2000-11-21 |
Novartis Ag |
Organic compounds
|
US6331547B1
(en)
|
1999-08-18 |
2001-12-18 |
American Home Products Corporation |
Water soluble SDZ RAD esters
|
AU6643200A
(en)
*
|
1999-08-18 |
2001-03-13 |
American Home Products Corporation |
Water soluble sdz-rad esters
|
ES2219388T3
(es)
|
1999-08-24 |
2004-12-01 |
Ariad Gene Therapeutics, Inc. |
28-epi-rapalogos.
|
US7067526B1
(en)
|
1999-08-24 |
2006-06-27 |
Ariad Gene Therapeutics, Inc. |
28-epirapalogs
|
US7807211B2
(en)
|
1999-09-03 |
2010-10-05 |
Advanced Cardiovascular Systems, Inc. |
Thermal treatment of an implantable medical device
|
US6790228B2
(en)
|
1999-12-23 |
2004-09-14 |
Advanced Cardiovascular Systems, Inc. |
Coating for implantable devices and a method of forming the same
|
US20070032853A1
(en)
*
|
2002-03-27 |
2007-02-08 |
Hossainy Syed F |
40-O-(2-hydroxy)ethyl-rapamycin coated stent
|
US6277983B1
(en)
|
2000-09-27 |
2001-08-21 |
American Home Products Corporation |
Regioselective synthesis of rapamycin derivatives
|
EP2298299A3
(de)
*
|
2000-01-14 |
2012-02-29 |
The Trustees Of The University Of Pennsylvania |
O-methylierte Rapamycinderivate zur Linderung und Verhinderung von lymphoproliferativen Erkrankungen
|
GB0008785D0
(en)
|
2000-04-10 |
2000-05-31 |
Novartis Ag |
Organic compounds
|
US8236048B2
(en)
|
2000-05-12 |
2012-08-07 |
Cordis Corporation |
Drug/drug delivery systems for the prevention and treatment of vascular disease
|
US6670355B2
(en)
*
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
PT1318837E
(pt)
|
2000-08-11 |
2004-12-31 |
Wyeth Corp |
Metodo de tratamenton de carcinoma positivo a receptor de estrogenio
|
JP2004509898A
(ja)
|
2000-09-19 |
2004-04-02 |
ワイス |
水溶性ラパマイシンエステル
|
US6399625B1
(en)
|
2000-09-27 |
2002-06-04 |
Wyeth |
1-oxorapamycins
|
MXPA03002871A
(es)
|
2000-09-29 |
2004-12-06 |
Johnson & Johnson |
Dispositivos medicos recubiertos.
|
US6399626B1
(en)
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
US6440991B1
(en)
|
2000-10-02 |
2002-08-27 |
Wyeth |
Ethers of 7-desmethlrapamycin
|
KR100600550B1
(ko)
|
2000-10-20 |
2006-07-13 |
에자이 가부시키가이샤 |
질소 함유 방향환 유도체
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
AU2016206379B2
(en)
*
|
2001-02-19 |
2017-09-14 |
Novartis Ag |
Cancer Treatment
|
EP2269603B1
(de)
*
|
2001-02-19 |
2015-05-20 |
Novartis AG |
Behandlung von Brusttumoren mit einem Rapamycinderivat in Kombination mit Exemestan
|
AU2005201004A1
(en)
*
|
2001-02-19 |
2005-03-24 |
Novartis Ag |
Cancer treatment
|
AU2011226833B9
(en)
*
|
2001-02-19 |
2014-07-03 |
Novartis Ag |
Cancer treatment
|
TWI233359B
(en)
*
|
2001-04-06 |
2005-06-01 |
Wyeth Corp |
Pharmaceutical composition for treating neoplasm
|
TWI296196B
(en)
*
|
2001-04-06 |
2008-05-01 |
Wyeth Corp |
Antineoplastic combinations
|
CN1259049C
(zh)
|
2001-07-06 |
2006-06-14 |
苏坎波公司 |
包含白介素-2抑制剂和抗菌剂的局部给药组合物
|
DE60234057D1
(de)
|
2001-07-25 |
2009-11-26 |
Raptor Pharmaceutical Inc |
Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
|
US6939376B2
(en)
|
2001-11-05 |
2005-09-06 |
Sun Biomedical, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
US7682387B2
(en)
|
2002-04-24 |
2010-03-23 |
Biosensors International Group, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
EP1458405A1
(de)
*
|
2001-11-21 |
2004-09-22 |
Sucampo AG |
Verwendung von fk506 und analoga zur behandlung von allergischen erkrankungen
|
PL216224B1
(pl)
|
2002-02-01 |
2014-03-31 |
Ariad Pharmaceuticals |
Pochodne rapamycyny zawierające fosfor, kompozycja je zawierająca oraz ich zastosowanie
|
US20030176455A1
(en)
*
|
2002-03-13 |
2003-09-18 |
Wyeth |
Method of inhibiting cell death
|
US20040024450A1
(en)
*
|
2002-04-24 |
2004-02-05 |
Sun Biomedical, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
CN1652757B
(zh)
|
2002-05-16 |
2012-02-08 |
诺瓦提斯公司 |
Edg受体结合剂在癌症中的应用
|
EP2277898A3
(de)
|
2002-07-16 |
2011-06-01 |
Biotica Technology Limited |
Rapamycinähnliche Substanzen
|
DK1553940T3
(da)
|
2002-07-30 |
2008-06-02 |
Wyeth Corp |
Patenterale formuleringer indeholdende en rapamycin-hydroxyester
|
AU2003272471B2
(en)
|
2002-09-18 |
2010-10-07 |
Trustees Of The University Of Pennsylvania |
Method of inhibiting choroidal neovascularization
|
TWI376363B
(en)
|
2002-09-24 |
2012-11-11 |
Novartis Ag |
Pharmaceutical combination for treating demyelinating disease
|
WO2004060283A2
(en)
|
2002-12-16 |
2004-07-22 |
Nitromed, Inc. |
Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
|
JP2006516548A
(ja)
|
2002-12-30 |
2006-07-06 |
アンジオテック インターナショナル アクツィエン ゲゼルシャフト |
迅速ゲル化ポリマー組成物からの薬物送達法
|
AR042938A1
(es)
*
|
2003-02-06 |
2005-07-06 |
Wyeth Corp |
Uso del cci-779 en el tratamiento de la fibrosis hepatica
|
US20090093875A1
(en)
|
2007-05-01 |
2009-04-09 |
Abbott Laboratories |
Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
|
AR043504A1
(es)
*
|
2003-03-17 |
2005-08-03 |
Novartis Ag |
Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias
|
GB0307867D0
(en)
*
|
2003-04-04 |
2003-05-14 |
Novartis Ag |
Pharmaceutical composition
|
US20070155771A1
(en)
*
|
2003-04-11 |
2007-07-05 |
David Rubinsztein |
Methods and means for treating protein conformational disorders
|
KR20060006058A
(ko)
*
|
2003-04-22 |
2006-01-18 |
와이어쓰 |
항신생물성 배합물
|
US7160867B2
(en)
*
|
2003-05-16 |
2007-01-09 |
Isotechnika, Inc. |
Rapamycin carbohydrate derivatives
|
US20050118344A1
(en)
|
2003-12-01 |
2005-06-02 |
Pacetti Stephen D. |
Temperature controlled crimping
|
ES2316995T3
(es)
*
|
2003-07-08 |
2009-04-16 |
Novartis Ag |
Uso de rapamicina y derivados de rapamicida para el tratamiento de la perdida osea.
|
CA2534549A1
(en)
*
|
2003-09-12 |
2005-03-24 |
4 Aza Bioscience Nv |
Pteridine derivatives for the treatment of septic shock and tnf-.alpha.-related diseases.
|
CA2539324A1
(en)
|
2003-09-18 |
2005-03-31 |
Macusight, Inc. |
Transscleral delivery
|
US20070032477A1
(en)
*
|
2003-10-17 |
2007-02-08 |
Waer Mark J A |
Pteridine derivatives useful for making pharmaceutical compositions
|
US7220755B2
(en)
*
|
2003-11-12 |
2007-05-22 |
Biosensors International Group, Ltd. |
42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
|
US9114198B2
(en)
|
2003-11-19 |
2015-08-25 |
Advanced Cardiovascular Systems, Inc. |
Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
|
GB0327840D0
(en)
*
|
2003-12-01 |
2003-12-31 |
Novartis Ag |
Organic compounds
|
JP4716280B2
(ja)
*
|
2004-03-01 |
2011-07-06 |
テルモ株式会社 |
O−アルキル化ラパマイシン誘導体の製造法
|
ES2315745T3
(es)
|
2004-03-01 |
2009-04-01 |
Terumo Kabushiki Kaisha |
Procedimiento para la fabricacion de derivados o-alquilados de rapamicina.
|
JP4540704B2
(ja)
|
2004-03-10 |
2010-09-08 |
セラディン インコーポレイテッド |
エベロリムスの測定方法および測定キット
|
AR047988A1
(es)
*
|
2004-03-11 |
2006-03-15 |
Wyeth Corp |
Combinaciones antineoplásicas de cci-779 y rituximab
|
US8551512B2
(en)
*
|
2004-03-22 |
2013-10-08 |
Advanced Cardiovascular Systems, Inc. |
Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
|
US8778014B1
(en)
|
2004-03-31 |
2014-07-15 |
Advanced Cardiovascular Systems, Inc. |
Coatings for preventing balloon damage to polymer coated stents
|
US7445916B2
(en)
*
|
2004-04-14 |
2008-11-04 |
Wyeth |
Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
|
CA2562164A1
(en)
*
|
2004-04-27 |
2005-11-10 |
Wyeth |
Labeling of rapamycin using rapamycin-specific methylases
|
US20110104186A1
(en)
|
2004-06-24 |
2011-05-05 |
Nicholas Valiante |
Small molecule immunopotentiators and assays for their detection
|
US8709469B2
(en)
|
2004-06-30 |
2014-04-29 |
Abbott Cardiovascular Systems Inc. |
Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
|
GB0417852D0
(en)
|
2004-08-11 |
2004-09-15 |
Biotica Tech Ltd |
Production of polyketides and other natural products
|
JP5117190B2
(ja)
|
2004-08-27 |
2013-01-09 |
コーディス・コーポレイション |
溶媒を含有しない非晶質ラパマイシン
|
WO2006030826A1
(ja)
|
2004-09-17 |
2006-03-23 |
Eisai R & D Management Co., Ltd. |
医薬組成物
|
US7901451B2
(en)
|
2004-09-24 |
2011-03-08 |
Biosensors International Group, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
US8313763B2
(en)
|
2004-10-04 |
2012-11-20 |
Tolmar Therapeutics, Inc. |
Sustained delivery formulations of rapamycin compounds
|
AU2005294382A1
(en)
*
|
2004-10-04 |
2006-04-20 |
Qlt Usa, Inc. |
Ocular delivery of polymeric delivery formulations
|
KR20070070184A
(ko)
*
|
2004-10-28 |
2007-07-03 |
와이어쓰 |
자궁근종의 치료에 있어서 mTOR 억제제의 용도
|
US8021849B2
(en)
|
2004-11-05 |
2011-09-20 |
Siemens Healthcare Diagnostics Inc. |
Methods and kits for the determination of sirolimus in a sample
|
WO2006053754A1
(en)
*
|
2004-11-19 |
2006-05-26 |
Novartis Ag |
COMBINATIONS OF ANTI-ATHEROSCLEROTIC PEPTIDES AND AN mTOR INHIBITING AGENT AND THEIR METHODS OF USE
|
US20060160837A1
(en)
*
|
2004-12-29 |
2006-07-20 |
The Brigham And Women's Hospital, Inc. |
Rapamycin compounds in the treatment of neurofibromatosis type 1
|
US8637070B2
(en)
|
2005-02-09 |
2014-01-28 |
Santen Pharmaceutical Co., Ltd. |
Rapamycin formulations and methods of their use
|
US8663639B2
(en)
|
2005-02-09 |
2014-03-04 |
Santen Pharmaceutical Co., Ltd. |
Formulations for treating ocular diseases and conditions
|
GB0503936D0
(en)
*
|
2005-02-25 |
2005-04-06 |
San Raffaele Centro Fond |
Method
|
GB0504544D0
(en)
|
2005-03-04 |
2005-04-13 |
Novartis Ag |
Organic compounds
|
JP2008533007A
(ja)
|
2005-03-07 |
2008-08-21 |
ワイス |
42−o−(2−ヒドロキシ)エチル−ラパマイシンのオキセパン異性体
|
KR20070116868A
(ko)
|
2005-03-11 |
2007-12-11 |
바이오티카 테크놀로지 리미티드 |
39데스메톡시라파마이신 및 그 유사체의 의학적 용도
|
GB0504994D0
(en)
*
|
2005-03-11 |
2005-04-20 |
Biotica Tech Ltd |
Novel compounds
|
US20100061994A1
(en)
*
|
2005-03-11 |
2010-03-11 |
Rose Mary Sheridan |
Medical uses of 39-desmethoxyrapamycin and analogues thereof
|
GT200600148A
(es)
*
|
2005-04-14 |
2006-11-22 |
|
Metodos para el tratamiento y la prevencion de fibrosis
|
US7189582B2
(en)
|
2005-04-27 |
2007-03-13 |
Dade Behring Inc. |
Compositions and methods for detection of sirolimus
|
CN103259027A
(zh)
|
2005-04-28 |
2013-08-21 |
普罗透斯数字保健公司 |
药物信息系统
|
AU2006254397A1
(en)
*
|
2005-05-31 |
2006-12-07 |
Novartis Ag |
Combination of HMG-CoA reductase inhibitors and mTOR inhibitors
|
US20070004767A1
(en)
*
|
2005-06-30 |
2007-01-04 |
Gutmann David H |
Methods for treating neurofibromatosis 1
|
CN105233349B
(zh)
|
2005-07-15 |
2019-06-18 |
胶束技术股份有限公司 |
包含受控形态的药物粉末的聚合物涂层
|
US20090062909A1
(en)
|
2005-07-15 |
2009-03-05 |
Micell Technologies, Inc. |
Stent with polymer coating containing amorphous rapamycin
|
EP2253320A1
(de)
|
2005-07-20 |
2010-11-24 |
Novartis AG |
Kombination aus Pyrimidylaminobenzamide und einem mTOR-Kinase-Hemmer
|
SI1912675T1
(sl)
|
2005-07-25 |
2014-07-31 |
Emergent Product Development Seattle, Llc |
zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20
|
EP1925676A4
(de)
|
2005-08-02 |
2010-11-10 |
Eisai R&D Man Co Ltd |
Testverfahren für die wirkung eines vaskularisierungsinhibitors
|
ES2611307T3
(es)
|
2005-08-30 |
2017-05-08 |
University Of Miami |
Inmunomodulación de agonistas, antagonistas e inmunotoxinas del receptor del factor de necrosis tumoral 25 (TNFR25)
|
EP1776970A1
(de)
|
2005-10-12 |
2007-04-25 |
Albert Schömig |
Implantat mit Mehrfachbeschichtung
|
AU2006311877A1
(en)
|
2005-11-04 |
2007-05-18 |
Wyeth Llc |
Antineoplastic combinations with mTOR inhibitor, herceptin, and/orHKI-272
|
GB0523659D0
(en)
*
|
2005-11-21 |
2005-12-28 |
Novartis Ag |
Organic compounds
|
CN101340901A
(zh)
*
|
2005-12-20 |
2009-01-07 |
惠氏公司 |
通过控制药物物质杂质控制cci-779剂型稳定性
|
KR20080085213A
(ko)
*
|
2006-01-12 |
2008-09-23 |
노파르티스 아게 |
Mtor 억제제 및 항엽산 화합물의 조합물
|
US20070173923A1
(en)
*
|
2006-01-20 |
2007-07-26 |
Savage Douglas R |
Drug reservoir stent
|
GB0601406D0
(en)
*
|
2006-01-24 |
2006-03-08 |
Novartis Ag |
Organic Compounds
|
CA2637255C
(en)
*
|
2006-02-02 |
2018-06-12 |
Novartis Ag |
40-o-(2-hydroxyethyl)-rapamycin for treating tuberous sclerosis disorders
|
EP2001438A2
(de)
|
2006-02-09 |
2008-12-17 |
Macusight, Inc. |
Stabile formulierungen sowie verfahren zu ihrer herstellung und verwendung
|
US7622477B2
(en)
*
|
2006-02-28 |
2009-11-24 |
Cordis Corporation |
Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same
|
US7678901B2
(en)
*
|
2006-02-28 |
2010-03-16 |
Wyeth |
Rapamycin analogs containing an antioxidant moiety
|
WO2007103348A2
(en)
*
|
2006-03-07 |
2007-09-13 |
Wyeth |
Process for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
|
ES2563288T3
(es)
|
2006-03-23 |
2016-03-14 |
Santen Pharmaceutical Co., Ltd |
Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
|
CA2650590C
(en)
|
2006-04-26 |
2018-04-03 |
Micell Technologies, Inc. |
Coatings containing multiple drugs
|
WO2007136103A1
(ja)
|
2006-05-18 |
2007-11-29 |
Eisai R & D Management Co., Ltd. |
甲状腺癌に対する抗腫瘍剤
|
GB0609962D0
(en)
*
|
2006-05-19 |
2006-06-28 |
Biotica Tech Ltd |
Novel compounds
|
GB0609963D0
(en)
*
|
2006-05-19 |
2006-06-28 |
Biotica Tech Ltd |
Novel compounds
|
AU2007315790A1
(en)
*
|
2006-06-30 |
2008-05-08 |
Interface Biologics, Inc. |
Bioresponsive polymers
|
US10144736B2
(en)
*
|
2006-07-20 |
2018-12-04 |
Gilead Sciences, Inc. |
Substituted pteridines useful for the treatment and prevention of viral infections
|
WO2008009078A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
WO2008016633A2
(en)
*
|
2006-08-02 |
2008-02-07 |
Ariad Gene Therapeutics, Inc. |
Combination therapy
|
WO2008026748A1
(fr)
|
2006-08-28 |
2008-03-06 |
Eisai R & D Management Co., Ltd. |
Agent antitumoral pour cancer gastrique non différencié
|
US20080051691A1
(en)
*
|
2006-08-28 |
2008-02-28 |
Wyeth |
Implantable shunt or catheter enabling gradual delivery of therapeutic agents
|
US10695327B2
(en)
|
2006-09-13 |
2020-06-30 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
WO2008033956A2
(en)
*
|
2006-09-13 |
2008-03-20 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
US8088789B2
(en)
*
|
2006-09-13 |
2012-01-03 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
KR20090071598A
(ko)
|
2006-09-18 |
2009-07-01 |
랩터 파마슈티컬 인코포레이티드 |
수용체 결합 단백질(rap)-접합체 투여에 의한 간 질환의 치료
|
US8067055B2
(en)
*
|
2006-10-20 |
2011-11-29 |
Biosensors International Group, Ltd. |
Drug-delivery endovascular stent and method of use
|
US20080097591A1
(en)
|
2006-10-20 |
2008-04-24 |
Biosensors International Group |
Drug-delivery endovascular stent and method of use
|
EP2090580B1
(de)
|
2006-11-27 |
2014-06-04 |
Terumo Kabushiki Kaisha |
Verfahren zur herstellung eines o-alkylierten rapamycinderivats, und o-alkyliertes rapamycinderivat
|
CN101711137B
(zh)
|
2007-01-08 |
2014-10-22 |
米歇尔技术公司 |
具有可生物降解层的支架
|
US11426494B2
(en)
|
2007-01-08 |
2022-08-30 |
MT Acquisition Holdings LLC |
Stents having biodegradable layers
|
EP2491962A1
(de)
|
2007-01-21 |
2012-08-29 |
Hemoteq AG |
Medizinprodukt zur Behandlung von Verschlüssen von Körperdurchgängen und zur Prävention drohender Wiederverschlüsse
|
CN101600694A
(zh)
|
2007-01-29 |
2009-12-09 |
卫材R&D管理有限公司 |
未分化型胃癌治疗用组合物
|
TW200845960A
(en)
*
|
2007-04-05 |
2008-12-01 |
Wyeth Corp |
Wortmannin-rapalog conjugate and uses thereof
|
TW200901989A
(en)
|
2007-04-10 |
2009-01-16 |
Wyeth Corp |
Anti-tumor activity of CCI-779 in papillary renal cell cancer
|
US9192697B2
(en)
|
2007-07-03 |
2015-11-24 |
Hemoteq Ag |
Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
|
WO2009043174A1
(en)
|
2007-10-05 |
2009-04-09 |
Interface Biologics Inc. |
Oligofluorinated cross-linked polymers and uses thereof
|
CA2703017C
(en)
|
2007-10-19 |
2017-04-25 |
Roseita Esfand |
Self-eliminating coatings
|
CA2704000C
(en)
|
2007-11-09 |
2016-12-13 |
Eisai R&D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
EP3459572A1
(de)
|
2007-11-14 |
2019-03-27 |
Biosensors International Group, Ltd. |
Automatische beschichtungsverfahren
|
US8921642B2
(en)
|
2008-01-11 |
2014-12-30 |
Massachusetts Eye And Ear Infirmary |
Conditional-stop dimerizable caspase transgenic animals
|
CN102215682A
(zh)
*
|
2008-03-11 |
2011-10-12 |
万能医药公司 |
大环内酯化合物及它们的使用方法
|
US20100048914A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
AU2009225434B2
(en)
|
2008-03-21 |
2014-05-22 |
The University Of Chicago |
Treatment with opioid antagonists and mTOR inhibitors
|
PT2132228E
(pt)
|
2008-04-11 |
2011-10-11 |
Emergent Product Dev Seattle |
Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
|
US20110098241A1
(en)
*
|
2008-04-14 |
2011-04-28 |
Poniard Pharmaceuticals, Inc. |
Rapamycin analogs as anti-cancer agents
|
CN102083397B
(zh)
|
2008-04-17 |
2013-12-25 |
米歇尔技术公司 |
具有生物可吸收层的支架
|
KR20170081755A
(ko)
|
2008-06-20 |
2017-07-12 |
노파르티스 아게 |
다발성 경화증을 치료하기 위한 소아용 조성물
|
US8765162B2
(en)
|
2008-06-30 |
2014-07-01 |
Abbott Cardiovascular Systems Inc. |
Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same
|
WO2010009335A1
(en)
|
2008-07-17 |
2010-01-21 |
Micell Technologies, Inc. |
Drug delivery medical device
|
US8092822B2
(en)
|
2008-09-29 |
2012-01-10 |
Abbott Cardiovascular Systems Inc. |
Coatings including dexamethasone derivatives and analogs and olimus drugs
|
WO2010040064A1
(en)
*
|
2008-10-03 |
2010-04-08 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
KR20110071014A
(ko)
|
2008-10-17 |
2011-06-27 |
위스콘신 얼럼나이 리서어치 화운데이션 |
생물학적으로 활성인 알파-베타 펩티드의 제조 방법
|
PT2365802T
(pt)
|
2008-11-11 |
2017-11-14 |
Univ Texas |
Microcápsulas de rapamicina e utilização para o tratamento de cancro
|
WO2010075517A2
(en)
|
2008-12-23 |
2010-07-01 |
Pharmasset, Inc. |
Nucleoside analogs
|
SG172363A1
(en)
|
2008-12-23 |
2011-07-28 |
Pharmasset Inc |
Synthesis of purine nucleosides
|
CL2009002207A1
(es)
|
2008-12-23 |
2011-02-18 |
Gilead Pharmasset Llc |
Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
|
US20110275798A1
(en)
*
|
2009-01-21 |
2011-11-10 |
Rakesh Bhaiyyaram Mendhe |
Method for Determination of Sirolimus Stability and Process for Preparing Its Stable Form
|
EP3023433A1
(de)
|
2009-02-05 |
2016-05-25 |
Tokai Pharmaceuticals, Inc. |
Neuartige prodrugs von steroidalen cyp17-hemmern/-antiandrogenen
|
ES2543216T3
(es)
|
2009-03-13 |
2015-08-17 |
Katholieke Universiteit Leuven, K.U. Leuven R&D |
Moduladores de tiazolopirimidina como agentes inmunosupresores
|
WO2010120552A2
(en)
|
2009-04-01 |
2010-10-21 |
Micell Technologies, Inc. |
Coated stents
|
JP5719347B2
(ja)
|
2009-04-16 |
2015-05-20 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
癌治療のための組成物及び方法
|
EP3366326A1
(de)
|
2009-04-17 |
2018-08-29 |
Micell Technologies, Inc. |
Stents mit gesteuerter elution
|
TWI556839B
(zh)
|
2009-05-06 |
2016-11-11 |
研究室護膚股份有限公司 |
包含活性劑-磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
|
ES2550634T3
(es)
|
2009-07-10 |
2015-11-11 |
Boston Scientific Scimed, Inc. |
Uso de nanocristales para un balón de suministro de fármaco
|
EP2453834A4
(de)
|
2009-07-16 |
2014-04-16 |
Micell Technologies Inc |
Medizinische wirkstofffreisetzungsvorrichtung
|
US10080821B2
(en)
|
2009-07-17 |
2018-09-25 |
Boston Scientific Scimed, Inc. |
Nucleation of drug delivery balloons to provide improved crystal size and density
|
CN102770455B
(zh)
|
2009-08-03 |
2017-02-08 |
迈阿密大学 |
用于体内扩增调节性t细胞的方法
|
CN102574852B
(zh)
|
2009-10-23 |
2014-06-25 |
伊莱利利公司 |
Akt抑制剂
|
KR20120115237A
(ko)
|
2009-10-30 |
2012-10-17 |
어리어드 파마슈티칼스, 인코포레이티드 |
암 치료 방법 및 조성물
|
US9283211B1
(en)
|
2009-11-11 |
2016-03-15 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
CN102665700A
(zh)
|
2009-11-18 |
2012-09-12 |
诺瓦提斯公司 |
治疗实体瘤和其它恶性肿瘤的方法和组合物
|
CN102933658A
(zh)
|
2009-12-18 |
2013-02-13 |
界面生物公司 |
从自组装涂层局部递送药物
|
CN102127092B
(zh)
*
|
2010-01-18 |
2013-04-17 |
东南大学 |
依维莫斯的制备
|
WO2011097103A1
(en)
|
2010-02-02 |
2011-08-11 |
Micell Technologies, Inc. |
Stent and stent delivery system with improved deliverability
|
US20130195919A1
(en)
|
2010-03-05 |
2013-08-01 |
President And Fellows Of Harvard College |
Induced dendritic cell compositions and uses thereof
|
AP3515A
(en)
|
2010-03-31 |
2016-01-11 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
KR101830455B1
(ko)
|
2010-04-13 |
2018-02-20 |
노파르티스 아게 |
시클린 의존성 키나제 4 또는 시클린 의존성 키나제 (cdk4/6) 억제제 및 mtor 억제제를 포함하는 암 치료를 위한 조합물
|
EP2558082A1
(de)
|
2010-04-16 |
2013-02-20 |
Novartis AG |
Kombination aus organischen verbindungen
|
CA2797110C
(en)
|
2010-04-22 |
2020-07-21 |
Micell Technologies, Inc. |
Stents and other devices having extracellular matrix coating
|
KR101620661B1
(ko)
|
2010-04-27 |
2016-05-12 |
로슈 글리카트 아게 |
어푸코실화된 CD20 항체와 mTOR 억제제의 복합 요법
|
GB201012889D0
(en)
|
2010-08-02 |
2010-09-15 |
Univ Leuven Kath |
Antiviral activity of novel bicyclic heterocycles
|
MX2012014776A
(es)
|
2010-06-25 |
2013-01-29 |
Eisai R&D Man Co Ltd |
Agente antitumoral que emplea compuestos con efecto inhibidor de cinasas combinados.
|
CA2805631C
(en)
|
2010-07-16 |
2018-07-31 |
Micell Technologies, Inc. |
Drug delivery medical device
|
US8889211B2
(en)
|
2010-09-02 |
2014-11-18 |
Boston Scientific Scimed, Inc. |
Coating process for drug delivery balloons using heat-induced rewrap memory
|
GB201015411D0
(en)
|
2010-09-15 |
2010-10-27 |
Univ Leuven Kath |
Anti-cancer activity of novel bicyclic heterocycles
|
US20120077778A1
(en)
|
2010-09-29 |
2012-03-29 |
Andrea Bourdelais |
Ladder-Frame Polyether Conjugates
|
CN102464669B
(zh)
*
|
2010-11-17 |
2014-04-16 |
浙江海正药业股份有限公司 |
无定形依维莫司及其制备方法
|
ES2753529T3
(es)
*
|
2010-11-19 |
2020-04-13 |
Biocon Ltd |
Procesos para la preparación de everolimús y productos intermedios del mismo
|
WO2012103960A1
(en)
|
2011-02-04 |
2012-08-09 |
Synthon Bv |
Process for making trisubstituted silyloxyethyl triflates
|
CN103732226B
(zh)
|
2011-02-18 |
2016-01-06 |
诺瓦提斯药物公司 |
mTOR/JAK抑制剂组合疗法
|
CN102174053B
(zh)
*
|
2011-03-09 |
2014-04-16 |
成都雅途生物技术有限公司 |
依维莫司的纯化方法
|
AU2012229236B2
(en)
|
2011-03-11 |
2017-05-18 |
Beth Israel Deaconess Medical Center, Inc. |
Anti-CD40 antibodies and uses thereof
|
EP2508525A1
(de)
|
2011-04-05 |
2012-10-10 |
Bayer Pharma Aktiengesellschaft |
Substituierte 2,3-Dihydroimidazo[1,2-c]chinazolinsalze
|
AU2012246490B2
(en)
|
2011-04-18 |
2016-08-04 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
CA2833962A1
(en)
|
2011-04-25 |
2012-11-01 |
Novartis Ag |
Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
EP2714937B1
(de)
|
2011-06-03 |
2018-11-14 |
Eisai R&D Management Co., Ltd. |
Biomarker zur vorhersage und beurteilung des ansprechens von schilddrüsen- und nierenkrebspatienten auf lenvatinibverbindungen
|
US8809562B2
(en)
|
2011-06-06 |
2014-08-19 |
Chevron Phillips Chemical Company Lp |
Use of metallocene compounds for cancer treatment
|
EP2532740A1
(de)
|
2011-06-11 |
2012-12-12 |
Michael Schmück |
Antigenspezifische CD4+ und CD8+ zentrale Gedächtnis-T-Zellpräparate für adoptive T-Zelltherapie
|
US10117972B2
(en)
|
2011-07-15 |
2018-11-06 |
Micell Technologies, Inc. |
Drug delivery medical device
|
WO2013013708A1
(en)
|
2011-07-26 |
2013-01-31 |
Fundació Institut D'investigació Biomèdica De Bellvitge |
Treatment of acute rejection in renal transplant
|
US20130028895A1
(en)
|
2011-07-27 |
2013-01-31 |
Gerald Wulf |
Exosome inhibiting agents and uses thereof
|
WO2013022458A1
(en)
|
2011-08-05 |
2013-02-14 |
Boston Scientific Scimed, Inc. |
Methods of converting amorphous drug substance into crystalline form
|
WO2013028208A1
(en)
|
2011-08-25 |
2013-02-28 |
Boston Scientific Scimed, Inc. |
Medical device with crystalline drug coating
|
CN102268015B
(zh)
*
|
2011-08-30 |
2013-08-28 |
成都摩尔生物医药有限公司 |
一种依维莫司的合成方法
|
GB201115665D0
(en)
|
2011-09-09 |
2011-10-26 |
Univ Leuven Kath |
Autoimmune and inflammatory disorder therapy
|
AU2012320563B2
(en)
|
2011-10-06 |
2016-05-12 |
Novartis Ag |
Pharmaceutical compositions comprising 40 - O - ( 2 - hydroxy) ethyl - rapamycin
|
US10188772B2
(en)
|
2011-10-18 |
2019-01-29 |
Micell Technologies, Inc. |
Drug delivery medical device
|
EP2589383A1
(de)
|
2011-11-06 |
2013-05-08 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin |
FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen
|
GB201122305D0
(en)
|
2011-12-23 |
2012-02-01 |
Biotica Tech Ltd |
Novel compound
|
RU2014149145A
(ru)
|
2012-05-23 |
2016-07-20 |
Ф. Хоффманн-Ля Рош Аг |
Композиции и способы получения и применения эндодермальных клеток и гепатоцитов
|
CN102786534A
(zh)
*
|
2012-05-25 |
2012-11-21 |
上海现代制药股份有限公司 |
一种依维莫司的制备方法
|
US9408884B2
(en)
|
2012-06-08 |
2016-08-09 |
Biotronik Ag |
Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods
|
WO2013192367A1
(en)
|
2012-06-22 |
2013-12-27 |
Novartis Ag |
Neuroendocrine tumor treatment
|
US9750728B2
(en)
|
2012-09-29 |
2017-09-05 |
Targeted Therapeutics, Llc |
Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
|
CN103705925B
(zh)
|
2012-09-29 |
2018-03-30 |
段磊 |
抑制PI3K/AKT/mTOR信号通路的药物组合
|
US20150290176A1
(en)
|
2012-10-12 |
2015-10-15 |
The Board Of Regents Of The University Of Texas System |
Use of mtor inhibitors to treat vascular cognitive impairment
|
US20150258127A1
(en)
|
2012-10-31 |
2015-09-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for preventing antiphospholipid syndrome (aps)
|
US9757432B2
(en)
|
2012-11-14 |
2017-09-12 |
Ohio State Innovation Foundation |
Materials and methods useful for treating glioblastorna
|
CN104854112A
(zh)
*
|
2012-11-30 |
2015-08-19 |
杭州归创生物医药有限公司 |
雷帕霉素类似物及其制备方法
|
KR20150098605A
(ko)
|
2012-12-21 |
2015-08-28 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
퀴놀린 유도체의 비정질 형태 및 그의 제조방법
|
EP2943253B1
(de)
|
2013-01-09 |
2021-10-20 |
University Of Miami |
Zusammensetzungen und verfahren zur regulierung regulatorischer t-zellen mit tl1a-ig-fusionsprotein und il-2
|
KR20150143476A
(ko)
|
2013-03-12 |
2015-12-23 |
미셀 테크놀로지즈, 인코포레이티드 |
생흡수성 생체의학적 임플란트
|
WO2014160328A1
(en)
|
2013-03-13 |
2014-10-02 |
The Board Of Regents Of The University Of Texas System |
Mtor inhibitors for prevention of intestinal polyp growth
|
EP2968370A4
(de)
|
2013-03-14 |
2016-09-21 |
Univ Maryland |
Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon
|
US10098871B2
(en)
*
|
2013-03-15 |
2018-10-16 |
Leslie B. Gordon |
Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis
|
TW201503912A
(zh)
|
2013-03-19 |
2015-02-01 |
Novartis Ag |
包含癌莫事(everolimus)之醫藥組合物
|
US10274503B2
(en)
|
2013-05-08 |
2019-04-30 |
Vegenics Pty Limited |
Methods of using VEGF-C biomarkers for age-related macular degeneration (AMD) diagnosis
|
JP6411379B2
(ja)
|
2013-05-14 |
2018-10-24 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
レンバチニブ化合物に対する子宮内膜がん対象の応答性を予測及び評価するためのバイオマーカー
|
WO2014186532A1
(en)
|
2013-05-15 |
2014-11-20 |
Micell Technologies, Inc. |
Bioabsorbable biomedical implants
|
CN105283553B
(zh)
|
2013-06-11 |
2021-06-25 |
克隆技术实验室有限公司 |
蛋白质富集的微泡及其制备和使用方法
|
BR112015029521A2
(pt)
*
|
2013-06-20 |
2017-07-25 |
Novartis Ag |
alquilação com um sulfonato de alquil fluoroalquila
|
CN103360411B
(zh)
*
|
2013-07-17 |
2015-09-30 |
成都雅途生物技术有限公司 |
依维莫司结晶提纯方法
|
BR112016002970A2
(pt)
|
2013-08-12 |
2017-09-12 |
Tokai Pharmaceuticals Inc |
biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio
|
US9580758B2
(en)
|
2013-11-12 |
2017-02-28 |
Luc Montagnier |
System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
|
US20150140036A1
(en)
|
2013-11-13 |
2015-05-21 |
Novartis Institutes For Biomedical Research, Inc. |
Low, immune enhancing, dose mtor inhibitors and uses thereof
|
CN116478927A
(zh)
|
2013-12-19 |
2023-07-25 |
诺华股份有限公司 |
人间皮素嵌合抗原受体及其用途
|
EP3087101B1
(de)
|
2013-12-20 |
2024-06-05 |
Novartis AG |
Regulierbarer chimärer antigenrezeptor
|
KR101529963B1
(ko)
*
|
2013-12-27 |
2015-06-19 |
주식회사 종근당바이오 |
에베로리무스의 제조방법 및 이의 중간체
|
EP3089737B1
(de)
|
2013-12-31 |
2021-11-03 |
Rapamycin Holdings, LLC |
Orale rapamycinnanopartikelzubereitungen und verwendung
|
US9700544B2
(en)
|
2013-12-31 |
2017-07-11 |
Neal K Vail |
Oral rapamycin nanoparticle preparations
|
US10428331B2
(en)
|
2014-01-16 |
2019-10-01 |
Musc Foundation For Research Development |
Targeted nanocarriers for the administration of immunosuppressive agents
|
KR20160110963A
(ko)
|
2014-02-11 |
2016-09-23 |
노파르티스 아게 |
암 치료를 위한 pi3k 억제제를 포함하는 제약 조합물
|
EP3593812A3
(de)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Behandlung von krebs mithilfe eines chimären antigenrezeptors
|
EP3811970A1
(de)
|
2014-03-15 |
2021-04-28 |
Novartis AG |
Regulierbarer chimärer antigenrezeptor
|
CN103848849B
(zh)
*
|
2014-03-24 |
2016-02-24 |
上海医药工业研究院 |
依维莫司的制备工艺
|
AU2015237200A1
(en)
|
2014-03-27 |
2016-10-06 |
The Brigham And Women's Hospital, Inc. |
Metabolically-activated drug conjugates to overcome resistance in cancer therapy
|
SG10202109752XA
(en)
|
2014-04-07 |
2021-10-28 |
Novartis Ag |
Treatment of cancer using anti-cd19 chimeric antigen receptor
|
CA2968049A1
(en)
|
2014-04-16 |
2015-10-22 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
US10258639B2
(en)
|
2014-05-06 |
2019-04-16 |
Research Development Foundation |
Methods for treating insulin resistance and for sensitizing patients to GLP1 agonist therapy
|
CN105254646A
(zh)
*
|
2014-05-28 |
2016-01-20 |
上海博邦医药科技有限公司 |
一种制备依维莫司的方法
|
CA2950589A1
(en)
|
2014-06-02 |
2015-12-10 |
Children's Medical Center Corporation |
Methods and compositions for immunomodulation
|
WO2016014576A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Treatment of cancer using a cd33 chimeric antigen receptor
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
MY181834A
(en)
|
2014-07-21 |
2021-01-08 |
Novartis Ag |
Treatment of cancer using humanized anti-bcma chimeric antigen receptor
|
EP3193915A1
(de)
|
2014-07-21 |
2017-07-26 |
Novartis AG |
Kombinationen aus niedrigen, immunfördernden dosen von mtor-inhibitoren und cars
|
EP4205749A1
(de)
|
2014-07-31 |
2023-07-05 |
Novartis AG |
Subset-optimierte chimäre antigenrezeptorhaltige zellen
|
US9938297B2
(en)
|
2014-08-04 |
2018-04-10 |
Cipia Limited |
Process for the synthesis of everolimus and intermediates thereof
|
CN117164657A
(zh)
|
2014-08-12 |
2023-12-05 |
莫纳什大学 |
定向淋巴的前药
|
JP6919118B2
(ja)
|
2014-08-14 |
2021-08-18 |
ノバルティス アーゲー |
GFRα−4キメラ抗原受容体を用いる癌の治療
|
RU2724999C2
(ru)
|
2014-08-19 |
2020-06-29 |
Новартис Аг |
Химерный антигенный рецептор (car) против cd123 для использования в лечении злокачественных опухолей
|
ES2926687T3
(es)
|
2014-08-28 |
2022-10-27 |
Eisai R&D Man Co Ltd |
Derivado de quinolina muy puro y método para su producción
|
CN113620978A
(zh)
|
2014-09-11 |
2021-11-09 |
加利福尼亚大学董事会 |
mTORC1抑制剂
|
WO2016044605A1
(en)
|
2014-09-17 |
2016-03-24 |
Beatty, Gregory |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
WO2016057705A1
(en)
|
2014-10-08 |
2016-04-14 |
Novartis Ag |
Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof
|
WO2016066608A1
(en)
|
2014-10-28 |
2016-05-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging
|
ES2898849T3
(es)
|
2014-10-28 |
2022-03-09 |
Koushi Yamaguchi |
Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
|
EP3212194A4
(de)
|
2014-10-29 |
2018-06-20 |
University Of Maryland |
Verfahren zur behandlung altersbedingter symptome bei säugetieren und zusammensetzungen dafür
|
CN104478898A
(zh)
*
|
2014-11-18 |
2015-04-01 |
连云港恒运医药科技有限公司 |
依维莫司及其中间体的制备方法
|
WO2016135740A1
(en)
|
2015-02-23 |
2016-09-01 |
Natco Pharma Limited |
Process for preparing stable oral compositions of everolimus
|
US20180028662A1
(en)
|
2015-02-25 |
2018-02-01 |
Eisai R&D Management Co., Ltd. |
Method for Suppressing Bitterness of Quinoline Derivative
|
CA2978226A1
(en)
|
2015-03-04 |
2016-09-09 |
Merck Sharpe & Dohme Corp. |
Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
|
CA2978188C
(en)
|
2015-03-04 |
2020-05-12 |
Gilead Sciences, Inc. |
Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
|
AU2016249005B2
(en)
|
2015-04-17 |
2022-06-16 |
Novartis Ag |
Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
|
US20180298068A1
(en)
|
2015-04-23 |
2018-10-18 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
CN107847491A
(zh)
|
2015-05-20 |
2018-03-27 |
诺华公司 |
依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合
|
CN104892632B
(zh)
*
|
2015-06-03 |
2017-12-26 |
道中道(菏泽)制药有限公司 |
一种晶体形式的依维莫司及其制备方法
|
CA2988707C
(en)
|
2015-06-16 |
2023-10-10 |
Eisai R&D Management Co., Ltd. |
Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
|
EP3109250A1
(de)
|
2015-06-23 |
2016-12-28 |
Synbias Pharma AG |
Verfahren zur synthese von rapamycinderivaten
|
WO2017029391A1
(en)
|
2015-08-20 |
2017-02-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method for treating cancer
|
AU2016315873B2
(en)
|
2015-09-04 |
2022-08-18 |
Primatope Therapeutics Inc. |
Humanized anti-CD40 antibodies and uses thereof
|
WO2017041139A1
(en)
|
2015-09-08 |
2017-03-16 |
Monash University |
Lymph directing prodrugs
|
IL258574B1
(en)
|
2015-11-11 |
2024-09-01 |
Novartis Ag |
Uses of myostatin antagonists, combinations containing them and their uses
|
CN105566348A
(zh)
*
|
2015-12-31 |
2016-05-11 |
哈药集团技术中心 |
一种依维莫司的制备方法
|
CA3021645A1
(en)
*
|
2016-04-29 |
2017-11-02 |
Icahn School Of Medicine At Mount Sinai |
Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis
|
EP3466424A1
(de)
|
2016-05-27 |
2019-04-10 |
Nippon Kayaku Kabushiki Kaisha |
Pharmazeutische zusammensetzung mit rapamycin oder derivat davon
|
CA3031542A1
(en)
|
2016-07-20 |
2018-01-25 |
University Of Utah Research Foundation |
Cd229 car t cells and methods of use thereof
|
US10640499B2
(en)
|
2016-09-02 |
2020-05-05 |
Gilead Sciences, Inc. |
Toll like receptor modulator compounds
|
WO2018045144A1
(en)
|
2016-09-02 |
2018-03-08 |
Gilead Sciences, Inc. |
Toll like receptor modulator compounds
|
TW202340473A
(zh)
|
2016-10-07 |
2023-10-16 |
瑞士商諾華公司 |
利用嵌合抗原受體之癌症治療
|
TW201825090A
(zh)
|
2016-11-23 |
2018-07-16 |
瑞士商諾華公司 |
增強免疫反應之方法
|
US20200081010A1
(en)
|
2016-12-02 |
2020-03-12 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and compositions for diagnosing renal cell carcinoma
|
HUE056777T2
(hu)
|
2016-12-22 |
2022-03-28 |
Amgen Inc |
Benzizotiazol-, izotiazolo[3,4-b]piridin-, kinazolin-, ftálazin-, pirido[2,3-d]piridazin- és pirido[2,3-d]pirimidin-származékok mint KRAS G12C inhibitorok tüdõ-, hasnyálmirigy- vagy vastagbélrák kezelésére
|
GB201701087D0
(en)
|
2017-01-23 |
2017-03-08 |
Univ Leuven Kath |
Novel prodrugs of mizoribine
|
EP3576736A4
(de)
*
|
2017-02-10 |
2020-08-26 |
Torcept Therapeutics Inc. |
Rapamycinanalogon
|
EP3615055A1
(de)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Zellen, die einen auf bcma abzielenden chimären antigenrezeptor exprimieren, und kombinationsbehandlung mit einem gamma-sekretase-inhibitor
|
EP3624863B1
(de)
|
2017-05-15 |
2021-04-14 |
C.R. Bard, Inc. |
Medizinische vorrichtung mit wirkstofffreisetzender beschichtung und zwischenschicht
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
US20200129486A1
(en)
|
2017-06-26 |
2020-04-30 |
Inserm (Institut National De La Santé Et De La Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of olmsted syndrome
|
EP3652306A1
(de)
|
2017-07-13 |
2020-05-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Verfahren zur erhöhung der expansion und der immunosuppressiven kapazität einer population von cd8+cd45rclow/-tregs
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
MA50077A
(fr)
|
2017-09-08 |
2020-07-15 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
UY37900A
(es)
|
2017-09-26 |
2019-04-30 |
Novartis Ag |
Nuevos derivados de rapamicina
|
CN108047265A
(zh)
*
|
2017-11-24 |
2018-05-18 |
成都海创药业有限公司 |
一种依维莫司中间体的制备纯化方法
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
US10596165B2
(en)
|
2018-02-12 |
2020-03-24 |
resTORbio, Inc. |
Combination therapies
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
EP3788369A1
(de)
|
2018-05-01 |
2021-03-10 |
Novartis Ag |
Biomarker zur auswertung von car-t-zellen zur vorhersage des klinischen ergebnisses
|
EP3788050B1
(de)
|
2018-05-01 |
2024-08-28 |
Revolution Medicines, Inc. |
C26-verknüpfte rapamycinanaloga als mtor-inhibitoren
|
IL300091A
(en)
|
2018-05-01 |
2023-03-01 |
Revolution Medicines Inc |
C40-, C28-, and C-32-linked rapamycin analogs as MTOR inhibitors
|
MX2020011582A
(es)
|
2018-05-04 |
2020-11-24 |
Amgen Inc |
Inhibidores de kras g12c y metodos para su uso.
|
CA3098574A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
MA52564A
(fr)
|
2018-05-10 |
2021-03-17 |
Amgen Inc |
Inhibiteurs de kras g12c pour le traitement du cancer
|
CN112638436A
(zh)
|
2018-05-22 |
2021-04-09 |
界面生物公司 |
用于将药物递送至血管壁的组合物和方法
|
AR126019A1
(es)
|
2018-05-30 |
2023-09-06 |
Novartis Ag |
Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
|
MA52765A
(fr)
|
2018-06-01 |
2021-04-14 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
AU2019284472B2
(en)
|
2018-06-11 |
2024-05-30 |
Amgen Inc. |
KRAS G12C inhibitors for treating cancer
|
CA3100390A1
(en)
|
2018-06-12 |
2020-03-12 |
Amgen Inc. |
Kras g12c inhibitors encompassing piperazine ring and use thereof in the treatment of cancer
|
TW202016139A
(zh)
|
2018-06-13 |
2020-05-01 |
瑞士商諾華公司 |
Bcma 嵌合抗原受體及其用途
|
CN108676014A
(zh)
*
|
2018-06-15 |
2018-10-19 |
国药集团川抗制药有限公司 |
纯化依维莫司中间体的方法以及制备依维莫司的方法
|
CN113164557A
(zh)
|
2018-07-23 |
2021-07-23 |
因柯利尔疗法公司 |
治疗神经性病症的方法
|
CA3107349A1
(en)
|
2018-07-23 |
2020-01-30 |
Enclear Therapies, Inc. |
Methods of treating neurological disorders
|
EP3849545A1
(de)
|
2018-09-10 |
2021-07-21 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Verfahren zur behandlung von neurofibromatose
|
US20210349097A1
(en)
|
2018-10-05 |
2021-11-11 |
Eisai R&D Management Co., Ltd. |
Biomarkers for a combination therapy comprising lenvatinib and everolimus
|
JP7262581B2
(ja)
|
2018-11-14 |
2023-04-21 |
ルトニックス,インコーポレーテッド |
改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
MX2021005700A
(es)
|
2018-11-19 |
2021-07-07 |
Amgen Inc |
Inhibidores de kras g12c y metodos de uso de los mismos.
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
MX2021007156A
(es)
|
2018-12-20 |
2021-08-16 |
Amgen Inc |
Inhibidores de kif18a.
|
CA3123227A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
EP3897855B1
(de)
|
2018-12-20 |
2023-06-07 |
Amgen Inc. |
Kif18a-inhibitoren
|
US20220002311A1
(en)
|
2018-12-20 |
2022-01-06 |
Amgen Inc. |
Kif18a inhibitors
|
US20220040324A1
(en)
|
2018-12-21 |
2022-02-10 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and kinase inhibitor
|
EA202191983A1
(ru)
*
|
2019-01-22 |
2021-12-01 |
Аеовиан Фармасьютикалз, Инк. |
МОДУЛЯТОРЫ mTORC И ИХ ПРИМЕНЕНИЕ
|
JP2022522778A
(ja)
|
2019-03-01 |
2022-04-20 |
レボリューション メディシンズ インコーポレイテッド |
二環式ヘテロシクリル化合物及びその使用
|
US20230148450A9
(en)
|
2019-03-01 |
2023-05-11 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
CN113939324A
(zh)
|
2019-04-08 |
2022-01-14 |
巴德外周血管股份有限公司 |
在经改性装置表面上具有药物洗脱涂层的医疗装置
|
CN114007665A
(zh)
|
2019-04-11 |
2022-02-01 |
因柯利尔疗法公司 |
改善脑脊液的方法及其装置和系统
|
TW202210480A
(zh)
|
2019-04-17 |
2022-03-16 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
TW202212339A
(zh)
|
2019-04-17 |
2022-04-01 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
EP3738593A1
(de)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosierung von kras-inhibitor zur behandlung von krebserkrankungen
|
US11236091B2
(en)
|
2019-05-21 |
2022-02-01 |
Amgen Inc. |
Solid state forms
|
TW202115056A
(zh)
|
2019-06-28 |
2021-04-16 |
美商基利科學股份有限公司 |
類鐸受體調節劑化合物的製備方法
|
WO2021001743A1
(en)
|
2019-07-02 |
2021-01-07 |
Effector Therapeutics, Inc. |
Translation inhibitors and uses thereof
|
WO2021026098A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
JP2022542319A
(ja)
|
2019-08-02 |
2022-09-30 |
アムジエン・インコーポレーテツド |
Kif18a阻害剤
|
MX2022001302A
(es)
|
2019-08-02 |
2022-03-02 |
Amgen Inc |
Inhibidores de kif18a.
|
CN114269731A
(zh)
|
2019-08-02 |
2022-04-01 |
美国安进公司 |
Kif18a抑制剂
|
EP4031578A1
(de)
|
2019-09-18 |
2022-07-27 |
Novartis AG |
Entpd2-antikörper, kombinationstherapien und verfahren zur verwendung der antikörper und kombinationstherapien
|
US20220402916A1
(en)
|
2019-09-18 |
2022-12-22 |
Merck Sharp & Dohme Corp. |
Small molecule inhibitors of kras g12c mutant
|
MX2022004656A
(es)
|
2019-10-24 |
2022-05-25 |
Amgen Inc |
Derivados de piridopirimidina utiles como inhibidores de kras g12c y kras g12d en el tratamiento del cancer.
|
CN114867726B
(zh)
|
2019-10-28 |
2023-11-28 |
默沙东有限责任公司 |
Kras g12c突变体的小分子抑制剂
|
US20230023023A1
(en)
|
2019-10-31 |
2023-01-26 |
Taiho Pharmaceutical Co., Ltd. |
4-aminobut-2-enamide derivatives and salts thereof
|
JP2022553859A
(ja)
|
2019-11-04 |
2022-12-26 |
レボリューション メディシンズ インコーポレイテッド |
Ras阻害剤
|
CA3159561A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
WO2021091967A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
US20210139517A1
(en)
|
2019-11-08 |
2021-05-13 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
US20230192681A1
(en)
|
2019-11-14 |
2023-06-22 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
MX2022005726A
(es)
|
2019-11-14 |
2022-06-09 |
Amgen Inc |
Sintesis mejorada del compuesto inhibidor de g12c de kras.
|
CN114980976A
(zh)
|
2019-11-27 |
2022-08-30 |
锐新医药公司 |
共价ras抑制剂及其用途
|
WO2021106231A1
(en)
|
2019-11-29 |
2021-06-03 |
Taiho Pharmaceutical Co., Ltd. |
A compound having inhibitory activity against kras g12d mutation
|
EP4073102A4
(de)
|
2019-12-12 |
2024-05-08 |
Ting Therapeutics LLC |
Zusammensetzungen und verfahren zur prävention und behandlung von gehörverlust
|
AU2021206217A1
(en)
|
2020-01-07 |
2022-09-01 |
Revolution Medicines, Inc. |
SHP2 inhibitor dosing and methods of treating cancer
|
KR20220149534A
(ko)
|
2020-02-05 |
2022-11-08 |
퓨어테크 엘와이티, 아이엔씨. |
신경스테로이드의 지질 전구약물
|
US20230181536A1
(en)
|
2020-04-24 |
2023-06-15 |
Taiho Pharmaceutical Co., Ltd. |
Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c
|
US20230174518A1
(en)
|
2020-04-24 |
2023-06-08 |
Taiho Pharmaceutical Co., Ltd. |
Kras g12d protein inhibitors
|
EP4183395A4
(de)
|
2020-07-15 |
2024-07-24 |
Taiho Pharmaceutical Co Ltd |
Pyrimidinverbindung enthaltende kombination zur verwendung bei der tumorbehandlung
|
MX2023002248A
(es)
|
2020-09-03 |
2023-05-16 |
Revolution Medicines Inc |
Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.
|
CA3194067A1
(en)
|
2020-09-15 |
2022-03-24 |
Revolution Medicines, Inc. |
Ras inhibitors
|
TW202241885A
(zh)
|
2020-12-22 |
2022-11-01 |
大陸商上海齊魯銳格醫藥研發有限公司 |
Sos1抑制劑及其用途
|
BR112023018950A2
(pt)
|
2021-03-19 |
2024-02-27 |
Icahn School Med Mount Sinai |
Composto, composições nanobiológica e farmacêutica, métodos para tratar um distúrbio de proliferação celular, para tratar sepse e para ativar um receptor nod2, processo para fabricação de uma composição nanobiológica e kit
|
WO2022235866A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
AR125787A1
(es)
|
2021-05-05 |
2023-08-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
PE20240088A1
(es)
|
2021-05-05 |
2024-01-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
WO2022250170A1
(en)
|
2021-05-28 |
2022-12-01 |
Taiho Pharmaceutical Co., Ltd. |
Small molecule inhibitors of kras mutated proteins
|
EP4370160A1
(de)
|
2021-07-15 |
2024-05-22 |
President And Fellows Of Harvard College |
Zusammensetzungen und verfahren in zusammenhang mit zellen mit anhaftenden partikeln
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
TW202340214A
(zh)
|
2021-12-17 |
2023-10-16 |
美商健臻公司 |
做為shp2抑制劑之吡唑并吡𠯤化合物
|
EP4227307A1
(de)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazinverbindungen als shp2-inhibitoren
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
WO2024008799A1
(en)
|
2022-07-06 |
2024-01-11 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of proliferative glomerulonephritis
|
WO2024028433A1
(en)
|
2022-08-04 |
2024-02-08 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of lymphoproliferative disorders
|
WO2024081916A1
(en)
|
2022-10-14 |
2024-04-18 |
Black Diamond Therapeutics, Inc. |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|
WO2024100236A1
(en)
|
2022-11-11 |
2024-05-16 |
Astrazeneca Ab |
Combination therapies for the treatment of cancer
|
WO2024167904A1
(en)
|
2023-02-07 |
2024-08-15 |
Arvinas Operations, Inc. |
Dosage regimens of estrogen receptor degraders in combination with an mtor inhibitor
|
WO2024206858A1
(en)
|
2023-03-30 |
2024-10-03 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
WO2024211712A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
WO2024211663A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
CN116813641A
(zh)
*
|
2023-06-09 |
2023-09-29 |
杭州华东医药集团康润制药有限公司 |
一种依维莫司的制备方法
|