ES2770342T3 - Procedimientos para pruebas prenatales no invasivas de paternidad - Google Patents

Procedimientos para pruebas prenatales no invasivas de paternidad Download PDF

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Publication number
ES2770342T3
ES2770342T3 ES11851621T ES11851621T ES2770342T3 ES 2770342 T3 ES2770342 T3 ES 2770342T3 ES 11851621 T ES11851621 T ES 11851621T ES 11851621 T ES11851621 T ES 11851621T ES 2770342 T3 ES2770342 T3 ES 2770342T3
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Prior art keywords
father
fetus
dna
probability
biological
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Spanish (es)
Inventor
Allison Ryan
Styrmir Sigurjonsson
Milena Banjevic
George Gemelos
Matthew Hill
Johan Baner
Matthew Rabinowitz
Zachary Demko
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Natera Inc
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Natera Inc
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Priority claimed from US13/110,685 external-priority patent/US8825412B2/en
Priority claimed from US13/300,235 external-priority patent/US10017812B2/en
Application filed by Natera Inc filed Critical Natera Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
ES11851621T 2010-12-22 2011-12-22 Procedimientos para pruebas prenatales no invasivas de paternidad Active ES2770342T3 (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201061426208P 2010-12-22 2010-12-22
US201161462972P 2011-02-09 2011-02-09
US201161448547P 2011-03-02 2011-03-02
US201161516996P 2011-04-12 2011-04-12
US13/110,685 US8825412B2 (en) 2010-05-18 2011-05-18 Methods for non-invasive prenatal ploidy calling
US201161571248P 2011-06-23 2011-06-23
US201161542508P 2011-10-03 2011-10-03
US13/300,235 US10017812B2 (en) 2010-05-18 2011-11-18 Methods for non-invasive prenatal ploidy calling
PCT/US2011/066938 WO2012088456A2 (en) 2010-12-22 2011-12-22 Methods for non-invasive prenatal paternity testing
US13/335,043 US10113196B2 (en) 2010-05-18 2011-12-22 Prenatal paternity testing using maternal blood, free floating fetal DNA and SNP genotyping

Publications (1)

Publication Number Publication Date
ES2770342T3 true ES2770342T3 (es) 2020-07-01

Family

ID=46314949

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11851621T Active ES2770342T3 (es) 2010-12-22 2011-12-22 Procedimientos para pruebas prenatales no invasivas de paternidad

Country Status (10)

Country Link
US (5) US10113196B2 (enExample)
EP (1) EP2656263B1 (enExample)
JP (1) JP6328934B2 (enExample)
CN (1) CN103608466B (enExample)
AU (1) AU2011348100B2 (enExample)
BR (1) BR112013016193B1 (enExample)
CA (1) CA2821906C (enExample)
ES (1) ES2770342T3 (enExample)
RU (1) RU2620959C2 (enExample)
WO (1) WO2012088456A2 (enExample)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8532930B2 (en) * 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8515679B2 (en) * 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
WO2009105531A1 (en) * 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
US20110092763A1 (en) * 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
US20110178719A1 (en) 2008-08-04 2011-07-21 Gene Security Network, Inc. Methods for Allele Calling and Ploidy Calling
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
US10131947B2 (en) * 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
CA2824387C (en) 2011-02-09 2019-09-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
GB2497838A (en) 2011-10-19 2013-06-26 Nugen Technologies Inc Compositions and methods for directional nucleic acid amplification and sequencing
AU2013209499B2 (en) 2012-01-20 2018-05-10 Sequenom, Inc. Diagnostic processes that factor experimental conditions
CA2862552A1 (en) 2012-01-26 2013-08-01 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
GB2513024B (en) * 2012-02-27 2016-08-31 Cellular Res Inc A clonal amplification method
ES2905448T3 (es) 2012-05-10 2022-04-08 Massachusetts Gen Hospital Métodos para determinar una secuencia nucleotídica
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013177581A2 (en) * 2012-05-24 2013-11-28 University Of Washington Through Its Center For Commercialization Whole genome sequencing of a human fetus
JP6181751B2 (ja) 2012-06-18 2017-08-16 ニューゲン テクノロジーズ， インコーポレイテッド 望まれない核酸配列のネガティブ選択のための組成物および方法
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
JP6392222B2 (ja) * 2012-07-24 2018-09-19 ナテラ， インコーポレイテッド 高度多重ｐｃｒ法および組成物
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP4036247B1 (en) 2012-09-04 2024-04-10 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2912468B1 (en) 2012-10-29 2018-09-12 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9235808B2 (en) 2013-03-14 2016-01-12 International Business Machines Corporation Evaluation of predictions in the absence of a known ground truth
EP3421613B1 (en) * 2013-03-15 2020-08-19 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
LT2981921T (lt) 2013-04-03 2023-02-27 Sequenom, Inc. Neinvazinio genetinių variacijų vertinimo būdai ir procesai
WO2014190286A2 (en) 2013-05-24 2014-11-27 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
KR102784584B1 (ko) 2013-06-21 2025-03-19 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
GB2546833B (en) 2013-08-28 2018-04-18 Cellular Res Inc Microwell for single cell analysis comprising single cell and single bead oligonucleotide capture labels
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10964409B2 (en) 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN111863131A (zh) 2013-10-07 2020-10-30 塞昆纳姆股份有限公司 用于非侵入性评估染色体改变的方法和过程
EP3068883B1 (en) 2013-11-13 2020-04-29 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
CN106661612A (zh) 2014-01-27 2017-05-10 通用医疗公司 制备用于测序的核酸的方法
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
GB2524948A (en) * 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
EP3656875B1 (en) * 2014-07-18 2021-09-22 Illumina, Inc. Non-invasive prenatal diagnosis
EP3175000B1 (en) 2014-07-30 2020-07-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2016038929A1 (ja) * 2014-09-11 2016-03-17 富士フイルム株式会社 胎児染色体の異数性の有無を検出する方法
WO2016040901A1 (en) 2014-09-12 2016-03-17 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acids
WO2016049878A1 (zh) * 2014-09-30 2016-04-07 深圳华大基因科技有限公司 一种基于snp分型的亲子鉴定方法及应用
US20180119210A1 (en) * 2014-11-24 2018-05-03 Shaare Zedek Scientific Ltd. Fetal haplotype identification
US20170351805A1 (en) * 2014-12-26 2017-12-07 National University Corporation Tohoku University Method for determining genotype of particular gene locus group or individual gene locus, determination computer system and determination program
EP3262192B1 (en) 2015-02-27 2020-09-16 Becton, Dickinson and Company Spatially addressable molecular barcoding
WO2016160844A2 (en) 2015-03-30 2016-10-06 Cellular Research, Inc. Methods and compositions for combinatorial barcoding
EP3286326B1 (en) 2015-04-23 2025-01-22 Becton, Dickinson and Company Method for whole transcriptome amplification
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
CN104946773B (zh) * 2015-07-06 2018-04-13 厦门万基生物科技有限公司 一种利用snp进行产前亲权关系判定的方法
KR101817785B1 (ko) * 2015-08-06 2018-01-11 이원다이애그노믹스(주) 다양한 플랫폼에서 태아의 성별과 성염색체 이상을 구분할 수 있는 새로운 방법
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
EP3347465B1 (en) 2015-09-11 2019-06-26 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
EP3375886A4 (en) * 2015-11-10 2018-09-19 Fujifilm Corporation Method for determining whether cells or cell masses are originated from same person, or unrelated persons, or parent and child, or related persons
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
WO2017214557A1 (en) 2016-06-10 2017-12-14 Counsyl, Inc. Nucleic acid sequencing adapters and uses thereof
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
CA3037185A1 (en) 2016-09-15 2018-03-22 ArcherDX, Inc. Methods of nucleic acid sample preparation
US10683531B2 (en) 2016-09-15 2020-06-16 ArcherDX, Inc. Methods of nucleic acid sample preparation for analysis of cell-free DNA
CN109791157B (zh) 2016-09-26 2022-06-07 贝克顿迪金森公司 使用具有条形码化的寡核苷酸序列的试剂测量蛋白质表达
US11854666B2 (en) 2016-09-29 2023-12-26 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
IL319365A (en) 2017-01-24 2025-05-01 Sequenom Inc Methods and processes for assessing genetic variations
WO2018144240A1 (en) 2017-02-01 2018-08-09 Cellular Research, Inc. Selective amplification using blocking oligonucleotides
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
PT3596233T (pt) 2017-03-17 2022-08-22 Sequenom Inc Métodos e processos para avaliação de mosaicismo genético
US11232850B2 (en) 2017-03-24 2022-01-25 Myriad Genetics, Inc. Copy number variant caller
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
CN107012226A (zh) * 2017-04-20 2017-08-04 司法部司法鉴定科学技术研究所 一种基于高通量测序的snp位点的检测试剂盒及其检测方法
AU2018281745B2 (en) 2017-06-05 2022-05-19 Becton, Dickinson And Company Sample indexing for single cells
CN107217095B (zh) * 2017-06-15 2021-06-04 广东腾飞基因科技股份有限公司 人类亲权鉴定用多重pcr引物组及检测方法
CN111051511A (zh) 2017-08-04 2020-04-21 十亿至一公司 用于与生物靶相关的表征的靶相关分子
IL319255A (en) 2017-08-07 2025-04-01 Univ Johns Hopkins Methods and materials for cancer assessment and treatment
CN107557458A (zh) * 2017-10-11 2018-01-09 华东医药（杭州）基因科技有限公司 一种有效检测基因型的方法及装置
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
JP2021500883A (ja) 2017-10-27 2021-01-14 ジュノ ダイアグノスティックス，インク． 超微量リキッドバイオプシーのためのデバイス、システム、および方法
CN108048575B (zh) * 2017-11-03 2021-06-15 中南大学湘雅医院 一种用于产前无创亲子鉴定的试剂盒及方法
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
CA3095030A1 (en) 2018-03-30 2019-10-03 Juno Diagnostics, Inc. Deep learning-based methods, devices, and systems for prenatal testing
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
ES2945191T3 (es) 2018-05-03 2023-06-29 Becton Dickinson Co Análisis de muestras multiómicas de alto rendimiento
EP3788170B1 (en) 2018-05-03 2025-01-01 Becton, Dickinson and Company Molecular barcoding on opposite transcript ends
CN108875307B (zh) * 2018-06-29 2021-12-03 上海欧易生物医学科技有限公司 一种基于孕妇外周血中胎儿游离dna的亲子鉴定方法
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3847653A2 (en) * 2018-09-07 2021-07-14 Illumina, Inc. A method to determine if a circulating fetal cell isolated from a pregnant mother is from either the current or a historical pregnancy
EP4471156A3 (en) 2018-10-01 2025-02-26 Becton, Dickinson and Company Determining 5' transcript sequences
WO2020097315A1 (en) 2018-11-08 2020-05-14 Cellular Research, Inc. Whole transcriptome analysis of single cells using random priming
CN113195717A (zh) 2018-12-13 2021-07-30 贝克顿迪金森公司 单细胞全转录组分析中的选择性延伸
CN110964690A (zh) * 2019-01-16 2020-04-07 北京大学深圳医院 辅助生殖技术实施过程中防止配子错配的方法
WO2020154247A1 (en) 2019-01-23 2020-07-30 Cellular Research, Inc. Oligonucleotides associated with antibodies
EP3924506A1 (en) 2019-02-14 2021-12-22 Becton Dickinson and Company Hybrid targeted and whole transcriptome amplification
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
AU2020296108B2 (en) 2019-06-21 2023-08-03 Coopersurgical, Inc. Systems and methods for determining pattern of inheritance in embryos
CN114051534B (zh) 2019-07-22 2025-02-21 贝克顿迪金森公司 单细胞染色质免疫沉淀测序测定
CN112466397A (zh) * 2019-09-09 2021-03-09 深圳乐土生物科技有限公司 一种用于亲缘关系检测的方法和装置
EP4407041A3 (en) 2019-11-08 2024-09-25 Becton Dickinson and Company Using random priming to obtain full-length v(d)j information for immune repertoire sequencing
CN110724732A (zh) * 2019-11-12 2020-01-24 陈洪亮 一种产前亲权关系鉴定的方法
WO2021137770A1 (en) * 2019-12-30 2021-07-08 Geneton S.R.O. Method for fetal fraction estimation based on detection and interpretation of single nucleotide variants
US11649497B2 (en) 2020-01-13 2023-05-16 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and RNA
EP4471155A3 (en) 2020-01-29 2024-12-18 Becton, Dickinson and Company Barcoded wells for spatial mapping of single cells through sequencing
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
IL295297A (en) 2020-02-14 2022-10-01 Univ Johns Hopkins Methods and materials for assessing nucleic acids
CN115151810A (zh) 2020-02-25 2022-10-04 贝克顿迪金森公司 实现使用单细胞样品作为单色补偿对照的双特异性探针
CA3173571A1 (en) * 2020-02-28 2021-09-02 Laboratory Corporation Of America Holdings Compositions, methods, and systems for paternity determination
CN111518917B (zh) * 2020-04-02 2022-06-07 中山大学 一种用于无创产前亲权关系判定的微单倍型遗传标记组合及方法
CN115605614A (zh) 2020-05-14 2023-01-13 贝克顿迪金森公司（Us） 用于免疫组库谱分析的引物
US12157913B2 (en) 2020-06-02 2024-12-03 Becton, Dickinson And Company Oligonucleotides and beads for 5 prime gene expression assay
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
US12391940B2 (en) 2020-07-31 2025-08-19 Becton, Dickinson And Company Single cell assay for transposase-accessible chromatin
CN112053743B (zh) * 2020-08-31 2024-11-22 济宁医学院 一种亲缘关系鉴定方法、系统及设备
US11739443B2 (en) 2020-11-20 2023-08-29 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
JP2023551906A (ja) 2020-12-02 2023-12-13 ジェネンテック， インコーポレイテッド ネオアジュバントおよびアジュバント尿路上皮癌腫療法のための方法および組成物
US12392771B2 (en) 2020-12-15 2025-08-19 Becton, Dickinson And Company Single cell secretome analysis
US20230227897A1 (en) 2020-12-16 2023-07-20 Seedna Inc. Method for calculating the fidelity of the signal of polymorphic genetic loci
US20220340971A1 (en) * 2021-03-23 2022-10-27 Billiontoone, Inc. Fragment analysis for quantitative diagnostics of biological targets
CN113549701B (zh) * 2021-07-21 2022-07-01 内蒙古农业大学 一种山羊亲子鉴定snp分子标记及其应用
JP2024528932A (ja) 2021-08-02 2024-08-01 ナテラ， インコーポレイテッド 妊娠中の女性における新生物を検出するための方法
CN118613594A (zh) 2021-09-01 2024-09-06 纳特拉公司 用于非侵入性产前测试的方法
CN113999900B (zh) * 2021-10-14 2024-02-20 武汉蓝沙医学检验实验室有限公司 以孕妇游离dna评估胎儿dna浓度的方法及应用
CN113969310B (zh) * 2021-10-14 2024-02-20 武汉蓝沙医学检验实验室有限公司 胎儿dna浓度的评估方法及应用
CN113981062B (zh) * 2021-10-14 2024-02-20 武汉蓝沙医学检验实验室有限公司 以非生父和母亲dna评估胎儿dna浓度的方法及应用
CN113889189B (zh) * 2021-10-14 2025-05-16 武汉蓝沙医学检验实验室有限公司 以生父和母亲dna评估胎儿dna浓度的方法及应用
JP7331325B1 (ja) 2022-08-30 2023-08-23 株式会社seeDNA ２種以上の検査を実施可能な遺伝学的解析方法
CN116240274A (zh) * 2022-11-10 2023-06-09 武汉蓝沙医学检验实验室有限公司 无需父本对妊娠胎儿进行亲子鉴定的方法
CN117116359A (zh) * 2023-08-07 2023-11-24 天津大学 Dna存储中基于最大后验概率的鲁棒多序列重建方法
JP7684727B2 (ja) * 2023-08-22 2025-05-28 株式会社seeDNA 非侵襲的出生前親子鑑定方法
CN117487932B (zh) * 2023-11-22 2024-09-03 复旦大学 一种用于亲子鉴定的snp位点组合、及其检测引物对和应用

Family Cites Families (329)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
SU1552642A3 (ru) * 1987-12-07 1994-03-15 Институт молекулярной генетики РАН Способ определения родства живых организмов
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
IL103935A0 (en) 1991-12-04 1993-05-13 Du Pont Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification
GB9305984D0 (en) 1993-03-23 1993-05-12 Royal Free Hosp School Med Predictive assay
WO1995006137A1 (en) 1993-08-27 1995-03-02 Australian Red Cross Society Detection of genes
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5716776A (en) 1994-03-04 1998-02-10 Mark H. Bogart Enrichment by preferential mitosis of fetal lymphocytes from a maternal blood sample
US6025128A (en) 1994-09-29 2000-02-15 The University Of Tulsa Prediction of prostate cancer progression by analysis of selected predictive parameters
US6479235B1 (en) 1994-09-30 2002-11-12 Promega Corporation Multiplex amplification of short tandem repeat loci
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU2324997A (en) 1996-03-15 1997-10-01 Penn State Research Foundation, The Detection of extracellular tumor-associated nucleic acid in blood plasma or ser um using nucleic acid amplification assays
US6108635A (en) 1996-05-22 2000-08-22 Interleukin Genetics, Inc. Integrated disease information system
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5860917A (en) 1997-01-15 1999-01-19 Chiron Corporation Method and apparatus for predicting therapeutic outcomes
US5824467A (en) 1997-02-25 1998-10-20 Celtrix Pharmaceuticals Methods for predicting drug response
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
ATE280177T1 (de) 1997-03-20 2004-11-15 Hoffmann La Roche Modifizierte primer
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US5994148A (en) 1997-06-23 1999-11-30 The Regents Of University Of California Method of predicting and enhancing success of IVF/ET pregnancy
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6124120A (en) 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
ATE347616T1 (de) 1999-04-30 2006-12-15 Cyclops Genome Sciences Ltd Ribonukleinsäurederivate
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
US7058517B1 (en) 1999-06-25 2006-06-06 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US6964847B1 (en) 1999-07-14 2005-11-15 Packard Biosciences Company Derivative nucleic acids and uses thereof
GB9917307D0 (en) 1999-07-23 1999-09-22 Sec Dep Of The Home Department Improvements in and relating to analysis of DNA
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6251604B1 (en) 1999-08-13 2001-06-26 Genopsys, Inc. Random mutagenesis and amplification of nucleic acid
US6221603B1 (en) 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7510834B2 (en) 2000-04-13 2009-03-31 Hidetoshi Inoko Gene mapping method using microsatellite genetic polymorphism markers
GB0009179D0 (en) 2000-04-13 2000-05-31 Imp College Innovations Ltd Non-invasive prenatal diagnosis
AU2001274869A1 (en) 2000-05-20 2001-12-03 The Regents Of The University Of Michigan Method of producing a dna library using positional amplification
JP2004511210A (ja) 2000-05-23 2004-04-15 バリアジェニックス　インコーポレーテッド 配列変動を検出する、ｄｎａを遺伝分析するための方法
US20030009295A1 (en) 2001-03-14 2003-01-09 Victor Markowitz System and method for retrieving and using gene expression data from multiple sources
US20020006622A1 (en) 2000-06-07 2002-01-17 Allan Bradley Novel compositions and methods for array-based nucleic acid hybridization
US7058616B1 (en) 2000-06-08 2006-06-06 Virco Bvba Method and system for predicting resistance of a disease to a therapeutic agent using a neural network
GB0016742D0 (en) 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
US20020107640A1 (en) 2000-11-14 2002-08-08 Ideker Trey E. Methods for determining the true signal of an analyte
EP1368369A4 (en) 2000-11-15 2006-02-22 Hoffmann La Roche METHODS AND REAGENTS FOR IDENTIFYING RARE EMBRYONIC CELLS IN THE MATERNAL CIRCULATORY SYSTEM
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
JP4276843B2 (ja) 2001-03-23 2009-06-10 芳之 金井 モノヌクレオソーム及びその製造方法、ヌクレオソームに特異的な抗体の測定方法、自己免疫病診断方法、ヌクレオソームｄｎａ製造方法、ｄｎａプレート、ｄｎａプレート製造方法、並びに抗ｄｎａ抗体測定法
US6489135B1 (en) 2001-04-17 2002-12-03 Atairgintechnologies, Inc. Determination of biological characteristics of embryos fertilized in vitro by assaying for bioactive lipids in culture media
FR2824144B1 (fr) 2001-04-30 2004-09-17 Metagenex S A R L Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
WO2002087431A1 (en) 2001-05-01 2002-11-07 Structural Bioinformatics, Inc. Diagnosing inapparent diseases from common clinical tests using bayesian analysis
AU2002305436A1 (en) 2001-05-09 2002-11-18 Virginia Commonwealth University Multiple sequencible and ligatible structures for genomic analysis
WO2003010537A1 (en) 2001-07-24 2003-02-06 Curagen Corporation Family based tests of association using pooled dna and snp markers
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
US6807491B2 (en) 2001-08-30 2004-10-19 Hewlett-Packard Development Company, L.P. Method and apparatus for combining gene predictions using bayesian networks
AUPR749901A0 (en) 2001-09-06 2001-09-27 Monash University Method of identifying chromosomal abnormalities and prenatal diagnosis
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
WO2003031646A1 (en) 2001-10-12 2003-04-17 The University Of Queensland Multiple genetic marker selection and amplification
US7297485B2 (en) 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
JP4229237B2 (ja) 2001-12-11 2009-02-25 株式会社ネーテック 血液細胞分離システム
US20030211522A1 (en) 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
CA2474982A1 (en) 2002-02-01 2003-08-07 Rosetta Inpharmatics Llc Computer systems and methods for identifying genes and determining pathways associated with traits
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
CA2477611A1 (en) 2002-03-01 2003-09-12 Ravgen, Inc. Rapid analysis of variations in a genome
US20060229823A1 (en) 2002-03-28 2006-10-12 Affymetrix, Inc. Methods and computer software products for analyzing genotyping data
CA2484360A1 (en) 2002-05-02 2003-11-13 The University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US20040229231A1 (en) 2002-05-28 2004-11-18 Frudakis Tony N. Compositions and methods for inferring ancestry
AU2003229397B2 (en) 2002-05-31 2009-04-23 Genetic Technologies Limited Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
WO2003106623A2 (en) 2002-06-13 2003-12-24 New York University Early noninvasive prenatal test for aneuploidies and heritable conditions
US20050009069A1 (en) 2002-06-25 2005-01-13 Affymetrix, Inc. Computer software products for analyzing genotyping
EP1388812A1 (en) 2002-07-04 2004-02-11 Ronald E. Dr. Kates Method for training a learning-capable system
US20040117346A1 (en) 2002-09-20 2004-06-17 Kilian Stoffel Computer-based method and apparatus for repurposing an ontology
US7459273B2 (en) 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
AU2003285861A1 (en) 2002-10-07 2004-05-04 University Of Medicine And Dentistry Of New Jersey High throughput multiplex dna sequence amplifications
WO2004044225A2 (en) 2002-11-11 2004-05-27 Affymetrix, Inc. Methods for identifying dna copy number changes
WO2004065617A2 (en) 2003-01-17 2004-08-05 The Trustees Of Boston University Haplotype analysis
WO2004065628A1 (en) 2003-01-21 2004-08-05 Guoliang Fu Quantitative multiplex detection of nucleic acids
EP1594950A4 (en) 2003-01-29 2007-07-25 454 Corp PRODUCT FOR THE PREPARATION OF SIMPLE STRANDED DNA BANKS
US20040209299A1 (en) 2003-03-07 2004-10-21 Rubicon Genomics, Inc. In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA
US20040197832A1 (en) 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
JP2004348437A (ja) 2003-05-22 2004-12-09 Matsushita Electric Ind Co Ltd リソース管理装置、リソース管理方法及び記録媒体
CA2525956A1 (en) 2003-05-28 2005-01-06 Pioneer Hi-Bred International, Inc. Plant breeding method
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP1660680B1 (en) 2003-07-31 2009-03-11 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms
AU2003263660A1 (en) 2003-08-29 2005-03-16 Pantarhei Bioscience B.V. Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
EP2354253A3 (en) 2003-09-05 2011-11-16 Trustees of Boston University Method for non-invasive prenatal diagnosis
US20050053950A1 (en) 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
WO2005028645A1 (ja) 2003-09-24 2005-03-31 Kyushu Tlo Company, Limited ＭＤＲ１遺伝子の５’制御領域におけるＳＮＰｓ
CA2541706C (en) 2003-10-08 2014-02-18 The Trustees Of Boston University Methods for prenatal diagnosis of chromosomal abnormalities
CA2482097C (en) 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
DE60328193D1 (de) 2003-10-16 2009-08-13 Sequenom Inc Nicht invasiver Nachweis fötaler genetischer Merkmale
US20050221341A1 (en) 2003-10-22 2005-10-06 Shimkets Richard A Sequence-based karyotyping
WO2005044086A2 (en) 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
EP1706488B1 (en) 2004-01-12 2013-07-24 Roche NimbleGen, Inc. Method of performing pcr amplification on a microarray
US20100216153A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US7035740B2 (en) 2004-03-24 2006-04-25 Illumina, Inc. Artificial intelligence and global normalization methods for genotyping
JP4437050B2 (ja) 2004-03-26 2010-03-24 株式会社日立製作所 診断支援システム、診断支援方法および診断支援サービスの提供方法
US7805282B2 (en) 2004-03-30 2010-09-28 New York University Process, software arrangement and computer-accessible medium for obtaining information associated with a haplotype
EP1732951B1 (en) 2004-03-31 2009-12-02 Adnagen AG Monoclonal antibodies with specificity for fetal erythroid cells
US7414118B1 (en) 2004-04-14 2008-08-19 Applied Biosystems Inc. Modified oligonucleotides and applications thereof
US7468249B2 (en) 2004-05-05 2008-12-23 Biocept, Inc. Detection of chromosomal disorders
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
EP1819734A2 (en) 2004-06-14 2007-08-22 The Board Of Trustees Of The University Of Illinois Antibodies binding to cd34+/cd36+ fetal but not to adult cells
EP1786924A4 (en) 2004-07-06 2008-10-01 Genera Biosystems Pty Ltd METHOD FOR DETECTING ANEUPLOIDIA
DE102004036285A1 (de) 2004-07-27 2006-02-16 Advalytix Ag Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe
EP1784508B1 (en) 2004-08-09 2012-10-03 Generation Biotech, LLC Method for nucleic acid isolation and amplification
EP1789786A4 (en) 2004-08-18 2008-02-13 Abbott Molecular Inc DETERMINING DATA QUALITY AND / OR SEGMENTAL ANEUMS USING A COMPUTER SYSTEM
US8024128B2 (en) 2004-09-07 2011-09-20 Gene Security Network, Inc. System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data
US20060088574A1 (en) 2004-10-25 2006-04-27 Manning Paul B Nutritional supplements
US20060134662A1 (en) 2004-10-25 2006-06-22 Pratt Mark R Method and system for genotyping samples in a normalized allelic space
WO2006055761A1 (en) 2004-11-17 2006-05-26 Mosaic Reproductive Health And Genetics, Llc Methods of determining human egg competency
US20070042384A1 (en) 2004-12-01 2007-02-22 Weiwei Li Method for isolating and modifying DNA from blood and body fluids
WO2006091979A2 (en) 2005-02-25 2006-08-31 The Regents Of The University Of California Full karyotype single cell chromosome analysis
US7618777B2 (en) 2005-03-16 2009-11-17 Agilent Technologies, Inc. Composition and method for array hybridization
CA2894337C (en) 2005-03-18 2018-08-28 The Chinese University Of Hong Kong Markers for prenatal diagnosis of trisomy 18
US7645576B2 (en) 2005-03-18 2010-01-12 The Chinese University Of Hong Kong Method for the detection of chromosomal aneuploidies
WO2007117256A1 (en) 2005-05-31 2007-10-18 Applera Corporation Multiplexed amplification of short nucleic acids
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
RU2290078C1 (ru) 2005-07-25 2006-12-27 Евгений Владимирович Новичков Способ прогнозирования рецидива серозного рака яичников
US8515679B2 (en) 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US20070027636A1 (en) 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20070178501A1 (en) 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
WO2007018601A1 (en) 2005-08-02 2007-02-15 Rubicon Genomics, Inc. Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
WO2007056601A2 (en) 2005-11-09 2007-05-18 The Regents Of The University Of California Methods and apparatus for context-sensitive telemedicine
GB0523276D0 (en) 2005-11-15 2005-12-21 London Bridge Fertility Chromosomal analysis by molecular karyotyping
JP6121642B2 (ja) 2005-11-26 2017-04-26 ナテラ， インコーポレイテッド 予測を行うための、遺伝子データを清浄化し、そして、そのデータを使用するためのシステムおよび方法
WO2007070482A2 (en) 2005-12-14 2007-06-21 Xueliang Xia Microarray-based preimplantation genetic diagnosis of chromosomal abnormalities
SI2385143T1 (sl) 2006-02-02 2016-11-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Neinvazivni genetski presejalni test ploda z digitalno analizo
WO2007092538A2 (en) 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
US9012184B2 (en) 2006-02-08 2015-04-21 Illumina Cambridge Limited End modification to prevent over-representation of fragments
ATE508209T1 (de) 2006-02-28 2011-05-15 Univ Louisville Res Found Erkennung von chromosomabnormalitäten im fötus mit hilfe der tandem-einzelnukleotid- polymorphismen
WO2007106523A2 (en) 2006-03-13 2007-09-20 Veridex, Llc Propagation of primary cells
US20080038733A1 (en) 2006-03-28 2008-02-14 Baylor College Of Medicine Screening for down syndrome
WO2007121276A2 (en) 2006-04-12 2007-10-25 Biocept, Inc. Enrichment of circulating fetal dna
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US7901884B2 (en) 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
WO2008111990A1 (en) 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
EP2061801A4 (en) 2006-06-14 2009-11-11 Living Microsystems Inc DIAGNOSIS OF FETAL ANOMALIES BY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS
CN101675169B (zh) 2006-06-14 2018-01-02 维里纳塔健康公司 使用样品拆分和dna标签进行稀有细胞分析
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
EP2366801B1 (en) 2006-06-14 2016-10-19 Verinata Health, Inc Methods for the diagnosis of fetal abnormalities
EP2035540A2 (en) 2006-06-15 2009-03-18 Stratagene System for isolating biomolecules from a sample
WO2007147063A2 (en) 2006-06-16 2007-12-21 Sequenom, Inc. Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample
US20080182244A1 (en) 2006-08-04 2008-07-31 Ikonisys, Inc. Pre-Implantation Genetic Diagnosis Test
EP2057282A4 (en) 2006-08-24 2010-10-27 Univ Massachusetts Medical MAPPING GENOMIC INTERACTIONS
WO2008143627A2 (en) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
US20080085836A1 (en) 2006-09-22 2008-04-10 Kearns William G Method for genetic testing of human embryos for chromosome abnormalities, segregating genetic disorders with or without a known mutation and mitochondrial disorders following in vitro fertilization (IVF), embryo culture and embryo biopsy
EP2094838A1 (en) 2006-10-16 2009-09-02 Cellula, Inc. Methods and compositions for differential expansion of fetal cells in maternal blood and their use
WO2008051928A2 (en) 2006-10-23 2008-05-02 The Salk Institute For Biological Studies Target-oriented whole genome amplification of nucliec acids
WO2008059578A1 (en) 2006-11-16 2008-05-22 Olympus Corporation Multiplex pcr method
WO2008081451A2 (en) * 2007-01-03 2008-07-10 Monaliza Medical Ltd. Methods and kits for analyzing genetic material of a fetus
US8173370B2 (en) 2007-02-08 2012-05-08 Sequenom, Inc. Nucleic acid-based tests for RHD typing, gender determination and nucleic acid quantification
CN101790731B (zh) 2007-03-16 2013-11-06 纳特拉公司 用于清除遗传数据干扰并确定染色体拷贝数的系统和方法
ITTO20070307A1 (it) 2007-05-04 2008-11-05 Silicon Biosystems Spa Metodo e dispositivo per la diagnosi prenatale non-invasiva
KR20100038330A (ko) 2007-05-31 2010-04-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 입체구조적 방해 및 효소 관련 신호 증폭 기반의 고 특이성 및 고 민감도 검출
WO2008157264A2 (en) 2007-06-15 2008-12-24 Sequenom, Inc. Combined methods for the detection of chromosomal aneuploidy
US20090023190A1 (en) 2007-06-20 2009-01-22 Kai Qin Lao Sequence amplification with loopable primers
AU2008272421B2 (en) 2007-07-03 2014-09-04 Genaphora Ltd. Chimeric primers for improved nucleic acid amplification reactions
WO2009009769A2 (en) 2007-07-11 2009-01-15 Artemis Health, Inc. Diagnosis of fetal abnormalities using nucleated red blood cells
KR102222378B1 (ko) 2007-07-23 2021-03-04 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
EP2191276B1 (en) 2007-08-03 2013-11-20 DKFZ Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
WO2009032779A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for the size-specific seperation of nucleic acid from a sample
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
US8748100B2 (en) 2007-08-30 2014-06-10 The Chinese University Of Hong Kong Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
JP5707132B2 (ja) 2007-09-07 2015-04-22 フルイダイム コーポレイション コピー数変動の決定、方法およびシステム
CA2697640C (en) 2007-09-21 2016-06-21 Katholieke Universiteit Leuven Tools and methods for genetic tests using next generation sequencing
US20090081678A1 (en) 2007-09-21 2009-03-26 Streck, Inc. Nucleic acid isolation in preserved whole blood
AU2008329833B2 (en) 2007-11-30 2014-04-17 Global Life Sciences Solutions Usa Llc Method for isolation of genomic DNA, RNA and proteins from a single sample
EP2077337A1 (en) 2007-12-26 2009-07-08 Eppendorf Array Technologies SA Amplification and detection composition, method and kit
EP3699291B1 (en) 2008-01-17 2024-08-07 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes and compositions
WO2009092035A2 (en) 2008-01-17 2009-07-23 Sequenom, Inc. Methods and compositions for the analysis of biological molecules
WO2009105531A1 (en) 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
US20090221620A1 (en) * 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
ES2586457T3 (es) 2008-04-03 2016-10-14 Cb Biotechnologies, Inc. Reacción en cadena de la polimerasa múltiple de rescate de amplicón para amplificación de dianas múltiples
US20110092763A1 (en) 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
US20110178719A1 (en) 2008-08-04 2011-07-21 Gene Security Network, Inc. Methods for Allele Calling and Ploidy Calling
CN102203287B (zh) 2008-08-26 2017-09-19 弗卢迪格姆公司 增加样本和/或靶通量的测定方法
DE102008045705A1 (de) 2008-09-04 2010-04-22 Macherey, Nagel Gmbh & Co. Kg Handelsgesellschaft Verfahren zur Gewinnung von kurzer RNA sowie Kit hierfür
US8586310B2 (en) 2008-09-05 2013-11-19 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
EP2324131A4 (en) 2008-09-17 2013-02-27 Ge Healthcare Bio Sciences PROCESS FOR ISOLATING SMALL RNA
CA2737643C (en) 2008-09-20 2020-10-06 Hei-Mun Fan Noninvasive diagnosis of fetal aneuploidy by sequencing
CN102325901A (zh) 2008-12-22 2012-01-18 赛卢拉有限公司 检测等位基因、基因组和转录物组的方法和基因型分析谱
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
WO2010088288A2 (en) 2009-01-28 2010-08-05 Fluidigm Corporation Determination of copy number differences by amplification
DK3290530T3 (da) 2009-02-18 2020-12-07 Streck Inc Konservering af cellefrie nukleinsyrer
US20100285537A1 (en) 2009-04-02 2010-11-11 Fluidigm Corporation Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
KR20110006112A (ko) 2009-07-13 2011-01-20 삼성전자주식회사 카메라 시스템에서 디스플레이 패널의 백라이트를 제어하는 장치 및 그 방법
US8563242B2 (en) 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
CA2773186A1 (en) 2009-09-24 2011-03-31 Qiagen Gaithersburg, Inc. Compositions, methods, and kits for isolating and analyzing nucleic acids using an anion exchange material
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
HUE061110T2 (hu) 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
GB2488289A (en) 2009-11-06 2012-08-22 Univ Leland Stanford Junior Non-invasive diagnosis of graft rejection in organ transplant patients
JP2013511991A (ja) 2009-11-25 2013-04-11 クアンタライフ， インコーポレイテッド 遺伝子材料を検出する方法および組成物
MA33899B1 (fr) 2009-12-08 2013-01-02 Hemaquest Pharmaceuticals Inc Procedes et regimes a faible dose pour des troubles des globules rouges
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US8574842B2 (en) 2009-12-22 2013-11-05 The Board Of Trustees Of The Leland Stanford Junior University Direct molecular diagnosis of fetal aneuploidy
EP2516680B1 (en) 2009-12-22 2016-04-06 Sequenom, Inc. Processes and kits for identifying aneuploidy
EP2848704B1 (en) 2010-01-19 2018-08-29 Verinata Health, Inc Sequencing methods for prenatal diagnoses
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US20190284623A1 (en) 2010-05-18 2019-09-19 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190309358A1 (en) 2010-05-18 2019-10-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20130123120A1 (en) 2010-05-18 2013-05-16 Natera, Inc. Highly Multiplex PCR Methods and Compositions
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20130196862A1 (en) 2010-05-18 2013-08-01 Natera, Inc. Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
WO2013052557A2 (en) 2011-10-03 2013-04-11 Natera, Inc. Methods for preimplantation genetic diagnosis by sequencing
US20140206552A1 (en) 2010-05-18 2014-07-24 Natera, Inc. Methods for preimplantation genetic diagnosis by sequencing
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20110301854A1 (en) 2010-06-08 2011-12-08 Curry Bo U Method of Determining Allele-Specific Copy Number of a SNP
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
CN103534591B (zh) 2010-10-26 2016-04-06 利兰·斯坦福青年大学托管委员会 通过测序分析进行的非侵入性胎儿遗传筛选
KR101891847B1 (ko) 2010-11-30 2018-08-24 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
EP2649199A2 (en) 2010-12-07 2013-10-16 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale
WO2012083250A2 (en) 2010-12-17 2012-06-21 Celula, Inc. Methods for screening and diagnosing genetic conditions
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20120190021A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
CA2824387C (en) 2011-02-09 2019-09-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP3760731A1 (en) 2011-02-09 2021-01-06 Natera, Inc. Methods for non-invasive prenatal ploidy calling
GB2488358A (en) 2011-02-25 2012-08-29 Univ Plymouth Enrichment of foetal DNA in maternal plasma
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
RS57837B1 (sr) 2011-04-12 2018-12-31 Verinata Health Inc Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama
CN103843001B (zh) 2011-04-14 2017-06-09 考利达基因组股份有限公司 复杂核酸序列数据的处理和分析
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US9957558B2 (en) 2011-04-28 2018-05-01 Life Technologies Corporation Methods and compositions for multiplex PCR
US8945844B2 (en) 2011-07-11 2015-02-03 Samsung Electronics Co., Ltd. Method of amplifying target nucleic acid with reduced amplification bias and method for determining relative amount of target nucleic acid in sample
US20130024127A1 (en) 2011-07-19 2013-01-24 John Stuelpnagel Determination of source contributions using binomial probability calculations
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
JP5536729B2 (ja) 2011-09-20 2014-07-02 株式会社ソニー・コンピュータエンタテインメント 情報処理装置、アプリケーション提供システム、アプリケーション提供サーバ、アプリケーション提供方法、および情報処理方法
CN113388606A (zh) 2011-09-26 2021-09-14 凯杰有限公司 用于分离细胞外核酸的快速方法
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
WO2013049892A1 (en) 2011-10-07 2013-04-11 Murdoch Childrens Research Institute Diagnostic assay for tissue transplantation status
WO2013078470A2 (en) 2011-11-22 2013-05-30 MOTIF, Active Multiplex isolation of protein-associated nucleic acids
WO2013086464A1 (en) 2011-12-07 2013-06-13 The Broad Institute, Inc. Markers associated with chronic lymphocytic leukemia prognosis and progression
US20130190653A1 (en) 2012-01-25 2013-07-25 Angel Gabriel Alvarez Ramos Device for blood collection from the placenta and the umbilical cord
WO2013128281A1 (en) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
WO2013130848A1 (en) 2012-02-29 2013-09-06 Natera, Inc. Informatics enhanced analysis of fetal samples subject to maternal contamination
WO2013138510A1 (en) 2012-03-13 2013-09-19 Patel Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
CA3209140A1 (en) 2012-04-19 2013-10-24 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
ES2905448T3 (es) 2012-05-10 2022-04-08 Massachusetts Gen Hospital Métodos para determinar una secuencia nucleotídica
WO2013177220A1 (en) 2012-05-21 2013-11-28 The Scripps Research Institute Methods of sample preparation
WO2013181651A1 (en) 2012-06-01 2013-12-05 Omega Bio-Tek, Inc. Selective nucleic acid fragment recovery
WO2014004726A1 (en) 2012-06-26 2014-01-03 Caifu Chen Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer
CA2878246C (en) 2012-07-20 2022-01-11 Verinata Health, Inc. Detecting and classifying copy number variation in a cancer genome
JP6392222B2 (ja) 2012-07-24 2018-09-19 ナテラ， インコーポレイテッド 高度多重ｐｃｒ法および組成物
US20140051585A1 (en) 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
CN105164509B (zh) 2012-08-28 2018-02-23 阿科尼生物系统公司 用于纯化核酸的方法和试剂盒
EP4036247B1 (en) 2012-09-04 2024-04-10 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US20140065621A1 (en) 2012-09-04 2014-03-06 Natera, Inc. Methods for increasing fetal fraction in maternal blood
EP2943590A4 (en) 2013-01-13 2017-02-15 Unitaq Bio Methods and compositions for pcr using blocked and universal primers
WO2014122288A1 (en) 2013-02-08 2014-08-14 Qiagen Gmbh Method for separating dna by size
US9982255B2 (en) 2013-03-11 2018-05-29 Kailos Genetics, Inc. Capture methodologies for circulating cell free DNA
US10385394B2 (en) 2013-03-15 2019-08-20 The Translational Genomics Research Institute Processes of identifying and characterizing X-linked disorders
US20140272956A1 (en) 2013-03-15 2014-09-18 Abbott Molecular Inc. Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits
EP3421613B1 (en) 2013-03-15 2020-08-19 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
GB2528205B (en) 2013-03-15 2020-06-03 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
WO2015083004A1 (en) 2013-12-02 2015-06-11 Population Genetics Technologies Ltd. Method for evaluating minority variants in a sample
SG10201804519RA (en) 2013-12-28 2018-07-30 Guardant Health Inc Methods and systems for detecting genetic variants
CN106029962A (zh) 2014-02-11 2016-10-12 豪夫迈·罗氏有限公司 靶向测序和uid过滤
US11767559B2 (en) 2014-03-14 2023-09-26 Caredx, Inc. Methods of monitoring immunosuppressive therapies in a transplant recipient
US9914973B2 (en) 2014-03-25 2018-03-13 Quest Diagnostics Investments Incorporated Detection of gene fusions by intragenic differential expression (IDE) using average cycle thresholds
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
WO2015164432A1 (en) 2014-04-21 2015-10-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US10619163B2 (en) 2014-07-03 2020-04-14 Rhodx, Inc. Tagging and assessing a target sequence
WO2016009059A1 (en) 2014-07-17 2016-01-21 Qiagen Gmbh Method for isolating rna with high yield
EP3656875B1 (en) 2014-07-18 2021-09-22 Illumina, Inc. Non-invasive prenatal diagnosis
EP3209403A4 (en) 2014-10-24 2018-09-12 Abbott Molecular Inc. Enrichment of small nucleic acids
CN107002130B (zh) 2014-11-11 2022-02-01 深圳华大基因研究院 多程测序
WO2016138080A1 (en) 2015-02-24 2016-09-01 Trustees Of Boston University Protection of barcodes during dna amplification using molecular hairpins
CN107208157B (zh) 2015-02-27 2022-04-05 贝克顿迪金森公司 用于条形编码核酸以用于测序的方法和组合物
WO2016160844A2 (en) 2015-03-30 2016-10-06 Cellular Research, Inc. Methods and compositions for combinatorial barcoding
KR101850437B1 (ko) 2015-04-14 2018-04-20 이원다이애그노믹스(주) 차세대 염기서열 분석기법을 이용한 장기 이식 거부 반응 예측 방법
EP3286326B1 (en) 2015-04-23 2025-01-22 Becton, Dickinson and Company Method for whole transcriptome amplification
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
ES2906751T3 (es) 2015-06-05 2022-04-20 Qiagen Gmbh Método para separar el DNA por tamaño
CN108138231A (zh) 2015-09-29 2018-06-08 路德维格癌症研究有限公司 分型和组装不连续基因组元件
EP3443066B1 (en) 2016-04-14 2024-10-02 Guardant Health, Inc. Methods for early detection of cancer
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
WO2017205540A1 (en) 2016-05-24 2017-11-30 The Translational Genomics Research Institute Molecular tagging methods and sequencing libraries
WO2017205826A1 (en) 2016-05-27 2017-11-30 Sequenom, Inc. Methods for detecting genetic variations
AU2017290809A1 (en) 2016-07-01 2018-12-13 Natera, Inc. Compositions and methods for detection of nucleic acid mutations
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
CN109906274B (zh) 2016-11-08 2023-08-25 贝克顿迪金森公司 用于细胞标记分类的方法
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
US11091800B2 (en) 2017-09-20 2021-08-17 University Of Utah Research Foundation Size-selection of cell-free DNA for increasing family size during next-generation sequencing
US20210071246A1 (en) 2018-01-12 2021-03-11 Natera, Inc. Novel primers and uses thereof
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US20210257048A1 (en) 2018-06-12 2021-08-19 Natera, Inc. Methods and systems for calling mutations
WO2020010255A1 (en) 2018-07-03 2020-01-09 Natera, Inc. Methods for detection of donor-derived cell-free dna
JP2021530231A (ja) 2018-07-17 2021-11-11 ナテラ， インコーポレイテッド ニューラルネットワークを使用して倍数性状態を呼び出すための方法およびシステム

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