|
EP2449112A1
(en)
|
2009-07-01 |
2012-05-09 |
Transposagen Biopharmaceuticals, Inc. |
Genetically modified rat models for severe combined immunodeficiency (scid)
|
|
US9719068B2
(en)
|
2010-05-06 |
2017-08-01 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
US10920242B2
(en)
|
2011-02-25 |
2021-02-16 |
Recombinetics, Inc. |
Non-meiotic allele introgression
|
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
|
MX2013010911A
(es)
|
2011-03-23 |
2015-03-03 |
Pioneer Hi Bred Int |
Metodos para producir un locus de rasgo transgenico complejo.
|
|
JP6261500B2
(ja)
|
2011-07-22 |
2018-01-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ヌクレアーゼ切断特異性の評価および改善
|
|
WO2013055995A2
(en)
|
2011-10-14 |
2013-04-18 |
President And Fellows Of Harvard College |
Sequencing by structure assembly
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
IN2014DN09261A
(https=)
|
2012-04-25 |
2015-07-10 |
Regeneron Pharma |
|
|
EP3597741A1
(en)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetic correction of mutated genes
|
|
EP3241902B1
(en)
|
2012-05-25 |
2018-02-28 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
DK3444342T3
(da)
|
2012-07-11 |
2020-08-24 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til behandlingen af lysosomale aflejringssygdomme
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
KR102530118B1
(ko)
*
|
2012-07-25 |
2023-05-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유도 dna 결합 단백질 및 게놈 교란 도구 및 이의 적용
|
|
EP4357457B1
(en)
*
|
2012-10-23 |
2024-10-16 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
WO2014071182A1
(en)
|
2012-11-01 |
2014-05-08 |
Massachusetts Institute Of Technology |
Directed evolution of synthetic gene cluster
|
|
EP3363902B1
(en)
|
2012-12-06 |
2019-11-27 |
Sigma Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
CA2894684A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes
|
|
DK2931898T3
(en)
|
2012-12-12 |
2016-06-20 |
Massachusetts Inst Technology |
CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
|
|
WO2014093718A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
DK2931897T3
(en)
|
2012-12-12 |
2018-02-05 |
Broad Inst Inc |
CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS
|
|
AU2013359262C1
(en)
|
2012-12-12 |
2021-05-13 |
Massachusetts Institute Of Technology |
CRISPR-Cas component systems, methods and compositions for sequence manipulation
|
|
CA2895155C
(en)
|
2012-12-17 |
2021-07-06 |
President And Fellows Of Harvard College |
Rna-guided human genome engineering
|
|
EP3919505B1
(en)
|
2013-01-16 |
2023-08-30 |
Emory University |
Uses of cas9-nucleic acid complexes
|
|
US11135273B2
(en)
|
2013-02-07 |
2021-10-05 |
The Rockefeller University |
Sequence specific antimicrobials
|
|
US10660943B2
(en)
*
|
2013-02-07 |
2020-05-26 |
The Rockefeller University |
Sequence specific antimicrobials
|
|
EP3578666A1
(en)
|
2013-03-12 |
2019-12-11 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
MX374090B
(es)
|
2013-03-14 |
2025-03-05 |
Caribou Biosciences Inc |
Composiciones y métodos de ácidos nucleicos dirigidos al ácido nucleico.
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
AU2014227653B2
(en)
|
2013-03-15 |
2017-04-20 |
The General Hospital Corporation |
Using RNA-guided foki nucleases (RFNs) to increase specificity for RNA-guided genome editing
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US20140364333A1
(en)
*
|
2013-03-15 |
2014-12-11 |
President And Fellows Of Harvard College |
Methods for Live Imaging of Cells
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
JP2016522679A
(ja)
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いたゲノム編集の治療的使用
|
|
SI2986729T1
(sl)
|
2013-04-16 |
2019-02-28 |
Regeneron Pharmaceuticals, Inc. |
Ciljana sprememba genoma podgane
|
|
US20160122774A1
(en)
*
|
2013-05-29 |
2016-05-05 |
Cellectis |
A method for producing precise dna cleavage using cas9 nickase activity
|
|
US11414695B2
(en)
|
2013-05-29 |
2022-08-16 |
Agilent Technologies, Inc. |
Nucleic acid enrichment using Cas9
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
EP4596565A3
(en)
|
2013-06-04 |
2025-11-05 |
President And Fellows Of Harvard College |
Rna-guided transcriptional regulation
|
|
EP3004370B1
(en)
*
|
2013-06-05 |
2024-08-21 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
US9982277B2
(en)
|
2013-06-11 |
2018-05-29 |
The Regents Of The University Of California |
Methods and compositions for target DNA modification
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3011030B1
(en)
|
2013-06-17 |
2023-11-08 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
KR20250012194A
(ko)
*
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
MX2015017312A
(es)
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
JP2016528890A
(ja)
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いるゲノム編集の治療用の使用
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
CA3109801C
(en)
|
2013-08-22 |
2024-01-09 |
Andrew Cigan |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
WO2015034872A2
(en)
*
|
2013-09-05 |
2015-03-12 |
Massachusetts Institute Of Technology |
Tuning microbial populations with programmable nucleases
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
EP3418379B1
(en)
|
2013-09-18 |
2020-12-09 |
Kymab Limited |
Methods, cells & organisms
|
|
WO2015054507A1
(en)
|
2013-10-10 |
2015-04-16 |
Pronutria, Inc. |
Nutritive polypeptide production systems, and methods of manufacture and use thereof
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
US11326209B2
(en)
|
2013-11-07 |
2022-05-10 |
Massachusetts Institute Of Technology |
Cell-based genomic recorded accumulative memory
|
|
AU2014346559B2
(en)
|
2013-11-07 |
2020-07-09 |
Editas Medicine,Inc. |
CRISPR-related methods and compositions with governing gRNAs
|
|
US9546384B2
(en)
|
2013-12-11 |
2017-01-17 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a mouse genome
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
US9994831B2
(en)
|
2013-12-12 |
2018-06-12 |
The Regents Of The University Of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
EP3470089A1
(en)
|
2013-12-12 |
2019-04-17 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
AU2014361781B2
(en)
|
2013-12-12 |
2021-04-01 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
|
|
BR112016013207A2
(pt)
|
2013-12-12 |
2017-09-26 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para o hbv e distúrbios e doenças virais
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
MX2016007325A
(es)
|
2013-12-12 |
2017-07-19 |
Broad Inst Inc |
Composiciones y metodos de uso de sistemas crispr-cas en desordenes debidos a repeticion de nucleotidos.
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
|
ES2918501T3
(es)
|
2013-12-19 |
2022-07-18 |
Novartis Ag |
Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos
|
|
US9963689B2
(en)
|
2013-12-31 |
2018-05-08 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
|
EP4063503A1
(en)
*
|
2014-02-11 |
2022-09-28 |
The Regents of the University of Colorado, a body corporate |
Crispr enabled multiplexed genome engineering
|
|
JP2017506893A
(ja)
|
2014-02-18 |
2017-03-16 |
デューク ユニバーシティ |
ウイルス複製不活化組成物並びにその製造方法及び使用
|
|
EP3110971B1
(en)
|
2014-02-27 |
2019-05-08 |
The Broad Institute Inc. |
T cell balance gene expression and methods of use thereof
|
|
US11186843B2
(en)
|
2014-02-27 |
2021-11-30 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
|
SG11201609211VA
(en)
|
2014-03-05 |
2016-12-29 |
Nat Univ Corp Univ Kobe |
Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
|
|
WO2015134812A1
(en)
|
2014-03-05 |
2015-09-11 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
WO2015138510A1
(en)
|
2014-03-10 |
2015-09-17 |
Editas Medicine., Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3593812A3
(en)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
|
US10349639B2
(en)
|
2014-03-26 |
2019-07-16 |
University Of Maryland, College Park |
Targeted genome editing in zygotes of domestic large animals
|
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
|
US12460231B2
(en)
|
2014-04-02 |
2025-11-04 |
Editas Medicine, Inc. |
Crispr/CAS-related methods and compositions for treating primary open angle glaucoma
|
|
AU2015244039B2
(en)
|
2014-04-07 |
2021-10-21 |
Novartis Ag |
Treatment of cancer using anti-CD19 chimeric antigen receptor
|
|
WO2015159068A1
(en)
*
|
2014-04-14 |
2015-10-22 |
Nemesis Bioscience Ltd |
Therapeutic
|
|
GB201406970D0
(en)
*
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
|
WO2015168125A1
(en)
|
2014-04-28 |
2015-11-05 |
Recombinetics, Inc. |
Multiplex gene editing in swine
|
|
EP3140403A4
(en)
*
|
2014-05-09 |
2017-12-20 |
Université Laval |
Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system
|
|
KR102149572B1
(ko)
|
2014-05-19 |
2020-08-28 |
화이자 인코포레이티드 |
아시알로당단백질 수용체의 표적화제로서 치환된-6,8-다이옥사바이사이클로[3.2.1]옥탄-2,3-다이올 화합물
|
|
CN106661548B
(zh)
|
2014-05-28 |
2020-12-11 |
儿童医院医疗中心 |
用于经由定向分化将前体细胞转化为胃组织的方法和系统
|
|
RS60359B1
(sr)
*
|
2014-06-06 |
2020-07-31 |
Regeneron Pharma |
Postupci i kompozicije za modifikovanje ciljanog lokusa
|
|
US11491480B2
(en)
|
2014-06-13 |
2022-11-08 |
Children's Medical Center Corporation |
Products and methods to isolate mitochondria
|
|
EP3919621A1
(en)
|
2014-06-23 |
2021-12-08 |
The General Hospital Corporation |
Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
|
|
AU2015288157A1
(en)
|
2014-07-11 |
2017-01-19 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
WO2016007948A1
(en)
*
|
2014-07-11 |
2016-01-14 |
Pioneer Hi-Bred International, Inc. |
Agronomic trait modification using guide rna/cas endonuclease systems and methods of use
|
|
WO2016011203A1
(en)
|
2014-07-15 |
2016-01-21 |
Life Technologies Corporation |
Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
|
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
TWI750110B
(zh)
|
2014-07-21 |
2021-12-21 |
瑞士商諾華公司 |
使用人類化抗-bcma嵌合抗原受體治療癌症
|
|
SG10201913765YA
(en)
|
2014-07-21 |
2020-03-30 |
Novartis Ag |
Treatment of cancer using a cd33 chimeric antigen receptor
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
ES2781175T3
(es)
|
2014-07-31 |
2020-08-31 |
Novartis Ag |
Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico
|
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
|
CA2958200A1
(en)
|
2014-08-14 |
2016-02-18 |
Novartis Ag |
Treatment of cancer using a gfr alpha-4 chimeric antigen receptor
|
|
EP3686279B1
(en)
|
2014-08-17 |
2023-01-04 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
ES2791248T3
(es)
|
2014-08-19 |
2020-11-03 |
Novartis Ag |
Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer
|
|
ES2730378T3
(es)
*
|
2014-08-27 |
2019-11-11 |
Caribou Biosciences Inc |
Procedimientos para incrementar la eficiencia de la modificación mediada por Cas9
|
|
EP3633032A3
(en)
|
2014-08-28 |
2020-07-29 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
WO2016036754A1
(en)
|
2014-09-02 |
2016-03-10 |
The Regents Of The University Of California |
Methods and compositions for rna-directed target dna modification
|
|
CN108064129A
(zh)
|
2014-09-12 |
2018-05-22 |
纳幕尔杜邦公司 |
玉米和大豆中复合性状基因座的位点特异性整合位点的产生和使用方法
|
|
KR20250067191A
(ko)
|
2014-09-17 |
2025-05-14 |
노파르티스 아게 |
입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화
|
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
|
EP3197272A4
(en)
|
2014-09-23 |
2018-05-23 |
AgGenetics, Inc. |
Materials and methods for producing animals with short hair
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049024A2
(en)
*
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
US10040048B1
(en)
|
2014-09-25 |
2018-08-07 |
Synthego Corporation |
Automated modular system and method for production of biopolymers
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
WO2016061073A1
(en)
*
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
|
CN105602935B
(zh)
*
|
2014-10-20 |
2020-11-13 |
聂凌云 |
一种新型线粒体基因组编辑工具
|
|
GB201418965D0
(https=)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
WO2016069591A2
(en)
|
2014-10-27 |
2016-05-06 |
The Broad Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
CN107406838A
(zh)
|
2014-11-06 |
2017-11-28 |
纳幕尔杜邦公司 |
Rna引导的内切核酸酶向细胞中的肽介导的递送
|
|
WO2016073955A2
(en)
|
2014-11-06 |
2016-05-12 |
President And Fellows Of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
CA2963820A1
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
ES2731437T3
(es)
|
2014-11-21 |
2019-11-15 |
Regeneron Pharma |
Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías
|
|
EP3224381B1
(en)
|
2014-11-25 |
2019-09-04 |
The Brigham and Women's Hospital, Inc. |
Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
CA2969145A1
(en)
|
2014-11-26 |
2016-06-02 |
The Regents Of The University Of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
US20180105834A1
(en)
*
|
2014-11-27 |
2018-04-19 |
Institute Of Animal Sciences, Chinese Academy Of Agrigultural Sciences |
A method of site-directed insertion to h11 locus in pigs by using site-directed cutting system
|
|
US10900034B2
(en)
|
2014-12-03 |
2021-01-26 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
|
AU2015360502A1
(en)
|
2014-12-10 |
2017-06-29 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
WO2016100333A1
(en)
|
2014-12-15 |
2016-06-23 |
Syngenta Participations Ag |
Pesticidal microrna carriers and use thereof
|
|
CA2971187C
(en)
*
|
2014-12-16 |
2023-10-24 |
Danisco Us Inc. |
Fungal genome modification systems and methods of use
|
|
JP6839082B2
(ja)
*
|
2014-12-17 |
2021-03-03 |
イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company |
環状ポリヌクレオチド修飾鋳型と組み合わせてガイドrna/casエンドヌクレアーゼ系を用いるe.コリ(e.coli)での効率的な遺伝子編集のための組成物および方法
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
US20190054117A1
(en)
|
2014-12-19 |
2019-02-21 |
Novartis Ag |
Dimerization switches and uses thereof
|
|
US10190106B2
(en)
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
CA2969151A1
(en)
|
2014-12-23 |
2016-06-30 |
Syngenta Participations Ag |
Methods and compositions for identifying and enriching for cells comprising site specific genomic modifications
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
SG11201704272YA
(en)
|
2014-12-31 |
2017-06-29 |
Synthetic Genomics Inc |
Compositions and methods for high efficiency in vivo genome editing
|
|
WO2016114972A1
(en)
|
2015-01-12 |
2016-07-21 |
The Regents Of The University Of California |
Heterodimeric cas9 and methods of use thereof
|
|
WO2016123243A1
(en)
|
2015-01-28 |
2016-08-04 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
EP3250691B9
(en)
|
2015-01-28 |
2023-08-02 |
Caribou Biosciences, Inc. |
Crispr hybrid dna/rna polynucleotides and methods of use
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
EP3262193A2
(en)
|
2015-02-26 |
2018-01-03 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
JP6871169B2
(ja)
|
2015-03-02 |
2021-05-12 |
シナイ ヘルス システム |
相同組換え因子
|
|
EP3265559B1
(en)
|
2015-03-03 |
2021-01-06 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
CN104673816A
(zh)
*
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
|
BR112017017260A2
(pt)
|
2015-03-27 |
2018-04-17 |
Du Pont |
construções de dna, vetor, célula, plantas, semente, método de expressão de rna e método de modificação de local alvo
|
|
EP3280803B1
(en)
|
2015-04-06 |
2021-05-26 |
The Board of Trustees of the Leland Stanford Junior University |
Chemically modified guide rnas for crispr/cas-mediated gene regulation
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
WO2016168594A1
(en)
*
|
2015-04-16 |
2016-10-20 |
President And Fellows Of Harvard College |
Sensor systems for target ligands and uses thereof
|
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
CA2982966C
(en)
|
2015-04-24 |
2024-02-20 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
WO2016176617A2
(en)
|
2015-04-29 |
2016-11-03 |
New York University |
Method for treating high-grade gliomas
|
|
CN106191040B
(zh)
*
|
2015-04-30 |
2021-09-14 |
杭州菁因康生物科技有限公司 |
基因打靶方法
|
|
CN107667173A
(zh)
|
2015-05-06 |
2018-02-06 |
斯尼普技术有限公司 |
改变微生物种群和改善微生物群
|
|
EP3294342A4
(en)
|
2015-05-08 |
2018-11-07 |
President and Fellows of Harvard College |
Universal donor stem cells and related methods
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
AU2016261358B2
(en)
|
2015-05-11 |
2021-09-16 |
Editas Medicine, Inc. |
Optimized CRISPR/Cas9 systems and methods for gene editing in stem cells
|
|
US10676723B2
(en)
|
2015-05-11 |
2020-06-09 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
WO2016183438A1
(en)
*
|
2015-05-14 |
2016-11-17 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
|
CN107849546A
(zh)
|
2015-05-15 |
2018-03-27 |
先锋国际良种公司 |
对cas内切核酸酶系统、pam序列和指导rna元件的快速表征
|
|
WO2016187904A1
(zh)
*
|
2015-05-22 |
2016-12-01 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
WO2016191684A1
(en)
*
|
2015-05-28 |
2016-12-01 |
Finer Mitchell H |
Genome editing vectors
|
|
KR20220139447A
(ko)
*
|
2015-05-29 |
2022-10-14 |
노쓰 캐롤라이나 스테이트 유니버시티 |
크리스퍼 핵산을 사용하여 박테리아, 고세균, 조류 및 효모를 스크리닝하는 방법
|
|
EA037359B1
(ru)
|
2015-06-01 |
2021-03-17 |
Тэмпл Юниверсити - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн |
Способы и композиции для рнк-направляемого лечения инфекции, вызываемой вич
|
|
WO2016196887A1
(en)
|
2015-06-03 |
2016-12-08 |
Board Of Regents Of The University Of Nebraska |
Dna editing using single-stranded dna
|
|
EP3303634B1
(en)
|
2015-06-03 |
2023-08-30 |
The Regents of The University of California |
Cas9 variants and methods of use thereof
|
|
EP3302525A2
(en)
|
2015-06-05 |
2018-04-11 |
Novartis AG |
Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
|
|
EP3307887A1
(en)
|
2015-06-09 |
2018-04-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
WO2016198500A1
(en)
*
|
2015-06-10 |
2016-12-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for rna-guided treatment of human cytomegalovirus (hcmv) infection
|
|
US20180177727A1
(en)
|
2015-06-10 |
2018-06-28 |
Board Of Regents, The University Of Texas System |
Use of exosomes for the treatment of disease
|
|
US20180187190A1
(en)
*
|
2015-06-12 |
2018-07-05 |
Erasmus University Medical Center Rotterdam |
New crispr assays
|
|
KR102468240B1
(ko)
|
2015-06-15 |
2022-11-17 |
노쓰 캐롤라이나 스테이트 유니버시티 |
핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물
|
|
US11643668B2
(en)
|
2015-06-17 |
2023-05-09 |
The Uab Research Foundation |
CRISPR/Cas9 complex for genomic editing
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
CA2989858A1
(en)
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
EP4159856A1
(en)
|
2015-06-18 |
2023-04-05 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
TWI813532B
(zh)
*
|
2015-06-18 |
2023-09-01 |
美商博得學院股份有限公司 |
降低脱靶效應的crispr酶突變
|
|
CA3012607A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Crispr enzymes and systems
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
EP4545544A3
(en)
|
2015-06-29 |
2025-10-08 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
CN108602729B
(zh)
|
2015-07-13 |
2022-07-05 |
皮沃特生物公司 |
改良植物性状的方法及组合物
|
|
US11479793B2
(en)
|
2015-07-15 |
2022-10-25 |
Rutgers, The State University Of New Jersey |
Nuclease-independent targeted gene editing platform and uses thereof
|
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
EP3331913A1
(en)
|
2015-08-07 |
2018-06-13 |
Novartis AG |
Treatment of cancer using chimeric cd3 receptor proteins
|
|
EP4512819A3
(en)
|
2015-08-12 |
2025-08-06 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
|
CA3033909A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
WO2017031370A1
(en)
|
2015-08-18 |
2017-02-23 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
EP3341727B1
(en)
|
2015-08-25 |
2022-08-10 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
|
AU2016316845B2
(en)
|
2015-08-28 |
2022-03-10 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
ES2938623T3
(es)
|
2015-09-09 |
2023-04-13 |
Univ Kobe Nat Univ Corp |
Método para convertir una secuencia del genoma de una bacteria gram-positiva mediante una conversión específica de una base de ácido nucleico de una secuencia de ADN seleccionada como diana y el complejo molecular utilizado en el mismo
|
|
IL241462A0
(en)
|
2015-09-10 |
2015-11-30 |
Yeda Res & Dev |
Heterologous engineering of betalain pigments in plants
|
|
JP2018530536A
(ja)
|
2015-09-11 |
2018-10-18 |
ザ ジェネラル ホスピタル コーポレイション |
ヌクレアーゼDSBの完全照合およびシーケンシング(FIND−seq)
|
|
AU2016326711B2
(en)
|
2015-09-24 |
2022-11-03 |
Editas Medicine, Inc. |
Use of exonucleases to improve CRISPR/Cas-mediated genome editing
|
|
JP2018529353A
(ja)
|
2015-09-30 |
2018-10-11 |
ザ ジェネラル ホスピタル コーポレイション |
配列決定法による切断事象の包括的生体外報告(CIRCLE−seq)
|
|
WO2017062412A1
(en)
|
2015-10-05 |
2017-04-13 |
Massachusetts Institute Of Technology |
Nitrogen fixation using refactored nif clusters
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
AU2016338785B2
(en)
|
2015-10-12 |
2022-07-14 |
E. I. Du Pont De Nemours And Company |
Protected DNA templates for gene modification and increased homologous recombination in cells and methods of use
|
|
EP4089175A1
(en)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
US10947559B2
(en)
|
2015-10-16 |
2021-03-16 |
Astrazeneca Ab |
Inducible modification of a cell genome
|
|
EP3365440B1
(en)
|
2015-10-20 |
2022-09-14 |
Pioneer Hi-Bred International, Inc. |
Restoring function to a non-functional gene product via guided cas systems and methods of use
|
|
WO2017068077A1
(en)
|
2015-10-20 |
2017-04-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
|
EP4636083A3
(en)
|
2015-10-20 |
2026-01-21 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods and products for genetic engineering
|
|
CN109153980B
(zh)
|
2015-10-22 |
2023-04-14 |
布罗德研究所有限公司 |
Vi-b型crispr酶和系统
|
|
JP7109784B2
(ja)
|
2015-10-23 |
2022-08-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
遺伝子編集のための進化したCas9蛋白質
|
|
DK3350327T3
(en)
|
2015-10-23 |
2019-01-21 |
Caribou Biosciences Inc |
CONSTRUCTED CRISPR CLASS-2-NUCLEIC ACID TARGETING-NUCLEIC ACID
|
|
EP3368687B1
(en)
|
2015-10-27 |
2021-09-29 |
The Broad Institute, Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
US11092607B2
(en)
|
2015-10-28 |
2021-08-17 |
The Board Institute, Inc. |
Multiplex analysis of single cell constituents
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
|
JP6882282B2
(ja)
|
2015-11-03 |
2021-06-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
三次元核酸含有マトリックスの立体撮像のための方法と装置
|
|
AU2016349738A1
(en)
*
|
2015-11-06 |
2018-05-24 |
The Jackson Laboratory |
Large genomic DNA knock-in and uses thereof
|
|
CA2947904A1
(en)
*
|
2015-11-12 |
2017-05-12 |
Pfizer Inc. |
Tissue-specific genome engineering using crispr-cas9
|
|
WO2017083766A1
(en)
*
|
2015-11-13 |
2017-05-18 |
Massachusetts Institute Of Technology |
High-throughput crispr-based library screening
|
|
ES2905558T3
(es)
|
2015-11-13 |
2022-04-11 |
Avellino Lab Usa Inc |
Procedimientos para el tratamiento de las distrofias corneales
|
|
CA3005633C
(en)
|
2015-11-16 |
2023-11-21 |
Research Institute Of Nationwide Children's Hospital |
Materials and methods for treatment of titin-based myopathies and other titinopathies
|
|
CN106893739A
(zh)
|
2015-11-17 |
2017-06-27 |
香港中文大学 |
用于靶向基因操作的新方法和系统
|
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
|
WO2017087885A1
(en)
|
2015-11-19 |
2017-05-26 |
Dana-Farber Cancer Institute, Inc. |
Methods of identifying compounds that interfere with erg-driven misguidance of baf complexes in tmprss2-erg driven prostate cancers
|
|
ES2914623T3
(es)
*
|
2015-11-27 |
2022-06-14 |
Univ Kobe Nat Univ Corp |
Método para convertir una secuencia genómica de una planta monocotiledónea en la que una base de ácido nucleico en la secuencia de ADN diana se convierte de manera específica y el complejo molecular utilizado en el mismo
|
|
EA201891317A3
(ru)
|
2015-11-30 |
2019-04-30 |
Дьюк Юниверсити |
Терапевтические мишени для коррекции гена дистрофина человека с помощью редактирования генов и способы их применения
|
|
US11903974B2
(en)
|
2015-11-30 |
2024-02-20 |
Flagship Pioneering Innovations V, Inc. |
Methods and compositions relating to chondrisomes from cultured cells
|
|
CN105296518A
(zh)
*
|
2015-12-01 |
2016-02-03 |
中国农业大学 |
一种用于CRISPR/Cas9技术的同源臂载体构建方法
|
|
AU2016363024B2
(en)
|
2015-12-04 |
2020-01-30 |
Caribou Biosciences, Inc. |
Engineered nucleic-acid targeting nucleic acids
|
|
US9988624B2
(en)
|
2015-12-07 |
2018-06-05 |
Zymergen Inc. |
Microbial strain improvement by a HTP genomic engineering platform
|
|
US11208649B2
(en)
|
2015-12-07 |
2021-12-28 |
Zymergen Inc. |
HTP genomic engineering platform
|
|
JP6821598B2
(ja)
|
2015-12-07 |
2021-01-27 |
ザイマージェン インコーポレイテッド |
Corynebacterium glutamicum由来のプロモーター
|
|
EP3387134B1
(en)
|
2015-12-11 |
2020-10-14 |
Danisco US Inc. |
Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
|
|
EP3708665A1
(en)
|
2015-12-18 |
2020-09-16 |
Danisco US Inc. |
Methods and compositions for t-rna based guide rna expression
|
|
WO2017106657A1
(en)
|
2015-12-18 |
2017-06-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
AU2016382512A1
(en)
|
2015-12-30 |
2018-07-12 |
Novartis Ag |
Immune effector cell therapies with enhanced efficacy
|
|
ES2875747T3
(es)
|
2016-01-11 |
2021-11-11 |
Univ Leland Stanford Junior |
Proteínas quiméricas y métodos de inmunoterapia
|
|
WO2017123559A2
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
|
SI4272834T1
(sl)
|
2016-01-15 |
2026-03-31 |
Beth Israel Deaconess Medical Center, Inc. |
Terapevtska uporaba mitohondrijev in kombiniranih mitohondrijskih sredstev
|
|
US11136589B2
(en)
|
2016-01-26 |
2021-10-05 |
Pioneer Hi-Bred International, Inc. |
Waxy corn
|
|
WO2017139309A1
(en)
|
2016-02-12 |
2017-08-17 |
Ceres, Inc. |
Methods and materials for high throughput testing of mutagenized allele combinations
|
|
US20190249172A1
(en)
|
2016-02-18 |
2019-08-15 |
The Regents Of The University Of California |
Methods and compositions for gene editing in stem cells
|
|
US10973930B2
(en)
|
2016-02-18 |
2021-04-13 |
The Penn State Research Foundation |
Generating GABAergic neurons in brains
|
|
WO2017147196A1
(en)
|
2016-02-22 |
2017-08-31 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating immune phenotypes
|
|
WO2017151444A1
(en)
|
2016-02-29 |
2017-09-08 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by crispr proteins
|
|
CA3016571A1
(en)
|
2016-03-04 |
2017-09-08 |
Indoor Biotechnologies Inc. |
Fel d 1 knockouts and associated compositions and methods based on crispr-cas9 genomic editing
|
|
EP3699281A1
(en)
|
2016-03-11 |
2020-08-26 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
CA3010628A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
WO2017155715A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
WO2017161043A1
(en)
|
2016-03-16 |
2017-09-21 |
The J. David Gladstone Institutes |
Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US11427861B2
(en)
|
2016-03-17 |
2022-08-30 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
EP3433362B1
(en)
*
|
2016-03-23 |
2021-05-05 |
Dana-Farber Cancer Institute, Inc. |
Methods for enhancing the efficiency of gene editing
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
|
MY209117A
(en)
|
2016-04-15 |
2025-06-23 |
Novartis Ag |
Compositions and methods for selective protein expression
|
|
CN110382692A
(zh)
|
2016-04-19 |
2019-10-25 |
博德研究所 |
新型crispr酶以及系统
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
CN105861485B
(zh)
*
|
2016-04-20 |
2021-08-17 |
上海伊丽萨生物科技有限公司 |
一种提高基因置换效率的方法
|
|
CA3021572A1
(en)
*
|
2016-04-20 |
2017-10-26 |
Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas |
Compositions and methods for enhanced gene expression of pklr
|
|
CN109415761B
(zh)
|
2016-04-25 |
2022-09-20 |
哈佛学院董事及会员团体 |
用于原位分子检测的杂交链反应方法
|
|
US20190203207A1
(en)
*
|
2016-05-20 |
2019-07-04 |
The Trustees Of Columbia University In The City Of New York |
Anabolic Enhancers for Ameliorating Neurodegeneration
|
|
EP3463371B1
(en)
|
2016-05-24 |
2022-02-23 |
Indiana University Research & Technology Corporation |
Ku inhibitors and their use
|
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CA3028158A1
(en)
|
2016-06-17 |
2017-12-21 |
The Broad Institute, Inc. |
Type vi crispr orthologs and systems
|
|
WO2017223128A1
(en)
|
2016-06-21 |
2017-12-28 |
The Curators Of The University Of Missouri |
Modified dystrophin proteins
|
|
US10017760B2
(en)
|
2016-06-24 |
2018-07-10 |
Inscripta, Inc. |
Methods for generating barcoded combinatorial libraries
|
|
MX2019000088A
(es)
|
2016-06-27 |
2019-08-29 |
Broad Inst Inc |
Composiciones y metodos para detectar y tratar la diabetes.
|
|
US12595478B2
(en)
|
2016-06-29 |
2026-04-07 |
The Broad Institute, Inc. |
Crispr-Cas systems having destabilization domain
|
|
JP2019519241A
(ja)
|
2016-06-30 |
2019-07-11 |
ザイマージェン インコーポレイテッド |
グルコース透過酵素ライブラリーを生成するための方法およびその使用
|
|
EP3478833A4
(en)
|
2016-06-30 |
2019-10-02 |
Zymergen, Inc. |
METHOD FOR PRODUCING A BACTERIAL HEMOGLOBIN LIBRARY AND ITS USE
|
|
CN109477130B
(zh)
|
2016-07-01 |
2022-08-30 |
微软技术许可有限责任公司 |
通过迭代dna编辑的存储
|
|
US20180004537A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Molecular State Machines
|
|
US11359234B2
(en)
|
2016-07-01 |
2022-06-14 |
Microsoft Technology Licensing, Llc |
Barcoding sequences for identification of gene expression
|
|
EP3484870B1
(en)
|
2016-07-13 |
2022-11-16 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
|
US20190336504A1
(en)
|
2016-07-15 |
2019-11-07 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
WO2018026976A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US11630103B2
(en)
|
2016-08-17 |
2023-04-18 |
The Broad Institute, Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
CN110312799A
(zh)
|
2016-08-17 |
2019-10-08 |
博德研究所 |
新型crispr酶和系统
|
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
|
JP2019524149A
(ja)
|
2016-08-20 |
2019-09-05 |
アベリノ ラボ ユーエスエー インコーポレイテッドAvellino Lab USA, Inc. |
一本鎖ガイドRNA、CRISPR/Cas9システム、及びそれらの使用方法
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CN109923216B
(zh)
|
2016-08-31 |
2024-08-02 |
哈佛学院董事及会员团体 |
将生物分子的检测组合到使用荧光原位测序的单个试验的方法
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
EP3510145A4
(en)
|
2016-09-06 |
2020-03-25 |
The Children's Medical Center Corporation |
IMMUNCELLS FROM INDUCED PLURIPOTENT STEM CELLS
|
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
WO2018049009A2
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
|
IL247752A0
(en)
|
2016-09-11 |
2016-11-30 |
Yeda Res & Dev |
Compositions and methods for modulating gene expression for site-directed mutagenesis
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
JP2019532672A
(ja)
|
2016-09-28 |
2019-11-14 |
ノバルティス アーゲー |
多孔質膜系巨大分子送達システム
|
|
WO2018064208A1
(en)
|
2016-09-28 |
2018-04-05 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
CA3038960A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
JP7306696B2
(ja)
|
2016-09-30 |
2023-07-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Rna誘導型核酸修飾酵素及びその使用方法
|
|
US11730823B2
(en)
|
2016-10-03 |
2023-08-22 |
President And Fellows Of Harvard College |
Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
CA3037560A1
(en)
|
2016-10-13 |
2018-04-19 |
Pioneer Hi-Bred International, Inc. |
Generating northern leaf blight resistant maize
|
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
US10738338B2
(en)
|
2016-10-18 |
2020-08-11 |
The Research Foundation for the State University |
Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
|
|
JP7181862B2
(ja)
|
2016-10-18 |
2022-12-01 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
腫瘍浸潤リンパ球および治療の方法
|
|
WO2018081531A2
(en)
|
2016-10-28 |
2018-05-03 |
Ariad Pharmaceuticals, Inc. |
Methods for human t-cell activation
|
|
CN110234762A
(zh)
*
|
2016-10-28 |
2019-09-13 |
吉尼松公司 |
用于治疗肌强直性营养不良的组合物和方法
|
|
WO2018076335A1
(en)
|
2016-10-31 |
2018-05-03 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Compositions and methods for enhancing abiotic stress tolerance
|
|
US20180245065A1
(en)
|
2016-11-01 |
2018-08-30 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
|
WO2018085693A1
(en)
|
2016-11-04 |
2018-05-11 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
|
KR102729404B1
(ko)
|
2016-11-04 |
2024-11-14 |
칠드런즈 호스피탈 메디칼 센터 |
간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
CN110168102A
(zh)
|
2016-11-15 |
2019-08-23 |
基因组影像公司 |
利用分子梳理监测经修饰的核酸酶诱导的基因编辑事件的方法
|
|
US20180150597A1
(en)
|
2016-11-29 |
2018-05-31 |
Genomic Vision Sa |
Method for optimal design of polynucleotides sequences for analysis of specific events in any genetic region of interest
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
US12404514B2
(en)
|
2016-12-09 |
2025-09-02 |
The Broad Institute, Inc. |
CRISPR-systems for modifying a trait of interest in a plant
|
|
CN110582301A
(zh)
|
2016-12-14 |
2019-12-17 |
利甘达尔股份有限公司 |
用于核酸和蛋白质有效负载递送的方法和组合物
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
CN110213961A
(zh)
|
2016-12-22 |
2019-09-06 |
孟山都技术公司 |
基于基因组编辑的作物工程化和生产矮秆植物
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
WO2018129129A1
(en)
|
2017-01-05 |
2018-07-12 |
Rutgers, The State University Of New Jersey |
Targeted gene editing platform independent of dna double strand break and uses thereof
|
|
EP3346001A1
(en)
|
2017-01-06 |
2018-07-11 |
TXCell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
WO2018127585A1
(en)
|
2017-01-06 |
2018-07-12 |
Txcell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
|
US11519009B2
(en)
|
2017-01-09 |
2022-12-06 |
University Of Massachusetts |
Complexes for gene deletion and editing
|
|
JP7234116B2
(ja)
|
2017-01-12 |
2023-03-07 |
ピボット バイオ, インコーポレイテッド |
植物形質を改善するための方法および組成物
|
|
EP4043485A1
(en)
|
2017-01-26 |
2022-08-17 |
Novartis AG |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
|
US11624071B2
(en)
|
2017-01-28 |
2023-04-11 |
Inari Agriculture Technology, Inc. |
Method of creating a plurality of targeted insertions in a plant cell
|
|
CN110582509A
(zh)
|
2017-01-31 |
2019-12-17 |
诺华股份有限公司 |
使用具有多特异性的嵌合t细胞受体蛋白治疗癌症
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
EP3580337A4
(en)
|
2017-02-10 |
2020-12-02 |
Zymergen, Inc. |
MODULAR UNIVERSAL PLASMID DESIGN STRATEGY FOR ASSEMBLY AND EDITING MULTIPLE MULTI-HOST DNA CONSTRUCTIONS
|
|
US10828330B2
(en)
|
2017-02-22 |
2020-11-10 |
IO Bioscience, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
|
US12440578B2
(en)
|
2017-02-22 |
2025-10-14 |
Io Biosciences, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
|
EP3589647A1
(en)
|
2017-02-28 |
2020-01-08 |
Novartis AG |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
|
JP2020510038A
(ja)
|
2017-03-09 |
2020-04-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
がんワクチン
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
AU2018234825B2
(en)
|
2017-03-15 |
2020-12-17 |
Massachusetts Institute Of Technology |
Novel CAS13B orthologues CRISPR enzymes and systems
|
|
US20180265887A1
(en)
|
2017-03-16 |
2018-09-20 |
Jacobs Farm Del Cabo |
Basil Plants With High Tolerance to Downy Mildew
|
|
US12180546B2
(en)
|
2017-03-17 |
2024-12-31 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
US12161694B2
(en)
|
2017-03-24 |
2024-12-10 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
WO2018183878A1
(en)
|
2017-03-31 |
2018-10-04 |
Pioneer Hi-Bred International, Inc. |
Expression modulating elements and use thereof
|
|
EP3606518A4
(en)
|
2017-04-01 |
2021-04-07 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTION AND MODULATION OF IMMUNOTHERAPY RESISTANCE GENE SIGNATURE IN CANCER
|
|
WO2018191558A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Modulation of epithelial cell differentiation, maintenance and/or function through t cell action, and markers and methods of use thereof
|
|
US12331319B2
(en)
|
2017-04-12 |
2025-06-17 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
AU2018251801B2
(en)
|
2017-04-12 |
2024-11-07 |
Massachusetts Institute Of Technology |
Novel type VI CRISPR orthologs and systems
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
US12281334B2
(en)
|
2017-04-14 |
2025-04-22 |
Children's Hospital Medical Center |
Multi donor stem cell compositions and methods of making same
|
|
US12350368B2
(en)
|
2017-04-14 |
2025-07-08 |
The Broad Institute, Inc. |
Delivery of large payloads
|
|
US20210293783A1
(en)
|
2017-04-18 |
2021-09-23 |
The General Hospital Corporation |
Compositions for detecting secretion and methods of use
|
|
US11834670B2
(en)
|
2017-04-19 |
2023-12-05 |
Global Life Sciences Solutions Usa Llc |
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
|
|
WO2018195402A1
(en)
|
2017-04-20 |
2018-10-25 |
Egenesis, Inc. |
Methods for generating genetically modified animals
|
|
WO2018195545A2
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
WO2018195486A1
(en)
|
2017-04-21 |
2018-10-25 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
WO2018201056A1
(en)
|
2017-04-28 |
2018-11-01 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
EP3615068A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
EP3622092A4
(en)
|
2017-05-11 |
2021-06-23 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
WO2018213708A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
EP3625342B1
(en)
|
2017-05-18 |
2022-08-24 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US20200172895A1
(en)
|
2017-05-25 |
2020-06-04 |
The General Hospital Corporation |
Using split deaminases to limit unwanted off-target base editor deamination
|
|
EP3409104A1
(en)
|
2017-05-31 |
2018-12-05 |
Vilmorin et Cie |
Tomato plant resistant to tomato yellow leaf curl virus, powdery mildew, and nematodes
|
|
WO2020249996A1
(en)
|
2019-06-14 |
2020-12-17 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus
|
|
EP3409106A1
(en)
|
2017-06-01 |
2018-12-05 |
Vilmorin et Cie |
Tolerance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus (tbrfv)
|
|
CA3065946A1
(en)
|
2017-06-05 |
2018-12-13 |
Research Institute At Nationwide Children's Hospital |
Enhanced modified viral capsid proteins
|
|
CA3102054A1
(en)
|
2017-06-05 |
2018-12-13 |
Fred Hutchinson Cancer Research Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
|
KR20200026878A
(ko)
|
2017-06-06 |
2020-03-11 |
지머젠 인코포레이티드 |
균류 균주를 개량하기 위한 htp 게놈 공학 플랫폼
|
|
KR20200026874A
(ko)
|
2017-06-06 |
2020-03-11 |
지머젠 인코포레이티드 |
대장균 개량을 위한 htp 게놈 공학 플랫폼
|
|
ES2980050T3
(es)
|
2017-06-08 |
2024-09-27 |
Univ Osaka |
Método para fabricar células eucariotas editadas con ADN
|
|
MA52134A
(fr)
|
2017-06-09 |
2020-04-15 |
Vilmorin & Cie |
Compositions et procédés pour l'édition génomique
|
|
WO2018227114A1
(en)
|
2017-06-09 |
2018-12-13 |
Editas Medicine, Inc. |
Engineered cas9 nucleases
|
|
IL271275B1
(en)
|
2017-06-13 |
2026-04-01 |
Flagship Pioneering Innovations V Inc |
Preparations containing croons and their uses
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
CA3067382A1
(en)
|
2017-06-15 |
2018-12-20 |
The Regents Of The University Of California |
Targeted non-viral dna insertions
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
AU2018290843B2
(en)
|
2017-06-26 |
2025-04-24 |
Massachusetts Institute Of Technology |
CRISPR/Cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
WO2019006418A2
(en)
|
2017-06-30 |
2019-01-03 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
US11168322B2
(en)
|
2017-06-30 |
2021-11-09 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
WO2019003193A1
(en)
|
2017-06-30 |
2019-01-03 |
Novartis Ag |
METHODS FOR TREATING DISEASES USING GENE EDITING SYSTEMS
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
EP3654993A4
(en)
|
2017-07-17 |
2021-08-25 |
The Broad Institute, Inc. |
CELL ATLAS OF HEALTHY HUMAN COLUMN AND HUMAN COLUMN WITH COLITIS ULCEROSA
|
|
US10510743B2
(en)
*
|
2017-07-18 |
2019-12-17 |
Hong Kong Applied Science and Technology Research Institute Company, Limited |
Step fin field-effect-transistor (FinFET) with slim top of fin and thick bottom of fin for electro-static-discharge (ESD) or electrical over-stress (EOS) protection
|
|
KR102652494B1
(ko)
*
|
2017-07-18 |
2024-03-28 |
제노비에 에이비 |
전장 t-세포 수용체 오픈 리딩 프레임의 신속한 조립 및 다양화를 위한 2-성분 벡터 라이브러리 시스템
|
|
US12239646B2
(en)
|
2017-07-19 |
2025-03-04 |
Dana-Farber Cancer Institute, Inc. |
Cancer diagnostic and treatment
|
|
WO2019023291A2
(en)
|
2017-07-25 |
2019-01-31 |
Dana-Farber Cancer Institute, Inc. |
COMPOSITIONS AND METHODS FOR PRODUCTION AND DECODING OF GUIDE RNA LIBRARIES AND USES THEREOF
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
WO2019030306A1
(en)
|
2017-08-08 |
2019-02-14 |
Depixus |
ISOLATION AND IN VITRO ENRICHMENT OF NUCLEIC ACIDS USING SITE-SPECIFIC NUCLEASES
|
|
US11970720B2
(en)
|
2017-08-22 |
2024-04-30 |
Salk Institute For Biological Studies |
RNA targeting methods and compositions
|
|
US10476825B2
(en)
|
2017-08-22 |
2019-11-12 |
Salk Institue for Biological Studies |
RNA targeting methods and compositions
|
|
CN118530967A
(zh)
|
2017-08-23 |
2024-08-23 |
通用医疗公司 |
具有改变的PAM特异性的工程化的CRISPR-Cas9核酸酶
|
|
EP3672573A4
(en)
|
2017-08-25 |
2021-05-26 |
Codiak BioSciences, Inc. |
PREPARATION OF THERAPEUTIC EXOSOMES USING MEMBRANE PROTEINS
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
EP3679143A1
(en)
*
|
2017-09-08 |
2020-07-15 |
Life Technologies Corporation |
Methods for improved homologous recombination and compositions thereof
|
|
US20190076814A1
(en)
|
2017-09-11 |
2019-03-14 |
Synthego Corporation |
Biopolymer synthesis system and method
|
|
US10709151B2
(en)
|
2017-09-15 |
2020-07-14 |
Covercress, Inc. |
Low fiber pennycress meal and methods of making
|
|
CA3076261A1
(en)
|
2017-09-19 |
2019-03-28 |
Admare Vintageco1 Investments Ltd. |
Anti-hla-a2 antibodies and methods of using the same
|
|
CN109517820B
(zh)
|
2017-09-20 |
2021-09-24 |
北京宇繁生物科技有限公司 |
一种靶向HPK1的gRNA以及HPK1基因编辑方法
|
|
EP3684822A4
(en)
|
2017-09-20 |
2021-06-16 |
The University of British Columbia |
NEW ANTI-HLA-A2 ANTIBODIES AND USES THEREOF
|
|
JP2020535802A
(ja)
|
2017-09-21 |
2020-12-10 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
標的化核酸編集のための系、方法、及び組成物
|
|
US11917978B2
(en)
|
2017-09-21 |
2024-03-05 |
The Conard Pyle Company |
Miniature rose plant named ‘meibenbino’
|
|
CA3076249A1
(en)
|
2017-09-21 |
2019-03-28 |
The Brigham And Women's Hospital, Inc. |
Isolation, preservation, compositions and uses of extracts from justicia plants
|
|
US11252928B2
(en)
|
2017-09-21 |
2022-02-22 |
The Condard-Pyle Company |
Miniature rose plant named ‘Meibenbino’
|
|
BR112020005803A2
(pt)
|
2017-09-25 |
2020-12-01 |
Agrospheres, Inc. |
composições e métodos para produção e administração moduláveis de produtos biológicos
|
|
EP3695408B1
(en)
|
2017-10-02 |
2026-01-21 |
The Broad Institute, Inc. |
Medical use of cdk4/6- and checkpoint-inhibitors in phased combination, in treatment of cancer
|
|
EP3692152B1
(en)
|
2017-10-04 |
2025-09-03 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
EP3694603B1
(en)
|
2017-10-10 |
2026-04-08 |
Children's Hospital Medical Center |
Esophageal tissue and/or organoid compositions and methods of making same
|
|
WO2019075197A1
(en)
|
2017-10-11 |
2019-04-18 |
The General Hospital Corporation |
METHODS OF DETECTION OF INDIVIDUAL SITE-SPECIFIC PARASITE GENOMIC DEAMINATION BY BASE EDITING TECHNOLOGIES
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
WO2019079362A1
(en)
|
2017-10-16 |
2019-04-25 |
Massachusetts Institute Of Technology |
HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS
|
|
EP3697452A4
(en)
|
2017-10-16 |
2021-11-24 |
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A., M.P. |
LENTIVIRAL VECTORS FOR ADMINISTRATION OF PKLR TO TREAT PYRUVATE KINASE DEFECTS
|
|
MX2020004063A
(es)
|
2017-10-20 |
2020-10-05 |
Hutchinson Fred Cancer Res |
Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados.
|
|
US12227742B2
(en)
|
2017-10-23 |
2025-02-18 |
The Broad Institute, Inc. |
Nucleic acid modifiers
|
|
AU2018354221B2
(en)
|
2017-10-25 |
2025-04-17 |
Pivot Bio, Inc. |
Methods and compositions for improving engineered microbes that fix nitrogen
|
|
JP2021500907A
(ja)
|
2017-10-25 |
2021-01-14 |
ピボット バイオ, インコーポレイテッド |
植物の形質の改良を目的とした窒素固定のための遺伝子標的
|
|
KR102503130B1
(ko)
|
2017-10-27 |
2023-02-24 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
내인성 t 세포 수용체의 표적화된 대체
|
|
US11547614B2
(en)
|
2017-10-31 |
2023-01-10 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
US20210179709A1
(en)
|
2017-10-31 |
2021-06-17 |
Novartis Ag |
Anti-car compositions and methods
|
|
WO2019087113A1
(en)
|
2017-11-01 |
2019-05-09 |
Novartis Ag |
Synthetic rnas and methods of use
|
|
JP2021503278A
(ja)
|
2017-11-01 |
2021-02-12 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
CasZ組成物及び使用方法
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
WO2019090175A1
(en)
|
2017-11-02 |
2019-05-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
|
WO2019084958A1
(en)
|
2017-11-06 |
2019-05-09 |
Shenzhen Cell Inspire Biotechnology Co., Ltd. |
Novel human induced pluripotent stem cell lines for modeling alzheimer's disease and usage thereof
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
WO2019094984A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
EP3710039A4
(en)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
|
|
EP4501408A3
(en)
|
2017-11-17 |
2025-04-09 |
Iovance Biotherapeutics, Inc. |
Til expansion from fine needle aspirates and small biopsies
|
|
EP3714041A1
(en)
|
2017-11-22 |
2020-09-30 |
Iovance Biotherapeutics, Inc. |
Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
|
|
WO2019112982A1
(en)
*
|
2017-12-05 |
2019-06-13 |
Synthetic Genomics, Inc |
Improving algal lipid productivity via genetic modification of a signaling protein
|
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
JP2021505158A
(ja)
|
2017-12-08 |
2021-02-18 |
シンセティック ジェノミクス インコーポレーテッド |
Tprドメイン含有タンパク質の遺伝子改変を介した藻類脂質生産性の改善方法
|
|
CN111465689B
(zh)
|
2017-12-15 |
2024-07-12 |
丹尼斯科美国公司 |
Cas9变体和使用方法
|
|
US20200354413A1
(en)
|
2017-12-15 |
2020-11-12 |
Dana-Farber Cancer Institute, Inc. |
Stabilized peptide-mediated targeted protein degradation
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
US12379372B2
(en)
|
2017-12-21 |
2025-08-05 |
Children's Hospital Medical Center |
Digitalized human organoids and methods of using same
|
|
AU2018394238A1
(en)
|
2017-12-28 |
2020-06-18 |
Lonza Sales Ag |
Exosomes for immuno-oncology and anti-inflammatory therapy
|
|
WO2019133881A1
(en)
|
2017-12-29 |
2019-07-04 |
Rubius Therapeutics, Inc. |
Gene editing and targeted transcriptional modulation for enginerering erythroid cells
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
CA3086620A1
(en)
|
2018-01-12 |
2019-07-18 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
MA51619A
(fr)
|
2018-01-17 |
2021-04-14 |
Vertex Pharma |
Inhibiteurs de la protéine kinase dépendante de l'adn
|
|
CA3088788A1
(en)
|
2018-01-17 |
2019-07-25 |
Vertex Pharmaceuticals Incorporated |
Dna-pk inhibitors
|
|
JP7483612B2
(ja)
|
2018-01-17 |
2024-05-15 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ゲノム編集効率を増加するためのキノキサリノン化合物、組成物、方法、およびキット
|
|
WO2019144061A1
(en)
|
2018-01-19 |
2019-07-25 |
Duke University |
Genome engineering with crispr-cas systems in eukaryotes
|
|
WO2019143926A1
(en)
|
2018-01-19 |
2019-07-25 |
Covercress Inc. |
Low glucosinolate pennycress meal and methods of making
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
WO2019152437A1
(en)
|
2018-01-30 |
2019-08-08 |
Foghorn Therapeutics Inc. |
Compounds and uses thereof
|
|
MX2020007876A
(es)
|
2018-01-31 |
2020-12-03 |
Res Inst Nationwide Childrens Hospital |
Terapia genica para la distrofia muscular de cinturas tipo 2c.
|
|
WO2019157326A1
(en)
|
2018-02-08 |
2019-08-15 |
Zymergen Inc. |
Genome editing using crispr in corynebacterium
|
|
CN111902536B
(zh)
*
|
2018-02-15 |
2024-07-30 |
西格马-奥尔德里奇有限责任公司 |
用于真核基因组修饰的改造的cas9系统
|
|
KR20200124702A
(ko)
|
2018-02-23 |
2020-11-03 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
신규한 cas9 오르소로그
|
|
WO2019173125A1
(en)
|
2018-03-09 |
2019-09-12 |
Pioneer Hi-Bred International, Inc. |
Compositions and methods for modification of fatty acids in soybean
|
|
EP3765616B1
(en)
|
2018-03-14 |
2023-07-19 |
Arbor Biotechnologies, Inc. |
Novel crispr dna and rna targeting enzymes and systems
|
|
PL3765615T3
(pl)
|
2018-03-14 |
2023-11-13 |
Arbor Biotechnologies, Inc. |
Nowe enzymy i układy crispr ukierunkowane na dna
|
|
WO2019178426A1
(en)
|
2018-03-14 |
2019-09-19 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
|
GB201805287D0
(en)
|
2018-03-29 |
2018-05-16 |
Univ Edinburgh |
Haematoietic stem cell treatment
|
|
AU2019247490A1
(en)
|
2018-04-06 |
2020-10-22 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
|
BR112020020841A2
(pt)
|
2018-04-11 |
2021-01-19 |
Fundacion Para La Investigacion Biomedica Del Hospital Infantil Universitario Nino Jesus |
Composições e métodos para transplante de célulastronco
|
|
SG11202010116PA
(en)
|
2018-04-13 |
2020-11-27 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
|
CA3097044A1
(en)
|
2018-04-17 |
2019-10-24 |
The General Hospital Corporation |
Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
|
|
US12338486B2
(en)
|
2018-04-19 |
2025-06-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded DNA
|
|
JP7555822B2
(ja)
|
2018-04-19 |
2024-09-25 |
ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア |
ゲノム編集のための組成物および方法
|
|
DK3560330T3
(da)
|
2018-04-24 |
2022-07-11 |
Kws Saat Se & Co Kgaa |
Planter med forbedret fordøjelighed og markørhaplotyper
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
EP3784351A1
(en)
|
2018-04-27 |
2021-03-03 |
Novartis AG |
Car t cell therapies with enhanced efficacy
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
SG11202010631UA
(en)
|
2018-04-27 |
2020-11-27 |
Genedit Inc |
Cationic polymer and use for biomolecule delivery
|
|
US20210130779A1
(en)
|
2018-04-27 |
2021-05-06 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
US20210386829A1
(en)
|
2018-05-04 |
2021-12-16 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
US12522812B2
(en)
|
2018-05-16 |
2026-01-13 |
Arbor Biotechnologies, Inc. |
CRISPR-associated systems and components
|
|
KR20210045360A
(ko)
|
2018-05-16 |
2021-04-26 |
신테고 코포레이션 |
가이드 rna 설계 및 사용을 위한 방법 및 시스템
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
CN112204156A
(zh)
|
2018-05-25 |
2021-01-08 |
先锋国际良种公司 |
用于通过调节重组率来改善育种的系统和方法
|
|
CN108707628B
(zh)
*
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
|
US20210371932A1
(en)
|
2018-06-01 |
2021-12-02 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
EP3578658A1
(en)
|
2018-06-08 |
2019-12-11 |
Johann Wolfgang Goethe-Universität Frankfurt |
Method for generating a gene editing vector with fixed guide rna pairs
|
|
WO2019241315A1
(en)
|
2018-06-12 |
2019-12-19 |
Obsidian Therapeutics, Inc. |
Pde5 derived regulatory constructs and methods of use in immunotherapy
|
|
CA3100724A1
(en)
|
2018-06-13 |
2019-12-19 |
Novartis Ag |
B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
CA3102264A1
(en)
*
|
2018-06-19 |
2019-12-26 |
Lunella Biotech, Inc. |
"energetic" cancer stem cells (e-cscs): a new hyper-metabolic and proliferative tumor cell phenotype, driven by mitochondrial energy
|
|
CA3102163A1
(en)
|
2018-06-26 |
2020-01-02 |
Massachusetts Institute Of Technology |
Crispr effector system based amplification methods, systems, and diagnostics
|
|
SG11202011240YA
(en)
|
2018-06-26 |
2020-12-30 |
Broad Inst Inc |
Crispr/cas and transposase based amplification compositions, systems and methods
|
|
CN112739668A
(zh)
|
2018-06-27 |
2021-04-30 |
皮沃特生物股份有限公司 |
包括重构固氮微生物的农业组合物
|
|
MX2020014119A
(es)
|
2018-06-29 |
2021-06-18 |
Res Inst Nationwide Childrens Hospital |
Productos y métodos de virus adenoasociado recombinante para el tratamiento de la distrofia muscular de cinturas 2a.
|
|
EP3823633A4
(en)
|
2018-06-29 |
2023-05-03 |
Editas Medicine, Inc. |
SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO
|
|
WO2020002592A1
(en)
|
2018-06-29 |
2020-01-02 |
Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis |
Traf2 inhibitors for use in the treatment of a cancer
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
KR20210060434A
(ko)
|
2018-07-11 |
2021-05-26 |
피벗 바이오, 인크. |
리모델링된 미생물에 의한 시간적 및 공간적 표적화 동적 질소 전달
|
|
JP2021530212A
(ja)
|
2018-07-13 |
2021-11-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
レトロトランスポゾンベースの送達媒体及びその使用方法
|
|
US12553045B2
(en)
|
2018-07-16 |
2026-02-17 |
Arbor Biotechnologies, Inc. |
Crispr DNA targeting enzymes and systems
|
|
KR102887406B1
(ko)
|
2018-07-26 |
2025-11-19 |
칠드런즈 호스피탈 메디칼 센터 |
간-담도-췌장 조직 및 이를 제조하는 방법
|
|
CN113348245A
(zh)
|
2018-07-31 |
2021-09-03 |
博德研究所 |
新型crispr酶和系统
|
|
EP3830301B1
(en)
|
2018-08-01 |
2024-05-22 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
|
CN113286884A
(zh)
|
2018-08-07 |
2021-08-20 |
博德研究所 |
新型cas12b酶和系统
|
|
EP3607819A1
(en)
|
2018-08-10 |
2020-02-12 |
Vilmorin et Cie |
Resistance to xanthomonas campestris pv. campestris (xcc) in cauliflower
|
|
WO2020030979A2
(en)
|
2018-08-10 |
2020-02-13 |
Sangamo Therapeutics France |
New car constructs comprising tnfr2 domains
|
|
CA3107002A1
(en)
|
2018-08-15 |
2020-04-30 |
Zymergen Inc. |
Applications of crispri in high throughput metabolic engineering
|
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
|
US12275964B2
(en)
|
2018-08-22 |
2025-04-15 |
The Regents Of The University Of California |
Variant type V CRISPR/Cas effector polypeptides and methods of use thereof
|
|
JP7541508B2
(ja)
|
2018-08-23 |
2024-08-28 |
サンガモ セラピューティクス, インコーポレイテッド |
操作された標的特異的な塩基エディター
|
|
IL280956B1
(en)
|
2018-08-30 |
2026-04-01 |
Univ North Carolina Chapel Hill |
Synthetic genes that enable feedback, target seed adaptation cassettes and their use
|
|
US12534743B2
(en)
|
2018-08-31 |
2026-01-27 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US11479762B1
(en)
|
2018-08-31 |
2022-10-25 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US12545910B2
(en)
|
2018-08-31 |
2026-02-10 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US20210317479A1
(en)
|
2018-09-06 |
2021-10-14 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
EP3849565A4
(en)
|
2018-09-12 |
2022-12-28 |
Fred Hutchinson Cancer Research Center |
REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS
|
|
AU2019339410A1
(en)
|
2018-09-12 |
2021-04-15 |
Children's Hospital Medical Center |
Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
|
|
JP7344300B2
(ja)
|
2018-09-18 |
2023-09-13 |
ブイエヌブイ ニューコ インク. |
Arcベースのカプシドおよびその使用
|
|
CN109265562B
(zh)
*
|
2018-09-26 |
2021-03-30 |
北京市农林科学院 |
一种切刻酶及其在基因组碱基替换中的应用
|
|
GB201815820D0
(en)
|
2018-09-28 |
2018-11-14 |
Univ Wageningen |
Off-target activity inhibitors for guided endonucleases
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
WO2020072250A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
US20220411783A1
(en)
|
2018-10-12 |
2022-12-29 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
WO2020081588A1
(en)
|
2018-10-17 |
2020-04-23 |
Dana-Farber Cancer Institute, Inc. |
Swi/snf family chromatin remodeling complexes and uses thereof
|
|
WO2020086742A1
(en)
|
2018-10-24 |
2020-04-30 |
Obsidian Therapeutics, Inc. |
Er tunable protein regulation
|
|
US12116458B2
(en)
|
2018-10-24 |
2024-10-15 |
Genedit Inc. |
Cationic polymer with alkyl side chains and use for biomolecule delivery
|
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
JP7216877B2
(ja)
*
|
2018-10-29 |
2023-02-02 |
中国▲農▼▲業▼大学 |
新規なCRISPR/Cas12f酵素およびシステム
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
EP3874037A4
(en)
|
2018-10-31 |
2021-12-15 |
Zymergen, Inc. |
DETERMINIST MULTIPLEXED SET OF DNA LIBRARIES
|
|
KR20210084557A
(ko)
|
2018-10-31 |
2021-07-07 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
오크로박트럼-매개 유전자 편집을 위한 조성물 및 방법
|
|
WO2020093025A1
(en)
*
|
2018-11-01 |
2020-05-07 |
Synthego Corporation |
Methods for knock-out of a target sequence through introduction of a premature stop codon
|
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
TW202039830A
(zh)
|
2018-11-05 |
2020-11-01 |
美商艾歐凡斯生物治療公司 |
用於製造腫瘤浸潤性淋巴細胞之方法及其在免疫療法中之用途
|
|
CA3118493A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathway inhibitors
|
|
TW202039831A
(zh)
|
2018-11-05 |
2020-11-01 |
美商艾歐凡斯生物治療公司 |
對抗pd-1抗體呈現難治性之非小細胞肺癌(nsclc)病患之治療
|
|
US20230039976A1
(en)
|
2018-11-05 |
2023-02-09 |
Iovance Biotherapeutics, Inc. |
Selection of improved tumor reactive t-cells
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
CA3117730A1
(en)
|
2018-11-09 |
2020-05-14 |
Inari Agriculture, Inc. |
Rna-guided nucleases and dna binding proteins
|
|
US20220282275A1
(en)
|
2018-11-15 |
2022-09-08 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
|
US12454701B2
(en)
|
2018-12-05 |
2025-10-28 |
Abeona Therapeutics Inc. |
Recombinant adeno-associated viral vector for gene delivery
|
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
|
US12365888B2
(en)
|
2018-12-14 |
2025-07-22 |
Pioneer Hi-Bred International, Inc. |
CRISPR-Cas systems for genome editing
|
|
US12264323B2
(en)
|
2018-12-17 |
2025-04-01 |
The Broad Institute, Inc. |
CRISPR CPF1 direct repeat variants
|
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
CA3124110A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
|
BR112021011629A2
(pt)
|
2018-12-18 |
2021-09-08 |
Braskem S.A. |
Via de coprodução de derivados de 3-hp e acetil-coa a partir de malonato semialdeído
|
|
JP7710372B2
(ja)
|
2018-12-19 |
2025-07-18 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
操作されたサイトカイン受容体対を使用して腫瘍浸潤リンパ球を拡大培養する方法及びその使用
|
|
US12390812B2
(en)
|
2018-12-19 |
2025-08-19 |
Nuclein, Llc |
Apparatus and methods for molecular diagnostics
|
|
WO2020132632A2
(en)
|
2018-12-21 |
2020-06-25 |
Pivot Bio, Inc. |
Methods, compositions, and media for improving plant traits
|
|
WO2020132737A2
(en)
|
2018-12-28 |
2020-07-02 |
Braskem S.A. |
Modulation of carbon flux through the meg and c3 pathways for the improved production of monoethylene glycol and c3 compounds
|
|
EP3906415B1
(en)
|
2019-01-03 |
2026-04-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer
|
|
EP3931313A2
(en)
|
2019-01-04 |
2022-01-05 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
WO2020146372A1
(en)
|
2019-01-07 |
2020-07-16 |
Pivot Bio, Inc. |
Plant colonization assays using natural microbial barcodes
|
|
WO2020148206A1
(en)
|
2019-01-14 |
2020-07-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and kits for generating and selecting a variant of a binding protein with increased binding affinity and/or specificity
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US12384776B2
(en)
|
2019-01-29 |
2025-08-12 |
Foghorn Therapeutics Inc. |
Compounds and uses thereof
|
|
WO2020160100A1
(en)
|
2019-01-29 |
2020-08-06 |
Foghorn Therapeutics Inc. |
Compounds and uses thereof
|
|
WO2020160371A1
(en)
|
2019-02-01 |
2020-08-06 |
The University Of Hong Kong |
Innervated organoid compositions and methods of making same
|
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
|
WO2020163655A1
(en)
|
2019-02-06 |
2020-08-13 |
Fred Hutchinson Cancer Research Center |
Minicircle producing bacteria engineered to differentially methylate nucleic acid molecules therein
|
|
JP2022519580A
(ja)
*
|
2019-02-06 |
2022-03-24 |
ティアークリアー コープ. |
複合体化剤を含む眼科用製剤から防腐剤を除去するためのシステムおよび方法
|
|
US12460230B2
(en)
|
2019-02-10 |
2025-11-04 |
The J. David Gladstone Institutes |
Modified mitochondrion and methods of use thereof
|
|
MX2021010356A
(es)
|
2019-02-26 |
2022-03-04 |
Res Inst Nationwide Childrens Hospital |
SUMINISTRO DE ß-SARCOGLICANO MEDIANTE VECTORES DE VIRUS ADENOASOCIADO Y EL TRATAMIENTO DE LA DISTROFIA MUSCULAR.
|
|
CN110177061B
(zh)
*
|
2019-03-01 |
2023-04-07 |
致讯科技(天津)有限公司 |
一种异构网络中信号干扰的协调方法
|
|
US11339414B2
(en)
|
2019-03-01 |
2022-05-24 |
Braskem S.A. |
Method for the in vivo synthesis of 4-hydroxymethylfurfural and derivatives thereof
|
|
US20220133795A1
(en)
|
2019-03-01 |
2022-05-05 |
Iovance Biotherapeutics, Inc. |
Expansion of Tumor Infiltrating Lymphocytes From Liquid Tumors and Therapeutic Uses Thereof
|
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
|
WO2020181193A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
|
WO2020181180A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to c:g base editors and uses thereof
|
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
|
CA3130789A1
(en)
|
2019-03-07 |
2020-09-10 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
KR20210149251A
(ko)
|
2019-03-08 |
2021-12-08 |
옵시디안 테라퓨틱스, 인크. |
조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법
|
|
CN113728106A
(zh)
|
2019-03-08 |
2021-11-30 |
齐默尔根公司 |
微生物中的迭代基因组编辑
|
|
US11053515B2
(en)
|
2019-03-08 |
2021-07-06 |
Zymergen Inc. |
Pooled genome editing in microbes
|
|
CA3127814C
(en)
|
2019-03-18 |
2024-05-14 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
|
US12534714B2
(en)
|
2019-03-18 |
2026-01-27 |
The Broad Institute, Inc. |
Type VII CRISPR proteins and systems
|
|
EP3768826B1
(en)
|
2019-03-18 |
2023-12-13 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
|
WO2020190363A1
(en)
|
2019-03-19 |
2020-09-24 |
Massachusetts Institute Of Technology |
Control of nitrogen fixation in rhizobia that associate with cereals
|
|
JP7657726B2
(ja)
|
2019-03-19 |
2025-04-07 |
ザ ブロード インスティテュート,インコーポレーテッド |
編集ヌクレオチド配列を編集するための方法および組成物
|
|
WO2020206036A1
(en)
|
2019-04-01 |
2020-10-08 |
The Broad Institute, Inc. |
Novel nucleic acid modifier
|
|
RU2710731C1
(ru)
*
|
2019-04-02 |
2020-01-10 |
Общество с ограниченной ответственностью "Зеленые линии" |
Система редактирования генома дрожжей debaryomyces hansenii на основе crispr/cas9
|
|
US11746361B2
(en)
|
2019-04-04 |
2023-09-05 |
Braskem S.A. |
Metabolic engineering for simultaneous consumption of Xylose and glucose for production of chemicals from second generation sugars
|
|
EP3953470A1
(en)
*
|
2019-04-12 |
2022-02-16 |
Astrazeneca AB |
Compositions and methods for improved gene editing
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
JP2022530224A
(ja)
|
2019-04-23 |
2022-06-28 |
ジーンエディット インコーポレイテッド |
アルキル側鎖を有するカチオン性ポリマー
|
|
US20220251152A1
(en)
|
2019-04-24 |
2022-08-11 |
Novartis Ag |
Compositions and methods for selective protein degradation
|
|
EP3959229A1
(en)
|
2019-04-24 |
2022-03-02 |
Pivot Bio, Inc. |
Gene targets for nitrogen fixation targeting for improving plant traits
|
|
CN113825838A
(zh)
|
2019-05-10 |
2021-12-21 |
巴斯夫欧洲公司 |
增强植物中基因表达的调节性核酸分子
|
|
US11162079B2
(en)
|
2019-05-10 |
2021-11-02 |
The Regents Of The University Of California |
Blood type O Rh-hypo-immunogenic pluripotent cells
|
|
US20220243287A1
(en)
|
2019-05-13 |
2022-08-04 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
|
US20220249559A1
(en)
|
2019-05-13 |
2022-08-11 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
AU2020274996B2
(en)
|
2019-05-14 |
2024-02-01 |
Nuseed Nutritional Us Inc. |
Modified plants comprising a polynucleotide comprising a non-cognate promoter operably linked to a coding sequence that encodes a transcription factor
|
|
WO2020236982A1
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Aav delivery of nucleobase editors
|
|
WO2020236972A2
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
EP3973067A1
(en)
|
2019-05-21 |
2022-03-30 |
Sangamo Therapeutics, Inc. |
Controlled transgene expression in regulatory t cells
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
WO2020243370A1
(en)
|
2019-05-28 |
2020-12-03 |
Genedit Inc. |
Polymer comprising multiple functionalized sidechains for biomolecule delivery
|
|
BR112021021149A2
(pt)
|
2019-05-29 |
2021-12-14 |
Monsanto Technology Llc |
Métodos e composições para a geração de alelos dominantes utilizando a edição de genomas
|
|
WO2020243633A1
(en)
|
2019-05-31 |
2020-12-03 |
Children's Hospital Medical Center |
Shaped organoid compositions and methods of making same
|
|
WO2020243613A1
(en)
|
2019-05-31 |
2020-12-03 |
Children's Hospital Medical Center |
Methods of generating and expanding hematopoietic stem cells
|
|
US20220243178A1
(en)
|
2019-05-31 |
2022-08-04 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
JP7644722B2
(ja)
*
|
2019-06-01 |
2025-03-12 |
シベック バイオテクノロジーズ,インコーポレイティド |
真核細胞への遺伝子編集システムの送達のための細菌プラットフォーム
|
|
WO2020244759A1
(en)
|
2019-06-05 |
2020-12-10 |
Klemm & Sohn Gmbh & Co. Kg |
New plants having a white foliage phenotype
|
|
US11845957B2
(en)
|
2019-06-14 |
2023-12-19 |
Regeneron Pharmaceuticals, Inc. |
Models of tauopathy
|
|
WO2020254850A1
(en)
|
2019-06-21 |
2020-12-24 |
Vilmorin & Cie |
Improvement of quality and permanence of green color of peppers at maturity and over-maturity
|
|
EP3986956A1
(en)
|
2019-06-24 |
2022-04-27 |
Promega Corporation |
Modified polyamine polymers for delivery of biomolecules into cells
|
|
MX2021014861A
(es)
|
2019-06-25 |
2022-06-22 |
Inari Agriculture Tech Inc |
Edicion genomica de reparacion dependiente de homologia mejorada.
|
|
JP2022539248A
(ja)
|
2019-07-02 |
2022-09-07 |
フレッド ハッチンソン キャンサー リサーチ センター |
組換えad35ベクター及び関連遺伝子治療改善
|
|
GB201909597D0
(en)
|
2019-07-03 |
2019-08-14 |
Univ Wageningen |
Crispr type v-u1 system from mycobacterium mucogenicum and uses thereof
|
|
WO2021007260A2
(en)
|
2019-07-08 |
2021-01-14 |
Research Institute At Nationwide Children's Hospital |
Antibody compositions for disrupting biofilms
|
|
WO2021009299A1
(en)
|
2019-07-17 |
2021-01-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Bcl-xl:fkbp12 fusion proteins suitable for screening agents capable of slowing down the aging process
|
|
CN110452966A
(zh)
*
|
2019-07-17 |
2019-11-15 |
浙江善测禾骑士生物科技有限公司 |
一种利用raa-crispr蛋白酶系统快速检测方法
|
|
CN110387405A
(zh)
*
|
2019-07-17 |
2019-10-29 |
浙江善测禾骑士生物科技有限公司 |
一种快速检测核酸的(rt)raa-crispr系统
|
|
WO2021016043A1
(en)
|
2019-07-19 |
2021-01-28 |
Inari Agriculture, Inc. |
Improved homology dependent repair genome editing
|
|
WO2021019272A1
(en)
|
2019-07-31 |
2021-02-04 |
Vilmorin & Cie |
Tolerance to tolcndv in cucumber
|
|
WO2021026294A1
(en)
|
2019-08-06 |
2021-02-11 |
Children's Medical Center Corporation |
Methods and compositions for reconstituting microglia
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
WO2021028359A1
(en)
|
2019-08-09 |
2021-02-18 |
Sangamo Therapeutics France |
Controlled expression of chimeric antigen receptors in t cells
|
|
US20220282284A1
(en)
*
|
2019-08-15 |
2022-09-08 |
The Rockefeller University |
Crispr genome editing with cell surface display to produce homozygously edited eukaryotic cells
|
|
WO2021030666A1
(en)
|
2019-08-15 |
2021-02-18 |
The Broad Institute, Inc. |
Base editing by transglycosylation
|
|
PT4017871T
(pt)
|
2019-08-21 |
2024-04-22 |
Res Inst Nationwide Childrens Hospital |
Distribuição de vetor de vírus adeno-associado de alfasarcoglicano e o tratamento da distrofia muscular
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
WO2021046451A1
(en)
|
2019-09-06 |
2021-03-11 |
Obsidian Therapeutics, Inc. |
Compositions and methods for dhfr tunable protein regulation
|
|
AU2020347147A1
(en)
|
2019-09-09 |
2022-03-03 |
Arbor Biotechnologies, Inc. |
Novel CRISPR DNA targeting enzymes and systems
|
|
WO2021048316A1
(en)
|
2019-09-12 |
2021-03-18 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
CN115175996A
(zh)
|
2019-09-20 |
2022-10-11 |
博德研究所 |
新颖vi型crispr酶和系统
|
|
CN110541001A
(zh)
*
|
2019-09-20 |
2019-12-06 |
福建上源生物科学技术有限公司 |
精确大片段基因删除结合终止密码子插入的基因敲除法
|
|
AU2020355000A1
(en)
|
2019-09-23 |
2022-03-17 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein B (APOB) gene expression
|
|
CN114729376A
(zh)
|
2019-09-23 |
2022-07-08 |
欧米茄治疗公司 |
用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法
|
|
KR20220108036A
(ko)
|
2019-09-26 |
2022-08-02 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
최소 아레스틴 도메인 함유 단백질 1 (arrdc1) 구축물
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
WO2021069387A1
(en)
|
2019-10-07 |
2021-04-15 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
EP3808766A1
(en)
|
2019-10-15 |
2021-04-21 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
|
US20230357788A1
(en)
|
2019-10-17 |
2023-11-09 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
|
JP2022553389A
(ja)
|
2019-10-25 |
2022-12-22 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の遺伝子編集及び免疫療法におけるその使用
|
|
EP4057802A1
(en)
|
2019-11-14 |
2022-09-21 |
Vilmorin & Cie |
Resistance to acidovorax valerianellae in corn salad
|
|
WO2021102084A1
(en)
|
2019-11-22 |
2021-05-27 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
|
US20230086199A1
(en)
|
2019-11-26 |
2023-03-23 |
The Broad Institute, Inc. |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
|
EP4064830A1
(en)
|
2019-11-29 |
2022-10-05 |
Basf Se |
Increasing resistance against fungal infections in plants
|
|
CA3163565A1
(en)
*
|
2019-12-02 |
2021-06-10 |
Council Of Scientific & Industrial Research |
Method and kit for detection of polynucleotide
|
|
CN114787365A
(zh)
|
2019-12-03 |
2022-07-22 |
巴斯夫欧洲公司 |
用于在植物中增强基因表达的调节性核酸分子
|
|
JP7677646B2
(ja)
|
2019-12-10 |
2025-05-15 |
ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー |
複製タンパク質a(rpa)-dna相互作用阻害剤
|
|
US12516291B2
(en)
|
2019-12-11 |
2026-01-06 |
Iovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (TILs) and methods of using the same
|
|
JP7765290B2
(ja)
|
2019-12-13 |
2025-11-06 |
中外製薬株式会社 |
細胞外プリン受容体リガンドを検出するシステムおよび当該システムを導入した非ヒト動物
|
|
US20230020092A1
(en)
|
2019-12-19 |
2023-01-19 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|
|
JP7793519B2
(ja)
|
2019-12-19 |
2026-01-05 |
ビーエーエスエフ ソシエタス・ヨーロピア |
ファインケミカルを生成する際の空時収率、炭素変換効率、及び炭素基質適応性の増加
|
|
KR20220119408A
(ko)
|
2019-12-20 |
2022-08-29 |
바스프 에스이 |
터펜의 독성 감소 및 미생물에서 생산 잠재성 증가
|
|
AU2021207810A1
(en)
|
2020-01-13 |
2022-08-04 |
Sana Biotechnology, Inc. |
Modification of blood type antigens
|
|
WO2021221690A1
(en)
|
2020-05-01 |
2021-11-04 |
Pivot Bio, Inc. |
Modified bacterial strains for improved fixation of nitrogen
|
|
AU2021211713A1
(en)
|
2020-01-23 |
2022-08-25 |
The Children's Medical Center Corporation |
Stroma-free T cell differentiation from human pluripotent stem cells
|
|
WO2021151085A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Crispr-cas enzymes with enhanced on-target activity
|
|
EP4093864A4
(en)
|
2020-01-24 |
2024-04-10 |
The General Hospital Corporation |
Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants
|
|
CA3167275A1
(en)
|
2020-01-29 |
2021-08-05 |
Foghorn Therapeutics Inc. |
Compounds and uses thereof
|
|
WO2021155063A1
(en)
|
2020-01-29 |
2021-08-05 |
Readcoor, Llc |
Compositions and methods for analyte detection
|
|
WO2021158921A2
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
|
US12116580B2
(en)
|
2020-02-21 |
2024-10-15 |
The Board Of Trustees Of The University Of Illinois |
Genetic toolbox for metabolic engineering of non-conventional yeast
|
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
|
CN116096886A
(zh)
|
2020-03-11 |
2023-05-09 |
欧米茄治疗公司 |
用于调节叉头框p3(foxp3)基因表达的组合物和方法
|
|
CA3172120A1
(en)
|
2020-03-20 |
2021-09-23 |
Inserm (Institut De La Sante Et De La Recherche Medicale) |
Chimeric antigen receptor specific for human cd45rc and uses thereof
|
|
WO2021202938A1
(en)
|
2020-04-03 |
2021-10-07 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
WO2021216622A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
|
WO2021216623A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
|
PY2134250A
(es)
|
2020-05-01 |
2022-01-28 |
Pivot Bio Inc |
Formulaciones líquidas estables para microorganismos fijadores de nitrógeno
|
|
EP4143211A2
(en)
|
2020-05-01 |
2023-03-08 |
Pivot Bio, Inc. |
Modified bacterial strains for improved fixation of nitrogen
|
|
AU2020445067A1
(en)
|
2020-05-01 |
2022-12-01 |
Pivot Bio, Inc. |
Measurement of nitrogen fixation and incorporation
|
|
EP4146794A1
(en)
|
2020-05-04 |
2023-03-15 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
EP4146797A1
(en)
|
2020-05-06 |
2023-03-15 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
EP4149245A2
(en)
|
2020-05-13 |
2023-03-22 |
Pivot Bio, Inc. |
De-repression of nitrogen fixation in gram-positive microorganisms
|
|
US12383555B2
(en)
|
2020-05-20 |
2025-08-12 |
Foghorn Therapeutics Inc. |
Methods of treating cancers
|
|
AU2021275995B2
(en)
|
2020-05-22 |
2026-02-12 |
Insitro, Inc. |
Predicting disease outcomes using machine learned models
|
|
GB202007943D0
(en)
|
2020-05-27 |
2020-07-08 |
Snipr Biome Aps |
Products & methods
|
|
PE20230080A1
(es)
|
2020-05-29 |
2023-01-11 |
Kws Saat Se And Co Kgaa |
Induccion de haploides en plantas
|
|
WO2021245435A1
(en)
|
2020-06-03 |
2021-12-09 |
Vilmorin & Cie |
Melon plants resistant to scab disease, aphids and powdery mildew
|
|
JP2023530234A
(ja)
|
2020-06-05 |
2023-07-14 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新生物を治療するための組成物および方法
|
|
CA3186284A1
(en)
|
2020-06-05 |
2021-12-09 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobrfv
|
|
CA3185455A1
(en)
|
2020-06-11 |
2021-12-16 |
Novartis Ag |
Zbtb32 inhibitors and uses thereof
|
|
EP4179079A1
(en)
|
2020-07-10 |
2023-05-17 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
|
US20230287458A1
(en)
|
2020-07-14 |
2023-09-14 |
Abeona Therapeutics Inc. |
Recombinant adeno-associated viral vectors for multipartite gene delivery
|
|
WO2022029080A1
(en)
|
2020-08-03 |
2022-02-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Population of treg cells functionally committed to exert a regulatory activity and their use for adoptive therapy
|
|
WO2022034474A1
(en)
|
2020-08-10 |
2022-02-17 |
Novartis Ag |
Treatments for retinal degenerative diseases
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
US20230295650A1
(en)
|
2020-08-18 |
2023-09-21 |
Pioneer Hi-Bred International, Inc. |
Multiple disease resistance genes and genomic stacks thereof
|
|
KR102859550B1
(ko)
|
2020-08-20 |
2025-09-16 |
에이투 바이오쎄라퓨틱스, 인크. |
Ceacam 양성 암을 치료하기 위한 조성물 및 방법
|
|
AU2021328478A1
(en)
|
2020-08-20 |
2023-04-20 |
A2 Biotherapeutics, Inc. |
Compositions and methods for treating egfr positive cancers
|
|
WO2022040454A1
(en)
|
2020-08-20 |
2022-02-24 |
A2 Biotherapeutics, Inc. |
Compositions and methods for treating mesothelin positive cancers
|
|
CN112080587A
(zh)
*
|
2020-08-31 |
2020-12-15 |
上海海关动植物与食品检验检疫技术中心 |
用于高效检测新型冠状病毒的raa-crispr扩增引物组、试剂盒及方法
|
|
WO2022188039A1
(en)
|
2021-03-09 |
2022-09-15 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
WO2022068912A1
(en)
|
2020-09-30 |
2022-04-07 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
US11944063B2
(en)
|
2020-09-30 |
2024-04-02 |
Spring Meadow Nursery, Inc. |
Hydrangea ‘SMNHPH’
|
|
MA63547B1
(fr)
|
2020-10-02 |
2025-08-29 |
Vilmorin & Cie |
Melon à durée de conservation prolongée
|
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
US20230372397A1
(en)
|
2020-10-06 |
2023-11-23 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
EP4321015A3
(en)
|
2020-10-16 |
2024-04-17 |
Klemm & Sohn GmbH & Co. KG |
Double-flowering dwarf calibrachoa
|
|
US11155884B1
(en)
|
2020-10-16 |
2021-10-26 |
Klemm & Sohn Gmbh & Co. Kg |
Double-flowering dwarf Calibrachoa
|
|
US20230147779A1
(en)
|
2020-10-28 |
2023-05-11 |
GeneEdit, Inc. |
Polymer with cationic and hydrophobic side chains
|
|
US11530419B2
(en)
|
2020-10-30 |
2022-12-20 |
Fortiphyte, Inc. |
Pathogen resistance in plants
|
|
KR20230107617A
(ko)
|
2020-11-13 |
2023-07-17 |
노파르티스 아게 |
키메라 항원 수용체(car)-발현 세포를 사용한 병용 요법
|
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
|
IL303102A
(en)
|
2020-12-03 |
2023-07-01 |
Vilmorin & Cie |
Tomato plants resistant to TOMMV, TOMV, TMV, TOBRFV and suitable resistant genes
|
|
US20240123067A1
(en)
|
2020-12-17 |
2024-04-18 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocyte therapies
|
|
CA3202483A1
(en)
|
2020-12-17 |
2022-06-23 |
Maria Fardis |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
|
EP4267157A4
(en)
|
2020-12-23 |
2025-05-07 |
Flagship Pioneering Innovations V, Inc. |
IN VITRO ASSEMBLY OF ANELLOVIRUS CAPSIDS WITH RNA
|
|
CA3207144A1
(en)
|
2021-01-05 |
2022-07-14 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
|
WO2022150776A1
(en)
*
|
2021-01-11 |
2022-07-14 |
Vedere Bio Ii, Inc. |
OPTOGENETIC COMPOSITIONS COMPRISING A CBh PROMOTER SEQUENCE AND METHODS FOR USE
|
|
JP2024502630A
(ja)
|
2021-01-12 |
2024-01-22 |
マーチ セラピューティクス, インコーポレイテッド |
コンテキスト依存性二本鎖dna特異的デアミナーゼ及びその使用
|
|
TW202241508A
(zh)
|
2021-01-29 |
2022-11-01 |
美商艾歐凡斯生物治療公司 |
細胞介素相關之腫瘤浸潤性淋巴球組合物及方法
|
|
EP4288541A1
(en)
|
2021-02-05 |
2023-12-13 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
IL304857A
(en)
|
2021-02-16 |
2023-10-01 |
A2 Biotherapeutics Inc |
Preparations and methods for treating HER2 POSITIVE cancer
|
|
CN115427561B
(zh)
|
2021-03-09 |
2024-06-04 |
辉大(上海)生物科技有限公司 |
工程化CRISPR/Cas13系统及其用途
|
|
JP2024509268A
(ja)
|
2021-03-09 |
2024-02-29 |
フォグホーン セラピューティクス インコーポレイテッド |
結晶形、それらを含有する組成物、及びそれらの使用方法
|
|
WO2022198141A1
(en)
|
2021-03-19 |
2022-09-22 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
|
AU2022246174A1
(en)
|
2021-03-25 |
2023-09-14 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for t-cell coculture potency assays and use with cell therapy products
|
|
US20250243244A1
(en)
|
2021-03-31 |
2025-07-31 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
|
WO2022208489A1
(en)
|
2021-04-02 |
2022-10-06 |
Vilmorin & Cie |
Semi-determinate or determinate growth habit trait in cucurbita
|
|
WO2022221699A1
(en)
|
2021-04-16 |
2022-10-20 |
Beam Therapeutics, Inc. |
Genetic modification of hepatocytes
|
|
EP4326287A2
(en)
|
2021-04-19 |
2024-02-28 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
|
US20240374761A1
(en)
|
2021-05-05 |
2024-11-14 |
Radius Pharmaceuticals, Inc. |
Animal model having homologous recombination of mouse pth1 receptor
|
|
WO2022240760A2
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING mRNA SPLICING
|
|
WO2022240721A1
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
|
US20240358845A1
(en)
|
2021-05-10 |
2024-10-31 |
Entrada Therapeutics, Inc. |
Compositions and methods for intracellular therapeutics
|
|
IL308337A
(en)
|
2021-05-13 |
2024-01-01 |
Us Health |
Preparations and methods for the treatment of sickle cell disease
|
|
WO2022245754A1
(en)
|
2021-05-17 |
2022-11-24 |
Iovance Biotherapeutics, Inc. |
Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
IL308806A
(en)
|
2021-06-01 |
2024-01-01 |
Arbor Biotechnologies Inc |
Gene editing systems including nuclease crisper and their uses
|
|
WO2022261561A1
(en)
|
2021-06-11 |
2022-12-15 |
Genedit Inc. |
Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups
|
|
US20240287487A1
(en)
|
2021-06-11 |
2024-08-29 |
The Broad Institute, Inc. |
Improved cytosine to guanine base editors
|
|
WO2022266105A1
(en)
*
|
2021-06-14 |
2022-12-22 |
The University Of Chicago |
Characterization and treatment of asthma
|
|
PE20242357A1
(es)
|
2021-06-23 |
2024-12-16 |
Entrada Therapeutics Inc |
Compuestos antisentido y metodos para dirigirse a repeticiones cug
|
|
CA3218556A1
(en)
|
2021-07-02 |
2023-01-05 |
Pivot Bio, Inc. |
Genetically-engineered bacterial strains for improved fixation of nitrogen
|
|
EP4367242A2
(en)
|
2021-07-07 |
2024-05-15 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
US20240365776A1
(en)
|
2021-07-22 |
2024-11-07 |
Iovance Biotherapeutics, Inc |
Method for cryopreservation of solid tumor fragments
|
|
US20240342285A1
(en)
|
2021-07-28 |
2024-10-17 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
|
AR126622A1
(es)
|
2021-07-30 |
2023-10-25 |
Kws Saat Se & Co Kgaa |
Plantas con digestibilidad mejorada y haplotipos marcadores
|
|
JP7756787B2
(ja)
|
2021-07-30 |
2025-10-20 |
ヘライナ,インコーポレーテッド |
タンパク質合成および分泌のための方法および組成物
|
|
US20250280784A1
(en)
|
2021-08-06 |
2025-09-11 |
Vilmorin & Cie |
Resistance to leveillula taurica in pepper
|
|
US20240368619A1
(en)
|
2021-09-02 |
2024-11-07 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
|
JP2024534945A
(ja)
|
2021-09-10 |
2024-09-26 |
アジレント・テクノロジーズ・インク |
化学修飾を有するプライム編集のためのガイドrna
|
|
WO2023056291A1
(en)
|
2021-09-28 |
2023-04-06 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
US20240342314A1
(en)
|
2021-09-30 |
2024-10-17 |
The Board Of Regents Of The University Of Texas System |
Slc13a5 gene therapy vectors and uses thereof
|
|
CN118382429A
(zh)
|
2021-10-08 |
2024-07-23 |
哈佛大学校长及研究员协会 |
用于药物递送的离子液体
|
|
AU2022366987A1
(en)
|
2021-10-14 |
2024-05-16 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
|
JP2023059858A
(ja)
|
2021-10-15 |
2023-04-27 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
自己相補的アデノ随伴ウイルスベクター及び筋ジストロフィーの治療におけるその使用
|
|
WO2023077015A2
(en)
|
2021-10-27 |
2023-05-04 |
Iovance Biotherapeutics, Inc. |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
|
KR20240099393A
(ko)
|
2021-11-01 |
2024-06-28 |
톰 바이오사이언시스, 인코포레이티드 |
유전자 편집 기구와 핵산 카고의 동시 전달을 위한 단일 작제물 플랫폼
|
|
EP4426832A1
(en)
|
2021-11-03 |
2024-09-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Precise genome editing using retrons
|
|
EP4427229A4
(en)
*
|
2021-11-03 |
2025-11-12 |
The Regents Of Univ Of California |
SErine RECOMBINASES
|
|
EP4430167A1
(en)
|
2021-11-10 |
2024-09-18 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
|
WO2023092153A2
(en)
*
|
2021-11-22 |
2023-05-25 |
The Texas A&M University System |
Methods and compositions targeting nucleus accumbens-associated protein-1 for treatment of autoimmune disorders and cancers
|
|
US20250295718A1
(en)
|
2021-11-24 |
2025-09-25 |
Research Institute At Nationwide Children's Hospital |
Chimeric hsv expressing hil21 to boost anti-tumor immune activity
|
|
EP4437092A1
(en)
|
2021-11-26 |
2024-10-02 |
Epigenic Therapeutics Inc. |
Method of modulating pcsk9 and uses thereof
|
|
WO2023102406A1
(en)
|
2021-12-01 |
2023-06-08 |
The Board Of Regents Of The Univesity Of Texas System |
Vector genome design to express optimized cln7 transgene
|
|
WO2023102518A1
(en)
|
2021-12-03 |
2023-06-08 |
The Board Of Regents Of The University Of Texas System |
Gnao1 gene therapy vectors and uses thereof
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
EP4448775A1
(en)
|
2021-12-17 |
2024-10-23 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
WO2023122805A1
(en)
|
2021-12-20 |
2023-06-29 |
Vestaron Corporation |
Sorbitol driven selection pressure method
|
|
WO2023122764A1
(en)
|
2021-12-22 |
2023-06-29 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
MX2024007908A
(es)
|
2021-12-23 |
2024-09-10 |
Univ Massachusetts |
Tratamiento terapeutico para trastorno asociado con x fragil.
|
|
WO2023133595A2
(en)
|
2022-01-10 |
2023-07-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2023147488A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
|
EP4469582A1
(en)
|
2022-01-28 |
2024-12-04 |
The Board Of Regents Of The University Of Texas System |
Transgene cassette designed to express the human codon-optimized gene
|
|
EP4472646A1
(en)
|
2022-02-01 |
2024-12-11 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
US20250144235A1
(en)
|
2022-02-02 |
2025-05-08 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
US20250099584A1
(en)
|
2022-02-18 |
2025-03-27 |
Institut National de la Santé et de la Recherche Médicale |
Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
|
|
AU2023248451A1
(en)
|
2022-04-04 |
2024-10-17 |
President And Fellows Of Harvard College |
Cas9 variants having non-canonical pam specificities and uses thereof
|
|
EP4504220A1
(en)
|
2022-04-06 |
2025-02-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
EP4256950A1
(en)
|
2022-04-06 |
2023-10-11 |
Vilmorin et Cie |
Tolerance to cgmmv in cucumber
|
|
CA3248034A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
CN120456933A
(zh)
|
2022-04-28 |
2025-08-08 |
布罗德研究所股份有限公司 |
编码碱基编辑器的aav载体及其用途
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
WO2023220040A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified capsid for gene therapy
|
|
EP4522201A1
(en)
|
2022-05-09 |
2025-03-19 |
Synteny Therapeutics, Inc. |
Erythroparvovirus compositions and methods for gene therapy
|
|
EP4522210A1
(en)
|
2022-05-09 |
2025-03-19 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified genome for gene therapy
|
|
EP4522221A1
(en)
|
2022-05-09 |
2025-03-19 |
Entrada Therapeutics, Inc. |
Compositions and methods for delivery of nucleic acid therapeutics
|
|
EP4522202A1
(en)
|
2022-05-10 |
2025-03-19 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
CA3253328A1
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and Modulation Methods of Genetic Drivers
|
|
EP4641202A3
(en)
|
2022-05-25 |
2026-01-21 |
Flagship Pioneering Innovations VII, LLC |
Compositions and methods for modulation of immune responses
|
|
US20250320254A1
(en)
|
2022-05-25 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and Methods for Modulating Circulating Factors
|
|
JP2025517969A
(ja)
|
2022-05-25 |
2025-06-12 |
フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー |
腫瘍抑制因子及び癌遺伝子の調節のための組成物及び方法
|
|
US20250319115A1
(en)
|
2022-05-25 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and Methods for Modulating Cytokines
|
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
|
GB202209518D0
(en)
|
2022-06-29 |
2022-08-10 |
Snipr Biome Aps |
Treating & preventing E coli infections
|
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024006802A1
(en)
|
2022-06-30 |
2024-01-04 |
Pioneer Hi-Bred International, Inc. |
Artificial intelligence-mediated methods and systems for genome editing
|
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
JP2025525569A
(ja)
|
2022-07-18 |
2025-08-05 |
レナゲード セラピューティクス マネージメント インコーポレイテッド |
遺伝子編集成分、システム、及び使用方法
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
EP4562168A1
(en)
|
2022-07-28 |
2025-06-04 |
Institut Pasteur |
Hsc70-4 in host-induced and spray-induced gene silencing
|
|
WO2024026406A2
(en)
|
2022-07-29 |
2024-02-01 |
Vestaron Corporation |
Next Generation ACTX Peptides
|
|
EP4569122A2
(en)
|
2022-08-09 |
2025-06-18 |
Pioneer Hi-Bred International, Inc. |
Guide polynucleotide multiplexing
|
|
CA3263821A1
(en)
|
2022-08-16 |
2024-02-22 |
The Broad Institute, Inc. |
ADVANCED CYTOSIN DESAMINASE AND DNA EDITING METHODS USING IT
|
|
WO2024040222A1
(en)
|
2022-08-19 |
2024-02-22 |
Generation Bio Co. |
Cleavable closed-ended dna (cedna) and methods of use thereof
|
|
US20260055146A1
(en)
|
2022-08-24 |
2026-02-26 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
US20250386788A1
(en)
|
2022-08-26 |
2025-12-25 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
|
WO2024050544A2
(en)
|
2022-09-01 |
2024-03-07 |
J.R. Simplot Company |
Enhanced targeted knock-in frequency in host genomes through crispr exonuclease processing
|
|
WO2024047605A1
(en)
|
2022-09-01 |
2024-03-07 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
|
WO2024052318A1
(en)
|
2022-09-06 |
2024-03-14 |
Institut National de la Santé et de la Recherche Médicale |
Novel dual split car-t cells for the treatment of cd38-positive hematological malignancies
|
|
US20260098062A1
(en)
|
2022-09-21 |
2026-04-09 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024064824A2
(en)
|
2022-09-21 |
2024-03-28 |
Yale University |
Compositions and methods for identification of membrane targets for enhancement of nk cell therapy
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
JP7353602B1
(ja)
|
2022-10-14 |
2023-10-02 |
株式会社インプランタイノベーションズ |
ゲノム編集方法およびゲノム編集用組成物
|
|
WO2024083579A1
(en)
|
2022-10-20 |
2024-04-25 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
WO2024098027A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
|
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
EP4615424A1
(en)
|
2022-11-10 |
2025-09-17 |
Sail Biomedicines, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
|
EP4623072A2
(en)
|
2022-11-21 |
2025-10-01 |
Iovance Biotherapeutics, Inc. |
Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
|
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
WO2024123786A1
(en)
|
2022-12-06 |
2024-06-13 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for co-delivery of t-dnas expressing multiple guide polynucleotides into plants
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
AU2023407654A1
(en)
|
2022-12-23 |
2025-06-12 |
Pivot Bio, Inc. |
Combination of various nitrogen fixing bacteria with various biological products to achieve synergistic effects
|
|
IL321652A
(en)
|
2022-12-29 |
2025-08-01 |
Vilmorin & Cie |
Tomato plants resistant to TSWV-resistant varieties and genes suitable for resistance
|
|
WO2024155745A1
(en)
|
2023-01-18 |
2024-07-25 |
The Broad Institute, Inc. |
Base editing-mediated readthrough of premature termination codons (bert)
|
|
EP4658061A1
(en)
|
2023-02-01 |
2025-12-10 |
United Beet Seeds |
Beet yellows virus resistance
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
WO2024173645A1
(en)
|
2023-02-15 |
2024-08-22 |
Arbor Biotechnologies, Inc. |
Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript
|
|
CN121152874A
(zh)
|
2023-03-20 |
2025-12-16 |
先锋国际良种公司 |
具有改变的PAM识别的Cas多肽
|
|
US12383615B2
(en)
|
2023-03-23 |
2025-08-12 |
Carbon Biosciences, Inc. |
Protoparvovirus compositions comprising a protoparvovirus variant VP1 capsid polypeptide and related methods
|
|
US12239091B2
(en)
|
2023-03-27 |
2025-03-04 |
Redsea Science And Technology Inc. |
Tomato plant designated ‘MX20-06’
|
|
WO2024206687A1
(en)
*
|
2023-03-29 |
2024-10-03 |
William Marsh Rice University |
Methods and compostions for engineered mitochondrial biogenesis
|
|
WO2024206911A2
(en)
|
2023-03-30 |
2024-10-03 |
Children's Hospital Medical Center |
Clinical-grade organoids
|
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
WO2024220719A1
(en)
|
2023-04-18 |
2024-10-24 |
Crystal Ronald G |
Modified aav capsids for gene delivery
|
|
EP4698666A1
(en)
|
2023-04-18 |
2026-02-25 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
EP4698665A1
(en)
|
2023-04-18 |
2026-02-25 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
US20240352485A1
(en)
|
2023-04-19 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for the production of libraries
|
|
CN121443140A
(zh)
|
2023-04-21 |
2026-01-30 |
非营利性组织佛兰芒综合大学生物技术研究所 |
用于作物产量提升的等位基因组合
|
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
|
EP4701406A1
(en)
|
2023-04-28 |
2026-03-04 |
Vilmorin & Cie |
Genetic determinants conferring improved tobrfv resistance
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
WO2024238977A2
(en)
|
2023-05-18 |
2024-11-21 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
|
KR20260016952A
(ko)
|
2023-05-23 |
2026-02-04 |
사나 바이오테크놀로지, 인크. |
탠덤 퓨소젠 및 관련 지질 입자
|
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
EP4731750A2
(en)
|
2023-06-23 |
2026-04-29 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
|
WO2025006419A1
(en)
|
2023-06-26 |
2025-01-02 |
Flagship Pioneering Innovations Vii, Llc |
Engineered plasmodia and related methods
|
|
WO2025003305A1
(en)
|
2023-06-28 |
2025-01-02 |
Vilmorin & Cie |
Pepper resistance to meloidogyne enterolobii
|
|
WO2025021893A1
(en)
|
2023-07-24 |
2025-01-30 |
Vilmorin & Cie |
Resistance to cysdv in melons
|
|
WO2025027165A1
(en)
|
2023-08-01 |
2025-02-06 |
Basf Plant Science Company Gmbh |
Increased resistance by expression of an ics protein
|
|
CN121605117A
(zh)
|
2023-08-01 |
2026-03-03 |
巴斯夫植物科学有限公司 |
通过表达msbp1蛋白增加抗性
|
|
US20250043304A1
(en)
|
2023-08-03 |
2025-02-06 |
J.R. Simplot Company |
Fusarium wilt resistance genes
|
|
WO2025038723A1
(en)
|
2023-08-14 |
2025-02-20 |
The Texas A&M University System |
Corn endotype-derived polypeptides capable of metabolizing fumonisin
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
AU2024335327A1
(en)
|
2023-09-01 |
2026-03-26 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025054540A1
(en)
|
2023-09-08 |
2025-03-13 |
Iovance Biotherapeutics, Inc. |
Methods of gene-editing using programmable nucleases
|
|
WO2025064408A1
(en)
|
2023-09-18 |
2025-03-27 |
The Broad Institute, Inc. |
Compositions and methods for treating cardiovascular disease
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025072803A1
(en)
|
2023-09-29 |
2025-04-03 |
Children's Hospital Medical Center |
Ntrk2 signaling-mediated alveolar capillary injury and repair
|
|
WO2025076141A1
(en)
|
2023-10-03 |
2025-04-10 |
Inari Agriculture Technology, Inc. |
Viral delivery of grna to the scion
|
|
WO2025081042A1
(en)
|
2023-10-12 |
2025-04-17 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
WO2025101484A1
(en)
|
2023-11-06 |
2025-05-15 |
Iovance Biotherapeutics, Inc. |
Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
|
|
US20250161347A1
(en)
|
2023-11-22 |
2025-05-22 |
Flagship Pioneering Innovations Vii, Llc |
Methods and compositions for treating non-alcoholic fatty liver disease
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025155753A2
(en)
|
2024-01-17 |
2025-07-24 |
Renagade Therapeutics Management Inc. |
Improved gene editing system, guides, and methods
|
|
WO2025155521A1
(en)
|
2024-01-18 |
2025-07-24 |
Pivot Bio, Inc. |
Host cells for enhanced plant growth
|
|
WO2025155518A1
(en)
|
2024-01-18 |
2025-07-24 |
Pivot Bio, Inc. |
Host cells for enhanced plant growth
|
|
WO2025158400A1
(en)
|
2024-01-24 |
2025-07-31 |
Yale University |
Compositions and methods of natural killer cell hyperboosts for enhancement of nk cell therapy
|
|
WO2025162985A1
(en)
|
2024-01-30 |
2025-08-07 |
Basf Plant Science Company Gmbh |
Increased plant disease resistance by expression of a glycine-rich protein
|
|
WO2025168705A1
(en)
|
2024-02-08 |
2025-08-14 |
Vib Vzw |
Means and methods for the production of saponins with endosomal escape-enhancing properties
|
|
WO2025171210A1
(en)
|
2024-02-09 |
2025-08-14 |
Arbor Biotechnologies, Inc. |
Compositions and methods for gene editing via homology-mediated end joining
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
WO2025184759A1
(en)
|
2024-03-04 |
2025-09-12 |
Pioneer Hi-Bred International, Inc. |
Maize plants comprising resistance to gray leaf spot and compositions and methods for selecting and producing the same
|
|
WO2025186284A1
(en)
|
2024-03-05 |
2025-09-12 |
Vilmorin & Cie |
Increased yield in cucumber
|
|
WO2025194019A1
(en)
|
2024-03-14 |
2025-09-18 |
Flagship Pioneering Innovations Vii, Llc |
Methods for treating liver fibrosis and non-alcoholic fatty liver disease
|
|
WO2025202473A1
(en)
|
2024-03-28 |
2025-10-02 |
Revvity Discovery Limited |
A nucleic acid deaminase, a base editor and uses thereof
|
|
WO2025212920A1
(en)
|
2024-04-03 |
2025-10-09 |
Children's Hospital Medical Center |
Multi-zonal liver organoids
|
|
WO2025217202A1
(en)
|
2024-04-08 |
2025-10-16 |
Children's Hospital Medical Center |
Bile duct organoid
|
|
EP4677108A1
(en)
|
2024-04-22 |
2026-01-14 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025232898A1
(en)
|
2024-05-10 |
2025-11-13 |
Yoltech Therapeutics Co., Ltd |
Lipid compounds and lipid nanoparticle compositions
|
|
WO2025240947A1
(en)
|
2024-05-17 |
2025-11-20 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
WO2025245188A2
(en)
|
2024-05-21 |
2025-11-27 |
Flagship Pioneering Innovations Vii, Llc |
Methods of treating liver steatosis and non-alcoholic fatty liver disease
|
|
WO2025259554A1
(en)
|
2024-06-13 |
2025-12-18 |
J.R. Simplot Company |
Engineering remontant flowering in rosaceae
|
|
WO2026006542A2
(en)
|
2024-06-26 |
2026-01-02 |
Yale University |
Compositions and methods for crispr/cas9 based reactivation of human angelman syndrome
|
|
WO2026015523A1
(en)
|
2024-07-09 |
2026-01-15 |
Pioneer Hi-Bred International, Inc. |
Methods and systems for use in plant breeding
|
|
WO2026015829A2
(en)
|
2024-07-12 |
2026-01-15 |
Arbor Biotechnologies, Inc. |
Small reverse transcriptases and gene editing systems comprising such
|
|
WO2026015832A2
(en)
|
2024-07-12 |
2026-01-15 |
Arbor Biotechnologies, Inc. |
Reverse transcriptases and gene editing systems comprising such
|
|
WO2026017833A1
(en)
|
2024-07-17 |
2026-01-22 |
Vilmorin & Cie |
Tswv-resistant pepper
|
|
US20260043035A1
(en)
|
2024-08-08 |
2026-02-12 |
Invaio Sciences, Inc. |
Nature-derived lipid particles for use in agriculture
|
|
WO2026047626A1
(en)
|
2024-08-30 |
2026-03-05 |
Inceptor Bio, Llc |
Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy
|
|
WO2026072421A2
(en)
|
2024-09-27 |
2026-04-02 |
The Broad Institute, Inc. |
Base editing methods and compositions for editing prnp in the treatment of prion disease
|
|
CN119601083A
(zh)
*
|
2024-11-16 |
2025-03-11 |
大连易康生物科技有限公司 |
一种基因测序数据处理方法及系统
|
|
CN119874861B
(zh)
*
|
2025-01-10 |
2025-11-25 |
中国科学院遗传与发育生物学研究所 |
SlABCG45基因在提高番茄的列当抗性和产量中的应用
|