DK3594348T3 - Kort c/ebp-alpha til aktivering af rna-sammensætninger og anvendelsesfremgangsmåder - Google Patents
Kort c/ebp-alpha til aktivering af rna-sammensætninger og anvendelsesfremgangsmåder Download PDFInfo
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- DK3594348T3 DK3594348T3 DK19190263.4T DK19190263T DK3594348T3 DK 3594348 T3 DK3594348 T3 DK 3594348T3 DK 19190263 T DK19190263 T DK 19190263T DK 3594348 T3 DK3594348 T3 DK 3594348T3
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- ebp
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
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- Biotechnology (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361907732P | 2013-11-22 | 2013-11-22 | |
EP14843226.3A EP3071696B1 (en) | 2013-11-22 | 2014-11-24 | C/ebp alpha short activating rna compositions and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3594348T3 true DK3594348T3 (da) | 2021-10-11 |
Family
ID=52649067
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14843226.3T DK3071696T3 (da) | 2013-11-22 | 2014-11-24 | C/ebp alfa kort aktiverings-rna-sammensætninger og fremgangsmåder til anvendelse |
DK19190263.4T DK3594348T3 (da) | 2013-11-22 | 2014-11-24 | Kort c/ebp-alpha til aktivering af rna-sammensætninger og anvendelsesfremgangsmåder |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14843226.3T DK3071696T3 (da) | 2013-11-22 | 2014-11-24 | C/ebp alfa kort aktiverings-rna-sammensætninger og fremgangsmåder til anvendelse |
Country Status (10)
Country | Link |
---|---|
US (4) | US10202601B2 (da) |
EP (3) | EP3985118A1 (da) |
JP (3) | JP6621409B2 (da) |
KR (3) | KR102688720B1 (da) |
CN (2) | CN112220797B (da) |
AU (3) | AU2014351482B2 (da) |
CA (2) | CA3236835A1 (da) |
DK (2) | DK3071696T3 (da) |
SI (2) | SI3594348T1 (da) |
WO (1) | WO2015075557A2 (da) |
Families Citing this family (73)
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WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
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US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
CA3236835A1 (en) * | 2013-11-22 | 2015-05-28 | Mina Therapeutics Limited | C/ebp alpha short activating rna compositions and methods of use |
US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
WO2015092707A2 (en) * | 2013-12-17 | 2015-06-25 | Csir | A method for identification of anti-hiv human mirna mimics and mirna inhibitors and anti-hiv pharmaceutical compounds |
WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
US20160060312A1 (en) | 2014-08-27 | 2016-03-03 | Cellivery Therapeutics, Inc. | Development of Protein-Based Biotherapeutics That Penetrates Cell-Membrane and Induces Anti-Pancreatic Cancer Effect - Improved Cell-Permeable Suppressor of Cytokine Signaling (iCP-SOCS3) Proteins, Polynucleotides Encoding the Same, and Anti-Pancreatic Cancer Compositions Comprising the Same |
WO2016054094A1 (en) | 2014-09-30 | 2016-04-07 | Research Institute At Nationwide Children's Hospital | Compositions and methods for treating hepatic fibrosis |
US10912790B2 (en) * | 2015-04-22 | 2021-02-09 | Mina Therapeutics Limited | C/EBP alpha saRNA compositions and methods of use |
EP3316894A4 (en) * | 2015-07-02 | 2019-06-19 | City of Hope | COMPOUNDS AND COMPOSITIONS USING PHOSPHOROIDED OLIGODESOXYNUCLEOTIDE AND METHOD OF USE THEREOF |
JP6824966B2 (ja) | 2015-09-21 | 2021-02-03 | インターセプト ファーマシューティカルズ, インコーポレイテッド | 肝臓の再生を促進する方法 |
IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and their uses |
CN106636312B (zh) * | 2015-10-30 | 2020-06-02 | 益善生物技术股份有限公司 | 肝癌相关microRNA检测试剂盒 |
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EP3254683A1 (en) * | 2016-06-06 | 2017-12-13 | Medizinische Hochschule Hannover | Medicament for the treatment of acute liver failure |
CN106244588B (zh) * | 2016-07-30 | 2019-07-12 | 内蒙古医科大学附属人民医院 | 激活肺癌细胞中RUNX3表达的saRNA及其应用 |
CA3032699A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
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WO2018104538A1 (en) * | 2016-12-08 | 2018-06-14 | Curevac Ag | Rna for treatment or prophylaxis of a liver disease |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
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JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
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WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
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CN108559750B (zh) * | 2018-01-16 | 2020-07-31 | 华南农业大学 | Stat3在猪卵巢颗粒细胞中的应用 |
US20210024928A1 (en) * | 2018-02-16 | 2021-01-28 | Mina Therapeutics Limited | C/ebp alpha sarna compositions and methods of use |
CN108959843B (zh) * | 2018-06-06 | 2021-07-06 | 北京箭牧科技有限公司 | 靶向rna的化学小分子药物计算机筛选方法 |
WO2019239144A1 (en) | 2018-06-15 | 2019-12-19 | Mina Therapeutics Limited | Combination therapies comprising c/ebp alpha sarna |
WO2020051243A1 (en) * | 2018-09-04 | 2020-03-12 | Ohio State Innovation Foundation | Lipid nanoparticles and methods of using thereof |
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