US6444798B1
(en)
*
|
1988-06-06 |
2002-09-03 |
Steven Albert Benner |
Chimeras of sulfur-linked oligonucleotide analogs and DNA and RNA
|
US6753423B1
(en)
|
1990-01-11 |
2004-06-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
US6005087A
(en)
*
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
US5681941A
(en)
*
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US5872232A
(en)
*
|
1990-01-11 |
1999-02-16 |
Isis Pharmaceuticals Inc. |
2'-O-modified oligonucleotides
|
US5859221A
(en)
*
|
1990-01-11 |
1999-01-12 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
US6783931B1
(en)
|
1990-01-11 |
2004-08-31 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
US20040142899A1
(en)
*
|
1990-01-11 |
2004-07-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
US6339066B1
(en)
|
1990-01-11 |
2002-01-15 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
|
US6358931B1
(en)
|
1990-01-11 |
2002-03-19 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating RNA
|
US6399754B1
(en)
*
|
1991-12-24 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides
|
US7037646B1
(en)
|
1990-01-11 |
2006-05-02 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
US5998603A
(en)
*
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
US6121433A
(en)
*
|
1990-07-27 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having nitrogen-containing linkages
|
US5618704A
(en)
*
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
US5602240A
(en)
*
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
US5541307A
(en)
*
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
US5378825A
(en)
*
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
US5386023A
(en)
*
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
US5623070A
(en)
*
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5610289A
(en)
*
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
HU217036B
(hu)
*
|
1990-08-03 |
1999-11-29 |
Sanofi |
Eljárás génexpresszió gátlására alkalmas vegyületek előállítására
|
US5789573A
(en)
*
|
1990-08-14 |
1998-08-04 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
|
US5596086A
(en)
*
|
1990-09-20 |
1997-01-21 |
Gilead Sciences, Inc. |
Modified internucleoside linkages having one nitrogen and two carbon atoms
|
US5965722A
(en)
*
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
US5359044A
(en)
*
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
WO1993018052A1
(en)
*
|
1992-03-05 |
1993-09-16 |
Isis Pharmaceuticals, Inc. |
Covalently cross-linked oligonucleotides
|
US5543507A
(en)
*
|
1992-03-05 |
1996-08-06 |
Isis Pharmaceuticals, Inc. |
Covalently cross-linked oligonucleotides
|
US6537973B1
(en)
|
1992-03-16 |
2003-03-25 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide inhibition of protein kinase C
|
US6117847A
(en)
*
|
1992-03-16 |
2000-09-12 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for enhanced modulation of protein kinase C expression
|
GB9207380D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Compounds
|
US5434257A
(en)
*
|
1992-06-01 |
1995-07-18 |
Gilead Sciences, Inc. |
Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
|
US5817781A
(en)
|
1992-06-01 |
1998-10-06 |
Gilead Sciences, Inc. |
Modified internucleoside linkages (II)
|
JP2879973B2
(ja)
*
|
1992-06-24 |
1999-04-05 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ヘテロ原子によるオリゴヌクレオシド連結
|
HUT73335A
(en)
*
|
1992-10-05 |
1996-07-29 |
Isis Pharmaceuticals Inc |
Antisense oligonucleotides and methods for inhibition of the human ras genes, methods for inhibition of tumour-cells proliferation and methods for detection of activated ras-genes
|
US5985558A
(en)
*
|
1997-04-14 |
1999-11-16 |
Isis Pharmaceuticals Inc. |
Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
|
US20030013670A1
(en)
*
|
1992-10-05 |
2003-01-16 |
Monia Brett P. |
Antisense oligonucleotide inhibition of ras
|
US5872242A
(en)
*
|
1992-10-05 |
1999-02-16 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide inhibition of ras
|
US6784290B1
(en)
|
1992-10-05 |
2004-08-31 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide inhibition of ras
|
WO1994022891A1
(en)
*
|
1993-03-31 |
1994-10-13 |
Sterling Winthrop Inc. |
Oligonucleotides with amide linkages replacing phosphodiester linkages
|
JPH08508489A
(ja)
*
|
1993-03-31 |
1996-09-10 |
スターリング ウィンスロップ インコーポレイティド |
二官能価ヌクレオシド、それらのオリゴマーならびにそれらの製造方法及び使用方法
|
GB9311682D0
(en)
*
|
1993-06-05 |
1993-07-21 |
Ciba Geigy Ag |
Chemical compounds
|
US6605708B1
(en)
*
|
1993-07-28 |
2003-08-12 |
Hybridon, Inc. |
Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
US6653458B1
(en)
|
1993-09-03 |
2003-11-25 |
Isis Pharmaceuticals, Inc. |
Modified oligonucleotides
|
JPH09508134A
(ja)
*
|
1994-01-26 |
1997-08-19 |
チバ−ガイギー アクチェンゲゼルシャフト |
変型オリゴヌクレオチド
|
US5625050A
(en)
*
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
US6391636B1
(en)
|
1994-05-31 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
US5981731A
(en)
*
|
1994-05-31 |
1999-11-09 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of B-raf gene expression
|
AU3222795A
(en)
*
|
1994-08-09 |
1996-03-07 |
Ciba-Geigy Ag |
Antitumor antisense oligonucleotides
|
GB9417746D0
(en)
*
|
1994-09-03 |
1994-10-19 |
Ciba Geigy Ag |
Chemical compounds
|
GB9417938D0
(en)
*
|
1994-09-06 |
1994-10-26 |
Ciba Geigy Ag |
Compounds
|
US5681940A
(en)
*
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
EP0714907A1
(de)
*
|
1994-11-30 |
1996-06-05 |
F. Hoffmann-La Roche Ag |
Oligonukleotide mit Amid-Hauptkette
|
US5807718A
(en)
|
1994-12-02 |
1998-09-15 |
The Scripps Research Institute |
Enzymatic DNA molecules
|
US6207826B1
(en)
|
1995-03-27 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Macrocyclic compounds having nitrogen-containing linkages
|
EP0817787A4
(de)
*
|
1995-03-27 |
2000-09-13 |
Isis Pharmaceuticals Inc |
Makrozyklische stickstoffverbindungen
|
US6420549B1
(en)
*
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
WO1996040726A1
(en)
|
1995-06-07 |
1996-12-19 |
Genta Incorporated |
Novel carbamate-based cationic lipids
|
US6143749A
(en)
*
|
1995-06-07 |
2000-11-07 |
Abbott Laboratories |
Heterocyclic substituted cyclopentane compounds
|
US5665721A
(en)
*
|
1995-06-07 |
1997-09-09 |
Abbott Laboratories |
Heterocyclic substituted cyclopentane compounds
|
US5855911A
(en)
*
|
1995-08-29 |
1999-01-05 |
Board Of Regents, The University Of Texas System |
Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
|
GB9604669D0
(en)
|
1996-03-05 |
1996-05-01 |
Ciba Geigy Ag |
Chemical compounds
|
US5856099A
(en)
*
|
1996-05-21 |
1999-01-05 |
Isis Pharmaceuticals, Inc. |
Antisense compositions and methods for modulating type I interleukin-1 receptor expression
|
US7812149B2
(en)
*
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20050119470A1
(en)
*
|
1996-06-06 |
2005-06-02 |
Muthiah Manoharan |
Conjugated oligomeric compounds and their use in gene modulation
|
US20040147022A1
(en)
*
|
1996-06-06 |
2004-07-29 |
Baker Brenda F. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
US20040203024A1
(en)
*
|
1996-06-06 |
2004-10-14 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US9096636B2
(en)
*
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US20040161777A1
(en)
*
|
1996-06-06 |
2004-08-19 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US20050053976A1
(en)
*
|
1996-06-06 |
2005-03-10 |
Baker Brenda F. |
Chimeric oligomeric compounds and their use in gene modulation
|
US20050042647A1
(en)
*
|
1996-06-06 |
2005-02-24 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
GB9612600D0
(en)
|
1996-06-13 |
1996-08-21 |
Ciba Geigy Ag |
Chemical compounds
|
AU3340797A
(en)
*
|
1996-06-28 |
1998-01-21 |
Novartis Ag |
Modified oligonucleotides
|
US7309692B1
(en)
*
|
1996-07-08 |
2007-12-18 |
Board Of Regents, The University Of Texas System |
Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
|
US6077954A
(en)
|
1996-08-01 |
2000-06-20 |
Isis Pharmaceuticals, Inc. |
Substituted heterocyclic compounds
|
JP4211948B2
(ja)
|
1996-08-02 |
2009-01-21 |
ベーイーオー・メリュー |
標的核酸配列の増幅方法
|
US6111085A
(en)
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
US6977244B2
(en)
*
|
1996-10-04 |
2005-12-20 |
Board Of Regents, The University Of Texas Systems |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
US5780241A
(en)
*
|
1996-11-05 |
1998-07-14 |
Isis Pharmaceuticals, Inc. |
Complex chemical libraries
|
US6077833A
(en)
*
|
1996-12-31 |
2000-06-20 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
US6319906B1
(en)
|
1996-12-31 |
2001-11-20 |
Isis Pharmaceuticals |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
US7235653B2
(en)
|
1996-12-31 |
2007-06-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
US6127533A
(en)
|
1997-02-14 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
2'-O-aminooxy-modified oligonucleotides
|
US6172209B1
(en)
*
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
US6639062B2
(en)
*
|
1997-02-14 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
|
US6576752B1
(en)
*
|
1997-02-14 |
2003-06-10 |
Isis Pharmaceuticals, Inc. |
Aminooxy functionalized oligomers
|
AU735522C
(en)
|
1997-04-29 |
2005-04-07 |
Scripps Research Institute, The |
Enzymatic dna molecules
|
ATE321882T1
(de)
|
1997-07-01 |
2006-04-15 |
Isis Pharmaceuticals Inc |
Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre
|
US5877309A
(en)
*
|
1997-08-13 |
1999-03-02 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides against JNK
|
US6133246A
(en)
*
|
1997-08-13 |
2000-10-17 |
Isis Pharmaceuticals Inc. |
Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
|
US6809193B2
(en)
|
1997-08-13 |
2004-10-26 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
|
US20070149472A1
(en)
*
|
1997-08-13 |
2007-06-28 |
Mckay Robert |
Antisense oligonucleotide compositions and methods for the modulation of jnk proteins
|
US6518017B1
(en)
*
|
1997-10-02 |
2003-02-11 |
Oasis Biosciences Incorporated |
Combinatorial antisense library
|
US20030165888A1
(en)
*
|
2001-07-18 |
2003-09-04 |
Brown Bob D. |
Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
|
US7704962B1
(en)
|
1997-10-03 |
2010-04-27 |
Board Of Regents, The University Of Texas System |
Small oligonucleotides with anti-tumor activity
|
US7285288B1
(en)
|
1997-10-03 |
2007-10-23 |
Board Of Regents, The University Of Texas System |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
US6232463B1
(en)
|
1997-10-09 |
2001-05-15 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US5948902A
(en)
*
|
1997-11-20 |
1999-09-07 |
South Alabama Medical Science Foundation |
Antisense oligonucleotides to human serine/threonine protein phosphatase genes
|
US5968748A
(en)
*
|
1998-03-26 |
1999-10-19 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of human HER-2 expression
|
US20040186071A1
(en)
*
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
US7321828B2
(en)
*
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
AU753270B2
(en)
*
|
1998-05-21 |
2002-10-10 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for topical delivery of oligonucleotides
|
CA2329130A1
(en)
*
|
1998-05-21 |
1999-11-25 |
Isis Pharmaceuticals Inc. |
Compositions and methods for non-parenteral delivery of oligonucleotides
|
US6300319B1
(en)
|
1998-06-16 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Targeted oligonucleotide conjugates
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
US6673912B1
(en)
|
1998-08-07 |
2004-01-06 |
Isis Pharmaceuticals, Inc. |
2′-O-aminoethyloxyethyl-modified oligonucleotides
|
US20040009938A1
(en)
*
|
1998-08-07 |
2004-01-15 |
Muthiah Manoharan |
Methods of enhancing renal uptake of oligonucleotides
|
US6175004B1
(en)
|
1998-09-01 |
2001-01-16 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligonucleotides incorporating 2-aminoadenosine
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
US6069243A
(en)
*
|
1998-10-06 |
2000-05-30 |
Isis Pharmaceuticals, Inc. |
Process for oligonucleotide synthesis
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
US6492111B1
(en)
|
1998-11-25 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
In situ binary synthesis of biologically effective molecules
|
US6087112A
(en)
*
|
1998-12-30 |
2000-07-11 |
Oligos Etc. Inc. |
Arrays with modified oligonucleotide and polynucleotide compositions
|
US20030180789A1
(en)
*
|
1998-12-30 |
2003-09-25 |
Dale Roderic M.K. |
Arrays with modified oligonucleotide and polynucleotide compositions
|
US6403779B1
(en)
|
1999-01-08 |
2002-06-11 |
Isis Pharmaceuticals, Inc. |
Regioselective synthesis of 2′-O-modified nucleosides
|
US6399765B1
(en)
|
1999-03-17 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Methods for removing dimethoxytrityl groups from oligonucleotides
|
AU3934000A
(en)
|
1999-03-18 |
2000-10-04 |
United Therapeutics Corporation |
Inhibitors of endothelin-1 synthesis
|
US6235891B1
(en)
|
1999-03-31 |
2001-05-22 |
South Alabama Medical Science Foundation |
Glucocorticoid receptor agonist and decreased PP5
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
JP2002541825A
(ja)
*
|
1999-04-08 |
2002-12-10 |
オアシス バイオサイエンシーズ インコーポレイティッド |
ユニバーサル及び/又は同義性塩基を含むアンチセンスオリゴヌクレオチド
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
US6277982B1
(en)
|
1999-08-20 |
2001-08-21 |
Isis Pharmaceuticals, Inc. |
Alkylation of alcohols, amines, thiols and their derivatives by cyclic sulfate intermediates
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
CN1274072C
(zh)
*
|
2000-08-03 |
2006-09-06 |
松下电器产业株式会社 |
无刷电机及其制造方法
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
AU2002315393A1
(en)
|
2001-06-21 |
2003-01-08 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
CA2457565A1
(en)
|
2001-10-09 |
2003-04-17 |
Genentech, Inc. |
Novel acidic mammalian proteins and polynucleotides encoding the same
|
NZ566396A
(en)
|
2001-10-09 |
2009-07-31 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expressions
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
DE10159904A1
(de)
*
|
2001-12-06 |
2003-07-03 |
Adnagen Ag |
Oligonukleotidanordnung, Verfahren zum Nukleotidnachweis sowie Vorrichtung hierfür
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
WO2003061386A1
(en)
*
|
2002-01-03 |
2003-07-31 |
Board Of Regents, The University Of Texas System |
Wt1 antisense oligos for the inhibition of breast cancer
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
US20030166282A1
(en)
*
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
ATE508188T1
(de)
|
2002-02-01 |
2011-05-15 |
Life Technologies Corp |
Oligonukleotid-zusammensetzungen mit verbesserter wirksamkeit
|
US20030191075A1
(en)
*
|
2002-02-22 |
2003-10-09 |
Cook Phillip Dan |
Method of using modified oligonucleotides for hepatic delivery
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
US20040106785A1
(en)
*
|
2002-07-25 |
2004-06-03 |
Micrologix Biotech Inc. |
Inhibitors of RNA dependent RNA polymerase and uses thereof
|
EP3222726A1
(de)
|
2002-08-05 |
2017-09-27 |
Silence Therapeutics GmbH |
Weitere neuartige formen von interferierenden rna-molekülen
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
WO2004024919A1
(en)
*
|
2002-09-13 |
2004-03-25 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
WO2004027030A2
(en)
*
|
2002-09-18 |
2004-04-01 |
Isis Pharmaceuticals, Inc. |
Efficient reduction of target rna’s by single- and double-stranded oligomeric compounds
|
AU2003278957A1
(en)
|
2002-09-26 |
2004-04-23 |
Amgen, Inc. |
Modulation of forkhead box o1a expression
|
CA2504720C
(en)
|
2002-11-05 |
2013-12-24 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
AU2003290597A1
(en)
*
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
EP2336318B1
(de)
|
2002-11-13 |
2013-04-24 |
Genzyme Corporation |
Antisense-modulation von apolipoprotein-b-expression
|
ES2417879T3
(es)
|
2002-11-13 |
2013-08-09 |
Genzyme Corporation |
Modulación antisentido de la expresión de la apolipoproteína B
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
ES2400033T3
(es)
|
2003-02-11 |
2013-04-05 |
Antisense Therapeutics Ltd |
Modulación de la expresión del receptor del factor de crecimiento I similar a la insulina
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
EP2216407B1
(de)
|
2003-03-07 |
2016-01-13 |
Alnylam Pharmaceuticals, Inc. |
Therapeutische Zusammensetzungen
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
WO2004094595A2
(en)
|
2003-04-17 |
2004-11-04 |
Alnylam Pharmaceuticals Inc. |
MODIFIED iRNA AGENTS
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
US20040219533A1
(en)
*
|
2003-04-29 |
2004-11-04 |
Jim Davis |
Biological bar code
|
US8679789B2
(en)
*
|
2003-05-01 |
2014-03-25 |
Gen-Probe Incorporated |
Oligonucleotides comprising a molecular switch
|
US7897582B2
(en)
|
2003-05-23 |
2011-03-01 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
US7960355B2
(en)
|
2003-05-23 |
2011-06-14 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of the expression of B7 protein
|
WO2004108081A2
(en)
*
|
2003-06-02 |
2004-12-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
US7541344B2
(en)
|
2003-06-03 |
2009-06-02 |
Eli Lilly And Company |
Modulation of survivin expression
|
ES2905724T3
(es)
|
2003-06-13 |
2022-04-11 |
Alnylam Europe Ag |
Acido ribonucleico bicatenario con elevada eficacia en un organismo
|
US20060241072A1
(en)
*
|
2003-06-20 |
2006-10-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds for use in gene modulation
|
WO2005017108A2
(en)
*
|
2003-06-30 |
2005-02-24 |
United Soybean Board |
Soybean selection system based on aec-resistance
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
US20070123480A1
(en)
*
|
2003-09-11 |
2007-05-31 |
Replicor Inc. |
Oligonucleotides targeting prion diseases
|
SG146682A1
(en)
|
2003-09-18 |
2008-10-30 |
Isis Pharmaceuticals Inc |
Modulation of eif4e expression
|
AU2004274021B2
(en)
*
|
2003-09-18 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
US7125945B2
(en)
*
|
2003-09-19 |
2006-10-24 |
Varian, Inc. |
Functionalized polymer for oligonucleotide purification
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
EP1711606A2
(de)
|
2004-01-20 |
2006-10-18 |
Isis Pharmaceuticals, Inc. |
Modulation der expression des glucocorticoidrezeptors
|
US8569474B2
(en)
*
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
US20050244869A1
(en)
*
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
EP3034510A1
(de)
|
2004-04-30 |
2016-06-22 |
Alnylam Pharmaceuticals Inc. |
Oligonukleotide mit c5-modifiziertem pyrimidin
|
JP2008509226A
(ja)
|
2004-05-24 |
2008-03-27 |
ジェンボールト コーポレイション |
回収可能な形式での安定なタンパク質保管および安定な核酸保管
|
EP2474616B1
(de)
|
2004-05-28 |
2015-07-08 |
Asuragen, Inc. |
Verfahren und Zusammensetzungen mit microRNA
|
EP1765416A4
(de)
*
|
2004-06-03 |
2010-03-24 |
Isis Pharmaceuticals Inc |
Doppelsträngige zusammensetzungen mit unterschiedlich modifizierten strängen zur verwendung bei der genmodulation
|
US8394947B2
(en)
*
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
CA2569036A1
(en)
*
|
2004-06-03 |
2005-12-22 |
Balkrishen Bhat |
Chimeric gapped oligomeric compositions
|
US7968762B2
(en)
*
|
2004-07-13 |
2011-06-28 |
Van Andel Research Institute |
Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF)
|
JP5192234B2
(ja)
|
2004-08-10 |
2013-05-08 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
化学修飾オリゴヌクレオチド
|
BRPI0514395A
(pt)
|
2004-08-16 |
2008-06-10 |
Quark Biotech Inc |
uso terapêutico de inibidores de rtp801
|
DK1797183T3
(da)
*
|
2004-09-02 |
2012-10-01 |
Univ Yale |
Regulering af onkogener med mikrornas
|
US7884086B2
(en)
*
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
AU2005286738A1
(en)
|
2004-09-17 |
2006-03-30 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
ES2503740T3
(es)
|
2004-11-12 |
2014-10-07 |
Asuragen, Inc. |
Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
|
US8067175B2
(en)
|
2005-02-11 |
2011-11-29 |
Memorial Sloan-Kettering Cancer Center |
Methods and compositions for detecting a drug resistant EGFR mutant
|
US20060257902A1
(en)
*
|
2005-03-25 |
2006-11-16 |
Ambion, Inc. |
Methods and compositions for depleting abundant RNA transcripts
|
EP1877418B1
(de)
|
2005-05-06 |
2013-11-20 |
Gen-Probe Incorporated |
Zusammensetzungen und testanordnungen zur erkennung von nukleinsäuren des influenza-virus a
|
US8354384B2
(en)
*
|
2005-06-23 |
2013-01-15 |
Yale University |
Anti-aging micrornas
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
WO2007047912A2
(en)
|
2005-10-17 |
2007-04-26 |
Gen-Probe Incorporated |
Compositions and methods to detect legionella pneumophila nucleic acid
|
CA2627025A1
(en)
*
|
2005-10-28 |
2007-05-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
AU2006311730B2
(en)
|
2005-11-09 |
2010-12-02 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Factor V Leiden mutant gene
|
NL2000439C2
(nl)
|
2006-01-20 |
2009-03-16 |
Quark Biotech |
Therapeutische toepassingen van inhibitoren van RTP801.
|
PL2314594T3
(pl)
|
2006-01-27 |
2014-12-31 |
Isis Pharmaceuticals Inc |
Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych
|
EP1987166A4
(de)
|
2006-02-03 |
2010-06-02 |
Univ Columbia |
Binäre deoxyribozym-sonden zur nukleinsäure-analyse
|
EP2511383B1
(de)
|
2006-03-31 |
2013-12-25 |
Columbia University |
Binäre Sonden für Fluoreszenzanalyse von Nukleinsäuren
|
DK2363481T3
(en)
|
2006-05-05 |
2017-06-26 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulating gene expression
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
KR101036126B1
(ko)
|
2006-05-11 |
2011-05-23 |
알닐람 파마슈티칼스 인코포레이티드 |
Pcsk9 유전자의 발현을 억제하기 위한 조성물 및 방법
|
JP5441688B2
(ja)
*
|
2006-05-11 |
2014-03-12 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
5’修飾二環式核酸類似体
|
ATE514794T1
(de)
*
|
2006-05-12 |
2011-07-15 |
Gen Probe Inc |
Zusammensetzungen und verfahren für den nachweis von enterokokken-nukleinsäuren
|
EP2023938A4
(de)
*
|
2006-05-23 |
2010-11-10 |
Isis Pharmaceuticals Inc |
Modulation von chrebp-expression
|
WO2008011473A2
(en)
|
2006-07-19 |
2008-01-24 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to hbxip
|
CN102321626B
(zh)
|
2006-07-21 |
2014-12-10 |
赛伦斯治疗有限公司 |
用于抑制蛋白激酶3表达的方法
|
US9051601B2
(en)
|
2006-08-01 |
2015-06-09 |
Gen-Probe Incorporated |
Methods of nonspecific target capture of nucleic acids
|
US20090131348A1
(en)
|
2006-09-19 |
2009-05-21 |
Emmanuel Labourier |
Micrornas differentially expressed in pancreatic diseases and uses thereof
|
WO2008036776A2
(en)
|
2006-09-19 |
2008-03-27 |
Asuragen, Inc. |
Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
|
WO2008036933A2
(en)
|
2006-09-21 |
2008-03-27 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the hamp gene
|
CN110066224A
(zh)
|
2006-10-03 |
2019-07-30 |
阿尔尼拉姆医药品有限公司 |
含脂质的制品
|
JP2010507387A
(ja)
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のsiRNAおよびその使用方法
|
US20100062436A1
(en)
|
2006-10-31 |
2010-03-11 |
Noxxon Pharma Ag |
Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule
|
AU2007333109A1
(en)
|
2006-12-08 |
2008-06-19 |
Asuragen, Inc. |
Functions and targets of let-7 micro RNAs
|
JP5340167B2
(ja)
|
2006-12-21 |
2013-11-13 |
ジェン−プロウブ インコーポレイテッド |
核酸増幅のための方法および組成物
|
EP2641971A1
(de)
|
2007-01-29 |
2013-09-25 |
Isis Pharmaceuticals, Inc. |
Verbindungen und Verfahren zur Modulation der Proteinexpression
|
PE20090064A1
(es)
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
|
WO2008140449A1
(en)
|
2007-05-11 |
2008-11-20 |
Thomas Jefferson University |
Methods of treatment and prevention of neurodegenerative diseases and disorders
|
EA018101B1
(ru)
*
|
2007-05-11 |
2013-05-30 |
Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания |
Способы лечения кожных язв
|
EP2170917B1
(de)
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
Über n-substituiertes aminomethylen verbrückte, bicyclische nukleinsäureanaloga
|
ES2386492T3
(es)
|
2007-06-08 |
2012-08-21 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos carbocíclicos
|
CA2691364C
(en)
|
2007-06-19 |
2020-06-16 |
Stratos Genomics, Inc. |
High throughput nucleic acid sequencing by expansion
|
CN101688206B
(zh)
|
2007-07-05 |
2013-05-15 |
诺瓦提斯公司 |
用于治疗病毒感染的dsRNA
|
US8278283B2
(en)
*
|
2007-07-05 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
6-disubstituted or unsaturated bicyclic nucleic acid analogs
|
ES2439591T3
(es)
*
|
2007-08-15 |
2014-01-23 |
Isis Pharmaceuticals, Inc. |
Análogos de ácido nucleico de tetrahidropirano
|
EP2205741A2
(de)
|
2007-10-02 |
2010-07-14 |
Amgen Inc. |
ERHÖHUNG DES ERYTHROPOIETINSPIEGELS MITTELS VERWENDUNG VON MIT miRNA HYBRIDISIERBAREN NUKLEINSÄUREN UND VORLÄUFER DAVON
|
CN103898110A
(zh)
|
2007-10-03 |
2014-07-02 |
夸克制药公司 |
新siRNA结构
|
WO2009067243A2
(en)
|
2007-11-20 |
2009-05-28 |
Isis Pharmaceuticals Inc. |
Modulation of cd40 expression
|
EP4074344A1
(de)
|
2007-12-04 |
2022-10-19 |
Arbutus Biopharma Corporation |
Targeting von lipiden
|
US7595164B2
(en)
*
|
2007-12-26 |
2009-09-29 |
Gen-Probe Incorporated |
Compositions and methods to detect Candida albicans nucleic acid
|
US9605035B2
(en)
|
2008-01-10 |
2017-03-28 |
Research Development Foundation |
Vaccines and diagnostics for the ehrlichioses
|
WO2009100320A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
AU2009222056A1
(en)
*
|
2008-03-01 |
2009-09-11 |
Abraxis Bioscience, Llc |
Treatment, diagnostic, and method for discovering antagonist using SPARC specific miRNAs
|
EP2282744B1
(de)
|
2008-03-21 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
Oligomere verbindungen mit trizyklischen nukleosiden und anwendungsverfahren dafür
|
DK2285819T3
(da)
*
|
2008-04-04 |
2013-12-02 |
Isis Pharmaceuticals Inc |
Oligomere forbindelser omfattende neutralt bundne, terminale bicykliske nukleosider
|
EP2274423A2
(de)
*
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Bicyclische nukleoside umfassende oligomere verbindungen mit verringerter toxizität
|
CA3044980A1
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
WO2009137660A2
(en)
*
|
2008-05-07 |
2009-11-12 |
Abraxis Bioscience, Llc |
Enhancement of drug therapy by mirna
|
EP2285960B1
(de)
|
2008-05-08 |
2015-07-08 |
Asuragen, INC. |
Zusammensetzungen und verfahren in zusammenhang mit der mirna-184modulation von neovaskularisation oder angiogenese
|
US20100209957A1
(en)
*
|
2008-06-20 |
2010-08-19 |
Genvault Corporation |
Biosample storage devices and methods of use thereof
|
EP2323667A4
(de)
*
|
2008-08-07 |
2012-07-25 |
Isis Pharmaceuticals Inc |
Modulierung der transthyretin-expression durch behandlung von zns-erkrankungen
|
WO2010031007A2
(en)
*
|
2008-09-12 |
2010-03-18 |
Genvault Corporation |
Matrices and media for storage and stabilization of biomolecules
|
JP2012513953A
(ja)
|
2008-09-23 |
2012-06-21 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾
|
DK2356129T3
(da)
*
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
US8604192B2
(en)
*
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
EP2379084B1
(de)
|
2008-10-15 |
2017-11-22 |
Ionis Pharmaceuticals, Inc. |
Modulation der expression von faktor 11
|
WO2010048549A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
WO2010048585A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
CA2743057C
(en)
|
2008-11-07 |
2019-11-26 |
Research Development Foundation |
Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling
|
EA037404B1
(ru)
|
2008-11-10 |
2021-03-24 |
Арбутус Биофарма Корпорэйшн |
Липиды и композиции для доставки лекарственных средств
|
WO2010059944A1
(en)
|
2008-11-21 |
2010-05-27 |
Columbia University |
A split dna enzyme for visual single nucleotide polymorphism typing
|
RU2015151857A
(ru)
|
2008-12-02 |
2019-01-15 |
Уэйв Лайф Сайенсес Джапан, Инк. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
WO2010080452A2
(en)
|
2008-12-18 |
2010-07-15 |
Quark Pharmaceuticals, Inc. |
siRNA COMPOUNDS AND METHODS OF USE THEREOF
|
US8853134B2
(en)
|
2009-01-28 |
2014-10-07 |
The Trustees Of Columbia University In The City Of New York |
Microarrays of binary nucleic acid probes for detecting nucleic acid analytes
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
WO2010091308A2
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
WO2010091878A2
(en)
|
2009-02-13 |
2010-08-19 |
Silence Therapeutics Ag |
Means for inhibiting the expression of opa1
|
WO2010094491A1
(en)
|
2009-02-18 |
2010-08-26 |
Silence Therapeutics Ag |
Means for inhibiting the expression of ang2
|
EP3424939A1
(de)
|
2009-03-02 |
2019-01-09 |
Alnylam Pharmaceuticals Inc. |
Chemische nukleinsäuremodifikationen
|
EP2408306A4
(de)
*
|
2009-03-20 |
2012-11-07 |
Alios Biopharma Inc |
Substituierte nukleosid- und nukleotid-analoga
|
US20110045080A1
(en)
*
|
2009-03-24 |
2011-02-24 |
William Marsh Rice University |
Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto
|
EP2258858A1
(de)
|
2009-06-05 |
2010-12-08 |
Universitätsklinikum Freiburg |
Für LSD1 transgenisches Tiermodell für Krebs
|
NZ712719A
(en)
|
2009-06-10 |
2017-03-31 |
Arbutus Biopharma Corp |
Improved lipid formulation
|
US9169512B2
(en)
|
2009-07-01 |
2015-10-27 |
Gen-Probe Incorporated |
Methods and compositions for nucleic acid amplification
|
WO2011005761A1
(en)
|
2009-07-06 |
2011-01-13 |
Ontorii, Inc |
Novel nucleic acid prodrugs and methods use thereof
|
US8927513B2
(en)
|
2009-07-07 |
2015-01-06 |
Alnylam Pharmaceuticals, Inc. |
5′ phosphate mimics
|
US9512164B2
(en)
|
2009-07-07 |
2016-12-06 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide end caps
|
EP2462153B1
(de)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclische cyclohexosenukleinsäureanaloga
|
WO2011020023A2
(en)
|
2009-08-14 |
2011-02-17 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
TW201124160A
(en)
|
2009-11-26 |
2011-07-16 |
Quark Pharmaceuticals Inc |
SiRNA compounds comprising terminal substitutions
|
CA2783372C
(en)
|
2009-12-07 |
2019-07-16 |
Muthiah Manoharan |
Compositions for nucleic acid delivery
|
WO2011072091A1
(en)
|
2009-12-09 |
2011-06-16 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the cns
|
AU2010328104B2
(en)
|
2009-12-09 |
2014-10-30 |
Nitto Denko Corporation |
Modulation of hsp47 expression
|
WO2011075656A1
(en)
|
2009-12-18 |
2011-06-23 |
The University Of British Columbia |
Methods and compositions for delivery of nucleic acids
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011100131A2
(en)
|
2010-01-28 |
2011-08-18 |
Alnylam Pharmacuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
WO2011103274A1
(en)
|
2010-02-17 |
2011-08-25 |
Gen-Probe Incorporated |
Compositions and methods to detect atopobium vaginae nucleic acid
|
WO2011108930A1
(en)
|
2010-03-04 |
2011-09-09 |
Interna Technologies Bv |
A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US9102938B2
(en)
|
2010-04-01 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
2′ and 5′ modified monomers and oligonucleotides
|
EP3037555B1
(de)
|
2010-04-21 |
2019-07-24 |
Gen-Probe Incorporated |
Zusammensetzungen, verfahren und kits für den nachweis von herpes-simplex-virusnukleinsäuren
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
US20130260460A1
(en)
|
2010-04-22 |
2013-10-03 |
Isis Pharmaceuticals Inc |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
EP3091027B1
(de)
|
2010-04-28 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
5'-modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
EP3173419A1
(de)
|
2010-04-28 |
2017-05-31 |
Ionis Pharmaceuticals, Inc. |
Modifizierte nukleoside, analoga davon und daraus hergestellte oligomere verbindungen
|
EP2563920B1
(de)
|
2010-04-29 |
2017-03-15 |
Ionis Pharmaceuticals, Inc. |
Modulation der transthyretin-expression
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
BR112012031363A2
(pt)
|
2010-05-28 |
2021-10-26 |
Sarepta Therapeutcs, Inc |
Análogos de oligonucleotídeo tendo ligações intersubunidades modificadas e/ou grupos terminais.
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2580228B1
(de)
|
2010-06-08 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Substituierte 2 '-amino- und 2 '-thio-bicyclische nukleoside und daraus hergestellte oligomere verbindungen
|
CN103097534B
(zh)
|
2010-06-24 |
2017-07-28 |
夸克制药公司 |
针对rhoa的双链rna化合物及其用途
|
EP2588629B1
(de)
|
2010-06-30 |
2017-05-17 |
Gen-Probe Incorporated |
Methode und apparatur zur identifizierung von analyt-beinhaltenden proben unter verwendung von single-read determination des analyten und prozesskontrollsignalen
|
NZ704322A
(en)
|
2010-07-06 |
2016-07-29 |
Interna Technologies Bv |
Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
|
WO2012009373A2
(en)
|
2010-07-12 |
2012-01-19 |
Gen-Probe Incorporated |
Compositions and assays to detect swine h1n1 influenza a virus, seasonal h1 influenza a virus and seasonal h3 influenza a virus nucleic acids
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
CN103328500B
(zh)
|
2010-08-04 |
2018-01-26 |
西兹尔生物技术有限公司 |
用于癌症的诊断和治疗的方法和化合物
|
WO2012030856A2
(en)
|
2010-08-30 |
2012-03-08 |
Gen-Probe Incorporated |
Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
|
US10017763B2
(en)
|
2010-09-03 |
2018-07-10 |
Sarepta Therapeutics, Inc. |
dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
|
US9938590B2
(en)
|
2010-09-16 |
2018-04-10 |
Gen-Probe Incorporated |
Capture probes immobilizable via L-nucleotide tail
|
KR20130110170A
(ko)
|
2010-09-22 |
2013-10-08 |
앨리오스 바이오파마 인크. |
치환된 뉴클레오타이드 유사체
|
EP2620428B1
(de)
|
2010-09-24 |
2019-05-22 |
Wave Life Sciences Ltd. |
Asymmetrische hilfsgruppe
|
GB2497495B
(en)
|
2010-10-04 |
2018-06-06 |
Gen Probe Prodesse Inc |
Compositions, methods and kits to detect adenovirus nucleic acids
|
US20140134231A1
(en)
|
2010-10-11 |
2014-05-15 |
Sanford-Burnham Medical Research Institute |
Mir-211 expression and related pathways in human melanoma
|
EP2635703B1
(de)
|
2010-11-01 |
2018-03-21 |
Gen-Probe Incorporated |
Integriertes binden und amplifikation von zielnukleinsäuren zum sequenzieren
|
US8569220B2
(en)
|
2010-11-12 |
2013-10-29 |
Jelmar, Llc |
Hard surface cleaning composition
|
EP2640853B1
(de)
|
2010-11-17 |
2018-12-26 |
Ionis Pharmaceuticals, Inc. |
Modulation von alpha-synukleinexpression
|
EP2649181B1
(de)
|
2010-12-06 |
2016-04-27 |
Quark Pharmaceuticals, Inc. |
Doppelsträngige oligonukleotidverbindungen mit positionsmodifikationen
|
EP2474617A1
(de)
|
2011-01-11 |
2012-07-11 |
InteRNA Technologies BV |
MIR zur Behandlung von Neoangiogenese
|
EP3202760B1
(de)
|
2011-01-11 |
2019-08-21 |
Alnylam Pharmaceuticals, Inc. |
Pegylierte lipide und deren verwendung zur wirkstofffreisetzung
|
JP6132775B2
(ja)
|
2011-03-03 |
2017-05-24 |
クォーク ファーマシューティカルズ インコーポレーティッドQuark Pharmaceuticals,Inc. |
Toll様受容体経路のオリゴヌクレオチド修飾因子
|
SG192961A1
(en)
|
2011-03-03 |
2013-09-30 |
Quark Pharmaceuticals Inc |
Compositions and methods for treating lung disease and injury
|
USRE49975E1
(en)
|
2011-03-10 |
2024-05-21 |
Gen-Probe Incorporated |
Methods and compositions for the selection and optimization of oligonucleotide tag sequences
|
US9657352B2
(en)
|
2011-04-25 |
2017-05-23 |
Gen-Probe Incorporated |
Compositions and methods for detecting BV-associated bacterial nucleic acid
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US20140227293A1
(en)
|
2011-06-30 |
2014-08-14 |
Trustees Of Boston University |
Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
|
CN113215308A
(zh)
|
2011-07-15 |
2021-08-06 |
简.探针公司 |
检测人细小病毒核酸和甲型肝炎病毒核酸的组合物和方法
|
MX347361B
(es)
|
2011-07-19 |
2017-04-12 |
Wave Life Sciences Ltd |
Metodos para la sintesis de acidos nucleicos funcionalizados.
|
EP4269584A3
(de)
|
2011-08-11 |
2024-03-27 |
Ionis Pharmaceuticals, Inc. |
Selektive antisense-verbindungen und verwendungen davon
|
EP3640332A1
(de)
|
2011-08-29 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Oligomer-konjugat-komplexe und deren verwendung
|
EP3225698B1
(de)
|
2011-09-06 |
2019-07-31 |
Gen-Probe Incorporated |
Geschlossene nukleinsäurestrukturen
|
AU2012304520B2
(en)
|
2011-09-06 |
2016-06-16 |
Gen-Probe Incorporated |
Circularized templates for sequencing
|
US9663829B2
(en)
|
2011-09-08 |
2017-05-30 |
Gen-Probe Incorporated |
Compositions and methods for detecting BV-associated bacterial nucleic acid
|
US9644241B2
(en)
|
2011-09-13 |
2017-05-09 |
Interpace Diagnostics, Llc |
Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
|
AU2012315965A1
(en)
|
2011-09-27 |
2014-04-03 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted PEGylated lipids
|
WO2013063519A1
(en)
|
2011-10-26 |
2013-05-02 |
Asuragen, Inc. |
Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
|
CA2851296C
(en)
|
2011-11-03 |
2020-08-25 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for neuroprotection
|
US9863004B2
(en)
|
2011-11-04 |
2018-01-09 |
Gen-Probe Incorporated |
Molecular assay reagents and methods
|
US20140323549A1
(en)
|
2011-11-08 |
2014-10-30 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the nervous system
|
AU2012340390B2
(en)
|
2011-11-18 |
2016-11-24 |
Sarepta Therapeutics, Inc. |
Functionally-modified oligonucleotides and subunits thereof
|
DE102011120550B4
(de)
|
2011-12-05 |
2013-11-07 |
Gen-Probe Prodesse, Inc. |
Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
|
US8980865B2
(en)
|
2011-12-22 |
2015-03-17 |
Alios Biopharma, Inc. |
Substituted nucleotide analogs
|
LT2794627T
(lt)
|
2011-12-22 |
2019-01-10 |
Alios Biopharma, Inc. |
Pakeistieji nukleozidai, nukleotidai ir jų analogai
|
EP2794881B1
(de)
|
2011-12-22 |
2018-06-27 |
InteRNA Technologies B.V. |
Mirna zur behandlung von kopf-hals-karzinom
|
CA2858336A1
(en)
|
2012-01-01 |
2013-07-04 |
Qbi Enterprises Ltd. |
Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
|
AU2013208012A1
(en)
|
2012-01-12 |
2014-07-03 |
Quark Pharmaceuticals, Inc. |
Combination therapy for treating hearing and balance disorders
|
AU2013205603B2
(en)
|
2012-02-01 |
2016-03-17 |
Gen-Probe Incorporated |
Asymmetric hairpin target capture oligomers
|
WO2013123996A1
(en)
|
2012-02-24 |
2013-08-29 |
Astrazeneca Uk Limited |
Novel sirna inhibitors of human icam-1
|
BR112014022195A2
(pt)
|
2012-03-09 |
2020-05-12 |
Vestaron Corporation |
Produção de peptídeo tóxico, expressão de peptídeo em plantas e combinações de peptídeos ricos em cisteína
|
EP2639238A1
(de)
|
2012-03-15 |
2013-09-18 |
Universität Bern |
Tricyclische Nukleoside und daraus hergestellte oligomere Verbindungen
|
CN104321333A
(zh)
|
2012-03-21 |
2015-01-28 |
沃泰克斯药物股份有限公司 |
硫代氨基磷酸酯核苷酸前药的固体形式
|
USRE48171E1
(en)
|
2012-03-21 |
2020-08-25 |
Janssen Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
US9441007B2
(en)
|
2012-03-21 |
2016-09-13 |
Alios Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
NZ630805A
(en)
|
2012-03-22 |
2016-01-29 |
Alios Biopharma Inc |
Pharmaceutical combinations comprising a thionucleotide analog
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
US9221864B2
(en)
|
2012-04-09 |
2015-12-29 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
AU2013205110B2
(en)
|
2012-04-24 |
2016-10-13 |
Gen-Probe Incorporated |
Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
|
WO2013179289A1
(en)
|
2012-05-31 |
2013-12-05 |
Bio-Lab Ltd. |
Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them
|
AU2013205064B2
(en)
|
2012-06-04 |
2015-07-30 |
Gen-Probe Incorporated |
Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
|
CA2879023C
(en)
|
2012-07-13 |
2017-03-28 |
Wave Life Sciences Japan |
Asymmetric auxiliary group
|
AU2013205087B2
(en)
|
2012-07-13 |
2016-03-03 |
Gen-Probe Incorporated |
Method for detecting a minority genotype
|
AU2013202793B2
(en)
|
2012-07-31 |
2014-09-18 |
Gen-Probe Incorporated |
System, method and apparatus for automated incubation
|
ES2761920T3
(es)
|
2012-08-30 |
2020-05-21 |
Gen Probe Inc |
Amplificación de ácido nucleico multifásica
|
DK2895608T3
(en)
|
2012-09-12 |
2019-01-21 |
Quark Pharmaceuticals Inc |
DOUBLE-STRENGTHED OIGONUCLEOTIDE MOLECULES FOR P53 AND PROCEDURES FOR USING IT
|
EP2895607B1
(de)
|
2012-09-12 |
2021-05-05 |
Quark Pharmaceuticals, Inc. |
Doppelsträngige oligonukleotidmoleküle an ddit4 und verfahren zur verwendung davon
|
US9611473B2
(en)
|
2012-09-12 |
2017-04-04 |
Quark Pharmaceuticals, Inc. |
Double-stranded nucleic acid compounds
|
US9993522B2
(en)
|
2012-09-18 |
2018-06-12 |
Uti Limited Partnership |
Treatment of pain by inhibition of USP5 de-ubiquitinase
|
US20140100124A1
(en)
|
2012-10-04 |
2014-04-10 |
Asuragen, Inc. |
Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
|
AU2013205122B2
(en)
|
2012-10-11 |
2016-11-10 |
Gen-Probe Incorporated |
Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2014072357A1
(en)
|
2012-11-06 |
2014-05-15 |
Interna Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
|
AU2013205090B2
(en)
|
2012-12-07 |
2016-07-28 |
Gen-Probe Incorporated |
Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
|
EP2961853B1
(de)
|
2013-02-28 |
2018-09-19 |
The Board of Regents of The University of Texas System |
Verfahren zur klassifizierung einer krebserkrankung als anfälligkeit für tmepai-gerichtete therapien und zur heilung solcher krebserkrankungen
|
US10174352B2
(en)
|
2013-03-14 |
2019-01-08 |
Aegea Biotechnologies, Inc. |
Methods for amplification of nucleic acids on solid support
|
WO2014145176A1
(en)
|
2013-03-15 |
2014-09-18 |
Arnold Lyle J |
Methods for amplifying fragmented target nucleic acids utilizing an assembler sequence
|
WO2014145138A2
(en)
|
2013-03-15 |
2014-09-18 |
Arnold Lyle J |
Methods for amplification of nucleic acids utilizing clamp oligonuleotides
|
EP4163387A1
(de)
|
2013-03-15 |
2023-04-12 |
The University of Chicago |
Verfahren und zusammensetzungen in zusammenhang mit t-zell-aktivität
|
US9937231B2
(en)
|
2013-03-27 |
2018-04-10 |
The General Hospital Corporation |
Methods and agents for treating Alzheimer's disease
|
WO2014179625A1
(en)
|
2013-05-01 |
2014-11-06 |
Isis Pharmaceuticals, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION
|
WO2015015498A1
(en)
|
2013-07-31 |
2015-02-05 |
Qbi Enterprises Ltd. |
Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
|
US9889200B2
(en)
|
2013-07-31 |
2018-02-13 |
Qbi Enterprises Ltd. |
Sphingolipid-polyalkylamine-oligonucleotide compounds
|
US10053742B2
(en)
|
2013-08-14 |
2018-08-21 |
Gen-Probe Incorporated |
Compositions and methods for detecting HEV nucleic acid
|
EP2853595A1
(de)
|
2013-09-30 |
2015-04-01 |
Soluventis GmbH |
NOTCH 1-spezifische siRNA-Moleküle
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
EP3065706A4
(de)
|
2013-11-08 |
2017-11-29 |
Baylor Research Institute |
Nukleare lokalisierung von glp-1 zur stimulation der herzmuskelregenerierung und reversion von herzversagen
|
ES2797679T3
(es)
|
2013-12-02 |
2020-12-03 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido y usos de los mismos
|
EP4137572A1
(de)
|
2014-01-16 |
2023-02-22 |
Wave Life Sciences Ltd. |
Chirales design
|
WO2015123551A1
(en)
|
2014-02-13 |
2015-08-20 |
Du Luqin |
Microrna composition for the treatment of neuroblastoma
|
US10036019B2
(en)
|
2014-03-17 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
EP3119888B1
(de)
|
2014-03-19 |
2021-07-28 |
Ionis Pharmaceuticals, Inc. |
Zusammensetzungen zur modulierung der ataxin-2-expression
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
PL3126499T3
(pl)
|
2014-04-01 |
2020-11-30 |
Biogen Ma Inc. |
Kompozycje do modulowania ekspresji sod-1
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
WO2015168172A1
(en)
|
2014-04-28 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
AU2015252858C1
(en)
|
2014-05-01 |
2021-09-16 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Complement Factor B expression
|
CA2946003A1
(en)
|
2014-05-01 |
2015-11-05 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating angiopoietin-like 3 expression
|
WO2015190922A1
(en)
|
2014-06-10 |
2015-12-17 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of pompe disease
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
WO2016044271A2
(en)
|
2014-09-15 |
2016-03-24 |
Children's Medical Center Corporation |
Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
|
WO2016057693A1
(en)
|
2014-10-10 |
2016-04-14 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
JP6767374B2
(ja)
|
2014-10-20 |
2020-10-14 |
ジェン−プローブ・インコーポレーテッド |
赤血球溶解溶液
|
WO2016083624A1
(en)
|
2014-11-28 |
2016-06-02 |
Silence Therapeutics Gmbh |
Means for inhibiting the expression of edn1
|
WO2016094845A2
(en)
|
2014-12-12 |
2016-06-16 |
Woolf Tod M |
Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
|
WO2016100716A1
(en)
|
2014-12-18 |
2016-06-23 |
Vasant Jadhav |
Reversirtm compounds
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
EP3242956B1
(de)
|
2015-01-09 |
2020-06-17 |
Gen-Probe Incorporated |
Verfahren und zusammensetzungen zur diagnose von bakterieller vaginose
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
US11421229B2
(en)
|
2015-02-20 |
2022-08-23 |
Baylor College Of Medicine |
p63 inactivation for the treatment of heart failure
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
WO2016149357A1
(en)
|
2015-03-16 |
2016-09-22 |
Gen-Probe Incorporated |
Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
US11020417B2
(en)
|
2015-06-04 |
2021-06-01 |
Sarepta Therapeutics, Inc |
Methods and compounds for treatment of lymphocyte-related diseases and conditions
|
EP3919619A1
(de)
|
2015-07-17 |
2021-12-08 |
Alnylam Pharmaceuticals, Inc. |
Mehrfach gerichtete einheitlichen konjugate
|
US10533175B2
(en)
|
2015-09-25 |
2020-01-14 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Ataxin 3 expression
|
BR112018007611A2
(pt)
|
2015-10-14 |
2018-10-23 |
Bio Path Holding Inc |
ácidos nucleicos p-etóxi para formulação lipossômica
|
MX2018005277A
(es)
|
2015-11-06 |
2018-08-01 |
Ionis Pharmaceuticals Inc |
Modular la expresion de apolipoproteina (a).
|
EP3389670A4
(de)
|
2015-12-04 |
2020-01-08 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur behandlung von brustkrebs
|
WO2017099579A1
(en)
|
2015-12-07 |
2017-06-15 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for pompe disease
|
EP4249609A3
(de)
|
2016-01-04 |
2023-12-20 |
Gen-Probe Incorporated |
Verfahren und zusammensetzungen zum nachweis von candida-spezies
|
EP3400300A4
(de)
|
2016-01-05 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur reduzierung der lrrk2-expression
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
CA3019635A1
(en)
|
2016-03-31 |
2017-10-05 |
Baylor Research Institute |
Angiopoietin-like protein 8 (angptl8)
|
EP3228326A1
(de)
|
2016-04-05 |
2017-10-11 |
Silence Therapeutics GmbH |
Nucleinsäure verbunden mit einem dreiwertigen glykokonjugat
|
EP3443090A4
(de)
|
2016-04-14 |
2019-12-11 |
University of Florida Research Foundation, Incorporated |
Verwendung von mir-223-3p als krebstherapeutikum und verfahren zur behandlung von krebs damit
|
CA3023514A1
(en)
|
2016-06-17 |
2017-12-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
EP3512525B1
(de)
|
2016-09-16 |
2022-07-27 |
Bio-Path Holdings, Inc. |
Kombinationstherapie mit liposomalen antisense-oligonukleotiden
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
JP7167013B2
(ja)
|
2016-10-19 |
2022-11-08 |
ジェン-プローブ・インコーポレーテッド |
C型肝炎ウイルスを検出または定量するための組成物および方法
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
JP7125395B2
(ja)
|
2016-11-21 |
2022-08-24 |
ジェン-プローブ・インコーポレーテッド |
B型肝炎ウイルスを検出または定量化するための組成物および方法
|
EP3548620A4
(de)
|
2016-12-02 |
2020-07-22 |
Cold Spring Harbor Laboratory |
Modulation der lnc05-expression
|
KR102551664B1
(ko)
|
2016-12-22 |
2023-07-05 |
인텔리아 테라퓨틱스, 인크. |
알파-1 항트립신 결핍을 치료하기 위한 조성물 및 방법
|
US11197928B2
(en)
|
2017-01-13 |
2021-12-14 |
Board Of Regents, The University Of Texas System |
Sustained production of high affinity antigen specific antibody by high dose BAFF receptor-targeting mAb-siRNA conjugate
|
WO2018165564A1
(en)
|
2017-03-09 |
2018-09-13 |
Ionis Pharmaceuticals, Inc. |
Morpholino modified oligomeric compounds
|
EP4056716A1
(de)
|
2017-03-24 |
2022-09-14 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus
|
CA3225861A1
(en)
|
2017-03-25 |
2018-10-04 |
Gen-Probe Incorporated |
Compositions to detect adenovirus nucleic acids
|
WO2018185253A1
(en)
|
2017-04-05 |
2018-10-11 |
Silence Therapeutics Gmbh |
Ligand modified double-stranded nucleic acids
|
EP3385272A1
(de)
|
2017-04-05 |
2018-10-10 |
Silence Therapeutics GmbH |
Weitere neuartige oligonukleotid-ligand-konjugate
|
WO2018185252A1
(en)
|
2017-04-05 |
2018-10-11 |
Silence Therapeutics Gmbh |
Nucleic acid conjugates
|
AU2018265274B2
(en)
|
2017-05-11 |
2021-10-07 |
Gen-Probe Incorporated |
Compositions and methods for isolating target nucleic acids
|
US11667978B2
(en)
|
2017-06-07 |
2023-06-06 |
Gen-Probe Incorporated |
Detecting Babesia species nucleic acid in a sample
|
CA3155871A1
(en)
|
2017-07-10 |
2019-01-17 |
Gen-Probe Incorporated |
Analytical systems and methods for nucleic acid amplification using sample assigning parameters
|
EP3665309B1
(de)
|
2017-08-11 |
2023-02-22 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von staphylococcus aureus
|
WO2019036613A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
MODULATION OF THE NOTCH SIGNALING PATHWAY FOR THE TREATMENT OF RESPIRATORY DISORDERS
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
CN111405912A
(zh)
|
2017-09-29 |
2020-07-10 |
因特利亚治疗公司 |
用于基因组编辑的多核苷酸、组合物及方法
|
BR112020005287A2
(pt)
|
2017-09-29 |
2020-09-24 |
Intellia Therapeutics, Inc. |
composições e métodos para edição de gene ttr e tratar amiloidose attr
|
MX2020004600A
(es)
|
2017-11-02 |
2020-10-05 |
Janssen Biopharma Inc |
Constructos de oligonucleotidos y usos de estos.
|
JP2021501594A
(ja)
|
2017-11-03 |
2021-01-21 |
インテアールエヌエー テクノロジーズ ビー.ヴイ.InteRNA Technologies B.V. |
ニューロンの欠損に関連する状態及び/又は疾患を処置及び/又は診断するため、或いはニューロンの再生/発生のための、miRNA分子、等価物、アンタゴミル、又はそれらの供給源
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
WO2019099629A1
(en)
|
2017-11-17 |
2019-05-23 |
Gen-Probe Incorporated |
COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID
|
US11662281B2
(en)
|
2017-12-13 |
2023-05-30 |
Gen-Probe Incorporated |
Compositions and methods for biological sample processing
|
EP3724354A1
(de)
|
2017-12-15 |
2020-10-21 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
JP2021511072A
(ja)
|
2018-01-15 |
2021-05-06 |
アイオニス・ファーマシューティカルズ・インコーポレイテッドIonis Pharmaceuticals,Inc. |
Dnm2発現のモジュレーター
|
US20190233816A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
EP3746225A1
(de)
|
2018-01-29 |
2020-12-09 |
Gen-Probe Incorporated |
Analytische systeme und verfahren
|
CN111936150A
(zh)
|
2018-02-12 |
2020-11-13 |
因特尔纳技术有限公司 |
抗癌微小rna及其脂质制剂
|
US11732260B2
(en)
|
2018-03-02 |
2023-08-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-β precursor protein
|
AU2019228607B2
(en)
|
2018-03-02 |
2024-03-07 |
Ionis Pharmaceuticals, Inc. |
Modulators of IRF4 expression
|
WO2019183440A1
(en)
|
2018-03-22 |
2019-09-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
EP3549610A1
(de)
|
2018-04-05 |
2019-10-09 |
Silence Therapeutics GmbH |
Nukleinsäurekonjugate
|
JP7275164B2
(ja)
|
2018-04-11 |
2023-05-17 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Ezh2発現の調節因子
|
MX2020011911A
(es)
|
2018-05-09 |
2021-01-29 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para reducir de la expresion de atxn3.
|
MX2020011913A
(es)
|
2018-05-09 |
2021-01-29 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para la reduccion de la expresion de fxi.
|
WO2019239394A1
(en)
|
2018-06-13 |
2019-12-19 |
Gen-Probe Incorporated |
Compositions and methods for detecting group b streptococcus nucleic acid
|
EP3807411A4
(de)
|
2018-06-14 |
2022-08-03 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur verminderung der atxn3-expression
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
CA3105684A1
(en)
|
2018-07-10 |
2020-01-16 |
Gen-Probe Incorporated |
Methods and systems for detecting and quantifying nucleic acids
|
MX2021000922A
(es)
|
2018-07-25 |
2021-03-31 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para reducir la expresion de la atxn2.
|
MX2021001070A
(es)
|
2018-07-31 |
2021-05-27 |
Intellia Therapeutics Inc |
Composiciones y métodos para editar el gen hidroxiácido oxidasa 1 (hao1) para tratar la hiperoxaluria primaria tipo 1 (ph1).
|
WO2020028631A1
(en)
|
2018-08-01 |
2020-02-06 |
Gen-Probe Incorporated |
Compositions and methods for detecting nucleic acids of epstein-barr virus
|
JP2021532808A
(ja)
|
2018-08-08 |
2021-12-02 |
ジェン−プローブ・インコーポレーテッド |
Mycoplasma genitaliumを検出するための組成物、方法、およびキット
|
US20210317461A1
(en)
|
2018-08-09 |
2021-10-14 |
Verseau Therapeutics, Inc. |
Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
|
US20220074002A1
(en)
|
2018-08-21 |
2022-03-10 |
Gen-Probe Incorporated |
Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
|
AU2019324196A1
(en)
|
2018-08-24 |
2021-03-18 |
Gen-Probe Incorporated |
Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
|
EP3856934A2
(de)
|
2018-09-27 |
2021-08-04 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zur detektion von bordetella-pertussis- und bordetella-parapertussis-nukleinsäure
|
JP2022502055A
(ja)
|
2018-09-28 |
2022-01-11 |
インテリア セラピューティクス,インコーポレイテッド |
乳酸デヒドロゲナーゼ(ldha)遺伝子編集のための組成物及び方法
|
MX2021004214A
(es)
|
2018-10-16 |
2021-07-15 |
Intellia Therapeutics Inc |
Composiciones y metodos de inmunoterapia.
|
KR20210102881A
(ko)
|
2018-10-18 |
2021-08-20 |
인텔리아 테라퓨틱스, 인크. |
인자 ix의 발현을 위한 조성물 및 방법
|
MX2021004276A
(es)
|
2018-10-18 |
2021-09-08 |
Intellia Therapeutics Inc |
Composiciones y metodos para tratar deficiencia de alfa-1 antitripsina.
|
JP2022512726A
(ja)
|
2018-10-18 |
2022-02-07 |
インテリア セラピューティクス,インコーポレーテッド |
核酸構築物及び使用方法
|
JP7472121B2
(ja)
|
2018-10-18 |
2024-04-22 |
インテリア セラピューティクス,インコーポレーテッド |
アルブミン遺伝子座からの導入遺伝子発現のための組成物及び方法
|
WO2020086546A1
(en)
|
2018-10-22 |
2020-04-30 |
Gen-Probe Incorporated |
Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
PE20211869A1
(es)
|
2018-11-15 |
2021-09-21 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresion de irf5
|
TW202030333A
(zh)
|
2018-12-20 |
2020-08-16 |
美商簡 探針公司 |
用於檢測瘧原蟲物種核酸之組成物及方法
|
SG11202107399WA
(en)
|
2019-01-31 |
2021-08-30 |
Ionis Pharmaceuticals Inc |
Modulators of yap1 expression
|
US11279932B2
(en)
|
2019-02-27 |
2022-03-22 |
Ionis Pharmaceuticals, Inc. |
Modulators of MALAT1 expression
|
EP4389916A2
(de)
|
2019-03-22 |
2024-06-26 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von gruppe-a-streptococcus
|
WO2020198706A1
(en)
|
2019-03-28 |
2020-10-01 |
Intellia Therapeutics, Inc. |
Compositions and methods for ttr gene editing and treating attr amyloidosis comprising a corticosteroid or use thereof
|
TW202102529A
(zh)
|
2019-03-28 |
2021-01-16 |
美商英特利亞醫療公司 |
用於多肽表現之多核苷酸、組合物及方法
|
AU2020244887A1
(en)
|
2019-03-28 |
2021-11-11 |
Intellia Therapeutics, Inc. |
Compositions and methods comprising a TTR guide RNA and a polynucleotide encoding an RNA-guided DNA binding agent
|
KR20210144822A
(ko)
|
2019-03-29 |
2021-11-30 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Ube3a-ats를 조절하기 위한 화합물 및 방법
|
EP4371667A2
(de)
|
2019-05-03 |
2024-05-22 |
Gen-Probe Incorporated |
Behältertransportsystem für ein analysesystem
|
WO2021003331A1
(en)
|
2019-07-03 |
2021-01-07 |
Gen-Probe Incorporated |
Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
|
EP3956450A4
(de)
|
2019-07-26 |
2022-11-16 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation von gfap
|
JP2022544587A
(ja)
|
2019-08-15 |
2022-10-19 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
結合修飾オリゴマー化合物及びその使用
|
AU2020335996A1
(en)
|
2019-08-23 |
2022-03-31 |
Gen-Probe Incorporated |
Compositions, methods and kits for detecting Treponema pallidum
|
EP4022057A1
(de)
|
2019-08-27 |
2022-07-06 |
Vertex Pharmaceuticals Incorporated |
Zusammensetzungen und verfahren zur behandlung von erkrankungen im zusammenhang mit repetitiver dna
|
AU2020343334A1
(en)
|
2019-09-05 |
2022-04-07 |
Gen-Probe Incorporated |
Detection of Chlamydia trachomatis nucleic acid variants
|
WO2021097358A1
(en)
|
2019-11-14 |
2021-05-20 |
Gen-Probe Incorporated |
Compositions and methods for capturing target nucleic acids
|
SG10201914033YA
(en)
|
2019-12-31 |
2021-07-29 |
Wilmar International Ltd |
Polypeptides with Lipase Activity and Uses Thereof
|
WO2021144587A1
(en)
|
2020-01-16 |
2021-07-22 |
Dnae Diagnostics Limited |
Compositions, kits and methods for isolating target polynucleotides
|
US20210239663A1
(en)
|
2020-01-31 |
2021-08-05 |
Regeneron Pharmaceuticals, Inc. |
Use of liquid chromatography and mass spectrometry to characterize oligonucleotides
|
CR20220485A
(es)
|
2020-02-28 |
2022-11-10 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
AU2021263745A1
(en)
|
2020-04-28 |
2022-12-08 |
Intellia Therapeutics, Inc. |
Methods of in vitro cell delivery
|
MX2022013707A
(es)
|
2020-05-01 |
2022-12-07 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para modular atxn1.
|
US20230220499A1
(en)
|
2020-05-07 |
2023-07-13 |
Grifols Diagnostic Solutions Inc. |
Methods and compositions for detecting sars-cov-2 nucleic acid
|
EP3922720A1
(de)
|
2020-06-09 |
2021-12-15 |
Universidad de Murcia |
Therapie zur verhinderung unerwünschter kardialer remodellierung nach einem akuten myokardinfarkt
|
CN116096899A
(zh)
|
2020-06-29 |
2023-05-09 |
Ionis制药公司 |
调节plp1的化合物和方法
|
CA3188657A1
(en)
|
2020-07-17 |
2022-01-20 |
Gen-Probe Incorporated |
Detection of macrolide-resistant mycoplasma genitalium
|
WO2022034555A1
(en)
|
2020-08-13 |
2022-02-17 |
Janssen Biopharma, Inc. |
Polynucleotide constructs and uses thereof
|
WO2022056000A1
(en)
|
2020-09-09 |
2022-03-17 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of duchenne muscular dystrophy
|
CA3177256A1
(en)
|
2020-10-21 |
2022-04-28 |
Gen-Probe Incorporated |
Fluid container management system
|
EP4240854A1
(de)
|
2020-11-06 |
2023-09-13 |
Vertex Pharmaceuticals Incorporated |
Zusammensetzungen und verfahren zur behandlung von dm1 mit sclucas9 und sacas9
|
KR20230108728A
(ko)
|
2020-11-18 |
2023-07-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
앤지오텐시노겐 발현을 조절하기 위한 화합물 및 방법
|
EP4259792A1
(de)
|
2020-12-11 |
2023-10-18 |
Intellia Therapeutics, Inc. |
Polynukleotide, zusammensetzungen und verfahren zur genomeditierung mit deaminierung
|
KR20230130635A
(ko)
|
2020-12-11 |
2023-09-12 |
인텔리아 테라퓨틱스, 인크. |
세포에서 mhc 클래스 ii를 감소시키기 위한 조성물및 방법
|
CA3205042A1
(en)
|
2020-12-23 |
2022-06-30 |
Intellia Therapeutics, Inc. |
Compositions and methods for genetically modifying ciita in a cell
|
CA3206284A1
(en)
|
2020-12-23 |
2022-06-30 |
Intellia Therapeutics, Inc. |
Compositions and methods for reducing hla-a in a cell
|
WO2022147133A1
(en)
|
2020-12-30 |
2022-07-07 |
Intellia Therapeutics, Inc. |
Engineered t cells
|
EP4277658A1
(de)
|
2021-01-15 |
2023-11-22 |
Board of Regents, The University of Texas System |
Trans-komplementierungssystem für sars-cov-2
|
WO2022170172A1
(en)
|
2021-02-08 |
2022-08-11 |
Intellia Therapeutics, Inc. |
Natural killer cell receptor 2b4 compositions and methods for immunotherapy
|
EP4288089A2
(de)
|
2021-02-08 |
2023-12-13 |
Intellia Therapeutics, Inc. |
T-zell immunglobulin und mucin domäne 3 (tim3) zusammensetzungen und verfahren zur immuntherapie
|
WO2022170194A2
(en)
|
2021-02-08 |
2022-08-11 |
Intellia Therapeutics, Inc. |
Lymphocyte activation gene 3 (lag3) compositions and methods for immunotherapy
|
WO2022182957A1
(en)
|
2021-02-26 |
2022-09-01 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of myotonic dystrophy type 1 with crispr/sacas9
|
WO2022182959A1
(en)
|
2021-02-26 |
2022-09-01 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of myotonic dystrophy type 1 with crispr/slucas9
|
EP4307916A1
(de)
|
2021-03-15 |
2024-01-24 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zur verarbeitung biologischer proben
|
EP4314295A1
(de)
|
2021-03-26 |
2024-02-07 |
The Board Of Regents Of The University Of Texas System |
Nukleotidbearbeitung zur neurahmung von dmd-transkripten durch basisbearbeitung und prime-bearbeitung
|
WO2022229851A1
(en)
|
2021-04-26 |
2022-11-03 |
Crispr Therapeutics Ag |
Compositions and methods for using slucas9 scaffold sequences
|
WO2022234519A1
(en)
|
2021-05-05 |
2022-11-10 |
Crispr Therapeutics Ag |
Compositions and methods for using sacas9 scaffold sequences
|
BR112023026050A2
(pt)
|
2021-06-18 |
2024-03-05 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para reduzir expressão de ifnar1
|
CA3224995A1
(en)
|
2021-06-22 |
2022-12-29 |
Intellia Therapeutics, Inc. |
Methods for in vivo editing of a liver gene
|
GB202110479D0
(en)
|
2021-07-21 |
2021-09-01 |
Dnae Diagnostics Ltd |
Compositions, kits and methods for sequencing target polynucleotides
|
GB202110485D0
(en)
|
2021-07-21 |
2021-09-01 |
Dnae Diagnostics Ltd |
Compositions, kits and methods for sequencing target polynucleotides
|
CA3226451A1
(en)
|
2021-07-21 |
2023-01-26 |
Sam Reed |
Method and system comprising a cartridge for sequencing target polynucleotides
|
EP4382624A2
(de)
|
2021-07-27 |
2024-06-12 |
Gen-Probe Incorporated |
Zusammensetzungen und verfahren zum nachweis von salmonella und mindestens einem von c. jejuni, c. coli, shigella und stec
|
WO2023018637A1
(en)
|
2021-08-09 |
2023-02-16 |
Vertex Pharmaceuticals Incorporated |
Gene editing of regulatory elements
|
CN117940153A
(zh)
|
2021-08-24 |
2024-04-26 |
因特利亚治疗公司 |
用于基于细胞的疗法的程序性细胞死亡蛋白1(pd1)组合物和方法
|
WO2023039444A2
(en)
|
2021-09-08 |
2023-03-16 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exon 51 for treatment of duchenne muscular dystrophy
|
WO2023049708A1
(en)
|
2021-09-22 |
2023-03-30 |
Herbalife International Of America, Inc. |
Methods and compositions for identifying botanical material using arms-pcr
|
AU2022382975A1
(en)
|
2021-11-03 |
2024-05-02 |
Intellia Therapeutics, Inc. |
Polynucleotides, compositions, and methods for genome editing
|
WO2023081200A2
(en)
|
2021-11-03 |
2023-05-11 |
Intellia Therapeutics, Inc. |
Cd38 compositions and methods for immunotherapy
|
TW202345911A
(zh)
|
2022-03-08 |
2023-12-01 |
美商維泰克斯製藥公司 |
用於治療杜興氏肌肉失養症(duchenne muscular dystrophy)之部分外顯子44、50及53之精確切除
|
WO2023172926A1
(en)
|
2022-03-08 |
2023-09-14 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exons for treatment of duchenne muscular dystrophy
|
WO2023185697A2
(en)
|
2022-03-29 |
2023-10-05 |
Accuredit Therapeutics (Suzhou) Co., Ltd. |
Compositions and methods for treatment of transthyretin amyloidosis
|
TW202405173A
(zh)
|
2022-04-18 |
2024-02-01 |
美商維泰克斯製藥公司 |
用於增強aav療法及降低aav向肝臟之趨性的組合物及方法
|
WO2023205148A1
(en)
|
2022-04-19 |
2023-10-26 |
Intellia Therapeutics, Inc. |
Chimeric antigen receptor compositions and uses
|
TW202408595A
(zh)
|
2022-06-16 |
2024-03-01 |
美商英特利亞醫療公司 |
用於對細胞進行遺傳修飾之方法及組合物
|
WO2023245109A2
(en)
|
2022-06-16 |
2023-12-21 |
Intellia Therapeutics, Inc. |
Compositions and methods for genomic editing
|
WO2023245108A2
(en)
|
2022-06-16 |
2023-12-21 |
Intellia Therapeutics, Inc. |
Compositions and methods for reducing mhc class i in a cell
|
WO2024006955A1
(en)
|
2022-06-29 |
2024-01-04 |
Intellia Therapeutics, Inc. |
Engineered t cells
|
WO2024020352A1
(en)
|
2022-07-18 |
2024-01-25 |
Vertex Pharmaceuticals Incorporated |
Tandem guide rnas (tg-rnas) and their use in genome editing
|
EP4311579A1
(de)
|
2022-07-29 |
2024-01-31 |
Association Française contre les Myopathies |
B-zell-spezifische mabsirna-konjugate verbessern myasthenie
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024035952A1
(en)
|
2022-08-12 |
2024-02-15 |
Remix Therapeutics Inc. |
Methods and compositions for modulating splicing at alternative splice sites
|
WO2024054924A1
(en)
|
2022-09-08 |
2024-03-14 |
Gen-Probe Incorporated |
Method of detecting nucleic acid analytes using dual-specificity primers
|
WO2024061296A2
(en)
|
2022-09-22 |
2024-03-28 |
Accuredit Therapeutics (Suzhou) Co., Ltd. |
Compositions and methods for treatment of hypercholesterolemia and/or cardiovascular disease
|
WO2024098002A1
(en)
|
2022-11-04 |
2024-05-10 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
WO2024102677A1
(en)
|
2022-11-08 |
2024-05-16 |
Orna Therapeutics, Inc. |
Circular rna compositions
|
WO2024107765A2
(en)
|
2022-11-14 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|