IL90359A0 - Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production - Google Patents
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their productionInfo
- Publication number
- IL90359A0 IL90359A0 IL90359A IL9035989A IL90359A0 IL 90359 A0 IL90359 A0 IL 90359A0 IL 90359 A IL90359 A IL 90359A IL 9035989 A IL9035989 A IL 9035989A IL 90359 A0 IL90359 A0 IL 90359A0
- Authority
- IL
- Israel
- Prior art keywords
- thiophosphoramidite
- nucleoside
- polynucleotide
- production
- phosphorodithioate compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11060089A IL110600A (en) | 1988-05-26 | 1989-05-19 | Nucleoside and polynucleotide phosphorodithioate compounds and their production |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19888688A | 1988-05-26 | 1988-05-26 | |
US31401189A | 1989-02-22 | 1989-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL90359A0 true IL90359A0 (en) | 1989-12-15 |
Family
ID=26894243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL90359A IL90359A0 (en) | 1988-05-26 | 1989-05-19 | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0378615A4 (en) |
JP (1) | JPH03501128A (en) |
KR (1) | KR900701813A (en) |
AU (1) | AU626305B2 (en) |
ES (1) | ES2015665A6 (en) |
IL (1) | IL90359A0 (en) |
WO (1) | WO1989011486A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194599A (en) * | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
US6756496B1 (en) | 1988-09-23 | 2004-06-29 | Isis Pharmaceuticals, Inc. | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues |
US5470967A (en) * | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
US5151510A (en) * | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
EP0463712A3 (en) | 1990-06-27 | 1992-04-08 | University Patents, Inc. | Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5623070A (en) * | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5602240A (en) * | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
US5610289A (en) * | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
US5596086A (en) * | 1990-09-20 | 1997-01-21 | Gilead Sciences, Inc. | Modified internucleoside linkages having one nitrogen and two carbon atoms |
US5965722A (en) * | 1991-05-21 | 1999-10-12 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ras gene with chimeric and alternating oligonucleotides |
DK0549107T3 (en) | 1991-10-11 | 1998-08-31 | Dade Behring Marburg Gmbh | Process for Preparing a Polynucleotide for Use in Single Primer Amplification and Phosphorothioate-Containing Oils |
AU3920293A (en) * | 1993-03-16 | 1994-10-11 | Board Of Regents Of The University Of Nebraska, The | Novel metal binding agents, and methods and compositions for their use to treat metal toxicity |
US6001982A (en) | 1993-07-29 | 1999-12-14 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
US5571902A (en) * | 1993-07-29 | 1996-11-05 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
WO1997036005A1 (en) * | 1996-03-26 | 1997-10-02 | Lynx Therapeutics, Inc. | Oligonucleotide treatments and compositions for human melanoma |
US7255874B1 (en) | 2001-12-21 | 2007-08-14 | Closure Medical Corporation | Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto |
US9725474B2 (en) | 2012-10-31 | 2017-08-08 | Takeda Pharmaceutical Company Limited | Modified nucleic acid |
JOP20170192A1 (en) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | Cyclic dinucleotide |
CN110678447B (en) | 2017-06-16 | 2023-12-12 | 卫材R&D管理有限公司 | Modified nucleic acid monomer compounds and oligonucleotide analogues |
EP4092117A1 (en) * | 2017-12-22 | 2022-11-23 | Roche Innovation Center Copenhagen A/S | Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage |
BR112020012427A8 (en) * | 2017-12-22 | 2024-04-02 | Roche Innovation Ct Copenhagen As | Oligonucleotides, pharmaceutically acceptable salt, conjugate, pharmaceutical composition and process for making an oligonucleotide |
CN111039977B (en) * | 2019-12-31 | 2022-11-08 | 广州同隽医药科技有限公司 | Phosphorylylation reagent and application thereof in oligonucleotide synthesis |
JP2023553069A (en) * | 2020-12-08 | 2023-12-20 | エフ. ホフマン-ラ ロシュ アーゲー | Novel synthesis of phosphorodithioate oligonucleotides |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US808708A (en) * | 1905-09-20 | 1906-01-02 | Earnest R Wingate | Clamp. |
US3451997A (en) * | 1965-11-30 | 1969-06-24 | Kyowa Hakko Kogyo Kk | Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives |
DE2122529A1 (en) * | 1971-05-06 | 1972-12-14 | Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen | Thiophosphate analogs of the nucleoside di and tnphosphate and processes for their preparation |
US3853844A (en) * | 1972-08-04 | 1974-12-10 | R Robins | Nucleoside 3{40 ,5{40 ,-cyclic phosphorothioates |
US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
US4415732A (en) * | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
US4373071A (en) * | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
US4728730A (en) * | 1984-09-12 | 1988-03-01 | Wisconsin Alumini Research Foundation | Synthesis of nucleoside thiophosphoanhydrides |
JPS6251695A (en) * | 1985-08-29 | 1987-03-06 | Yuki Gosei Yakuhin Kogyo Kk | Synthesis of phosphoroamidite |
AU5418290A (en) * | 1989-03-31 | 1990-11-05 | University Patents Inc. | Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections |
AU6603690A (en) * | 1989-10-05 | 1991-04-28 | University Patents Inc. | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes |
-
1989
- 1989-05-19 IL IL90359A patent/IL90359A0/en unknown
- 1989-05-25 EP EP19890906571 patent/EP0378615A4/en not_active Withdrawn
- 1989-05-25 JP JP1506397A patent/JPH03501128A/en active Pending
- 1989-05-25 KR KR1019900700156A patent/KR900701813A/en not_active Application Discontinuation
- 1989-05-25 WO PCT/US1989/002293 patent/WO1989011486A1/en not_active Application Discontinuation
- 1989-05-25 AU AU37392/89A patent/AU626305B2/en not_active Ceased
- 1989-05-26 ES ES8901786A patent/ES2015665A6/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU3739289A (en) | 1989-12-12 |
AU626305B2 (en) | 1992-07-30 |
ES2015665A6 (en) | 1990-09-01 |
WO1989011486A1 (en) | 1989-11-30 |
JPH03501128A (en) | 1991-03-14 |
EP0378615A4 (en) | 1992-04-08 |
KR900701813A (en) | 1990-12-04 |
EP0378615A1 (en) | 1990-07-25 |
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