ES2015665A6 - Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes. - Google Patents
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes.Info
- Publication number
- ES2015665A6 ES2015665A6 ES8901786A ES8901786A ES2015665A6 ES 2015665 A6 ES2015665 A6 ES 2015665A6 ES 8901786 A ES8901786 A ES 8901786A ES 8901786 A ES8901786 A ES 8901786A ES 2015665 A6 ES2015665 A6 ES 2015665A6
- Authority
- ES
- Spain
- Prior art keywords
- polynucleotide
- processes
- thiophosphoramidite
- nucleoside
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Abstract
The present invention relates to new and useful nucleoside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorthioamidate phosphoramidite compounds as well as the processes whereby these compounds can be used for synthesizing new mononucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters, and phosphorothioate internucleotide linkages.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19888688A | 1988-05-26 | 1988-05-26 | |
US31401189A | 1989-02-22 | 1989-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2015665A6 true ES2015665A6 (en) | 1990-09-01 |
Family
ID=26894243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8901786A Expired - Fee Related ES2015665A6 (en) | 1988-05-26 | 1989-05-26 | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0378615A4 (en) |
JP (1) | JPH03501128A (en) |
KR (1) | KR900701813A (en) |
AU (1) | AU626305B2 (en) |
ES (1) | ES2015665A6 (en) |
IL (1) | IL90359A0 (en) |
WO (1) | WO1989011486A1 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194599A (en) * | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
US6756496B1 (en) | 1988-09-23 | 2004-06-29 | Isis Pharmaceuticals, Inc. | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues |
US5470967A (en) * | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
US5151510A (en) * | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
EP0463712A3 (en) | 1990-06-27 | 1992-04-08 | University Patents, Inc. | Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections |
US5602240A (en) * | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
US5623070A (en) * | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5610289A (en) * | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
CA2092002A1 (en) * | 1990-09-20 | 1992-03-21 | Mark Matteucci | Modified internucleoside linkages |
US5965722A (en) * | 1991-05-21 | 1999-10-12 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ras gene with chimeric and alternating oligonucleotides |
CA2080305A1 (en) | 1991-10-11 | 1993-04-12 | Linda M. Western | Method for producing a polynucleotide for use in single primer amplification and phosphorothioate-containing oligonucleotides as primers in nucleic acid amplification |
AU3920293A (en) * | 1993-03-16 | 1994-10-11 | Board Of Regents Of The University Of Nebraska, The | Novel metal binding agents, and methods and compositions for their use to treat metal toxicity |
US5571902A (en) * | 1993-07-29 | 1996-11-05 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
US6001982A (en) * | 1993-07-29 | 1999-12-14 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
AU2542097A (en) * | 1996-03-26 | 1997-10-17 | Lynx Therapeutics, Inc. | Oligonucleotide treatments and compositions for human melanoma |
US7255874B1 (en) | 2001-12-21 | 2007-08-14 | Closure Medical Corporation | Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto |
JP6358955B2 (en) | 2012-10-31 | 2018-07-18 | 武田薬品工業株式会社 | Novel modified nucleic acid |
JOP20170192A1 (en) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | Cyclic dinucleotide |
EP3643706B1 (en) | 2017-06-16 | 2023-11-15 | Eisai R&D Management Co., Ltd. | Modified nucleic acid monomers and oligonucleic acid analogues, with high biological stability and target gene silencing activity, for use in therapy and diagnosis of cancer and viral diseases |
CN111039977B (en) * | 2019-12-31 | 2022-11-08 | 广州同隽医药科技有限公司 | Phosphorylylation reagent and application thereof in oligonucleotide synthesis |
JP2023553069A (en) * | 2020-12-08 | 2023-12-20 | エフ. ホフマン-ラ ロシュ アーゲー | Novel synthesis of phosphorodithioate oligonucleotides |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US808708A (en) * | 1905-09-20 | 1906-01-02 | Earnest R Wingate | Clamp. |
US3451997A (en) * | 1965-11-30 | 1969-06-24 | Kyowa Hakko Kogyo Kk | Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives |
DE2122529A1 (en) * | 1971-05-06 | 1972-12-14 | Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen | Thiophosphate analogs of the nucleoside di and tnphosphate and processes for their preparation |
US3853844A (en) * | 1972-08-04 | 1974-12-10 | R Robins | Nucleoside 3{40 ,5{40 ,-cyclic phosphorothioates |
US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
US4415732A (en) * | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
US4373071A (en) * | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
US4728730A (en) * | 1984-09-12 | 1988-03-01 | Wisconsin Alumini Research Foundation | Synthesis of nucleoside thiophosphoanhydrides |
JPS6251695A (en) * | 1985-08-29 | 1987-03-06 | Yuki Gosei Yakuhin Kogyo Kk | Synthesis of phosphoroamidite |
WO1990012022A1 (en) * | 1989-03-31 | 1990-10-18 | University Patents, Inc. | Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections |
WO1991004983A1 (en) * | 1989-10-05 | 1991-04-18 | University Patents, Inc. | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes |
-
1989
- 1989-05-19 IL IL90359A patent/IL90359A0/en unknown
- 1989-05-25 EP EP19890906571 patent/EP0378615A4/en not_active Withdrawn
- 1989-05-25 JP JP1506397A patent/JPH03501128A/en active Pending
- 1989-05-25 AU AU37392/89A patent/AU626305B2/en not_active Ceased
- 1989-05-25 KR KR1019900700156A patent/KR900701813A/en not_active Application Discontinuation
- 1989-05-25 WO PCT/US1989/002293 patent/WO1989011486A1/en not_active Application Discontinuation
- 1989-05-26 ES ES8901786A patent/ES2015665A6/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1989011486A1 (en) | 1989-11-30 |
JPH03501128A (en) | 1991-03-14 |
KR900701813A (en) | 1990-12-04 |
AU3739289A (en) | 1989-12-12 |
IL90359A0 (en) | 1989-12-15 |
EP0378615A4 (en) | 1992-04-08 |
AU626305B2 (en) | 1992-07-30 |
EP0378615A1 (en) | 1990-07-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2015665A6 (en) | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes. | |
IL97804A0 (en) | Oligonucleotide analogs | |
CA2017369A1 (en) | Modified phosphoramidite process for the production or modified nucleic acids | |
EP0977767A4 (en) | Aminooxy-modified oligonucleotides | |
GR3024597T3 (en) | 7-deazapurine modified oligonucleotides | |
CA2153898A1 (en) | Method for generating single-stranded dna molecules | |
ZA8845B (en) | T7 dna polymerase | |
AU2874892A (en) | Oligonucleotides having chiral phosphorus linkages | |
IL103960A0 (en) | Improved electrochemiluminescent label for dna probe assays | |
CA2184375A1 (en) | Oligonucleotide n3'-p5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties | |
NZ335397A (en) | Immunostimulatory unmethylated CpG dinucleotides | |
CA2266748A1 (en) | Three component chimeric antisense oligonucleotides | |
AU8771398A (en) | Novel hiv-specific synthetic oligonucleotides and methods of their use | |
HK1001060A1 (en) | Chiral phospholanes via chiral 1,4-diol cyclic sulfates | |
DE3468220D1 (en) | Compounds containing an oligonucleotide bonded to an intercallating agent, a process for their preparation and their application | |
EP0663447A3 (en) | Method of detecting a specific polynucleotide | |
BG101620A (en) | Dna purification by the formation of a triple spiral with immobilized oligonucleotide | |
AU1079499A (en) | Improved synthesis of sulfurized oligonucleotides | |
MX9605381A (en) | Complementary dna and toxins. | |
DE69824843D1 (en) | METHOD FOR PRODUCING MODIFIED P-CHIRAL NUCLEOTIDE ANALOGS | |
EP0253200A3 (en) | Printhead shifting for wear distribution | |
IL129329A0 (en) | Chiral ferrocenyls | |
MX9700643A (en) | 5'-dithio-modified oligonucleotides. | |
AU581043B2 (en) | Printing plate for offset printing | |
DE3263508D1 (en) | Phosphorylating agent and process for the phosphorylation of organic hydroxyl compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000201 |