NO924258L - Antisense-inhibitorer for det humane immunsvikt viruset - Google Patents

Antisense-inhibitorer for det humane immunsvikt viruset

Info

Publication number
NO924258L
NO924258L NO92924258A NO924258A NO924258L NO 924258 L NO924258 L NO 924258L NO 92924258 A NO92924258 A NO 92924258A NO 924258 A NO924258 A NO 924258A NO 924258 L NO924258 L NO 924258L
Authority
NO
Norway
Prior art keywords
rna
human immune
antisense inhibitors
tat
oligonucleotide
Prior art date
Application number
NO92924258A
Other languages
English (en)
Other versions
NO924258D0 (no
Inventor
David J Ecker
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of NO924258D0 publication Critical patent/NO924258D0/no
Publication of NO924258L publication Critical patent/NO924258L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

Det ble beskrevet fremgangsmåter for modulering av ekspressjonen av HIV tat-genet som omfatter å bringe tat-RNA l kontakt med oligonukleotid eller oligonukleo- tldanaloger som kan binde seg med minst en del av RNA. Ifølge de foretrukne utførelsene, blir ollgonukleotlder eller oligonukleotidanaloger utformet for å binde seg til deler av tat RNA som har en signlfikans for ekspress;)onen av genet som koder for nevnte RNA. Ifølge en foretrukket utførelse, ble .det beskrevet metoder for behandling for humant immunsviktvirus.
NO92924258A 1990-05-11 1992-11-05 Antisense-inhibitorer for det humane immunsvikt viruset NO924258L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/521,907 US5166195A (en) 1990-05-11 1990-05-11 Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
PCT/US1991/002734 WO1991018004A1 (en) 1990-05-11 1991-04-22 Antisense inhibitors of the human immunodeficiency virus

Publications (2)

Publication Number Publication Date
NO924258D0 NO924258D0 (no) 1992-11-05
NO924258L true NO924258L (no) 1992-11-05

Family

ID=24078638

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92924258A NO924258L (no) 1990-05-11 1992-11-05 Antisense-inhibitorer for det humane immunsvikt viruset

Country Status (13)

Country Link
US (2) US5166195A (no)
EP (1) EP0527916B1 (no)
JP (1) JPH0832242B2 (no)
KR (1) KR0149680B1 (no)
AT (1) ATE181960T1 (no)
AU (1) AU651593B2 (no)
BR (1) BR9106440A (no)
CA (1) CA2082631A1 (no)
DE (1) DE69131422T2 (no)
FI (1) FI925103A0 (no)
HU (1) HUT62912A (no)
NO (1) NO924258L (no)
WO (1) WO1991018004A1 (no)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
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EP0527916B1 (en) 1999-07-07
KR0149680B1 (ko) 1998-08-17
AU651593B2 (en) 1994-07-28
US5591600A (en) 1997-01-07
DE69131422T2 (de) 1999-10-28
AU7882691A (en) 1991-12-10
NO924258D0 (no) 1992-11-05
WO1991018004A1 (en) 1991-11-28
HU9203538D0 (en) 1993-03-29
HUT62912A (en) 1993-06-28
DE69131422D1 (de) 1999-08-12
EP0527916A4 (no) 1994-04-06
FI925103A (fi) 1992-11-10
FI925103A0 (fi) 1992-11-10
CA2082631A1 (en) 1991-11-12
ATE181960T1 (de) 1999-07-15
JPH06500005A (ja) 1994-01-06
JPH0832242B2 (ja) 1996-03-29
EP0527916A1 (en) 1993-02-24
BR9106440A (pt) 1993-05-18
US5166195A (en) 1992-11-24

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