DE3111405C2 - - Google Patents

Info

Publication number
DE3111405C2
DE3111405C2 DE3111405A DE3111405A DE3111405C2 DE 3111405 C2 DE3111405 C2 DE 3111405C2 DE 3111405 A DE3111405 A DE 3111405A DE 3111405 A DE3111405 A DE 3111405A DE 3111405 C2 DE3111405 C2 DE 3111405C2
Authority
DE
Germany
Prior art keywords
polypeptide
plasmid
gene
heterologous
vector according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3111405A
Other languages
German (de)
English (en)
Other versions
DE3111405A1 (de
Inventor
Dennis G. San Mateo Calif. Us Kleid
Daniel G. San Francisco Calif. Us Yansura
Herbert L. Burlingame Calif. Us Heyneker
Giuseppe F. Augarten Rheinfelder Ch Miozzari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE3111405A1 publication Critical patent/DE3111405A1/de
Application granted granted Critical
Publication of DE3111405C2 publication Critical patent/DE3111405C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE19813111405 1980-03-24 1981-03-23 Bakterielle expression von polypeptiden unter verwendung eines tryptophan-promoter-operator-systems Granted DE3111405A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13329680A 1980-03-24 1980-03-24

Publications (2)

Publication Number Publication Date
DE3111405A1 DE3111405A1 (de) 1982-03-25
DE3111405C2 true DE3111405C2 (enExample) 1990-06-21

Family

ID=22457906

Family Applications (5)

Application Number Title Priority Date Filing Date
DE8383200301T Expired DE3176205D1 (en) 1980-03-24 1981-03-23 A method of cleaving double stranded dna
DE8181301227T Expired DE3176737D1 (en) 1980-03-24 1981-03-23 A method of creating an expression plasmid
DE19813111405 Granted DE3111405A1 (de) 1980-03-24 1981-03-23 Bakterielle expression von polypeptiden unter verwendung eines tryptophan-promoter-operator-systems
DE8585100548T Expired - Lifetime DE3177179D1 (de) 1980-03-24 1981-03-23 Plasmidische expressionsvektoren und verfahren zur herstellung eines polypeptids mittels derselben.
DE3153606A Expired - Lifetime DE3153606C2 (enExample) 1980-03-24 1981-03-23

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE8383200301T Expired DE3176205D1 (en) 1980-03-24 1981-03-23 A method of cleaving double stranded dna
DE8181301227T Expired DE3176737D1 (en) 1980-03-24 1981-03-23 A method of creating an expression plasmid

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE8585100548T Expired - Lifetime DE3177179D1 (de) 1980-03-24 1981-03-23 Plasmidische expressionsvektoren und verfahren zur herstellung eines polypeptids mittels derselben.
DE3153606A Expired - Lifetime DE3153606C2 (enExample) 1980-03-24 1981-03-23

Country Status (35)

Country Link
US (2) US5888808A (enExample)
EP (3) EP0086548B1 (enExample)
JP (3) JPH0724582B2 (enExample)
KR (2) KR830005351A (enExample)
AR (1) AR248050A1 (enExample)
AT (3) ATE52802T1 (enExample)
AU (3) AU542640B2 (enExample)
BG (3) BG46005A3 (enExample)
BR (1) BR8101712A (enExample)
CA (2) CA1198068A (enExample)
CS (3) CS238645B2 (enExample)
DD (3) DD159435A5 (enExample)
DE (5) DE3176205D1 (enExample)
DK (1) DK173085B1 (enExample)
DZ (1) DZ278A1 (enExample)
ES (3) ES8207220A1 (enExample)
FI (3) FI853488L (enExample)
FR (2) FR2480781B1 (enExample)
GB (1) GB2073203B (enExample)
GR (1) GR74818B (enExample)
HU (1) HU195534B (enExample)
IE (3) IE51892B1 (enExample)
IL (3) IL71885A (enExample)
IT (1) IT1144324B (enExample)
MX (1) MX7689E (enExample)
MY (1) MY8500896A (enExample)
NO (3) NO810986L (enExample)
NZ (3) NZ196584A (enExample)
OA (1) OA06774A (enExample)
PH (4) PH17537A (enExample)
PL (2) PL147727B1 (enExample)
PT (1) PT72716B (enExample)
YU (2) YU45534B (enExample)
ZA (1) ZA811368B (enExample)
ZW (1) ZW5481A1 (enExample)

Families Citing this family (378)

* Cited by examiner, † Cited by third party
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US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes
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US5525484A (en) * 1981-01-16 1996-06-11 Genome Therapeutics Corp. Recombinant DNA means and method for producing rennin, prorenin and pre-prorennin
BR8205954A (pt) * 1981-10-14 1983-09-13 Unilever Nv Sequencia de dna,plasmidio recombinante,cultura bacteriana e microorganismos
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
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EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
US4499188A (en) * 1982-05-05 1985-02-12 Cetus Corporation Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator
US4863855A (en) * 1982-05-14 1989-09-05 The Research Foundation Of State University Of New York Novel cloning vehicles for polypeptide expression in microbial hosts
EP0108045B1 (en) * 1982-10-25 1988-12-07 Monsanto Company Reca promoter dependent polypeptide production
CA1252046A (en) * 1982-11-04 1989-04-04 Martin J. Cline Methods for oncogenic detection
DE3247922A1 (de) * 1982-12-24 1984-06-28 Boehringer Ingelheim International GmbH, 6507 Ingelheim Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten
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