KR830005351A - 트립토판 촉진유전자-작동유전자를 이용한 세균성 폴리펩티드의 제조방법 - Google Patents
트립토판 촉진유전자-작동유전자를 이용한 세균성 폴리펩티드의 제조방법 Download PDFInfo
- Publication number
- KR830005351A KR830005351A KR1019810000949A KR810000949A KR830005351A KR 830005351 A KR830005351 A KR 830005351A KR 1019810000949 A KR1019810000949 A KR 1019810000949A KR 810000949 A KR810000949 A KR 810000949A KR 830005351 A KR830005351 A KR 830005351A
- Authority
- KR
- South Korea
- Prior art keywords
- polypeptide
- gene
- heterologous
- trp
- plasmid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229920001184 polypeptide Polymers 0.000 title claims description 48
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 48
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 48
- 108090000623 proteins and genes Proteins 0.000 title claims description 31
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title claims 8
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title claims 8
- 230000001580 bacterial effect Effects 0.000 title claims 8
- 230000001737 promoting effect Effects 0.000 title description 2
- 239000013612 plasmid Substances 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 102000002265 Human Growth Hormone Human genes 0.000 claims description 3
- 108010000521 Human Growth Hormone Proteins 0.000 claims description 3
- 239000000854 Human Growth Hormone Substances 0.000 claims description 3
- 102000005157 Somatostatin Human genes 0.000 claims description 3
- 108010056088 Somatostatin Proteins 0.000 claims description 3
- 108010078233 Thymalfasin Proteins 0.000 claims description 3
- 102400000800 Thymosin alpha-1 Human genes 0.000 claims description 3
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims description 3
- 229960000553 somatostatin Drugs 0.000 claims description 3
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims description 3
- 229960004231 thymalfasin Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 15
- 150000001413 amino acids Chemical class 0.000 claims 12
- 108020004414 DNA Proteins 0.000 claims 11
- 102000053602 DNA Human genes 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims 4
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 230000015556 catabolic process Effects 0.000 claims 3
- 238000006731 degradation reaction Methods 0.000 claims 3
- 210000003705 ribosome Anatomy 0.000 claims 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108010076181 Proinsulin Proteins 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000000975 bioactive effect Effects 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 230000001036 exonucleolytic effect Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 230000003362 replicative effect Effects 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- 230000014621 translational initiation Effects 0.000 claims 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 229930024421 Adenine Natural products 0.000 claims 1
- 108091033380 Coding strand Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 229960000723 ampicillin Drugs 0.000 claims 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 239000013613 expression plasmid Substances 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 239000002054 inoculum Substances 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 229960002180 tetracycline Drugs 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019860002404A KR860001230B1 (ko) | 1980-03-24 | 1986-03-29 | 이중 가닥 dna의 분할 방법 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13329680A | 1980-03-24 | 1980-03-24 | |
| US133296 | 1980-03-24 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860002404A Division KR860001230B1 (ko) | 1980-03-24 | 1986-03-29 | 이중 가닥 dna의 분할 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830005351A true KR830005351A (ko) | 1983-08-13 |
Family
ID=22457906
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810000949A Ceased KR830005351A (ko) | 1980-03-24 | 1981-03-23 | 트립토판 촉진유전자-작동유전자를 이용한 세균성 폴리펩티드의 제조방법 |
| KR1019860002404A Expired KR860001230B1 (ko) | 1980-03-24 | 1986-03-29 | 이중 가닥 dna의 분할 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860002404A Expired KR860001230B1 (ko) | 1980-03-24 | 1986-03-29 | 이중 가닥 dna의 분할 방법 |
Country Status (35)
Families Citing this family (371)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1202581A (en) * | 1980-03-27 | 1986-04-01 | Saran A. Narang | Adaptor molecules for dna and their application to synthesis of gene-derived products |
| AU564690B2 (en) | 1980-04-03 | 1987-08-20 | Biogen Idec Ma Inc. | Process for producing human fibroblast interferon-like polypeptides using recombinant dna |
| US4874702A (en) * | 1980-09-08 | 1989-10-17 | Biogen, Inc. | Vectors and methods for making such vectors and for expressive cloned genes |
| DK489481A (da) * | 1980-11-10 | 1982-05-11 | Searle & Co | Plasmidvektor og frmgangsmaade til fremstilling deraf |
| US5525484A (en) * | 1981-01-16 | 1996-06-11 | Genome Therapeutics Corp. | Recombinant DNA means and method for producing rennin, prorenin and pre-prorennin |
| BR8205954A (pt) * | 1981-10-14 | 1983-09-13 | Unilever Nv | Sequencia de dna,plasmidio recombinante,cultura bacteriana e microorganismos |
| JPS58110600A (ja) * | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
| JPS58141796A (ja) * | 1982-02-18 | 1983-08-23 | Kyowa Hakko Kogyo Co Ltd | ペプチドの製造法 |
| EP0088994B1 (en) * | 1982-03-15 | 1991-06-19 | Schering Corporation | Hybrid dna, binding composition prepared thereby and processes therefor |
| US4499188A (en) * | 1982-05-05 | 1985-02-12 | Cetus Corporation | Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator |
| US4863855A (en) * | 1982-05-14 | 1989-09-05 | The Research Foundation Of State University Of New York | Novel cloning vehicles for polypeptide expression in microbial hosts |
| EP0108045B1 (en) * | 1982-10-25 | 1988-12-07 | Monsanto Company | Reca promoter dependent polypeptide production |
| IE56509B1 (en) * | 1982-11-04 | 1991-08-28 | Univ California | Methods for oncogenic detection |
| DE3247922A1 (de) * | 1982-12-24 | 1984-06-28 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten |
| US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
| DK161152C (da) | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US4701416A (en) * | 1983-12-09 | 1987-10-20 | Cetus Corporation | Feline leukemia virus vaccine plasmids for fusion protein of the gp70 envelope protein of FELV |
| US4935370A (en) * | 1983-12-23 | 1990-06-19 | Pfizer Inc. | Expression plasmids for improved production of heterologous protein in bacteria |
| JP2595205B2 (ja) * | 1984-02-08 | 1997-04-02 | カロイン コーポレイション | 発現カセット |
| US5028531A (en) * | 1984-03-19 | 1991-07-02 | Fujisawa Pharmaceutical Company, Ltd. | IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof |
| GB8407044D0 (en) * | 1984-03-19 | 1984-04-26 | Fujisawa Pharmaceutical Co | Producing human insulin |
| US4894334A (en) * | 1984-03-28 | 1990-01-16 | Cetus Corporation | Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria |
| US4656132A (en) | 1984-03-28 | 1987-04-07 | Cetus Corporation | Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria |
| US5268278A (en) * | 1984-03-30 | 1993-12-07 | Istituto Farmacologico Serono S.P.A. | Genetic expression of somatostatin as hybrid polypeptide |
| US4789702A (en) * | 1984-05-18 | 1988-12-06 | Cetus Corporation | Feline leukemia virus vaccine |
| US5683688A (en) | 1984-05-31 | 1997-11-04 | Genentech, Inc. | Unglycosylated recombinant human lymphotoxin polypeptides and compositions |
| JPS619282A (ja) * | 1984-06-22 | 1986-01-16 | Hitachi Ltd | 遺伝子組換え菌の培養方法 |
| DE3585176D1 (de) * | 1984-06-22 | 1992-02-27 | Hitachi Ltd | Verfahren zum kontrollieren der zuechtung von rekombinanten. |
| EP0178764A1 (en) * | 1984-08-28 | 1986-04-23 | Genex Corporation | Method of stabilizing a host microorganism/expression vector system for large scale production of proteins |
| US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
| US5075224A (en) * | 1984-10-19 | 1991-12-24 | Genentech, Inc. | Prepro-LHRH C-terminal peptide DNA |
| NZ213759A (en) * | 1984-10-19 | 1989-01-27 | Genentech Inc | Lhrh-ctp protein conjugates influencing prolactin fsh and lh release |
| FI90990C (fi) * | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi |
| EP0460709B1 (en) | 1985-01-28 | 1997-05-21 | Xoma Corporation | AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques |
| IT1234977B (it) * | 1985-03-22 | 1992-06-09 | Serono Ist Farm | Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| ES8706823A1 (es) * | 1985-03-28 | 1987-06-16 | Cetus Corp | Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| GB8509289D0 (en) * | 1985-04-11 | 1985-05-15 | Fujisawa Pharmaceutical Co | Production of somatostatin |
| DE3526995A1 (de) * | 1985-07-27 | 1987-02-05 | Hoechst Ag | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
| AU6104786A (en) * | 1985-08-12 | 1987-02-19 | Syntex (U.S.A.) Inc. | Fusion proteins using trple gene |
| ES2000859A6 (es) * | 1985-08-12 | 1988-03-16 | Syntex Inc | Un metodo para producir un vector de expresion bacteriana para la expresion de proteinas de fusion |
| JPH0775536B2 (ja) * | 1986-03-26 | 1995-08-16 | 猛 小林 | 遺伝子組み換え菌を用いた酵素生産装置 |
| DE3642096A1 (de) * | 1986-12-10 | 1988-06-16 | Boehringer Ingelheim Int | Pferde-(gamma)-interferon |
| US6994988B1 (en) | 1987-02-12 | 2006-02-07 | Genetech, Inc. | Methods and deoxyribonucleic acid for the preparation of tissue factor protein |
| DE68915841T2 (de) * | 1988-03-30 | 1995-02-02 | Hitachi Chemical Co Ltd | Verfahren zur Herstellung von Epidermal-Wachstumsfaktor durch genetische Transformation. |
| JPH01247099A (ja) * | 1988-03-30 | 1989-10-02 | Hitachi Ltd | ヒトの上皮細胞増殖因子の遺伝子工学的生産方法 |
| JPH01247098A (ja) * | 1988-03-30 | 1989-10-02 | Hitachi Ltd | ヒトの上皮細胞増殖因子の遺伝子工学的生産方法 |
| JPH0227993A (ja) * | 1988-07-15 | 1990-01-30 | Nippon Shinyaku Co Ltd | ｈＥＧＦの製法 |
| IL92937A0 (en) | 1989-01-31 | 1990-09-17 | Us Health | Human derived monocyte attracting protein,pharmaceutical compositions comprising it and dna encoding it |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| JP4236698B2 (ja) | 1990-11-26 | 2009-03-11 | ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー | 宿主細胞でのｐａｃｅの発現およびその使用法 |
| DK0786257T3 (da) | 1992-06-03 | 2003-10-06 | Genentech Inc | Glycolyseringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber |
| GB9325182D0 (en) * | 1993-12-08 | 1994-02-09 | T Cell Sciences Inc | Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions |
| US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| US5708142A (en) | 1994-05-27 | 1998-01-13 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
| US6455304B1 (en) | 1994-07-01 | 2002-09-24 | The Board Of Regents Of The University Of Oklahoma | Hyaluronate synthase gene and uses thereof |
| US6951743B2 (en) | 1997-10-31 | 2005-10-04 | University Of Oklahoma Board Of Regents | Hyaluronan synthase genes and expression thereof in bacillus hosts |
| US7091008B1 (en) | 1994-07-01 | 2006-08-15 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase genes and expression thereof in Bacillus hosts |
| US6015660A (en) * | 1995-01-06 | 2000-01-18 | The Regents Of The University Of California | Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases |
| US6113905A (en) * | 1995-01-06 | 2000-09-05 | The Regents Of The University Of California | Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases |
| US6077510A (en) * | 1995-01-06 | 2000-06-20 | Regents Of The University Of California | Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases |
| US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| KR101004174B1 (ko) | 1995-06-29 | 2010-12-24 | 임뮤넥스 코포레이션 | 세포소멸을 유도하는 시토킨 |
| US7005505B1 (en) | 1995-08-25 | 2006-02-28 | Genentech, Inc. | Variants of vascular endothelial cell growth factor |
| US6020473A (en) | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
| US6030945A (en) * | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| US6998116B1 (en) | 1996-01-09 | 2006-02-14 | Genentech, Inc. | Apo-2 ligand |
| WO1997037020A1 (en) | 1996-04-01 | 1997-10-09 | Genentech, Inc. | Apo-2li and apo-3 apoptosis polypeptides |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US6159462A (en) * | 1996-08-16 | 2000-12-12 | Genentech, Inc. | Uses of Wnt polypeptides |
| US5851984A (en) * | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| US6462176B1 (en) | 1996-09-23 | 2002-10-08 | Genentech, Inc. | Apo-3 polypeptide |
| US5990281A (en) * | 1996-09-30 | 1999-11-23 | Genentech, Inc. | Vertebrate smoothened proteins |
| US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
| WO1998028424A2 (en) | 1996-12-23 | 1998-07-02 | Immunex Corporation | Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily |
| WO2000039297A2 (en) | 1998-12-23 | 2000-07-06 | Genentech, Inc. | Il-1 related polypeptides |
| WO1999021998A1 (en) | 1997-10-29 | 1999-05-06 | Genentech, Inc. | Wnt-1 induced secreted polypeptides: wisp-1, -2 and -3 |
| AU743394B2 (en) * | 1997-04-04 | 2002-01-24 | University Of Southern California | Article, method, and apparatus for electrochemical fabrication |
| US6384203B1 (en) | 1999-05-12 | 2002-05-07 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) |
| US6448035B1 (en) | 1997-04-24 | 2002-09-10 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR) |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| WO1998055615A1 (en) | 1997-06-05 | 1998-12-10 | The University Of Texas Board Or Regents | Apaf-1, the ced-4 human homolog, an activator of caspase-3 |
| EP1032661A1 (en) | 1997-06-18 | 2000-09-06 | Genentech, Inc. | Apo-2DcR |
| US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| EP1007546B1 (en) | 1997-08-27 | 2009-01-21 | Novartis Vaccines and Diagnostics, Inc. | Molecular mimetics of meningococcal b epitopes |
| US6610838B1 (en) | 1997-09-10 | 2003-08-26 | Symbicom Aktiebolag | P13 antigens from Borrelia |
| JP4303883B2 (ja) | 1997-09-18 | 2009-07-29 | ジェネンテック・インコーポレーテッド | ＤｃＲ３ポリペプチドというＴＮＦＲ相同体 |
| WO1999019490A1 (en) | 1997-10-10 | 1999-04-22 | Genentech, Inc. | Apo-3 ligand |
| ATE409225T1 (de) | 1997-10-29 | 2008-10-15 | Genentech Inc | Durch wnt-1 induzierbare gene |
| CN101113436B (zh) | 1997-10-31 | 2013-02-06 | 俄克拉何马大学董事会 | 透明质酸合酶基因及其应用 |
| EP1522579A3 (en) | 1997-10-31 | 2007-11-07 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase gene and uses thereof |
| EP1900818A3 (en) | 1997-11-06 | 2008-06-11 | Novartis Vaccines and Diagnostics S.r.l. | Neisserial antigens |
| ATE364049T1 (de) | 1997-11-21 | 2007-06-15 | Genentech Inc | Mit a33 verwandte antigene und deren pharmazeutische verwendungen |
| US7192589B2 (en) | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
| SG152917A1 (en) | 1998-01-14 | 2009-06-29 | Chiron Srl | Neisseria meningitidis antigens |
| WO1999036535A1 (en) | 1998-01-15 | 1999-07-22 | Genentech, Inc. | Apo-2 ligand |
| US6727079B1 (en) | 1998-02-25 | 2004-04-27 | The United States Of America As Represented By The Department Of Health And Human Services | cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product |
| NZ525914A (en) | 1998-03-10 | 2004-03-26 | Genentech Inc | Novel polypeptides and nucleic acids encoding the same |
| ES2389387T3 (es) | 1998-03-17 | 2012-10-25 | Genentech, Inc. | Polipéptidos homólogos de VEGF y de BMP1 |
| US20060188966A1 (en) | 1998-04-02 | 2006-08-24 | Deangelis Paul L | Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same |
| US7223571B2 (en) | 1998-04-02 | 2007-05-29 | The Board Of Regents Of The Universtiy Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
| US6987023B2 (en) | 1998-04-02 | 2006-01-17 | The Board Of Regents Of The University Of Oklahoma | DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| EP2261350A3 (en) | 1998-05-01 | 2012-01-04 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
| EP1865061A3 (en) | 1998-05-15 | 2007-12-19 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| EP3112468A1 (en) | 1998-05-15 | 2017-01-04 | Genentech, Inc. | Il-17 homologous polypeptides and therapeutic uses thereof |
| DK1076703T4 (da) | 1998-05-15 | 2011-03-28 | Genentech Inc | Terapeutiske anvendelser af IL-17-homologe polypeptider |
| US20020172678A1 (en) | 2000-06-23 | 2002-11-21 | Napoleone Ferrara | EG-VEGF nucleic acids and polypeptides and methods of use |
| WO2000011174A1 (en) | 1998-08-21 | 2000-03-02 | Immunex Corporation | Human il-1 epsilon dna and polypeptides |
| AU758062B2 (en) | 1998-09-03 | 2003-03-13 | Bristol-Myers Squibb Company | Enzymatic oxidative deamination process |
| WO2001051635A2 (en) | 2000-01-13 | 2001-07-19 | Genentech, Inc. | Novel stra6 polypeptides |
| WO2000022130A2 (en) | 1998-10-15 | 2000-04-20 | Chiron Corporation | Metastatic breast and colon cancer regulated genes |
| US7094581B2 (en) | 1998-10-26 | 2006-08-22 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthases and methods of making and using same |
| DE69939599D1 (de) | 1998-12-16 | 2008-10-30 | Novartis Vaccines & Diagnostic | MENSCHLICHE CYCLIN-ABHÄNGIGE KINASE (hPNQALRE) |
| CA2450402A1 (en) | 1998-12-22 | 2000-06-29 | Genentech, Inc. | Methods and compositions for inhibiting cancer cell growth comprising pro224 |
| US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| EP1978029A3 (en) | 1999-06-15 | 2008-10-15 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids endoding the same |
| US7101989B1 (en) | 1999-07-09 | 2006-09-05 | University Of North Carolina At Chapel Hill | DsrA protein and polynucleotides encoding the same |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| AU783767B2 (en) | 1999-10-14 | 2005-12-01 | Takara Bio Usa, Inc. | Anthozoa derived chromophores/fluorophores and methods for using the same |
| MXPA02003897A (es) | 1999-10-20 | 2002-12-13 | Genentech Inc | Modulacion de la diferenciacion de celulas t para el tratamiento de enfermedades mediadas por las celulas t auxiliares. |
| EP1801219B1 (en) | 1999-10-29 | 2015-10-14 | GlaxoSmithKline Biologicals S.A. | Neisserial antigenic peptides |
| US7078382B1 (en) | 1999-11-02 | 2006-07-18 | Genentech, Inc. | Modulation of eNOS activity and therapeutic uses thereof |
| AU782918B2 (en) | 1999-11-10 | 2005-09-08 | University Of Washington | Compositions and methods for modulation of plant cell division |
| EP1666494A1 (en) | 1999-12-01 | 2006-06-07 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2394015C (en) | 1999-12-20 | 2013-11-05 | Immunex Corporation | Tweak receptor |
| EP1897945B1 (en) | 1999-12-23 | 2012-01-18 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| NZ520022A (en) | 1999-12-30 | 2005-01-28 | Genencor Int | Protein and DNA sequences for XYL-IV from Trichoderma reesei |
| DE60134956D1 (de) | 2000-01-10 | 2008-09-04 | Novartis Vaccines & Diagnostic | Gene differentiell experimiert in brudtkrebs |
| ATE476988T1 (de) | 2000-01-17 | 2010-08-15 | Novartis Vaccines & Diagnostic | Membranvesikel (omv) impfstoff, der n. meningitidis serogruppe b membranproteine enthält |
| ES2275675T3 (es) | 2000-03-23 | 2007-06-16 | Elan Pharmaceuticals, Inc. | Compuestos y metodos para tratar la enfermedad de alzheimer. |
| US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| EP2275549A1 (en) | 2000-06-23 | 2011-01-19 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| EP2168980A1 (en) | 2000-06-23 | 2010-03-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogensis |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| CN1217920C (zh) | 2000-06-30 | 2005-09-07 | 艾兰制药公司 | 治疗早老性痴呆的化合物 |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| EP2014298A3 (en) | 2000-08-24 | 2009-10-07 | Genentech, Inc. | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
| EP1944317A3 (en) | 2000-09-01 | 2008-09-17 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| ES2330083T3 (es) | 2000-10-27 | 2009-12-04 | Novartis Vaccines And Diagnostics S.R.L. | Acidos nucleicos y proteinas de estreptococos de los grupos a y b. |
| US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| WO2002081642A2 (en) | 2001-04-06 | 2002-10-17 | Georgetown University | Gene brcc-3 and diagnostic and therapeutic uses thereof |
| AU2002305151A1 (en) | 2001-04-06 | 2002-10-21 | Georgetown University | Gene scc-112 and diagnostic and therapeutic uses thereof |
| WO2002081639A2 (en) | 2001-04-06 | 2002-10-17 | Georgetown University | Gene brcc2 and diagnostic and therapeutic uses thereof |
| US7384775B2 (en) | 2001-04-16 | 2008-06-10 | Wyeth | Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
| US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| AU2002318371B2 (en) | 2001-06-20 | 2006-06-15 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP1401452A1 (en) | 2001-06-27 | 2004-03-31 | Elan Pharmaceuticals, Inc. | Beta-hydroxyamine derivatives useful in the treatment of alzheimer's disease |
| US6867189B2 (en) | 2001-07-26 | 2005-03-15 | Genset S.A. | Use of adipsin/complement factor D in the treatment of metabolic related disorders |
| BR0211494A (pt) | 2001-07-27 | 2004-08-17 | Chiron Srl | Adesinas de meningococo nada, app e orf 40 |
| MY144532A (en) | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| MXPA04001720A (es) | 2001-08-29 | 2004-05-31 | Genentech Inc | Acido nucleicos bv8 y polipeptidos con actividad mitogenica. |
| WO2003024392A2 (en) | 2001-09-18 | 2003-03-27 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US20030228319A1 (en) | 2002-04-16 | 2003-12-11 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| EP1456223B1 (en) | 2001-12-19 | 2009-08-12 | The University Of Chicago | Rapidly maturing fluorescent proteins and methods for using the same |
| NZ533933A (en) | 2002-01-02 | 2008-06-30 | Genentech Inc | Compositions and methods for the diagnosis and treatment of glioma tumor |
| US20040258678A1 (en) | 2002-02-22 | 2004-12-23 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US7244565B2 (en) | 2002-04-10 | 2007-07-17 | Georgetown University | Gene shinc-3 and diagnostic and therapeutic uses thereof |
| US7138512B2 (en) | 2002-04-10 | 2006-11-21 | Georgetown University | Gene SHINC-2 and diagnostic and therapeutic uses thereof |
| AU2003239865A1 (en) | 2002-05-24 | 2003-12-12 | Restoragen Inc. | Method for universal enzymatic production of bioactive peptides |
| EP1572720A4 (en) | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | PROCESS FOR THE ENZYMATIC PRODUCTION OF GLP-2 (1-34) AND GLP-2 (1-33) PEPTIDES |
| EP2305710A3 (en) | 2002-06-03 | 2013-05-29 | Genentech, Inc. | Synthetic antibody phage libraries |
| IL165392A0 (en) | 2002-06-05 | 2006-01-15 | Genentech Inc | Compositions and methods for liver growth and liver protection |
| EP1553912A4 (en) | 2002-06-07 | 2007-08-08 | Genentech Inc | COMPOSITIONS AND METHODS FOR TUMOR DIAGNOSIS AND TREATMENT |
| JP2006517384A (ja) | 2002-07-08 | 2006-07-27 | ジェネンテック・インコーポレーテッド | 免疫関連疾患の治療のための組成物と方法 |
| EP1539228B1 (en) | 2002-09-11 | 2010-12-29 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| US20060199181A1 (en) | 2002-09-11 | 2006-09-07 | Genentch, Inc. | Compositions and methods for the treatment of immune related diseases |
| WO2004024097A2 (en) | 2002-09-16 | 2004-03-25 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| WO2004028479A2 (en) | 2002-09-25 | 2004-04-08 | Genentech, Inc. | Nouvelles compositions et methodes de traitement du psoriasis |
| RU2005113300A (ru) | 2002-10-04 | 2005-10-27 | Фирмениш Са (Ch) | Сесквитерпенсинтазы и способы их применения |
| WO2004039956A2 (en) | 2002-10-29 | 2004-05-13 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| EP1581169A4 (en) | 2002-11-08 | 2008-09-17 | Genentech Inc | COMPOSITIONS AND METHODS FOR TREATING DISEASES RELATED TO NATURAL K CELLS |
| DE60332477D1 (de) | 2002-11-15 | 2010-06-17 | Novartis Vaccines & Diagnostic | Unerwartete oberflächenproteine in neisseria meningitidis |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| EP2311870A1 (en) | 2002-11-26 | 2011-04-20 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| KR101118340B1 (ko) | 2003-03-12 | 2012-04-12 | 제넨테크, 인크. | 조혈을 촉진하기 위한 ｂｖ８ 및(또는) ｅｇ-ｖｅｇｆ의용도 |
| WO2004091658A1 (en) | 2003-04-04 | 2004-10-28 | Genentech, Inc. | High concentration antibody and protein formulations |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| EP2228379A1 (en) | 2003-04-25 | 2010-09-15 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore |
| DE602004032144D1 (de) | 2003-06-23 | 2011-05-19 | Univ North Carolina State | Für fructooligosaccharid-nutzende verbindungen codierende nukleinsäuren aus lactobacillus acidophilus und verwendungen davon |
| EP2784084B2 (en) | 2003-07-08 | 2023-10-04 | Novartis Pharma AG | Antagonist antibodies to IL-17A/F heterologous polypeptides |
| US7442785B2 (en) | 2003-07-24 | 2008-10-28 | The University Of Kentucky Research Foundation | Sesquiterpene synthase gene and protein |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| EP2336360A1 (en) | 2003-09-23 | 2011-06-22 | University Of North Carolina At Chapel Hill | Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage |
| EP2272951B1 (en) | 2003-10-14 | 2014-07-23 | Baxter International Inc. | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives |
| NZ596984A (en) | 2003-11-17 | 2013-10-25 | Genentech Inc | Compositions and methods for the treatment of tumor of hematopoietic origin |
| WO2005067368A2 (en) | 2003-11-21 | 2005-07-28 | Nps Allelix Corp. | Production of glucagon like peptide 2 and analogs |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| US7459289B2 (en) | 2004-03-08 | 2008-12-02 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor |
| EP1736541B1 (en) | 2004-03-29 | 2013-01-23 | Galpharma Co., Ltd. | Novel modified galectin 9 protein and use thereof |
| WO2005100387A1 (en) | 2004-04-07 | 2005-10-27 | The University Of Chicago | Monomeric red fluorescent proteins |
| WO2006009901A2 (en) | 2004-06-18 | 2006-01-26 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| EP1802335A2 (en) | 2004-10-21 | 2007-07-04 | Wyeth a Corporation of the State of Delaware | Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens |
| CN101128586A (zh) | 2004-12-22 | 2008-02-20 | 健泰科生物技术公司 | 制备可溶性多跨膜蛋白的方法 |
| NZ584597A (en) | 2004-12-22 | 2011-09-30 | Ambrx Inc | Modified human growth hormone |
| EP1828224B1 (en) | 2004-12-22 | 2016-04-06 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| US20090325226A1 (en) | 2005-03-15 | 2009-12-31 | Stafford Darrel W | Methods and Compositions for Producing Active Vitamin K-Dependent Proteins |
| EA201201550A1 (ru) | 2005-03-21 | 2013-08-30 | Вайробей, Инк. | Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз |
| BRPI0610609A2 (pt) | 2005-04-15 | 2010-07-06 | Univ North Carolina State | métodos e composições para modular a adesão e toleráncia ao estresse em bactérias |
| EP3473646A1 (en) | 2005-05-04 | 2019-04-24 | Zealand Pharma A/S | Glucagon-like-peptide-2 (glp-2) analogues |
| JP2008544746A (ja) | 2005-05-12 | 2008-12-11 | ザイモジェネティクス， インコーポレイテッド | 免疫応答を調節するための組成物および方法 |
| EP2186402A1 (en) | 2005-06-06 | 2010-05-19 | Genentech, Inc. | Knock-out animal models for novel genes and methods of use |
| CN101296613B (zh) | 2005-07-29 | 2016-02-10 | 目标栽培公司 | 显性失活突变体krp蛋白保护活性细胞周期蛋白-cdk复合物不受野生型krp抑制 |
| AU2006280321A1 (en) | 2005-08-15 | 2007-02-22 | Genentech, Inc. | Gene disruptions, compositions and methods relating thereto |
| CA2620886C (en) | 2005-08-31 | 2017-03-14 | The Regents Of The University Of California | Cellular libraries of peptide sequences (clips) and methods of using the same |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| DE102005048898A1 (de) | 2005-10-12 | 2007-04-19 | Sanofi-Aventis Deutschland Gmbh | EGLN2-Varianten und ihre Verwendung bei der Vorbeugung oder Behandlung thromboembolischer Erkrankungen und koronarer Herzerkrankungen |
| CA3065947C (en) | 2005-10-18 | 2023-03-07 | National Jewish Health | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| US7749704B2 (en) | 2005-11-01 | 2010-07-06 | Mayo Foundation For Medical Education And Research | Promoter polymorphisms of the BLyS gene and use in diagnostic methods |
| CN106443006A (zh) | 2005-11-16 | 2017-02-22 | Ambrx公司 | 包括非天然氨基酸的方法和组合物 |
| JP2009516514A (ja) | 2005-11-21 | 2009-04-23 | ジェネンテック・インコーポレーテッド | 新規遺伝子破壊、それらに関する組成物および方法 |
| US8026354B2 (en) | 2005-11-23 | 2011-09-27 | Institut Pasteur | Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| EP2336164A1 (en) | 2005-12-22 | 2011-06-22 | Genentech, Inc. | Recombinant production of heparin binding proteins |
| US20080311107A1 (en) | 2006-02-17 | 2008-12-18 | Genetech, Inc. | Novel Gene Disruptions, Compositions and Methods Relating Thereto |
| JP2009536022A (ja) | 2006-04-19 | 2009-10-08 | ジェネンテック・インコーポレーテッド | 新規の遺伝子破壊、それに関連する組成物および方法 |
| US8592149B2 (en) | 2006-04-27 | 2013-11-26 | Pikamab, Inc. | Methods and compositions for antibody therapy |
| WO2009030978A2 (en) | 2006-06-09 | 2009-03-12 | Novartis Ag | Conformers of bacterial adhesins |
| WO2008005847A2 (en) | 2006-06-30 | 2008-01-10 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
| CA2663083A1 (en) | 2006-09-08 | 2008-03-13 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and their uses |
| US7985783B2 (en) | 2006-09-21 | 2011-07-26 | The Regents Of The University Of California | Aldehyde tags, uses thereof in site-specific protein modification |
| BRPI0716680A2 (pt) | 2006-11-02 | 2013-09-24 | Daniel J Capon | "composto, multÍmero, composiÇço, mÉtodo de afetar a atividade de um alvo, complexo, processo de produÇço do composto, mÉtodo de produÇço de um extensço de aminoÁcidos consecutivos, processo de produÇço de uma extensço de aminoacidos consecutivos , processo para a produÇço de um composto , mÉtodo de produÇço de uma proteina e polipeptÍdeo" |
| SI2140021T1 (sl) | 2007-02-22 | 2012-04-30 | Genentech Inc | Postopki za detekcijo vnetne ÄŤrevesne bolezni |
| CN107501407B (zh) | 2007-03-30 | 2022-03-18 | Ambrx公司 | 经修饰fgf-21多肽和其用途 |
| US8071741B2 (en) | 2007-04-20 | 2011-12-06 | Defiante Farmaceutica, S.A. | Stable recombinant adenosine deaminase |
| CA3090908A1 (en) | 2007-04-26 | 2008-11-06 | Aptevo Biotherapeutics Llc | Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same |
| SI2474557T1 (sl) | 2007-07-16 | 2014-12-31 | Genentech, Inc. | Protiteles proti CD79b in imunokonjugati in postopki za uporabo |
| CL2008002083A1 (es) | 2007-07-16 | 2008-11-21 | Genentech Inc | Anticuerpo humanizado anti-cd79b/igbeta/b29; inmunoconjugado; metodo in vitro para determinar presencia de cd79b, inhibir crecimiento de celula con cd79b, o para detectara celula b; metodo para elaborar dicho anticyerpo humanizado; acido nucleico; celula huesped; composicion; metodo de elaboracion de inmunoconjugado; uso medico |
| US8293685B2 (en) | 2007-07-26 | 2012-10-23 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| CN101361968B (zh) | 2007-08-06 | 2011-08-03 | 健能隆医药技术（上海）有限公司 | 白介素-22在治疗脂肪肝中的应用 |
| EA201000343A1 (ru) | 2007-10-04 | 2011-10-31 | Займодженетикс, Инк. | ЧЛЕН СЕМЕЙСТВА B7, zB7H6 И РОДСТВЕННЫЕ КОМПОЗИЦИИ И СПОСОБЫ |
| US20090233991A1 (en) | 2007-11-01 | 2009-09-17 | Hee Cheol Cho | Generation of biological pacemaker activity |
| WO2009059305A2 (en) | 2007-11-01 | 2009-05-07 | The University Of Chicago | Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation |
| MX338336B (es) | 2007-11-20 | 2016-04-07 | Ambrx Inc | Polipeptidos de insulina modificados y sus usos. |
| EP2222700A2 (en) | 2007-11-27 | 2010-09-01 | Medtronic, Inc. | Humanized anti-amyloid beta antibodies |
| WO2009073511A2 (en) | 2007-11-30 | 2009-06-11 | Mayo Foundation For Medical Education And Research | Polymorphisms of the blys gene and use in diagnostic methods |
| RS54883B1 (sr) | 2008-01-31 | 2016-10-31 | Genentech Inc | Anti-cd79b antitela i imunokonjugati i metode upotrebe |
| CA2712606A1 (en) | 2008-02-08 | 2009-08-13 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
| NZ587382A (en) | 2008-02-21 | 2012-01-12 | Novartis Ag | Meningococcal fhbp polypeptides |
| EP2279412B1 (en) | 2008-04-09 | 2017-07-26 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
| US8986702B2 (en) | 2008-05-16 | 2015-03-24 | Taiga Biotechnologies, Inc. | Antibodies and processes for preparing the same |
| UA118536C2 (uk) | 2008-07-23 | 2019-02-11 | Амбркс, Інк. | Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування |
| SG193831A1 (en) | 2008-08-28 | 2013-10-30 | Taiga Biotechnologies Inc | Modulators of myc, methods of using the same, and methods of identifying agents that modulate myc |
| NZ592249A (en) | 2008-09-26 | 2013-03-28 | Ambrx Inc | Non-natural amino acid replication-dependent microorganisms and vaccines |
| HUE035168T2 (en) | 2008-09-26 | 2018-05-02 | Ambrx Inc | Modified animal erythropoietin polypeptides and their applications |
| US9702877B2 (en) | 2008-10-31 | 2017-07-11 | Quest Diagnostics Investments Incorporated | BCR-ABL variants |
| CA2744555A1 (en) | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Compositions and methods for regulating collagen and smooth muscle actin expression by serpine2 |
| KR101544245B1 (ko) | 2009-02-03 | 2015-08-12 | 아뮤닉스 오퍼레이팅 인코포레이티드 | 연장된 재조합 폴리펩티드 및 이를 포함하는 조성물 |
| MX2011010264A (es) | 2009-04-01 | 2011-10-11 | Genentech Inc | Anticuerpos anti-fcrh5 e inmunoconjugados y metodos de uso. |
| EP2251025A1 (en) | 2009-05-12 | 2010-11-17 | Universitat Autònoma De Barcelona | Use of inclusion bodies as therapeutic agents |
| ITMI20090946A1 (it) | 2009-05-28 | 2010-11-29 | Novartis Ag | Espressione di proteine ricombinanti |
| LT2440241T (lt) | 2009-06-08 | 2017-10-10 | Amunix Operating Inc. | Augimo hormonų polipeptidai ir jų gamybos bei panaudojimo būdai |
| CA2764108A1 (en) | 2009-06-08 | 2010-12-16 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
| NZ597458A (en) | 2009-07-03 | 2014-01-31 | Bionor Immuno As | Hiv related peptides combination or fusion for use in hiv vaccine composition or as diagnostic means |
| JP5813641B2 (ja) | 2009-08-24 | 2015-11-17 | アムニクス オペレーティング インコーポレイテッド | 凝固第ｉｘ因子組成物ならびにそれを製造および使用する方法 |
| AU2010288240B2 (en) | 2009-08-27 | 2014-03-27 | Novartis Ag | Hybrid polypeptides including meningococcal fHBP sequences |
| WO2011041308A1 (en) | 2009-09-30 | 2011-04-07 | Quest Diagnostics Investments Incorporated | Bcr-abl truncation mutations |
| US20120219952A1 (en) | 2009-10-06 | 2012-08-30 | Patrice Nordmann | Carbapenemase and antibacterial treatment |
| RU2573896C2 (ru) | 2009-10-15 | 2016-01-27 | Дженентек, Инк. | Химерные факторы роста фибробластов с измененной рецепторной специфичностью |
| EP2490718B1 (en) | 2009-10-22 | 2016-01-13 | F.Hoffmann-La Roche Ag | Methods and compositions for modulating hepsin activation of macrophage-stimulating protein |
| WO2011056502A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Bone morphogenetic protein receptor type ii compositions and methods of use |
| WO2011056497A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use |
| WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| BR112012009997A2 (pt) | 2009-11-12 | 2019-09-24 | Genentech Inc | ''método para aumentar a densidade de espinhas dentriticas nos neurônios de um paciente com um distúrbios cognitivo ou psiquiatrico,método de manutenção da cognição em um sujeito durante o processo de envelhecimento,uso de um antagonista de dr6 na preparação de um medicamento para uso em um paciente com um disturbio cognitivo uo psiquíatrico e uso de um antagonista de p75 na preparação de um medicamento para uso em um paciente com um distúrbio cognitivo ou psiquiátrico'' |
| BR112012012750A2 (pt) | 2009-11-30 | 2020-08-11 | Genentech Inc | anticorpo isolado, célula, ácido nucleíco isolado e método |
| EA201290541A1 (ru) | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
| EP2516455A4 (en) | 2009-12-21 | 2013-05-22 | Ambrx Inc | MODIFIED SWINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES |
| FR2954349A1 (fr) | 2009-12-22 | 2011-06-24 | Agronomique Inst Nat Rech | Sulfatase modifiant selectivement les glycosaminoglycanes |
| AU2011221226A1 (en) | 2010-02-23 | 2012-08-16 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP2552967A4 (en) | 2010-04-02 | 2014-10-08 | Amunix Operating Inc | BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE |
| RU2636461C2 (ru) | 2010-05-03 | 2017-11-23 | Дженентек, Инк. | Композиции и способы для диагностики и лечения опухоли |
| EP2571894A1 (en) | 2010-05-19 | 2013-03-27 | North Carolina State University | Compositions and methods for the delivery of therapeutic peptides |
| WO2011149461A1 (en) | 2010-05-27 | 2011-12-01 | Medtronic, Inc. | Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules |
| ES2690760T3 (es) | 2010-06-25 | 2018-11-22 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Polipéptido de flagelina como agonista de TLR5 para su uso en el tratamiento de infecciones de las vías respiratorias |
| BR112013003646B1 (pt) | 2010-07-29 | 2021-09-08 | Eleven Biotherapeutics, Inc. | Proteína isolada que compreende um domínio de citocina da família de interleucina-1 (il-1) quimérica, seu método de preparação, composição farmacêutica e usos, bem como, ácido nucleico, vetor, e célula hospedeira |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| KR101963460B1 (ko) | 2010-08-17 | 2019-03-28 | 암브룩스, 인코포레이티드 | 변형된 릴랙신 폴리펩타이드 및 그것의 용도 |
| EP2420253A1 (en) | 2010-08-20 | 2012-02-22 | Leadartis, S.L. | Engineering multifunctional and multivalent molecules with collagen XV trimerization domain |
| US8846890B2 (en) | 2010-08-30 | 2014-09-30 | Board Of Trustees Of Michigan State University | Microbial nanowires |
| CN102380091A (zh) | 2010-08-31 | 2012-03-21 | 健能隆医药技术（上海）有限公司 | 白介素-22在治疗病毒性肝炎中的应用 |
| EP2616481A4 (en) | 2010-09-15 | 2014-04-02 | Aligna Technologies Inc | BIOPRODUCTION OF AROMATIC CHEMICALS FROM LIGNIN DERIVED COMPOUNDS |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| US20150139991A1 (en) | 2010-10-15 | 2015-05-21 | Leadartis, S.L. | Generation of multifunctional and multivalent polypeptide complexes with collagen xviii trimerization domain |
| EP2441776A1 (en) | 2010-10-15 | 2012-04-18 | Leadartis, S.L. | Generation of multifunctional and multivalent polypeptide complexes with collagen XVIII trimerization domain |
| EP2655607A4 (en) | 2010-12-21 | 2014-05-14 | Univ North Carolina | METHOD AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS |
| US8603740B2 (en) | 2010-12-29 | 2013-12-10 | Quest Diagnostics Investments Incorporated | BCR-ABL1 splice variants and uses thereof |
| WO2012095684A1 (en) | 2011-01-10 | 2012-07-19 | Inserm ( Institut National De La Sante Et De La Recherche Medicale) | Methods for the screening of substances useful for the prevention and treatment of neisseria infections |
| WO2012103240A2 (en) | 2011-01-25 | 2012-08-02 | Eleven Biotherapeutics, Inc. | Receptor binding agents |
| AU2012240102C1 (en) | 2011-04-08 | 2016-09-08 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) |
| WO2013011072A1 (en) | 2011-07-20 | 2013-01-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Carbapenemase and antibacterial treatment |
| WO2013019652A1 (en) | 2011-07-29 | 2013-02-07 | Eleven Biotherapeutics, Inc. | Purified proteins |
| WO2013033456A2 (en) | 2011-09-02 | 2013-03-07 | Board Of Trustees Of Michigan State University | Microbial nanowires and methods of making and using |
| EP2807266B1 (en) | 2012-01-26 | 2020-01-15 | Amgen Inc. | Growth differentiation factor 15 (gdf-15) polypeptides |
| SI2822577T1 (sl) | 2012-02-15 | 2019-07-31 | Bioverativ Therapeutics Inc. | Rekombinantni proteini faktorja VIII |
| EP3564260B1 (en) | 2012-02-15 | 2022-10-19 | Bioverativ Therapeutics Inc. | Factor viii compositions and methods of making and using same |
| MX366864B (es) | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Composiciones de conjugados de xten y métodos para realizarlas. |
| SG11201406112TA (en) | 2012-03-27 | 2014-10-30 | Genentech Inc | Improved harvest operations for recombinant proteins |
| EP2841087B1 (en) | 2012-04-27 | 2017-08-23 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Vascular endothelial growth factor antagonists and methods for their use |
| EA028929B1 (ru) | 2012-05-03 | 2018-01-31 | Зилэнд Фарма А/С | Аналоги глюкагоноподобного пептида-2 (glp-2) |
| HK1207829A1 (zh) | 2012-06-06 | 2016-02-12 | Bionor Immuno As | 疫苗 |
| AU2013292330B2 (en) | 2012-07-20 | 2018-07-12 | Htyr Acquisition Llc | Enhanced reconstitution and autoreconstitution of the hematopoietic compartment |
| WO2014026136A2 (en) | 2012-08-10 | 2014-02-13 | Cytomx Therapeutics, Inc. | Protease-resistant systems for polypeptide display and methods of making and using thereof |
| JP2015536148A (ja) | 2012-11-20 | 2015-12-21 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 改変第ｉｘ因子タンパク質についての方法および組成物 |
| WO2014088934A1 (en) | 2012-12-07 | 2014-06-12 | Danisco Us Inc. | Compositions and methods of use |
| BR112015012968A2 (pt) | 2012-12-07 | 2017-09-12 | Danisco Us Inc | composições e métodos de uso |
| US10272115B2 (en) | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
| CN105392494A (zh) | 2013-03-13 | 2016-03-09 | 十一生物治疗股份有限公司 | 用于眼部递送的嵌合细胞因子制剂 |
| ES2759061T3 (es) | 2013-03-15 | 2020-05-07 | Biomolecular Holdings Llc | Inmunoglobulina híbrida que contiene unión no peptidílica |
| HK1218424A1 (zh) | 2013-03-15 | 2017-02-17 | F. Hoffmann-La Roche Ag | Il-22多肽和il-22 fc融合蛋白及其使用方法 |
| WO2015007337A1 (en) | 2013-07-19 | 2015-01-22 | Bionor Immuno As | Method for the vaccination against hiv |
| WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
| US10767156B2 (en) | 2013-10-24 | 2020-09-08 | Yeda Research And Development Co., Ltd. | Polynucleotides encoding BREX system polypeptides and methods of using same |
| RU2016117275A (ru) | 2013-11-01 | 2017-12-04 | Сфериум Биомед С.Л. | Тельца включения для трансдермальной доставки терапевтических и косметических средств |
| CN104623637A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术（上海）有限公司 | Il-22二聚体在制备静脉注射药物中的应用 |
| WO2015116902A1 (en) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | G-protein coupled receptors in hedgehog signaling |
| PT3116486T (pt) | 2014-03-14 | 2020-03-12 | Biomolecular Holdings Llc | Imunoglobulina híbrida que contém uma ligação não peptídica |
| WO2016005508A1 (en) | 2014-07-11 | 2016-01-14 | Bionor Immuno As | Method for reducing and/or delaying pathological effects of human immunodeficiency virus i (hiv) or for reducing the risk of developing acquired immunodeficiency syndrome (aids) |
| US20170233707A1 (en) | 2014-09-30 | 2017-08-17 | Danisco Us Inc | Compositions comprising beta-mannanase and methods of use |
| US20170226494A1 (en) | 2014-09-30 | 2017-08-10 | Danisco Us Inc. | Compositions comprising beta-mannanase and methods of use |
| US20170218351A1 (en) | 2014-09-30 | 2017-08-03 | Danisco Us Inc. | Compositions comprising beta-mannanase and methods of use |
| EP3201330A1 (en) | 2014-09-30 | 2017-08-09 | Danisco US Inc. | Compositions comprising beta mannanase and methods of use |
| WO2016054168A1 (en) | 2014-09-30 | 2016-04-07 | Danisco Us Inc | Compositions comprising beta mannanase and methods of use |
| HUE055311T2 (hu) | 2014-10-24 | 2021-11-29 | Bristol Myers Squibb Co | Módosított FGF-21 polipeptidek és azok felhasználása |
| WO2016100837A1 (en) | 2014-12-18 | 2016-06-23 | Danisco Us Inc | Engineered multifunctional enzymes and methods of use |
| US20180002683A1 (en) | 2014-12-18 | 2018-01-04 | Danisco Us Inc. | Engineered multifunctional enzymes and methods of use |
| CA2975734C (en) | 2015-02-06 | 2025-02-18 | Univ North Carolina Chapel Hill | OPTIMIZED GENE EXPRESSION CASSETTES FOR HUMAN COAGULATION FACTOR VIII AND THEIR USE |
| PT3277821T (pt) | 2015-03-31 | 2019-10-31 | Novimmune Sa | Método para otimizar a montagem e produção de complexos proteicos hetero-multiméricos |
| WO2016177833A1 (en) | 2015-05-04 | 2016-11-10 | Bionor Immuno As | Dosage regimen for hiv vaccine |
| JP6909203B2 (ja) | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ｉｘ因子融合タンパク質及びそれらの製造方法及び使用方法 |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| MX394122B (es) | 2016-03-29 | 2025-03-24 | Geltor Inc | Expresión de proteínas en bacterias gram negativas en la que la relación del volumen periplasmático con respecto al volumen citoplasmático está entre 0.5:1 y 10:1 |
| CN109328069B (zh) | 2016-04-15 | 2023-09-01 | 亿一生物医药开发(上海)有限公司 | Il-22在治疗坏死性小肠结肠炎中的用途 |
| US10590426B2 (en) | 2016-08-22 | 2020-03-17 | Board Of Trustees Of Michigan State University | Genetic control of cell size |
| AU2017367730A1 (en) | 2016-12-02 | 2019-06-06 | Taiga Biotechnologies, Inc. | Nanoparticle formulations |
| ES2967947T3 (es) | 2016-12-06 | 2024-05-06 | Dsm Nutritional Products Llc | Polímeros de glicano y métodos relacionados de los mismos |
| IL250479A0 (en) | 2017-02-06 | 2017-03-30 | Sorek Rotem | Genetically engineered cells expressing a disarm system that confers resistance to phages and methods for their production |
| AU2018219283B2 (en) | 2017-02-08 | 2022-05-19 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| WO2018152496A1 (en) | 2017-02-17 | 2018-08-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Compositions and methods for the diagnosis and treatment of zika virus infection |
| US10149898B2 (en) | 2017-08-03 | 2018-12-11 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
| EP3490584B1 (en) | 2017-08-03 | 2021-12-08 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
| US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
| RU2020127792A (ru) | 2018-01-26 | 2022-02-28 | Дженентек, Инк. | СЛИТЫЕ БЕЛКИ IL-22- Fc И СПОСОБЫ ПРИМЕНЕНИЯ |
| CN112020365A (zh) | 2018-01-26 | 2020-12-01 | 豪夫迈·罗氏有限公司 | 组合物和使用方法 |
| EP3755364A1 (en) | 2018-02-21 | 2020-12-30 | F. Hoffmann-La Roche AG | Dosing for treatment with il-22 fc fusion proteins |
| IL258467A (en) | 2018-03-29 | 2018-07-04 | Ilana Kolodkin Gal | Methods of disrupting a biofilm and/or preventing formation of same |
| MA52205A (fr) | 2018-04-09 | 2021-02-17 | Amgen Inc | Protéines de fusion du facteur de différenciation de croissance 15 |
| TW202015723A (zh) | 2018-05-18 | 2020-05-01 | 美商百歐維拉提夫治療公司 | 治療ａ型血友病的方法 |
| CN112566939A (zh) | 2018-06-06 | 2021-03-26 | 利达提斯有限公司 | 三聚体多肽复合物及其用途 |
| EP4389145A3 (en) | 2018-09-11 | 2024-08-21 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
| WO2020202142A2 (en) | 2019-03-31 | 2020-10-08 | Yeda Research And Development Co. Ltd. | Anti-viral and anti-tumoral compounds |
| CA3132857A1 (en) | 2019-04-08 | 2020-10-15 | Yosef Refaeli | Compositions and methods for the cryopreservation of immune cells |
| CA3136691A1 (en) | 2019-04-12 | 2020-10-15 | Geltor, Inc. | Recombinant elastin and production thereof |
| KR20220034041A (ko) | 2019-05-14 | 2022-03-17 | 타이가 바이오테크놀로지스, 인코포레이티드 | T 세포 탈진을 치료하기 위한 조성물 및 방법 |
| KR102134418B1 (ko) * | 2019-06-17 | 2020-07-16 | 씨제이제일제당 주식회사 | L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법 |
| US20210070811A1 (en) | 2019-09-05 | 2021-03-11 | Board Of Trustees Of Michigan State University | Method for protein nanowire synthesis and tunable control of nanowire length |
| JP2023517595A (ja) | 2020-03-11 | 2023-04-26 | アンブルックス，インコーポレイテッド | インターロイキン－２ポリペプチド結合物およびその使用方法 |
| WO2021207662A1 (en) | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome |
| WO2022038539A2 (en) | 2020-08-18 | 2022-02-24 | Yeda Research And Development Co. Ltd. | Anti-viral and anti-tumoral compounds |
| US12448633B2 (en) | 2021-08-06 | 2025-10-21 | The Board Of Trustees Of The University Of Alabama | Bacterial N-demthylases as biocatalysts for the production of methylxanthines |
| IL288680A (en) | 2021-12-05 | 2023-07-01 | Yeda Res & Dev | Genetically modified phages and their use |
| EP4638773A1 (en) | 2022-12-23 | 2025-10-29 | Thermo Fisher Scientific Baltics Uab | Closed system for expressing recombinant proteins using e. coli and methods for producing clarified cell cultures thereof |
| WO2024175778A2 (en) | 2023-02-23 | 2024-08-29 | Micropep Technologies S.A. | Antifungal peptides to control plant pathogens |
| WO2025215636A1 (en) | 2024-04-08 | 2025-10-16 | Yeda Research And Development Co. Ltd. | Anti-defense system polypeptides and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237224A (en) * | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
| US4366246A (en) * | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
| DK173092B1 (da) * | 1977-11-08 | 2000-01-10 | Genentech Inc | Rekombinant plasmid, fremgangsmåde til fremstilling af plasmidet, bakterie indeholdende plasmidet, samt fremgangsmåde til f |
| US4631257A (en) | 1978-12-26 | 1986-12-23 | Cetus Corporation | Stable high copy number plasmids |
| FI793884A7 (fi) * | 1978-12-26 | 1981-01-01 | Cetus Corp | Vakaita runsaasti jäljentyviä plasmideja. |
| US4332892A (en) | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
| DK159976C (da) | 1979-06-01 | 1991-05-27 | Searle & Co | Plasmidvektorer, fremgangsmaade til fremstilling deraf, bakterieceller transformeret med plasmidvektorer samt udtrykkelse af protein i transformerede bakterieceller |
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| GB2068970B (en) * | 1980-02-06 | 1983-06-22 | Searle & Co | Recombinant dna technique for the preparation of a protein resembling human interferon |
| DK33181A (da) * | 1980-02-06 | 1981-08-07 | Searle & Co | Fremgangsmaade til fremstilling af et interferonlignende protein |
| CH651308A5 (de) * | 1980-07-01 | 1985-09-13 | Hoffmann La Roche | Interferone und deren herstellung. |
| GR81946B (enExample) * | 1980-09-25 | 1984-12-12 | Genentech Inc | |
| JPS5780398A (en) * | 1980-11-05 | 1982-05-19 | Sanraku Inc | Plasmid produced by genetic manipulation, coliform bacillus having the same and preparation of tryptophan with said bacillus |
| DK489481A (da) * | 1980-11-10 | 1982-05-11 | Searle & Co | Plasmidvektor og frmgangsmaade til fremstilling deraf |
| US5145782A (en) * | 1980-12-08 | 1992-09-08 | The Regents Of The University Of California | DNA expression vector suitable for direct expression of a foreign gene |
| ATE22327T1 (de) * | 1980-12-12 | 1986-10-15 | Unilever Nv | Dna-sequenzen fuer verschiedene allele formen des reifen thaumatins, diese sequenzen enthaltende rekombinante plasmide, verfahren zur herstellung dieser plasmide, diese rekombinante plasmide enthaltende bakterielle kulturen und verfahren zur herstellung von reifen thaumatin. |
-
1981
- 1981-03-02 ZA ZA00811368A patent/ZA811368B/xx unknown
- 1981-03-03 BG BG078443A patent/BG46005A3/xx unknown
- 1981-03-13 ZW ZW54/81A patent/ZW5481A1/xx unknown
- 1981-03-20 CA CA000373565A patent/CA1198068A/en not_active Expired
- 1981-03-20 FI FI810876A patent/FI810876L/fi not_active Application Discontinuation
- 1981-03-20 FI FI853488A patent/FI853488L/fi not_active Application Discontinuation
- 1981-03-20 GR GR64454A patent/GR74818B/el unknown
- 1981-03-23 DE DE19813111405 patent/DE3111405A1/de active Granted
- 1981-03-23 NZ NZ207659A patent/NZ207659A/en unknown
- 1981-03-23 DE DE8383200301T patent/DE3176205D1/de not_active Expired
- 1981-03-23 AT AT85100548T patent/ATE52802T1/de not_active IP Right Cessation
- 1981-03-23 PH PH25398A patent/PH17537A/en unknown
- 1981-03-23 BG BG051341A patent/BG42526A3/xx unknown
- 1981-03-23 HU HU81732A patent/HU195534B/hu unknown
- 1981-03-23 DE DE3153606A patent/DE3153606C2/de not_active Expired - Lifetime
- 1981-03-23 EP EP85100548A patent/EP0154133B1/en not_active Expired - Lifetime
- 1981-03-23 AT AT81301227T patent/ATE34183T1/de active
- 1981-03-23 PT PT72716A patent/PT72716B/pt unknown
- 1981-03-23 NO NO810986A patent/NO810986L/no unknown
- 1981-03-23 DE DE8181301227T patent/DE3176737D1/de not_active Expired
- 1981-03-23 AT AT83200301T patent/ATE27306T1/de not_active IP Right Cessation
- 1981-03-23 CS CS816230A patent/CS238645B2/cs unknown
- 1981-03-23 EP EP81301227A patent/EP0036776B1/en not_active Expired
- 1981-03-23 DD DD81243409A patent/DD204494A5/de unknown
- 1981-03-23 ES ES500617A patent/ES8207220A1/es not_active Expired
- 1981-03-23 IT IT67406/81A patent/IT1144324B/it active
- 1981-03-23 AU AU68636/81A patent/AU542640B2/en not_active Expired
- 1981-03-23 OA OA57360A patent/OA06774A/xx unknown
- 1981-03-23 IE IE636/81A patent/IE51892B1/en not_active IP Right Cessation
- 1981-03-23 GB GB8108986A patent/GB2073203B/en not_active Expired
- 1981-03-23 FR FR8105732A patent/FR2480781B1/fr not_active Expired
- 1981-03-23 CS CS816231A patent/CS238646B2/cs unknown
- 1981-03-23 DD DD81243408A patent/DD203746A5/de unknown
- 1981-03-23 BG BG078444A patent/BG45220A3/xx unknown
- 1981-03-23 DE DE8585100548T patent/DE3177179D1/de not_active Expired - Lifetime
- 1981-03-23 EP EP83200301A patent/EP0086548B1/en not_active Expired
- 1981-03-23 JP JP56040529A patent/JPH0724582B2/ja not_active Expired - Lifetime
- 1981-03-23 DK DK198101299A patent/DK173085B1/da active
- 1981-03-23 IE IE656/86A patent/IE51893B1/en not_active IP Right Cessation
- 1981-03-23 BR BR8101712A patent/BR8101712A/pt not_active IP Right Cessation
- 1981-03-23 IL IL62460A patent/IL62460A/xx not_active IP Right Cessation
- 1981-03-23 YU YU756/81A patent/YU45534B/xx unknown
- 1981-03-23 IL IL71885A patent/IL71885A/xx not_active IP Right Cessation
- 1981-03-23 NZ NZ207660A patent/NZ207660A/en unknown
- 1981-03-23 AR AR81284705A patent/AR248050A1/es active
- 1981-03-23 DD DD81228534A patent/DD159435A5/de unknown
- 1981-03-23 CS CS812106A patent/CS238612B2/cs unknown
- 1981-03-23 NZ NZ196584A patent/NZ196584A/en unknown
- 1981-03-23 KR KR1019810000949A patent/KR830005351A/ko not_active Ceased
- 1981-03-23 IE IE657/86A patent/IE51894B1/en not_active IP Right Cessation
- 1981-03-24 MX MX81101935U patent/MX7689E/es unknown
- 1981-03-24 PL PL1981252630A patent/PL147727B1/pl unknown
- 1981-03-24 PL PL81230296A patent/PL162227B1/pl unknown
- 1981-03-24 DZ DZ816135A patent/DZ278A1/fr active
-
1982
- 1982-02-26 ES ES509935A patent/ES509935A0/es active Granted
- 1982-02-26 ES ES509936A patent/ES509936A0/es active Granted
- 1982-11-12 PH PH28135A patent/PH20736A/en unknown
- 1982-11-12 PH PH28133A patent/PH18915A/en unknown
- 1982-11-12 PH PH28134A patent/PH20110A/en unknown
-
1984
- 1984-02-14 YU YU00260/84A patent/YU26084A/xx unknown
- 1984-05-21 IL IL71885A patent/IL71885A0/xx unknown
- 1984-06-27 AU AU29963/84A patent/AU585832B2/en not_active Expired
- 1984-06-27 AU AU29964/84A patent/AU580959B2/en not_active Expired
- 1984-09-18 NO NO84843719A patent/NO165644C/no not_active IP Right Cessation
- 1984-09-18 NO NO84843718A patent/NO161572C/no not_active IP Right Cessation
- 1984-12-19 FR FR8419450A patent/FR2555199B1/fr not_active Expired
-
1985
- 1985-05-21 CA CA000482003A patent/CA1213539A/en not_active Expired
- 1985-09-12 FI FI853489A patent/FI72344C/fi not_active IP Right Cessation
- 1985-12-30 MY MY896/85A patent/MY8500896A/xx unknown
-
1986
- 1986-03-29 KR KR1019860002404A patent/KR860001230B1/ko not_active Expired
-
1992
- 1992-10-13 JP JP4274172A patent/JPH0734747B2/ja not_active Expired - Lifetime
- 1992-10-13 JP JP4274165A patent/JPH0673469B2/ja not_active Expired - Lifetime
-
1993
- 1993-04-29 US US08/055,960 patent/US5888808A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/482,321 patent/US6333174B1/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR830005351A (ko) | 트립토판 촉진유전자-작동유전자를 이용한 세균성 폴리펩티드의 제조방법 | |
| Rosenberg et al. | Effects of consecutive AGG codons on translation in Escherichia coli, demonstrated with a versatile codon test system | |
| KR830005355A (ko) | 박테리아숙주내에서 각종 폴리펩타이드를 합성하는 방법 및 폴리펩타이드 dna | |
| Chen et al. | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA | |
| Zieg et al. | Analysis of the nucleotide sequence of an invertible controlling element. | |
| KR880014110A (ko) | 인체 프로아포지방단백질 a-i의 발현 | |
| Peschke et al. | Efficient utilization of Escherichia coli transcriptional signals in Bacillus subtilis | |
| KR860000381A (ko) | 트롬빈 억제제의 제조방법 | |
| HK87584A (en) | Bacterial plasmid encoding human growth hormone | |
| ATE42114T1 (de) | Mikrobiologisch hergestelltes interferon alpha2(arg), dna-sequenz, die fuer dieses interferon codiert, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung. | |
| SE455794B (sv) | Plasmid med nukleotidsekvens som kodar for aminosyrasekvensen i humant tillvexthormon och forfarande for framstellning derav | |
| NO874879L (no) | Fremgangsmaate til syntese av sukkernukleotider ved bruk av rekombinant-dna-metoder. | |
| Olsson et al. | Identification of a novel ampC beta‐lactamase promoter in a clinical isolate of Escherichia coli. | |
| Reznikoff et al. | E. coli promoters. | |
| US4663283A (en) | Method of altering double-stranded DNA | |
| Renaudin et al. | Spiroplasma virus 4: nucleotide sequence of the viral DNA, regulatory signals, and proposed genome organization | |
| ATE542913T1 (de) | Promotorvarianten zur expression von genen in einer pilzzelle | |
| HU202585B (en) | Process for protecting e. coli bacterium from natural bacteriofag | |
| PT80542B (pt) | Processo de tecnologia genetica para a preparacao de interleucina-2 humana | |
| US6063595A (en) | Method of forming a macromolecular microgene polymer | |
| KR870003201A (ko) | 새로운 플라스미드의 제조방법 | |
| Osipiuk et al. | Cloning, sequencing, and expression of dnaK-operon proteins from the thermophilic bacterium Thermus thermophilus | |
| US6506590B1 (en) | Plasmids, their construction and their use in the manufacture of interleukin-4 and interleukin-4 muteins | |
| RU98121521A (ru) | Модифицированная днк-полимераза из carboxydothermus hydrogenoformans и ее применение для спаренной (сопряженной) обратной транскрипции и цепной полимеразной реакции | |
| KR20050009118A (ko) | 티벡터와 발현벡터로의 기능을 동시에 가지는 플라스미드및 이를 이용한 목적유전자의 발현 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19810323 |
|
| PG1501 | Laying open of application | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19860129 Patent event code: PE09021S01D |
|
| PE0601 | Decision on rejection of patent |
Patent event date: 19860729 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19860129 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |