KR880014110A - 인체 프로아포지방단백질 a-i의 발현 - Google Patents
인체 프로아포지방단백질 a-i의 발현 Download PDFInfo
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- KR880014110A KR880014110A KR1019880006286A KR880006286A KR880014110A KR 880014110 A KR880014110 A KR 880014110A KR 1019880006286 A KR1019880006286 A KR 1019880006286A KR 880006286 A KR880006286 A KR 880006286A KR 880014110 A KR880014110 A KR 880014110A
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- dna sequence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1a, b도는 인간의 프레프로아포 A-I에 대한 누클레오티드 및 아미노산 배열을 타나낸도. 제 2 도는 개시 ATG 코돈과 함께, 프로펩티드의 6아미노산 및 성숙한 아포 A-I 폴리펩티드의 처음 14 아미노산에 대한 DNA 조각 코딩의 조립을 위한 올리고누클레오틱어댑러의 합성개략도를 나타낸도, 제 3 도는 PL람다 조절 부위 및 프로아포 A-I 누클레오티드 배열을 지니는 PULB9291의 조립을 나타낸도.
Claims (13)
- 천연 암호배열의 부분이, 동일한 아미노산을 암호와 하지만, 헤이핀의 형성을 감소시키거나 또는 방지시키는 것과 같은 상이한 누클레오티드 배열로 이루어지는 DNA 조각에 의해서 교체되었음을 특징으로 하는, 인간의 프로아포지방단백 A-I를 암호화하는 배열로 이루어 지는 재조합 DNA 배열.
- 제 1 항에 있어서, 프로아포지방단백 A-I의 아니모산 -6 내지 +14를 암호화하는 천연배열이 배열(한가닥만 나타냈음); 5' -ATGAGACATTTCTGGCAGCAGGACGAACCTCCACAATCTCCTTGGGATAGAGTTAAGGACTTG-3'에 의해 교체되고, 이 배열을 첨가된 ATG 해독개시코돈 및 아미노산 잔기 -6, -1, +1, +3, +4, +5, +6, +7, +10, +11 및 +14에 대한 변경된 코돈으로 이루어짐을 특징으로 하는 재조합 DNA 배열.
- 제 1 또는 2 항의 재조합 DNA 배열로 이루어지는 복제성 클로닝 벡타.
- 조작에 의해 조절 DNA 배열에 결합되며 해독개시 및 정지신호에 의해 플랭크 되는 제1 또는 2항의 재조합 DNA 배열로 이루어지는 발현 벡타.
- 제 4 항에 있어서, 조절 DNA 배열이 파지람다 PL프로모터 부위로 이루어짐을 특징으로 하는 발현 벡타.
- 제 4 항에 있어서, 인간의 프로아포지방단백 A-I DNA 배열이 베타-갈락토시데이스 DNA 배열에 융합되고 조절 DNA 배열이 lac 프로모터부위로 이루어짐을 특징으로 하는 발현 벡타.
- 제 4 항에 있어서, 조절 DNA 배열이 효모 ARG3 프로모터 및 전사 종결부위로 이루어짐을 특징으로 하는 발현 섹타.
- 제 4 항에 있어서, ATG 코돈이 부족한 인간의 프로아포지방단백 A-I DNA 배열이 E.Coli OmpA 단백질 신호펩티드의 DNA 배열에 융합되고 조절 1pp 배열이 및 프로모터 lac 프로모터-오페레이터 부위로 이루어짐을 특징으로 하는 발현 벡타.
- 제 4 항에 있어서, 조절 DNA 배열이 바클로비루스 폴리헤드린 유전자 프로모터 부위로 이루어짐을 특징으로 하는 발현 벡타.
- PULB 9291, PULB 9292, PULB 9296, PULB 9299, PNIV1612 및 PNIV1613으로 이루어지는군으로부터 선택된 재조합 플라스미드.
- 제 4 내지 9항의 어느 한 항의 발현 벡타로 전형된 세포 배양물 또는 미생물.
- 제 10 항의 재조합 플라스미드로 전형된 세포 배양물 또는 미생물.
- 제 11 또는 12항의 전형된 세포 또는 미생물을 적당한 배양조건하에서 배양하고 이렇게 생산된 인간의 프로아포지방단백 A-I 회수하는 것으로 이루어지는 인간의 프로아포지방단백 A-I를 생산하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878712540A GB8712540D0 (en) | 1987-05-28 | 1987-05-28 | Expression of human proapolipoprotein a-i |
| BE8712540 | 1987-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR880014110A true KR880014110A (ko) | 1988-12-22 |
| KR970000808B1 KR970000808B1 (en) | 1997-01-20 |
Family
ID=10618034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR88006286A KR970000808B1 (en) | 1987-05-28 | 1988-05-28 | Human proapolipoprotein a-1 expression |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5059528A (ko) |
| EP (1) | EP0293357B1 (ko) |
| JP (1) | JP2634193B2 (ko) |
| KR (1) | KR970000808B1 (ko) |
| CN (1) | CN1031892C (ko) |
| AT (1) | ATE89006T1 (ko) |
| AU (1) | AU615654B2 (ko) |
| CA (1) | CA1323851C (ko) |
| CY (1) | CY1809A (ko) |
| CZ (1) | CZ283648B6 (ko) |
| DD (1) | DD291093A5 (ko) |
| DE (1) | DE3880739T2 (ko) |
| DK (1) | DK175686B1 (ko) |
| EG (1) | EG19101A (ko) |
| ES (1) | ES2054878T3 (ko) |
| FI (1) | FI100056B (ko) |
| GB (1) | GB8712540D0 (ko) |
| HK (1) | HK137794A (ko) |
| HU (1) | HU204562B (ko) |
| IE (1) | IE62422B1 (ko) |
| IL (1) | IL86480A (ko) |
| LT (1) | LT3600B (ko) |
| LV (1) | LV5288A3 (ko) |
| NO (1) | NO179253C (ko) |
| NZ (1) | NZ224808A (ko) |
| PL (1) | PL158064B1 (ko) |
| PT (1) | PT87562B (ko) |
| RU (1) | RU2009198C1 (ko) |
| SG (1) | SG131594G (ko) |
| SK (1) | SK279166B6 (ko) |
| SU (1) | SU1834904A3 (ko) |
| UA (1) | UA19765A (ko) |
| ZA (1) | ZA883824B (ko) |
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| JP2606228B2 (ja) * | 1987-09-18 | 1997-04-30 | 三菱化学株式会社 | ヒトプロアポリポプロテインａ−ｉ様蛋白の産生法 |
| EP0345155B1 (en) * | 1988-05-31 | 1994-08-10 | Mitsubishi Kasei Corporation | Process for producing natural human apolipoprotein e-like proteins |
| US5846799A (en) * | 1988-06-14 | 1998-12-08 | La Region Wallone | Human myeloperoxidase and its therapeutic application |
| US5460961A (en) * | 1988-06-14 | 1995-10-24 | La Region Wallonne | Human myeloperoxidase and its therapeutic application |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| DK0574402T3 (da) * | 1990-11-26 | 1998-05-18 | Chiron Corp | Ekspression af PACE i værtsceller og fremgangsmåder til anvendelse deraf |
| WO1992010760A1 (en) * | 1990-11-30 | 1992-06-25 | Monoclonetics International, Incorporated | Methods for the diagnosis of chronic lower back and cervical pain |
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| US5994061A (en) * | 1995-09-29 | 1999-11-30 | Queen's University At Kingston | DNA constructs and methods for screening for increased expression of human apo AI gene |
| SE9603068D0 (sv) | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
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|---|---|---|---|---|
| AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
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| WO1986004920A1 (en) | 1985-02-13 | 1986-08-28 | Biotechnology Research Partners, Limited | Human metallothionein-ii promoter in mammalian expression system |
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-
1987
- 1987-05-28 GB GB878712540A patent/GB8712540D0/en active Pending
-
1988
- 1988-05-16 CA CA000566894A patent/CA1323851C/en not_active Expired - Fee Related
- 1988-05-24 DE DE8888870095T patent/DE3880739T2/de not_active Expired - Lifetime
- 1988-05-24 AT AT88870095T patent/ATE89006T1/de not_active IP Right Cessation
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