ATE89006T1 - Expression von menschlichem proapolipoprotein a- 1. - Google Patents
Expression von menschlichem proapolipoprotein a- 1.Info
- Publication number
- ATE89006T1 ATE89006T1 AT88870095T AT88870095T ATE89006T1 AT E89006 T1 ATE89006 T1 AT E89006T1 AT 88870095 T AT88870095 T AT 88870095T AT 88870095 T AT88870095 T AT 88870095T AT E89006 T1 ATE89006 T1 AT E89006T1
- Authority
- AT
- Austria
- Prior art keywords
- proapolipoprotein
- sequence
- expression
- expression vectors
- dna sequences
- Prior art date
Links
- 239000013604 expression vector Substances 0.000 abstract 2
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 101500024696 Homo sapiens Proapolipoprotein A-I Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 101800000571 Proapolipoprotein A-I Proteins 0.000 abstract 1
- 102400000658 Proapolipoprotein A-I Human genes 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878712540A GB8712540D0 (en) | 1987-05-28 | 1987-05-28 | Expression of human proapolipoprotein a-i |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE89006T1 true ATE89006T1 (de) | 1993-05-15 |
Family
ID=10618034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88870095T ATE89006T1 (de) | 1987-05-28 | 1988-05-24 | Expression von menschlichem proapolipoprotein a- 1. |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5059528A (de) |
| EP (1) | EP0293357B1 (de) |
| JP (1) | JP2634193B2 (de) |
| KR (1) | KR970000808B1 (de) |
| CN (1) | CN1031892C (de) |
| AT (1) | ATE89006T1 (de) |
| AU (1) | AU615654B2 (de) |
| CA (1) | CA1323851C (de) |
| CY (1) | CY1809A (de) |
| CZ (1) | CZ283648B6 (de) |
| DD (1) | DD291093A5 (de) |
| DE (1) | DE3880739T2 (de) |
| DK (1) | DK175686B1 (de) |
| EG (1) | EG19101A (de) |
| ES (1) | ES2054878T3 (de) |
| FI (1) | FI100056B (de) |
| GB (1) | GB8712540D0 (de) |
| HK (1) | HK137794A (de) |
| HU (1) | HU204562B (de) |
| IE (1) | IE62422B1 (de) |
| IL (1) | IL86480A (de) |
| LT (1) | LT3600B (de) |
| LV (1) | LV5288A3 (de) |
| NO (1) | NO179253C (de) |
| NZ (1) | NZ224808A (de) |
| PL (1) | PL158064B1 (de) |
| PT (1) | PT87562B (de) |
| RU (1) | RU2009198C1 (de) |
| SG (1) | SG131594G (de) |
| SK (1) | SK279166B6 (de) |
| SU (1) | SU1834904A3 (de) |
| UA (1) | UA19765A (de) |
| ZA (1) | ZA883824B (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
| JP2606228B2 (ja) * | 1987-09-18 | 1997-04-30 | 三菱化学株式会社 | ヒトプロアポリポプロテインａ−ｉ様蛋白の産生法 |
| DE68917379T2 (de) * | 1988-05-31 | 1994-12-01 | Mitsubishi Chem Ind | Verfahren zur Herstellung von Proteinen, die ähnlich dem natürlich-menschlichen Apolipoprotein-E sind. |
| US5846799A (en) * | 1988-06-14 | 1998-12-08 | La Region Wallone | Human myeloperoxidase and its therapeutic application |
| US5460961A (en) * | 1988-06-14 | 1995-10-24 | La Region Wallonne | Human myeloperoxidase and its therapeutic application |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| ES2109336T3 (es) * | 1990-11-26 | 1998-01-16 | Genetics Inst | Expresion de pace en celulas huesped y metodos de utilizacion de la misma. |
| US5844097A (en) * | 1990-11-30 | 1998-12-01 | Monoclonetics International, Inc. | Methods for the diagnosis of peripheral nerve damage |
| DK0559795T3 (da) * | 1990-11-30 | 1996-01-29 | Monoclonetics Int | Fremgangsmåder til diagnosticering af kroniske smerter i lænderegionen og halshvrivelsøjlen |
| GB9508618D0 (en) * | 1995-04-28 | 1995-06-14 | Applied Research Systems | Therapeutic protein |
| SE9500778D0 (sv) | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| US5994061A (en) * | 1995-09-29 | 1999-11-30 | Queen's University At Kingston | DNA constructs and methods for screening for increased expression of human apo AI gene |
| SE9603068D0 (sv) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603303D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (sv) * | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
| KR100330355B1 (ko) * | 1999-06-04 | 2002-04-01 | 장인순 | 회전유동발생 날개를 가진 덕트형 핵연료 집합체 지지격자 |
| US20040047853A1 (en) * | 2000-06-09 | 2004-03-11 | Dahl Soren W | Purified proenzyme of dipeptidyl peptidase i (pro-dppi) |
| EP1341919A2 (de) * | 2000-12-12 | 2003-09-10 | Lexicon Genetics Incorporated | Neuartige menschliche kinasen sowie anwendungen derselben |
| KR100560102B1 (ko) * | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | 프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제 |
| US7427662B2 (en) * | 2005-02-01 | 2008-09-23 | Baord Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Inhibition of angiogenesis and destruction of angiogenic vessels by apolipoprotein A-I and high density lipoprotein |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| EP1917278A2 (de) * | 2005-08-26 | 2008-05-07 | Cerenis Therapeutics Holding SA | Zusammensetzungen und verfahren für die herstellung von apolipoprotein gene produkten in lactic acid bakterien |
| US20080293102A1 (en) * | 2007-02-28 | 2008-11-27 | Cerenis Therapeutics Holding, S.A. | Compositions and methods for producing apolipoprotein |
| RU2604489C2 (ru) * | 2008-10-03 | 2016-12-10 | КьюРНА,Инк.,US | Лечение заболеваний, связанных с аполипопротеином-а1, путем ингибирования природного антисмыслового транскрипта аполипопротеина-а1 |
| CN111909020A (zh) | 2008-11-10 | 2020-11-10 | 阿布特斯生物制药公司 | 用于递送治疗剂的脂质和组合物 |
| US20120101148A1 (en) | 2009-01-29 | 2012-04-26 | Alnylam Pharmaceuticals, Inc. | lipid formulation |
| CA2754043A1 (en) | 2009-03-12 | 2010-09-16 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes |
| KR20240015723A (ko) | 2009-05-05 | 2024-02-05 | 알닐람 파마슈티칼스 인코포레이티드 | 지질 조성물 |
| CN102459596B (zh) | 2009-05-06 | 2016-09-07 | 库尔纳公司 | 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病 |
| CA2764609C (en) | 2009-06-10 | 2018-10-02 | Alnylam Pharmaceuticals, Inc. | Improved cationic lipid of formula i |
| WO2011020023A2 (en) | 2009-08-14 | 2011-02-17 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
| WO2011044545A2 (en) | 2009-10-09 | 2011-04-14 | Sigalov Alexander B | Methods and compositions for targeted imaging |
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| AU2010328336B2 (en) | 2009-12-07 | 2017-03-02 | Arbutus Biopharma Corporation | Compositions for nucleic acid delivery |
| WO2011075656A1 (en) | 2009-12-18 | 2011-06-23 | The University Of British Columbia | Methods and compositions for delivery of nucleic acids |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| WO2011143362A1 (en) | 2010-05-11 | 2011-11-17 | Esperion Therapeutics, Inc. | Dimeric oxidation-resistant apolipoprotein a1 variants |
| ES3053320T3 (en) | 2010-06-03 | 2026-01-21 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| WO2012016188A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| WO2012016184A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| US9339513B2 (en) | 2010-11-09 | 2016-05-17 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes |
| EP3202760B1 (de) | 2011-01-11 | 2019-08-21 | Alnylam Pharmaceuticals, Inc. | Pegylierte lipide und deren verwendung zur wirkstofffreisetzung |
| CN103443123B (zh) | 2011-02-07 | 2020-05-29 | 塞勒尼斯医疗控股公司 | 脂蛋白复合物及其制备和用途 |
| JP6250543B2 (ja) | 2011-09-27 | 2017-12-20 | アルニラム・ファーマシューティカルズ・インコーポレーテッド | ジ脂肪族置換ｐｅｇ化脂質 |
| US9610324B2 (en) * | 2012-07-11 | 2017-04-04 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
| DK2991656T3 (da) * | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| EP2853259A1 (de) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Rekonstituierte hochdichte Lipoproteinzusammensetzung und Verwendungen davon |
| MX2016014306A (es) | 2014-05-02 | 2017-06-12 | Cerenis Therapeutics Holding Sa | Marcadores para terapia con lipoproteinas de alta densidad (hdl). |
| CN108473990A (zh) * | 2016-10-27 | 2018-08-31 | 中国科学院微生物研究所 | 氨基酸衰减子的改造方法及其在生产中的应用 |
| TW201919686A (zh) | 2017-08-10 | 2019-06-01 | 法商塞勒尼斯醫療控股公司 | 脫輔基子(apomers) |
| EP3668600B1 (de) | 2017-08-10 | 2024-05-15 | Abionyx Pharma SA | Cargomere |
| US11461863B2 (en) | 2018-08-24 | 2022-10-04 | Bright Marbles, Inc. | Idea assessment and landscape mapping |
| US11164065B2 (en) | 2018-08-24 | 2021-11-02 | Bright Marbles, Inc. | Ideation virtual assistant tools |
| US11081113B2 (en) | 2018-08-24 | 2021-08-03 | Bright Marbles, Inc. | Idea scoring for creativity tool selection |
| US11189267B2 (en) | 2018-08-24 | 2021-11-30 | Bright Marbles, Inc. | Intelligence-driven virtual assistant for automated idea documentation |
| JP2023522889A (ja) | 2020-04-16 | 2023-06-01 | アビオニクス ファーマ エスエー | 脂質結合タンパク質ベースの複合体を使用した、急性病態を治療するための方法 |
| JP2023543498A (ja) | 2020-10-01 | 2023-10-16 | アビオニクス ファーマ エスエー | 脂質結合タンパク質ベースの複合体を使用した、眼疾患を治療するための方法 |
| CN117479834A (zh) | 2021-04-15 | 2024-01-30 | 阿比奥尼克斯制药公司 | 基于脂质结合蛋白的复合物在器官保存溶液中的用途 |
| WO2023194798A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes |
| IL316110A (en) | 2022-04-06 | 2024-12-01 | Abionyx Pharma Sa | Methods for treating eye diseases using complexes based on fat-binding protein |
| CA3258787A1 (en) | 2022-06-10 | 2023-12-14 | Stanislas FAGUER | METHODS OF TREATMENT OF HYPERINFLAMMATORY DISEASES USING LIPID-BINDING PROTEIN COMPLEXES |
| EP4536269A2 (de) | 2022-06-10 | 2025-04-16 | Abionyx Pharma SA | Verfahren zur behandlung akuter erkrankungen mit lipidbindenden komplexen auf proteinbasis |
| IL322074A (en) | 2023-01-13 | 2025-09-01 | Abionyx Pharma Sa | Treatment using a lipid-binding protein molecule |
| WO2025093929A1 (en) | 2023-10-31 | 2025-05-08 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
| JPS6198998A (ja) | 1984-10-18 | 1986-05-17 | Matsushita Electric Ind Co Ltd | 電動送風機 |
| BE901119A (fr) | 1984-11-23 | 1985-03-15 | Wallone Region | Procede de preparation de plasmides vecteurs capables de transformer un hote bacterien escherichia coli et d'y promouvoir et controler l'expression d'un adn heterologue. |
| ATE89314T1 (de) | 1985-02-13 | 1993-05-15 | Scios Nova Inc | Menschlicher metallothionein ii-promotor in saeugetierexpressionssystemen. |
| GB8507833D0 (en) * | 1985-03-26 | 1985-05-01 | Biogen Nv | Production of human somatomedin c |
| AU6522486A (en) | 1985-10-04 | 1987-04-24 | Biotechnology Research Partners Limited | Recombinant apolipoproteins and methods |
| GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
| AU8273987A (en) * | 1986-10-29 | 1988-05-25 | Biotechnology Research Partners Limited | Apoai-ciii-aiv, apoaii apob , apoci, and ldl receptor polymorphisms for genetic fingerprinting and predictive of atherosclerosis |
-
1987
- 1987-05-28 GB GB878712540A patent/GB8712540D0/en active Pending
-
1988
- 1988-05-16 CA CA000566894A patent/CA1323851C/en not_active Expired - Fee Related
- 1988-05-24 DE DE8888870095T patent/DE3880739T2/de not_active Expired - Lifetime
- 1988-05-24 EP EP88870095A patent/EP0293357B1/de not_active Expired - Lifetime
- 1988-05-24 IL IL86480A patent/IL86480A/xx not_active IP Right Cessation
- 1988-05-24 AT AT88870095T patent/ATE89006T1/de not_active IP Right Cessation
- 1988-05-24 ES ES88870095T patent/ES2054878T3/es not_active Expired - Lifetime
- 1988-05-24 PT PT87562A patent/PT87562B/pt not_active IP Right Cessation
- 1988-05-25 FI FI882456A patent/FI100056B/fi not_active IP Right Cessation
- 1988-05-26 EG EG28288A patent/EG19101A/xx active
- 1988-05-26 UA UA4613079A patent/UA19765A/uk unknown
- 1988-05-26 NZ NZ224808A patent/NZ224808A/en unknown
- 1988-05-26 PL PL1988272698A patent/PL158064B1/pl unknown
- 1988-05-26 DD DD88316110A patent/DD291093A5/de not_active IP Right Cessation
- 1988-05-26 US US07/198,830 patent/US5059528A/en not_active Expired - Lifetime
- 1988-05-26 SU SU884356123A patent/SU1834904A3/ru active
- 1988-05-27 CZ CS883638A patent/CZ283648B6/cs not_active IP Right Cessation
- 1988-05-27 IE IE159788A patent/IE62422B1/en not_active IP Right Cessation
- 1988-05-27 SK SK3638-88A patent/SK279166B6/sk unknown
- 1988-05-27 AU AU16723/88A patent/AU615654B2/en not_active Ceased
- 1988-05-27 DK DK198802896A patent/DK175686B1/da not_active IP Right Cessation
- 1988-05-27 CN CN88103118A patent/CN1031892C/zh not_active Expired - Fee Related
- 1988-05-27 HU HU882707A patent/HU204562B/hu not_active IP Right Cessation
- 1988-05-27 ZA ZA883824A patent/ZA883824B/xx unknown
- 1988-05-27 JP JP63130033A patent/JP2634193B2/ja not_active Expired - Fee Related
- 1988-05-27 NO NO882341A patent/NO179253C/no not_active IP Right Cessation
- 1988-05-28 KR KR88006286A patent/KR970000808B1/ko not_active Expired - Fee Related
- 1988-12-20 RU SU884613079A patent/RU2009198C1/ru active
-
1993
- 1993-06-01 LV LV930445A patent/LV5288A3/xx unknown
- 1993-08-03 LT LTIP828A patent/LT3600B/lt not_active IP Right Cessation
-
1994
- 1994-09-12 SG SG131594A patent/SG131594G/en unknown
- 1994-12-08 HK HK137794A patent/HK137794A/xx not_active IP Right Cessation
-
1995
- 1995-10-20 CY CY180995A patent/CY1809A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |