HUT47153A - Process for producing recombinant dna sequence encoding human proapolypoprotein a-i, expression vector comprising it, as well as human proapolypoprotein a-i by applying same - Google Patents

Process for producing recombinant dna sequence encoding human proapolypoprotein a-i, expression vector comprising it, as well as human proapolypoprotein a-i by applying same

Info

Publication number
HUT47153A
HUT47153A HU882707A HU270788A HUT47153A HU T47153 A HUT47153 A HU T47153A HU 882707 A HU882707 A HU 882707A HU 270788 A HU270788 A HU 270788A HU T47153 A HUT47153 A HU T47153A
Authority
HU
Hungary
Prior art keywords
proapolypoprotein
human
recombinant dna
well
expression vector
Prior art date
Application number
HU882707A
Other languages
Hungarian (hu)
Other versions
HU204562B (en
Inventor
Alex Bollen
Jean Gobert
Ernst Wuelfert
Original Assignee
Alex Bollen
Jean Gobert
Ernst Wuelfert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alex Bollen, Jean Gobert, Ernst Wuelfert filed Critical Alex Bollen
Publication of HUT47153A publication Critical patent/HUT47153A/en
Publication of HU204562B publication Critical patent/HU204562B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.
HU882707A 1987-05-28 1988-05-27 Process for producing recombinant dns-sequency codin human proapolypo-protein a-i, expressing vector containing them, transformed hoste celle and human proapolypoprotein a-i HU204562B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878712540A GB8712540D0 (en) 1987-05-28 1987-05-28 Expression of human proapolipoprotein a-i

Publications (2)

Publication Number Publication Date
HUT47153A true HUT47153A (en) 1989-01-30
HU204562B HU204562B (en) 1992-01-28

Family

ID=10618034

Family Applications (1)

Application Number Title Priority Date Filing Date
HU882707A HU204562B (en) 1987-05-28 1988-05-27 Process for producing recombinant dns-sequency codin human proapolypo-protein a-i, expressing vector containing them, transformed hoste celle and human proapolypoprotein a-i

Country Status (33)

Country Link
US (1) US5059528A (en)
EP (1) EP0293357B1 (en)
JP (1) JP2634193B2 (en)
KR (1) KR970000808B1 (en)
CN (1) CN1031892C (en)
AT (1) ATE89006T1 (en)
AU (1) AU615654B2 (en)
CA (1) CA1323851C (en)
CY (1) CY1809A (en)
CZ (1) CZ283648B6 (en)
DD (1) DD291093A5 (en)
DE (1) DE3880739T2 (en)
DK (1) DK175686B1 (en)
EG (1) EG19101A (en)
ES (1) ES2054878T3 (en)
FI (1) FI100056B (en)
GB (1) GB8712540D0 (en)
HK (1) HK137794A (en)
HU (1) HU204562B (en)
IE (1) IE62422B1 (en)
IL (1) IL86480A (en)
LT (1) LT3600B (en)
LV (1) LV5288A3 (en)
NO (1) NO179253C (en)
NZ (1) NZ224808A (en)
PL (1) PL158064B1 (en)
PT (1) PT87562B (en)
RU (1) RU2009198C1 (en)
SG (1) SG131594G (en)
SK (1) SK363888A3 (en)
SU (1) SU1834904A3 (en)
UA (1) UA19765A (en)
ZA (1) ZA883824B (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU587989B2 (en) * 1984-10-16 1989-09-07 Mitsubishi Chemical Corporation DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins
JP2606228B2 (en) * 1987-09-18 1997-04-30 三菱化学株式会社 Method for producing human proapolipoprotein AI-like protein
DE68917379T2 (en) * 1988-05-31 1994-12-01 Mitsubishi Chem Ind Process for the production of proteins similar to natural human apolipoprotein-E.
US5460961A (en) * 1988-06-14 1995-10-24 La Region Wallonne Human myeloperoxidase and its therapeutic application
US5846799A (en) * 1988-06-14 1998-12-08 La Region Wallone Human myeloperoxidase and its therapeutic application
IT1229996B (en) * 1989-04-20 1991-09-20 Cesare Sirtori EXPRESSION OF APOLIPOPROTEIN AI AND APOLIPOPROTEIN AI-MILAN IN YEAST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE APOLIPOPROTEINS.
IE914102A1 (en) * 1990-11-26 1992-06-03 Genetics Inst Expression of pace in host cells and methods of use thereof
US5844097A (en) * 1990-11-30 1998-12-01 Monoclonetics International, Inc. Methods for the diagnosis of peripheral nerve damage
AU667462B2 (en) * 1990-11-30 1996-03-28 Monoclonetics International Incorporated Methods for the diagnosis of chronic lower back and cervical pain
SE9500778D0 (en) * 1995-03-03 1995-03-03 Pharmacia Ab Process for producing a protein
US5994061A (en) * 1995-09-29 1999-11-30 Queen's University At Kingston DNA constructs and methods for screening for increased expression of human apo AI gene
SE9603068D0 (en) * 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603304D0 (en) * 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a compound
SE9603303D0 (en) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a protein
KR100330355B1 (en) * 1999-06-04 2002-04-01 장인순 Duct type spacer grid with swirl flow vane in nuclear fuel assembly
US20040047853A1 (en) * 2000-06-09 2004-03-11 Dahl Soren W Purified proenzyme of dipeptidyl peptidase i (pro-dppi)
JP2004530417A (en) * 2000-12-12 2004-10-07 レキシコン・ジェネティクス・インコーポレーテッド Novel human kinase and polynucleotide encoding it
KR100560102B1 (en) * 2004-06-25 2006-03-13 한국생명공학연구원 Prophylactic and therapeutic agents containing point mutants of proapolipoprotein A-I for anti-atherosclerosis and anti-hyperlipidemia
US7427662B2 (en) * 2005-02-01 2008-09-23 Baord Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Inhibition of angiogenesis and destruction of angiogenic vessels by apolipoprotein A-I and high density lipoprotein
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
CN101253195A (en) * 2005-08-26 2008-08-27 科莱尼斯医疗控股公司 Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria
WO2008104890A2 (en) * 2007-02-28 2008-09-04 Cerenis Therapeutics Holding Sa Compositions and methods for producing apolipoprotein
MX339820B (en) * 2008-10-03 2016-06-13 Curna Inc Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1.
AU2009313201B2 (en) 2008-11-10 2016-06-16 Arbutus Biopharma Corporation Novel lipids and compositions for the delivery of therapeutics
CA3036963A1 (en) 2009-01-29 2010-08-05 Arbutus Biopharma Corporation Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
EP2406376A1 (en) 2009-03-12 2012-01-18 Alnylam Pharmaceuticals, Inc. LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
KR20220150411A (en) 2009-05-05 2022-11-10 알닐람 파마슈티칼스 인코포레이티드 Lipid compositions
JP5883782B2 (en) 2009-05-06 2016-03-15 クルナ・インコーポレーテッド Treatment of lipid transport metabolism gene-related diseases by suppression of natural antisense transcripts on lipid transport metabolism genes
PL3431076T3 (en) 2009-06-10 2022-01-31 Arbutus Biopharma Corporation Improved lipid formulation
US9029338B2 (en) 2009-08-14 2015-05-12 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
WO2011044545A2 (en) 2009-10-09 2011-04-14 Sigalov Alexander B Methods and compositions for targeted imaging
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
EP3296398A1 (en) 2009-12-07 2018-03-21 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
CA2784568A1 (en) 2009-12-18 2011-06-23 Martin A. Maier Lipid particles for delivery of nucleic acids
WO2011139911A2 (en) 2010-04-29 2011-11-10 Isis Pharmaceuticals, Inc. Lipid formulated single stranded rna
WO2011143362A1 (en) 2010-05-11 2011-11-17 Esperion Therapeutics, Inc. Dimeric oxidation-resistant apolipoprotein a1 variants
KR20190039347A (en) 2010-06-03 2019-04-10 알닐람 파마슈티칼스 인코포레이티드 Biodegradable lipids for the delivery of active agents
US20130323269A1 (en) 2010-07-30 2013-12-05 Muthiah Manoharan Methods and compositions for delivery of active agents
US20130202652A1 (en) 2010-07-30 2013-08-08 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
CN110123830A (en) 2010-11-09 2019-08-16 阿尔尼拉姆医药品有限公司 Composition and method for inhibiting the lipid of the expression of Eg5 and VEGF gene to prepare
AU2012207606B2 (en) 2011-01-11 2017-02-23 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
SI2673296T1 (en) 2011-02-07 2019-03-29 Cerenis Therapeutics Holding Sa Lipoprotein complexes and manufacturing and uses thereof
EP2760477B1 (en) 2011-09-27 2018-08-08 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted pegylated lipids
WO2014011908A1 (en) 2012-07-11 2014-01-16 Esperion Therapeutics, Inc. Apolipoprotein mixtures
BR112015027377B1 (en) * 2013-05-01 2023-01-10 Ionis Pharmaceuticals, Inc OLIGOMERIC COMPOUNDS WITH CONJUGATE GROUPS, COMPOSITIONS COMPRISING THE SAID COMPOUNDS AND USES THEREOF
EP2853259A1 (en) 2013-09-30 2015-04-01 Université Pierre et Marie Curie (Paris 6) Reconstituted high density lipoproteins composition and uses thereof
KR20170003611A (en) 2014-05-02 2017-01-09 세레니스 쎄라퓨틱스 홀딩 에스에이 Hdl therapy markers
CN108473990A (en) * 2016-10-27 2018-08-31 中国科学院微生物研究所 The remodeling method of amino acid attenuator and its application in production
EP3668549A1 (en) 2017-08-10 2020-06-24 Abionyx Pharma SA Apomers
WO2019030574A1 (en) 2017-08-10 2019-02-14 Cerenis Therapeutics Holding Cargomers
US11081113B2 (en) 2018-08-24 2021-08-03 Bright Marbles, Inc. Idea scoring for creativity tool selection
US11164065B2 (en) 2018-08-24 2021-11-02 Bright Marbles, Inc. Ideation virtual assistant tools
US11461863B2 (en) 2018-08-24 2022-10-04 Bright Marbles, Inc. Idea assessment and landscape mapping
US11189267B2 (en) 2018-08-24 2021-11-30 Bright Marbles, Inc. Intelligence-driven virtual assistant for automated idea documentation
AU2021256086A1 (en) 2020-04-16 2022-12-15 Abionyx Pharma Sa Methods for treating acute conditions using lipid binding protein- based complexes
CA3197168A1 (en) 2020-10-01 2022-04-07 Abionyx Pharma Sa Methods for treating eye diseases using lipid binding protein-based complexes
AU2022258815A1 (en) 2021-04-15 2023-10-19 Abionyx Pharma Sa Use of lipid binding protein-based complexes in organ preservation solutions
WO2023194797A1 (en) 2022-04-06 2023-10-12 Abionyx Pharma Sa Methods for treating eye diseases using lipid binding protein-based complexes
WO2023194798A1 (en) 2022-04-06 2023-10-12 Abionyx Pharma Sa Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes
WO2023237935A2 (en) 2022-06-10 2023-12-14 Abionyx Pharma Sa Methods for treating acute conditions using lipid binding protein-based complexes
WO2023237927A2 (en) 2022-06-10 2023-12-14 Abionyx Pharma Sa Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU587989B2 (en) * 1984-10-16 1989-09-07 Mitsubishi Chemical Corporation DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins
JPS6198998A (en) 1984-10-18 1986-05-17 Matsushita Electric Ind Co Ltd Electric fan
BE901119A (en) 1984-11-23 1985-03-15 Wallone Region PROCESS FOR THE PREPARATION OF VECTOR PLASMIDS CAPABLE OF TRANSFORMING A BACTERIAL HOST ESCHERICHIA COLI AND OF PROMOTING AND CONTROLLING THE EXPRESSION OF HETEROLOGOUS DNA IN IT.
AU580145B2 (en) 1985-02-13 1989-01-05 Scios Nova Inc. Human metallothionein-ii promoter in mammalian expression system
GB8507833D0 (en) * 1985-03-26 1985-05-01 Biogen Nv Production of human somatomedin c
WO1987002062A1 (en) 1985-10-04 1987-04-09 Biotechnology Research Partners, Ltd. Recombinant apolipoproteins and methods
GB8625435D0 (en) * 1986-10-23 1986-11-26 Erba Farmitalia Human apolipoprotein ai
AU8273987A (en) * 1986-10-29 1988-05-25 Biotechnology Research Partners Limited Apoai-ciii-aiv, apoaii apob , apoci, and ldl receptor polymorphisms for genetic fingerprinting and predictive of atherosclerosis

Also Published As

Publication number Publication date
EG19101A (en) 1994-09-29
LTIP828A (en) 1995-02-27
LV5288A3 (en) 1993-10-10
DK175686B1 (en) 2005-01-17
DE3880739T2 (en) 1993-08-19
AU615654B2 (en) 1991-10-10
CY1809A (en) 1995-10-20
KR970000808B1 (en) 1997-01-20
JPS6416589A (en) 1989-01-20
DD291093A5 (en) 1991-06-20
US5059528A (en) 1991-10-22
ATE89006T1 (en) 1993-05-15
ZA883824B (en) 1989-02-22
UA19765A (en) 1997-12-25
PL158064B1 (en) 1992-07-31
DK289688D0 (en) 1988-05-27
GB8712540D0 (en) 1987-07-01
CN1031892C (en) 1996-05-29
CN88103118A (en) 1988-12-14
HU204562B (en) 1992-01-28
IL86480A0 (en) 1988-11-15
KR880014110A (en) 1988-12-22
ES2054878T3 (en) 1994-08-16
NZ224808A (en) 1990-01-29
PT87562B (en) 1992-09-30
SG131594G (en) 1995-01-13
FI100056B (en) 1997-09-15
FI882456A0 (en) 1988-05-25
FI882456A (en) 1988-11-29
RU2009198C1 (en) 1994-03-15
SU1834904A3 (en) 1993-08-15
CA1323851C (en) 1993-11-02
DK289688A (en) 1988-11-29
AU1672388A (en) 1988-12-01
IE62422B1 (en) 1995-02-08
EP0293357B1 (en) 1993-05-05
NO179253B (en) 1996-05-28
CZ283648B6 (en) 1998-05-13
NO882341D0 (en) 1988-05-27
IE881597L (en) 1988-11-28
DE3880739D1 (en) 1993-06-09
LT3600B (en) 1995-12-27
SK279166B6 (en) 1998-07-08
PT87562A (en) 1989-05-31
IL86480A (en) 1992-08-18
SK363888A3 (en) 1998-07-08
HK137794A (en) 1994-12-16
NO882341L (en) 1988-11-29
JP2634193B2 (en) 1997-07-23
PL272698A1 (en) 1989-03-06
NO179253C (en) 1996-09-04
CZ363888A3 (en) 1998-02-18
EP0293357A1 (en) 1988-11-30

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Legal Events

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HPC4 Succession in title of patentee

Owner name: MINISTERE DE LA REGION WALLONNE, BE

HMM4 Cancellation of final prot. due to non-payment of fee