LTIP828A - Nucleic acid fragment which codes for human proapolipoprotein a-1 - Google Patents
Nucleic acid fragment which codes for human proapolipoprotein a-1Info
- Publication number
- LTIP828A LTIP828A LTIP828A LTIP828A LTIP828A LT IP828 A LTIP828 A LT IP828A LT IP828 A LTIP828 A LT IP828A LT IP828 A LTIP828 A LT IP828A LT IP828 A LTIP828 A LT IP828A
- Authority
- LT
- Lithuania
- Prior art keywords
- codes
- proapolipoprotein
- nucleic acid
- acid fragment
- sequence
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 239000013604 expression vector Substances 0.000 abstract 2
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 101500024696 Homo sapiens Proapolipoprotein A-I Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 101800000571 Proapolipoprotein A-I Proteins 0.000 abstract 1
- 102400000658 Proapolipoprotein A-I Human genes 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878712540A GB8712540D0 (en) | 1987-05-28 | 1987-05-28 | Expression of human proapolipoprotein a-i |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP828A true LTIP828A (en) | 1995-02-27 |
| LT3600B LT3600B (en) | 1995-12-27 |
Family
ID=10618034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP828A LT3600B (en) | 1987-05-28 | 1993-08-03 | Nucleic acid fragment which codes for human proapolipoprotein a-i |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5059528A (en) |
| EP (1) | EP0293357B1 (en) |
| JP (1) | JP2634193B2 (en) |
| KR (1) | KR970000808B1 (en) |
| CN (1) | CN1031892C (en) |
| AT (1) | ATE89006T1 (en) |
| AU (1) | AU615654B2 (en) |
| CA (1) | CA1323851C (en) |
| CY (1) | CY1809A (en) |
| CZ (1) | CZ283648B6 (en) |
| DD (1) | DD291093A5 (en) |
| DE (1) | DE3880739T2 (en) |
| DK (1) | DK175686B1 (en) |
| EG (1) | EG19101A (en) |
| ES (1) | ES2054878T3 (en) |
| FI (1) | FI100056B (en) |
| GB (1) | GB8712540D0 (en) |
| HK (1) | HK137794A (en) |
| HU (1) | HU204562B (en) |
| IE (1) | IE62422B1 (en) |
| IL (1) | IL86480A (en) |
| LT (1) | LT3600B (en) |
| LV (1) | LV5288A3 (en) |
| NO (1) | NO179253C (en) |
| NZ (1) | NZ224808A (en) |
| PL (1) | PL158064B1 (en) |
| PT (1) | PT87562B (en) |
| RU (1) | RU2009198C1 (en) |
| SG (1) | SG131594G (en) |
| SK (1) | SK279166B6 (en) |
| SU (1) | SU1834904A3 (en) |
| UA (1) | UA19765A (en) |
| ZA (1) | ZA883824B (en) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
| JP2606228B2 (en) * | 1987-09-18 | 1997-04-30 | 三菱化学株式会社 | Method for producing human proapolipoprotein AI-like protein |
| EP0345155B1 (en) * | 1988-05-31 | 1994-08-10 | Mitsubishi Kasei Corporation | Process for producing natural human apolipoprotein e-like proteins |
| US5460961A (en) * | 1988-06-14 | 1995-10-24 | La Region Wallonne | Human myeloperoxidase and its therapeutic application |
| US5846799A (en) * | 1988-06-14 | 1998-12-08 | La Region Wallone | Human myeloperoxidase and its therapeutic application |
| IT1229996B (en) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | EXPRESSION OF APOLIPOPROTEIN AI AND APOLIPOPROTEIN AI-MILAN IN YEAST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE APOLIPOPROTEINS. |
| EP0785273A1 (en) * | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Paired basic amino acid converting enzyme and DNA sequence encoding it |
| US5844097A (en) * | 1990-11-30 | 1998-12-01 | Monoclonetics International, Inc. | Methods for the diagnosis of peripheral nerve damage |
| EP0559795B1 (en) * | 1990-11-30 | 1995-12-27 | Monoclonetics International, Inc. | Methods for the diagnosis of chronic lower back and cervical pain |
| GB9508618D0 (en) * | 1995-04-28 | 1995-06-14 | Applied Research Systems | Therapeutic protein |
| SE9500778D0 (en) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| US5994061A (en) * | 1995-09-29 | 1999-11-30 | Queen's University At Kingston | DNA constructs and methods for screening for increased expression of human apo AI gene |
| SE9603068D0 (en) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603303D0 (en) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (en) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
| KR100330355B1 (en) * | 1999-06-04 | 2002-04-01 | 장인순 | Duct type spacer grid with swirl flow vane in nuclear fuel assembly |
| US20040047853A1 (en) * | 2000-06-09 | 2004-03-11 | Dahl Soren W | Purified proenzyme of dipeptidyl peptidase i (pro-dppi) |
| WO2002048333A2 (en) * | 2000-12-12 | 2002-06-20 | Lexicon Genetics Incorporated | Novel human kinases and uses thereof |
| KR100560102B1 (en) * | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | Proapolipoprotein A-I variants and antilipidemia or arteriosclerosis comprising the same |
| US7427662B2 (en) * | 2005-02-01 | 2008-09-23 | Baord Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Inhibition of angiogenesis and destruction of angiogenic vessels by apolipoprotein A-I and high density lipoprotein |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| JP2009505652A (en) * | 2005-08-26 | 2009-02-12 | セレニス セラピューティクス ホールディング エスア | Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria |
| US20080293102A1 (en) * | 2007-02-28 | 2008-11-27 | Cerenis Therapeutics Holding, S.A. | Compositions and methods for producing apolipoprotein |
| CA2739464C (en) * | 2008-10-03 | 2020-03-31 | Curna, Inc. | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
| EP4241767B1 (en) | 2008-11-10 | 2024-10-23 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
| US20120101148A1 (en) | 2009-01-29 | 2012-04-26 | Alnylam Pharmaceuticals, Inc. | lipid formulation |
| AU2010223967B2 (en) | 2009-03-12 | 2015-07-30 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes |
| SG176553A1 (en) | 2009-05-05 | 2012-01-30 | Muthiah Manoharan | Lipid compositions |
| CN102459596B (en) | 2009-05-06 | 2016-09-07 | 库尔纳公司 | Treatment of Lipid Transport and Metabolism Gene-Associated Diseases by Inhibition of Natural Antisense Transcripts Targeting Lipid Transport and Metabolism Genes |
| TR201811076T4 (en) | 2009-06-10 | 2018-08-27 | Arbutus Biopharma Corp | Improved lipid formulation. |
| EP2464336A4 (en) | 2009-08-14 | 2013-11-20 | Alnylam Pharmaceuticals Inc | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US10525152B2 (en) | 2009-10-09 | 2020-01-07 | Signablok, Inc. | Methods and compositions for targeted imaging |
| WO2011071860A2 (en) | 2009-12-07 | 2011-06-16 | Alnylam Pharmaceuticals, Inc. | Compositions for nucleic acid delivery |
| EP3494963A1 (en) | 2009-12-18 | 2019-06-12 | The University of British Columbia | Methods and compositions for delivery of nucleic acids |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| WO2011143362A1 (en) | 2010-05-11 | 2011-11-17 | Esperion Therapeutics, Inc. | Dimeric oxidation-resistant apolipoprotein a1 variants |
| CA2800401C (en) | 2010-06-03 | 2020-09-15 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| WO2012016188A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| US20130323269A1 (en) | 2010-07-30 | 2013-12-05 | Muthiah Manoharan | Methods and compositions for delivery of active agents |
| CN110123830A (en) | 2010-11-09 | 2019-08-16 | 阿尔尼拉姆医药品有限公司 | Composition and method for inhibiting the lipid of the expression of Eg5 and VEGF gene to prepare |
| JP5902197B2 (en) | 2011-01-11 | 2016-04-13 | アルニラム・ファーマシューティカルズ・インコーポレーテッド | PEGylated lipids and their use for drug delivery |
| PT2673296T (en) | 2011-02-07 | 2019-01-31 | Cerenis Therapeutics Holding Sa | Lipoprotein complexes and manufacturing and uses thereof |
| EP2760477B1 (en) | 2011-09-27 | 2018-08-08 | Alnylam Pharmaceuticals, Inc. | Di-aliphatic substituted pegylated lipids |
| US9610324B2 (en) * | 2012-07-11 | 2017-04-04 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
| CA2921162A1 (en) * | 2013-05-01 | 2014-11-06 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| EP2853259A1 (en) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Reconstituted high density lipoproteins composition and uses thereof |
| KR20170003611A (en) | 2014-05-02 | 2017-01-09 | 세레니스 쎄라퓨틱스 홀딩 에스에이 | Hdl therapy markers |
| WO2018077159A1 (en) * | 2016-10-27 | 2018-05-03 | 中国科学院微生物研究所 | Method for modifying amino acid attenuator and use of same in production |
| WO2019030574A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding | CARGOMÈRES |
| WO2019030575A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding | Apomers |
| US11164065B2 (en) | 2018-08-24 | 2021-11-02 | Bright Marbles, Inc. | Ideation virtual assistant tools |
| US11461863B2 (en) | 2018-08-24 | 2022-10-04 | Bright Marbles, Inc. | Idea assessment and landscape mapping |
| US11081113B2 (en) | 2018-08-24 | 2021-08-03 | Bright Marbles, Inc. | Idea scoring for creativity tool selection |
| US11189267B2 (en) | 2018-08-24 | 2021-11-30 | Bright Marbles, Inc. | Intelligence-driven virtual assistant for automated idea documentation |
| IL297336A (en) | 2020-04-16 | 2022-12-01 | Abionyx Pharma Sa | Methods for the treatment of serious conditions by lipid binding complexes of basic proteins |
| KR20230079132A (en) | 2020-10-01 | 2023-06-05 | 아비오닉스 파마 에스에이 | Compositions comprising lipid binding protein-based complexes for use in treating eye disorders |
| AU2022258815A1 (en) | 2021-04-15 | 2023-10-19 | Abionyx Pharma Sa | Use of lipid binding protein-based complexes in organ preservation solutions |
| KR20240167701A (en) | 2022-04-06 | 2024-11-27 | 아비오닉스 파마 에스에이 | Method for treating ocular diseases using lipid-binding protein-based complexes |
| CN119317440A (en) | 2022-04-06 | 2025-01-14 | 阿比奥尼克斯制药公司 | Methods of treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes |
| US20250352613A1 (en) | 2022-06-10 | 2025-11-20 | Stanislas FAGUER | Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes |
| EP4536269A2 (en) | 2022-06-10 | 2025-04-16 | Abionyx Pharma SA | Methods for treating acute conditions using lipid binding protein-based complexes |
| KR20260010675A (en) | 2023-01-13 | 2026-01-21 | 아비오닉스 파마 에스에이 | Lipid-binding protein molecular therapy |
| WO2025093929A1 (en) | 2023-10-31 | 2025-05-08 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
| JPS6198998A (en) | 1984-10-18 | 1986-05-17 | Matsushita Electric Ind Co Ltd | electric blower |
| BE901119A (en) | 1984-11-23 | 1985-03-15 | Wallone Region | PROCESS FOR THE PREPARATION OF VECTOR PLASMIDS CAPABLE OF TRANSFORMING A BACTERIAL HOST ESCHERICHIA COLI AND OF PROMOTING AND CONTROLLING THE EXPRESSION OF HETEROLOGOUS DNA IN IT. |
| ATE89314T1 (en) | 1985-02-13 | 1993-05-15 | Scios Nova Inc | HUMAN METALLOTHIONEIN II PROMOTOR IN MAMMALIAN EXPRESSION SYSTEMS. |
| GB8507833D0 (en) * | 1985-03-26 | 1985-05-01 | Biogen Nv | Production of human somatomedin c |
| AU6522486A (en) | 1985-10-04 | 1987-04-24 | Biotechnology Research Partners Limited | Recombinant apolipoproteins and methods |
| GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
| WO1988003175A1 (en) * | 1986-10-29 | 1988-05-05 | Biotechnology Research Partners, Ltd. | Apoai-ciii-aiv, apoaii, apob, apoci, and ldl receptor polymorphisms for genetic fingerprinting and predictive of atherosclerosis |
-
1987
- 1987-05-28 GB GB878712540A patent/GB8712540D0/en active Pending
-
1988
- 1988-05-16 CA CA000566894A patent/CA1323851C/en not_active Expired - Fee Related
- 1988-05-24 AT AT88870095T patent/ATE89006T1/en not_active IP Right Cessation
- 1988-05-24 DE DE8888870095T patent/DE3880739T2/en not_active Expired - Lifetime
- 1988-05-24 PT PT87562A patent/PT87562B/en not_active IP Right Cessation
- 1988-05-24 EP EP88870095A patent/EP0293357B1/en not_active Expired - Lifetime
- 1988-05-24 ES ES88870095T patent/ES2054878T3/en not_active Expired - Lifetime
- 1988-05-24 IL IL86480A patent/IL86480A/en not_active IP Right Cessation
- 1988-05-25 FI FI882456A patent/FI100056B/en not_active IP Right Cessation
- 1988-05-26 EG EG28288A patent/EG19101A/en active
- 1988-05-26 SU SU884356123A patent/SU1834904A3/en active
- 1988-05-26 DD DD88316110A patent/DD291093A5/en not_active IP Right Cessation
- 1988-05-26 US US07/198,830 patent/US5059528A/en not_active Expired - Lifetime
- 1988-05-26 NZ NZ224808A patent/NZ224808A/en unknown
- 1988-05-26 UA UA4613079A patent/UA19765A/en unknown
- 1988-05-26 PL PL1988272698A patent/PL158064B1/en unknown
- 1988-05-27 JP JP63130033A patent/JP2634193B2/en not_active Expired - Fee Related
- 1988-05-27 AU AU16723/88A patent/AU615654B2/en not_active Ceased
- 1988-05-27 IE IE159788A patent/IE62422B1/en not_active IP Right Cessation
- 1988-05-27 HU HU882707A patent/HU204562B/en not_active IP Right Cessation
- 1988-05-27 NO NO882341A patent/NO179253C/en not_active IP Right Cessation
- 1988-05-27 SK SK3638-88A patent/SK279166B6/en unknown
- 1988-05-27 ZA ZA883824A patent/ZA883824B/en unknown
- 1988-05-27 DK DK198802896A patent/DK175686B1/en not_active IP Right Cessation
- 1988-05-27 CZ CS883638A patent/CZ283648B6/en not_active IP Right Cessation
- 1988-05-27 CN CN88103118A patent/CN1031892C/en not_active Expired - Fee Related
- 1988-05-28 KR KR88006286A patent/KR970000808B1/en not_active Expired - Fee Related
- 1988-12-20 RU SU884613079A patent/RU2009198C1/en active
-
1993
- 1993-06-01 LV LV930445A patent/LV5288A3/en unknown
- 1993-08-03 LT LTIP828A patent/LT3600B/en not_active IP Right Cessation
-
1994
- 1994-09-12 SG SG131594A patent/SG131594G/en unknown
- 1994-12-08 HK HK137794A patent/HK137794A/en not_active IP Right Cessation
-
1995
- 1995-10-20 CY CY180995A patent/CY1809A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR970000808B1 (en) | Human proapolipoprotein a-1 expression | |
| NO177433C (en) | DNA Vector for Expression of Desulfatohirudin in Yeast or E.coli and Method of Preparation of Desulfatohirudin and Salts thereof | |
| DE3586189D1 (en) | QUANTITY AND METHOD FOR PRODUCING RECOMBINED PRODUCTS IN LARGE YIELD. | |
| ATE386800T1 (en) | IMMUNOGENIC CHIMERAS COMPRISING NUCLEIC ACID SEQUENCES ENCODING ENDOPLASMATIC RETICULUM SIGNAL SEQUENCE PEPTIDES AND AT LEAST ONE OTHER PEPTIDE, THEIR USE IN VACCINES AND FOR THE TREATMENT OF DISEASES | |
| ES2059354T3 (en) | A METHOD TO PRODUCE A POLYPEPTIDE. | |
| ZA200006041B (en) | Nucleotide sequences coding for the export of branched-chain amino acids, process for the isolation thereof and use thereof. | |
| NO177570C (en) | Process for the preparation of peptides with fibronectin binding properties, microorganism and DNA sequence encoding peptides with fibronectin binding properties | |
| HUT52551A (en) | Process for production of neutrophil-activizating factor | |
| IL110942A0 (en) | Grb3-3 gene, its variants and their uses | |
| ATE166390T1 (en) | ANTI-CAT IMMUNODEFICIENCY VIRUS (FIV) VACCINES | |
| EP0238275A3 (en) | Recombinant product | |
| DK0422217T3 (en) | Human, recombinant, placental ribonuclease inhibitor and method of production | |
| ATE87977T1 (en) | PREPARATION OF HUMAN SOMATOMEDINS C. | |
| ATE188997T1 (en) | CLONING OF MALARIA-SPECIFIC DNA SEQUENCES: ISOLATION OF THE GENE FOR THE 140 KD PROTEIN | |
| DE69636737D1 (en) | NEW IMMUNOREGULATORY PROTEIN LST-1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC9A | Transfer of patents |
Free format text: 20010321 * MINISTERIE DE LA REGION WALLONNE,BE |
|
| MM9A | Lapsed patents |
Effective date: 20020803 |