ES2059354T3 - Un metodo para producir un polipeptido. - Google Patents
Un metodo para producir un polipeptido.Info
- Publication number
- ES2059354T3 ES2059354T3 ES87119157T ES87119157T ES2059354T3 ES 2059354 T3 ES2059354 T3 ES 2059354T3 ES 87119157 T ES87119157 T ES 87119157T ES 87119157 T ES87119157 T ES 87119157T ES 2059354 T3 ES2059354 T3 ES 2059354T3
- Authority
- ES
- Spain
- Prior art keywords
- getting
- amino acid
- polypeptide
- polips
- purges
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
NUEVOS DERIVADOS DEL POLIPEPTIDO HG-CSF QUE TIENEN UNA SECUENCIA DE AMINOACIDOS DERIVADA DE LA SECUENCIA DE AMINOACIDOS DE POLIPEPTIDO FACTOR ESTIMULANTE DE COLONIAS DE GRANULOCITOS HUMANOS POR SUSTITUCION DE AL MENOS UN AMINOACIDO POR UN AMINOACIDO DIFERENTE Y/O ELIMINACION DE AL MENOS UN AMINOACIDO. TAMBIEN SE DESCRIBEN PLASMIDOS RECOMBINANTES QUE CONTIENEN UN INJERTO DE FRAGMENTO DE ADN QUE CODIFICA ALGUNO DE ESTOS DERIVADOS DEL POLIPEPTIDO HG-CSF, MICROORGANISMOS PORTADORES DE UNO DE DICHOS PLASMIDOS Y METODOS DE OBTENER LOS DERIVADOS DEL POLIPEPTIDO HG-CSF UTILIZANDO LOS MICROORGANISMOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30679986 | 1986-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2059354T3 true ES2059354T3 (es) | 1994-11-16 |
ES2059354T5 ES2059354T5 (es) | 1998-03-16 |
Family
ID=17961392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87119157T Expired - Lifetime ES2059354T5 (es) | 1986-12-23 | 1987-12-23 | Nuevo polipeptido. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0272703B2 (es) |
JP (1) | JPH068317B2 (es) |
KR (1) | KR960016560B1 (es) |
CA (1) | CA1341522C (es) |
DE (1) | DE3786767T3 (es) |
DK (1) | DK174044B1 (es) |
ES (1) | ES2059354T5 (es) |
HK (1) | HK164195A (es) |
NO (1) | NO176799C (es) |
PT (1) | PT86465B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5718893A (en) * | 1984-04-15 | 1998-02-17 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
US5298603A (en) * | 1985-12-21 | 1994-03-29 | Hoechst Aktiengesellschaft | GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use |
GB9107846D0 (en) * | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
DE4014750A1 (de) * | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
US5688768A (en) | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
US7119182B1 (en) | 1991-02-19 | 2006-10-10 | The Regents Of The University Of California | Recombinant thrombin receptor and related pharmaceuticals |
US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
HU217872B (hu) | 1994-02-23 | 2000-04-28 | Kyowa Hakko Kogyo Co., Ltd. | Polipeptid alkalmazása vérlemezke termelődést elősegítő gyógyszer előállítására |
US5536495A (en) * | 1994-04-15 | 1996-07-16 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6100070A (en) * | 1995-10-05 | 2000-08-08 | G. D. Searle & Co. | G-CSF receptor agonists |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
DE19860801A1 (de) * | 1998-12-30 | 2000-07-06 | Rhein Biotech Proz & Prod Gmbh | Rekombinanter Wachstumsfaktor mit der biologischen Aktivität eines G-CSF (Granulocyte Colony Stimulating Factor) |
US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
JP2004524005A (ja) | 2000-09-08 | 2004-08-12 | マサチューセッツ インスティテュート オブ テクノロジー | G−csfアナログ組成物および方法 |
US7392141B2 (en) | 2001-02-06 | 2008-06-24 | Merck Patent Gmbh | Method of preparing a modified granulocyte colony stimulating factor (G-CSF) with reduced immunogenicity |
EP1998266A3 (en) | 2001-02-19 | 2009-02-11 | Merck Patent GmbH | Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
AU2002325819B2 (en) | 2001-07-11 | 2008-06-19 | Maxygen, Inc. | G-CSF Conjugates |
WO2003078461A1 (en) | 2002-03-20 | 2003-09-25 | Biopolymed Inc. | Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue |
EP1541585B1 (en) | 2002-08-27 | 2013-01-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist and use thereof |
US7785601B2 (en) * | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7695723B2 (en) * | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
CA2517310C (en) | 2003-02-28 | 2015-11-24 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations comprising a poloxamer |
US7220407B2 (en) | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
EP1817047B1 (en) | 2004-11-05 | 2012-02-08 | Northwestern University | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
KR20080027291A (ko) | 2005-06-01 | 2008-03-26 | 맥시겐 홀딩스 엘티디 | 피이지화된 지-씨에스에프 폴리펩타이드 및 그 제조방법 |
WO2008075371A2 (en) | 2006-12-21 | 2008-06-26 | Biokine Therapeutics Ltd. | T-140 peptide analogs having cxcr4 super-agonist activity for immunomodulation |
CA2697265A1 (en) | 2007-08-09 | 2009-02-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
US8758761B2 (en) | 2007-09-30 | 2014-06-24 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
US9155780B2 (en) | 2009-02-11 | 2015-10-13 | Yeda Research And Development Co. Ltd. | Short beta-defensin-derived peptides |
WO2010146578A2 (en) | 2009-06-14 | 2010-12-23 | Biokine Therapeutics Ltd. | Peptide therapy for increasing platelet levels |
EP2525787B1 (en) | 2010-01-19 | 2017-03-15 | Hanmi Science Co., Ltd. | Liquid formulations for long-acting g-csf conjugate |
CN102906108B (zh) | 2010-03-04 | 2016-01-20 | 菲尼克斯公司 | 用于无变性制备可溶性重组干扰素蛋白的方法 |
PL2552949T3 (pl) | 2010-04-01 | 2017-01-31 | Pfenex Inc. | Sposoby wytwarzania G-CSF w komórce gospodarza Pseudomonas |
EP2841084B1 (en) | 2012-04-24 | 2018-05-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist peptide for use in the treatment of large cell lung cancer |
EP3943098A3 (en) | 2015-07-16 | 2022-05-11 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
KR102033920B1 (ko) | 2016-02-23 | 2019-10-18 | 바이오라인알엑스 리미티드 | 급성 골수성 백혈병을 치료하는 방법 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4869987A (es) | 1971-12-27 | 1973-09-22 | ||
JPS58110600A (ja) | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
EP0215126B1 (en) * | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
DE3681551D1 (de) * | 1985-09-30 | 1991-10-24 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
EP0256843A1 (en) | 1986-08-11 | 1988-02-24 | Cetus Corporation | Expression of g-csf and muteins thereof and their use |
JP2581110B2 (ja) * | 1987-10-26 | 1997-02-12 | いすゞ自動車株式会社 | パティキュレートトラップの再燃焼装置 |
-
1987
- 1987-12-22 NO NO875378A patent/NO176799C/no not_active IP Right Cessation
- 1987-12-22 DK DK198706809A patent/DK174044B1/da not_active IP Right Cessation
- 1987-12-23 KR KR1019870014791A patent/KR960016560B1/ko not_active IP Right Cessation
- 1987-12-23 JP JP62326384A patent/JPH068317B2/ja not_active Expired - Lifetime
- 1987-12-23 CA CA000555332A patent/CA1341522C/en not_active Expired - Lifetime
- 1987-12-23 EP EP87119157A patent/EP0272703B2/en not_active Expired - Lifetime
- 1987-12-23 PT PT86465A patent/PT86465B/pt unknown
- 1987-12-23 ES ES87119157T patent/ES2059354T5/es not_active Expired - Lifetime
- 1987-12-23 DE DE3786767T patent/DE3786767T3/de not_active Expired - Lifetime
-
1995
- 1995-10-19 HK HK164195A patent/HK164195A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS63267292A (ja) | 1988-11-04 |
JPH068317B2 (ja) | 1994-02-02 |
DE3786767T3 (de) | 1998-04-16 |
NO875378L (no) | 1988-06-24 |
EP0272703B1 (en) | 1993-07-28 |
NO176799B (no) | 1995-02-20 |
DK680987A (da) | 1988-06-24 |
ES2059354T5 (es) | 1998-03-16 |
DK174044B1 (da) | 2002-05-06 |
PT86465A (en) | 1988-01-01 |
HK164195A (en) | 1995-10-27 |
DE3786767T2 (de) | 1994-01-13 |
DK680987D0 (da) | 1987-12-22 |
CA1341522C (en) | 2007-03-13 |
NO176799C (no) | 1995-05-31 |
PT86465B (pt) | 1990-11-20 |
KR880007734A (ko) | 1988-08-29 |
KR960016560B1 (ko) | 1996-12-14 |
DE3786767D1 (de) | 1993-09-02 |
NO875378D0 (no) | 1987-12-22 |
EP0272703B2 (en) | 1997-10-15 |
EP0272703A1 (en) | 1988-06-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2059354T3 (es) | Un metodo para producir un polipeptido. | |
DE3880739D1 (de) | Expression von menschlichem proapolipoprotein a-1. | |
ES2073571T3 (es) | Aplicacion de nuevos fragmentos de adn como secuencia que codifica un peptido señal para la secrecion de proteinas maduras, mediante levaduras recombinantes, cassettes de expresion, levaduras transformadas y procedimiento correspondiente de preparacion de proteinas. | |
DE69518751D1 (de) | Gereinigte scytalidium lacassen und nukleinsäuren dafür kodierend | |
ES2054638T3 (es) | Gen codificante de los factores humanos de estimulacion colonial. | |
HUT46061A (en) | Dna sequences encoding hirudin-like protein and process for producing such proteins | |
DE3683447D1 (de) | Verfahren zur herstellung von humanlysozym. | |
ATE43139T1 (de) | Klonierungs- und expressionsvektoren fuer gammainterferon, transformierte bakterien und verfahren zur herstellung von gamma-interferon. | |
ES553374A0 (es) | Un procedimiento para mejorar la produccion de un polipeptido deseado en un hospedante transformado con una molecula de adn recombinantes. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 272703 Country of ref document: ES |