ES2054638T3 - Gen codificante de los factores humanos de estimulacion colonial. - Google Patents

Gen codificante de los factores humanos de estimulacion colonial.

Info

Publication number
ES2054638T3
ES2054638T3 ES87113614T ES87113614T ES2054638T3 ES 2054638 T3 ES2054638 T3 ES 2054638T3 ES 87113614 T ES87113614 T ES 87113614T ES 87113614 T ES87113614 T ES 87113614T ES 2054638 T3 ES2054638 T3 ES 2054638T3
Authority
ES
Spain
Prior art keywords
human
colonial
coding gene
stimulation factors
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87113614T
Other languages
English (en)
Inventor
Masayuki Takahashi
Tohru Hirato
Satoru Nakai
Yeong-Man Sanraunjihausu Hong
Naomi Kouno
Yoshikatsu Hirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27279216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2054638(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2054638T3 publication Critical patent/ES2054638T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

LA INVENCION SE REFIERE A UN GEN QUE CODIFICA UN FACTOR ESTIMULANTE DE COLONIAS FEC-M HUMANO BIOLOGICAMENTE ACTIVO QUE TIENE UNA SECUENCIA NUCLEOTIDICA QUE CODIFICA LA SECUENCIA AMINOACIDO DE LA FORMULA (I) O UNA PORCION DE ELLA; A UN VECTOR DE EXPRESION QUE INCLUYE EL GEN ANTES DEFINIDO Y CAPAZ DE EXPRESAR UN FEC-M HUMANO BIOLOGICAMENTE ACTICO Y UN TRANSFORMANTE QUE CONTIENE EL VECTOR DE EXPRESION INDICADO, Y CAPAZ DE PRODUCIR UN FEC-M HUMANO BIOLOGICAMENTE ACTIVO.
ES87113614T 1986-09-17 1987-09-17 Gen codificante de los factores humanos de estimulacion colonial. Expired - Lifetime ES2054638T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22075086 1986-09-17
JP1102587 1987-01-19
JP16638887 1987-07-02

Publications (1)

Publication Number Publication Date
ES2054638T3 true ES2054638T3 (es) 1994-08-16

Family

ID=27279216

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87113614T Expired - Lifetime ES2054638T3 (es) 1986-09-17 1987-09-17 Gen codificante de los factores humanos de estimulacion colonial.

Country Status (6)

Country Link
EP (2) EP0547026A1 (es)
JP (1) JP2583770B2 (es)
KR (1) KR910000460B1 (es)
DE (1) DE3750113T2 (es)
DK (1) DK486587A (es)
ES (1) ES2054638T3 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
US6156300A (en) * 1985-02-05 2000-12-05 Chiron Corporation Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof
US6146851A (en) * 1985-02-05 2000-11-14 Chiron Corporation DNA encoding NV2 (long form) and carboxy truncated fragments thereof
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
AU594045B2 (en) * 1985-02-05 1990-03-01 Chiron Corporation Recombinant colony stimulating factor-1
US5573930A (en) * 1985-02-05 1996-11-12 Cetus Oncology Corporation DNA encoding various forms of colony stimulating factor-1
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US4879227A (en) * 1986-05-06 1989-11-07 Genetics Institute, Inc. Production of a recombinant human colony stimulating factor
JP2579981B2 (ja) * 1986-05-06 1997-02-12 ジェネティックス・インスチチュート・インコーポレーテッド Ｍ―ｃｓｆの生産方法
US4868119A (en) * 1986-12-11 1989-09-19 Genetics Institute, Inc. Hematopoietic growth factors
US5650297A (en) * 1986-09-17 1997-07-22 Otsuka Pharmaceutical Co., Ltd. DNA encoding human colony-stimulating factors
HU215241B (hu) * 1986-10-24 1998-11-30 Cetus Corp. Eljárás telepstimuláló faktor-1 új formáinak előállítására, valamint az eljárásban alkalmazható expressziós kazetta, vektor és rekombináns gazdasejtek előállítására
ATE213950T1 (de) * 1987-09-22 2002-03-15 Chiron Corp Verwendung von rekombinantem koloniestimulierendem faktor-1 zur herstellung eines medikaments gegen cytomegalovirusinfektionen
DK54589A (da) * 1988-02-08 1989-08-09 Otsuka Pharma Co Ltd Humane kolonistmulerende faktorer
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
WO1990014351A1 (en) * 1989-05-23 1990-11-29 Chandra Choudhury Hematopoietic growth factor derived form t lymphocytes and methods of use therefor
US6254861B1 (en) 1989-05-23 2001-07-03 Chandra Choudhury Hematopoietic growth factor derived from T lymphocytes
DE69026440T2 (de) * 1989-07-27 1996-10-17 Denki Kagaku Kogyo Kk Für M-CSF kodierendes Gen und dazu gehörende rekombinante Systeme
WO1991006567A1 (en) * 1989-11-07 1991-05-16 Otsuka Pharmaceutical Co., Ltd. M-csf derivative, expression vector of said derivative, product of transformation by said vector, and production of them
WO1991008754A1 (en) * 1989-12-13 1991-06-27 Otsuka Pharmaceutical Co., Ltd. Medicinal application of m-csf
US5714140A (en) * 1989-12-13 1998-02-03 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting the production of bioactive IL-1 by administering M-CSF
JP2747355B2 (ja) * 1990-03-16 1998-05-06 電気化学工業株式会社 ヒト血中単球増殖剤
JPH04148687A (ja) * 1990-10-09 1992-05-21 Asahi Chem Ind Co Ltd Ｍ―ｃｓｆ活性ポリペプチドの安定的高発現組換えベクター
US5087453A (en) * 1990-11-01 1992-02-11 Otsuka Pharmaceutical Co., Ltd. Method for the treatment of bacterial caused weight loss and/or hypoglycemia
AU6125294A (en) * 1993-01-13 1994-08-15 Genetics Institute Inc. Process for producing m-csf 223
KR100440460B1 (ko) * 1998-07-08 2004-10-08 주식회사유한양행 인체 과립구 콜로니 자극인자의 유전자, 재조합 벡터 및 형질 전환체 및 그들을 이용한 인체 과립구 콜로니 자극인자의 제조방법
US8603303B2 (en) * 2010-03-15 2013-12-10 International Business Machines Corporation Nanopore based device for cutting long DNA molecules into fragments
US8986524B2 (en) 2011-01-28 2015-03-24 International Business Machines Corporation DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA
US20120193231A1 (en) 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases
US8852407B2 (en) 2011-01-28 2014-10-07 International Business Machines Corporation Electron beam sculpting of tunneling junction for nanopore DNA sequencing
US10029915B2 (en) 2012-04-04 2018-07-24 International Business Machines Corporation Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores
US9046511B2 (en) 2013-04-18 2015-06-02 International Business Machines Corporation Fabrication of tunneling junction for nanopore DNA sequencing
US9188578B2 (en) 2013-06-19 2015-11-17 Globalfoundries Inc. Nanogap device with capped nanowire structures
US9182369B2 (en) 2013-06-19 2015-11-10 Globalfoundries Inc. Manufacturable sub-3 nanometer palladium gap devices for fixed electrode tunneling recognition

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US923067A (en) * 1907-07-26 1909-05-25 Jesse E Mcroberts Ash-pan cleaner.
JPS59169489A (ja) 1983-03-15 1984-09-25 Otsuka Pharmaceut Co Ltd ヒト培養株化細胞
JPS61227526A (ja) * 1984-07-25 1986-10-09 Chugai Pharmaceut Co Ltd 新規なコロニー刺激因子
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
PT81513B (pt) * 1984-11-20 1988-03-03 Schering Biotech Corp Clones de dna codificando polipeptideos que apresentam actividade de factor de crescimento celular para granulocitos, madrofagos e eosinofilos humanos
DK172052B1 (da) 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
AU594045B2 (en) * 1985-02-05 1990-03-01 Chiron Corporation Recombinant colony stimulating factor-1
EP0215126B1 (en) * 1985-02-08 1991-07-31 Chugai Seiyaku Kabushiki Kaisha Human granulocyte colony stimulating factor
EP0220520B1 (en) * 1985-09-30 1991-09-18 Chugai Seiyaku Kabushiki Kaisha Human granulocyte colony stimulating factor
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
JP2579981B2 (ja) * 1986-05-06 1997-02-12 ジェネティックス・インスチチュート・インコーポレーテッド Ｍ―ｃｓｆの生産方法
HU215241B (hu) * 1986-10-24 1998-11-30 Cetus Corp. Eljárás telepstimuláló faktor-1 új formáinak előállítására, valamint az eljárásban alkalmazható expressziós kazetta, vektor és rekombináns gazdasejtek előállítására

Also Published As

Publication number Publication date
KR880004089A (ko) 1988-06-01
JP2583770B2 (ja) 1997-02-19
DK486587D0 (da) 1987-09-16
EP0261592B1 (en) 1994-06-22
EP0547026A1 (en) 1993-06-16
EP0261592A1 (en) 1988-03-30
DE3750113T2 (de) 1994-11-24
DE3750113D1 (de) 1994-07-28
JPH01104176A (ja) 1989-04-21
DK486587A (da) 1988-03-18
KR910000460B1 (ko) 1991-01-25

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