ATE85081T1 - Analoge des gewebespezifischen plasminogenaktivators. - Google Patents

Analoge des gewebespezifischen plasminogenaktivators.

Info

Publication number
ATE85081T1
ATE85081T1 AT86309704T AT86309704T ATE85081T1 AT E85081 T1 ATE85081 T1 AT E85081T1 AT 86309704 T AT86309704 T AT 86309704T AT 86309704 T AT86309704 T AT 86309704T AT E85081 T1 ATE85081 T1 AT E85081T1
Authority
AT
Austria
Prior art keywords
analogs
tpa
plasminogen activator
tissue specific
specific plasminogen
Prior art date
Application number
AT86309704T
Other languages
English (en)
Inventor
Keith R Marotti
Edward F Rehberg
Nicole Y Theriault
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE85081T1 publication Critical patent/ATE85081T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT86309704T 1985-12-20 1986-12-12 Analoge des gewebespezifischen plasminogenaktivators. ATE85081T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81160785A 1985-12-20 1985-12-20
US90948286A 1986-09-19 1986-09-19
EP86309704A EP0231624B1 (de) 1985-12-20 1986-12-12 Analoge des gewebespezifischen Plasminogenaktivators

Publications (1)

Publication Number Publication Date
ATE85081T1 true ATE85081T1 (de) 1993-02-15

Family

ID=27123502

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86309704T ATE85081T1 (de) 1985-12-20 1986-12-12 Analoge des gewebespezifischen plasminogenaktivators.

Country Status (12)

Country Link
EP (2) EP0231624B1 (de)
JP (1) JPH0659223B2 (de)
KR (2) KR950000303B1 (de)
AT (1) ATE85081T1 (de)
AU (1) AU600463B2 (de)
DE (1) DE3687651T2 (de)
DK (1) DK431887A (de)
ES (1) ES2053449T3 (de)
FI (1) FI97809C (de)
GR (1) GR3007280T3 (de)
NO (1) NO176921C (de)
WO (1) WO1987003906A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA869626B (en) * 1985-12-23 1987-10-28 Chiron Corp Peptide plasminogen activators
DE3682891D1 (de) * 1986-02-17 1992-01-23 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
WO1987005934A1 (en) * 1986-03-28 1987-10-08 Roberto Crea Protein analogues of tissue plasminogen activator
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
JP2983997B2 (ja) * 1987-01-30 1999-11-29 アメリカン・ホーム・プロダクツ・コーポレイション 脱―表皮細胞成長因子プラスミノーゲンアクチベーター
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
JPH01132377A (ja) * 1987-10-09 1989-05-24 Monsanto Co 修正型組織プラスミノーゲンアクチベーター
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
WO1989003874A1 (en) * 1987-10-29 1989-05-05 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
JPH04500752A (ja) * 1988-02-05 1992-02-13 ジェンザイム・コーポレーション 修飾ｔＰＡをコードする修飾遺伝子配列、並びにその産物
AU619803B2 (en) * 1988-02-05 1992-02-06 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same
WO1989007146A1 (en) * 1988-02-05 1989-08-10 Integrated Genetics, Inc. Rearranged tissue plasminogen activators and method for producing same
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
DE3823805A1 (de) * 1988-07-14 1990-01-18 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3836200A1 (de) * 1988-10-24 1990-04-26 Boehringer Mannheim Gmbh Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
DE68922859T2 (de) * 1988-10-27 1995-09-21 Tno Trombolytischer wirkstoff mit modifikation der domäne der kringle.
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
DE3927865A1 (de) * 1989-08-23 1991-02-28 Boehringer Mannheim Gmbh T-pa-mutante gk1l
ATE155816T1 (de) * 1992-06-03 1997-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
IL104355A (en) * 1993-01-10 2006-08-20 Yeda Res & Dev Tnf receptor promoter
US5795975A (en) * 1993-01-10 1998-08-18 Yeda Research And Development Co. Ltd. TNF receptor promoter
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
ZA837173B (en) 1982-11-08 1984-05-30 Univ Case Western Reserve Genomic bovine growth hormone
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR860875B (en) * 1985-04-04 1986-07-29 Beecham Group Plc Novel compounds
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product

Also Published As

Publication number Publication date
KR950000303B1 (ko) 1995-01-13
KR880700856A (ko) 1988-04-12
FI97809C (fi) 1997-02-25
FI97809B (fi) 1996-11-15
EP0289508A1 (de) 1988-11-09
EP0231624B1 (de) 1993-01-27
DK431887D0 (da) 1987-08-19
JPH05344892A (ja) 1993-12-27
EP0231624A1 (de) 1987-08-12
DE3687651D1 (de) 1993-03-11
AU600463B2 (en) 1990-08-16
NO873517D0 (no) 1987-08-20
JPH0659223B2 (ja) 1994-08-10
FI882922A0 (fi) 1988-06-17
ES2053449T3 (es) 1994-08-01
AU6770187A (en) 1987-07-15
DE3687651T2 (de) 1993-06-24
NO176921B (no) 1995-03-13
WO1987003906A1 (en) 1987-07-02
FI882922A (fi) 1988-06-17
NO873517L (no) 1987-08-20
DK431887A (da) 1987-08-19
GR3007280T3 (de) 1993-07-30
NO176921C (no) 1995-06-21

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