DE3687651T2 - Analoge des gewebespezifischen plasminogenaktivators. - Google Patents

Analoge des gewebespezifischen plasminogenaktivators.

Info

Publication number
DE3687651T2
DE3687651T2 DE8686309704T DE3687651T DE3687651T2 DE 3687651 T2 DE3687651 T2 DE 3687651T2 DE 8686309704 T DE8686309704 T DE 8686309704T DE 3687651 T DE3687651 T DE 3687651T DE 3687651 T2 DE3687651 T2 DE 3687651T2
Authority
DE
Germany
Prior art keywords
analogs
tpa
plasminogen activator
tissue
specific plasminogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686309704T
Other languages
English (en)
Other versions
DE3687651D1 (de
Inventor
Keith R Marotti
Edward F Rehberg
Nicole Y Theriault
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE3687651D1 publication Critical patent/DE3687651D1/de
Application granted granted Critical
Publication of DE3687651T2 publication Critical patent/DE3687651T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE8686309704T 1985-12-20 1986-12-12 Analoge des gewebespezifischen plasminogenaktivators. Expired - Fee Related DE3687651T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81160785A 1985-12-20 1985-12-20
US90948286A 1986-09-19 1986-09-19

Publications (2)

Publication Number Publication Date
DE3687651D1 DE3687651D1 (de) 1993-03-11
DE3687651T2 true DE3687651T2 (de) 1993-06-24

Family

ID=27123502

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686309704T Expired - Fee Related DE3687651T2 (de) 1985-12-20 1986-12-12 Analoge des gewebespezifischen plasminogenaktivators.

Country Status (12)

Country Link
EP (2) EP0231624B1 (de)
JP (1) JPH0659223B2 (de)
KR (2) KR880700856A (de)
AT (1) ATE85081T1 (de)
AU (1) AU600463B2 (de)
DE (1) DE3687651T2 (de)
DK (1) DK431887A (de)
ES (1) ES2053449T3 (de)
FI (1) FI97809C (de)
GR (1) GR3007280T3 (de)
NO (1) NO176921C (de)
WO (1) WO1987003906A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK623186A (da) * 1985-12-23 1987-08-26 Chiron Corp Polypeptid med vaevsplasminogen-aktivator-virkning
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
AU7282687A (en) * 1986-03-28 1987-10-20 Gabriel Alvarado-Urbina Protein analogues of tissue plasminogen activator
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
AU1295088A (en) * 1987-01-30 1988-08-24 American Home Products Corporation Des-epidermal growth factor plasminogen activators
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
JPH01132377A (ja) * 1987-10-09 1989-05-24 Monsanto Co 修正型組織プラスミノーゲンアクチベーター
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
WO1989003874A1 (en) * 1987-10-29 1989-05-05 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
EP0398962A1 (de) * 1988-02-05 1990-11-28 Genzyme Corporation Geänderte gewebsplasminogenaktivatoren und verfahren zu ihrer herstellung
AU3064989A (en) * 1988-02-05 1989-08-25 Genzyme Corporation Modified gene sequences encoding modified tpa and products therefrom
AU619803B2 (en) * 1988-02-05 1992-02-06 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3823805A1 (de) * 1988-07-14 1990-01-18 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3836200A1 (de) * 1988-10-24 1990-04-26 Boehringer Mannheim Gmbh Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
EP0440709B1 (de) * 1988-10-27 1995-05-24 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Trombolytischer wirkstoff mit modifikation der domäne der kringle
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
DE3927865A1 (de) * 1989-08-23 1991-02-28 Boehringer Mannheim Gmbh T-pa-mutante gk1l
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
US5795975A (en) * 1993-01-10 1998-08-18 Yeda Research And Development Co. Ltd. TNF receptor promoter
IL104355A (en) * 1993-01-10 2006-08-20 Yeda Res & Dev Tnf receptor promoter
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
ZA837173B (en) 1982-11-08 1984-05-30 Univ Case Western Reserve Genomic bovine growth hormone
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0207589A1 (de) 1985-04-03 1987-01-07 Beecham Group Plc Modifiziertes fibrinolytisches Enzym
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product

Also Published As

Publication number Publication date
ES2053449T3 (es) 1994-08-01
DK431887D0 (da) 1987-08-19
EP0289508A1 (de) 1988-11-09
FI97809B (fi) 1996-11-15
NO176921B (no) 1995-03-13
GR3007280T3 (de) 1993-07-30
JPH05344892A (ja) 1993-12-27
FI97809C (fi) 1997-02-25
NO176921C (no) 1995-06-21
EP0231624B1 (de) 1993-01-27
DE3687651D1 (de) 1993-03-11
AU600463B2 (en) 1990-08-16
DK431887A (da) 1987-08-19
JPH0659223B2 (ja) 1994-08-10
AU6770187A (en) 1987-07-15
KR880700856A (ko) 1988-04-12
FI882922A0 (fi) 1988-06-17
EP0231624A1 (de) 1987-08-12
FI882922A (fi) 1988-06-17
ATE85081T1 (de) 1993-02-15
KR950000303B1 (ko) 1995-01-13
NO873517D0 (no) 1987-08-20
WO1987003906A1 (en) 1987-07-02
NO873517L (no) 1987-08-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee