FI882922A0 - Rekombinantti-DNA-molekyyli, joka koodaa kudosperäisen plasminogeenin aktivaattorin (TPA) analogia - Google Patents

Rekombinantti-DNA-molekyyli, joka koodaa kudosperäisen plasminogeenin aktivaattorin (TPA) analogia

Info

Publication number
FI882922A0
FI882922A0 FI882922A FI882922A FI882922A0 FI 882922 A0 FI882922 A0 FI 882922A0 FI 882922 A FI882922 A FI 882922A FI 882922 A FI882922 A FI 882922A FI 882922 A0 FI882922 A0 FI 882922A0
Authority
FI
Finland
Prior art keywords
tpa
analogs
recombinant dna
plasminogen activator
tissue
Prior art date
Application number
FI882922A
Other languages
English (en)
Swedish (sv)
Other versions
FI97809B (fi
FI97809C (fi
FI882922A (fi
Inventor
Keith P Marotti
Edward F Rehberg
Nicole Y Theriault
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI882922A0 publication Critical patent/FI882922A0/fi
Publication of FI882922A publication Critical patent/FI882922A/fi
Publication of FI97809B publication Critical patent/FI97809B/fi
Application granted granted Critical
Publication of FI97809C publication Critical patent/FI97809C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI882922A 1985-12-20 1988-06-17 Rekombinantti-DNA-molekyyli, joka koodaa kudosperäisen plasminogeenin aktivaattorin (TPA) analogia FI97809C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US81160785A 1985-12-20 1985-12-20
US81160785 1985-12-20
US90948286A 1986-09-19 1986-09-19
US90948286 1986-09-19
US8602684 1986-12-12
PCT/US1986/002684 WO1987003906A1 (en) 1985-12-20 1986-12-12 Tissue plasminogen activator (tpa) analogs

Publications (4)

Publication Number Publication Date
FI882922A0 true FI882922A0 (fi) 1988-06-17
FI882922A FI882922A (fi) 1988-06-17
FI97809B FI97809B (fi) 1996-11-15
FI97809C FI97809C (fi) 1997-02-25

Family

ID=27123502

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882922A FI97809C (fi) 1985-12-20 1988-06-17 Rekombinantti-DNA-molekyyli, joka koodaa kudosperäisen plasminogeenin aktivaattorin (TPA) analogia

Country Status (12)

Country Link
EP (2) EP0231624B1 (fi)
JP (1) JPH0659223B2 (fi)
KR (2) KR880700856A (fi)
AT (1) ATE85081T1 (fi)
AU (1) AU600463B2 (fi)
DE (1) DE3687651T2 (fi)
DK (1) DK431887A (fi)
ES (1) ES2053449T3 (fi)
FI (1) FI97809C (fi)
GR (1) GR3007280T3 (fi)
NO (1) NO176921C (fi)
WO (1) WO1987003906A1 (fi)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK623186A (da) * 1985-12-23 1987-08-26 Chiron Corp Polypeptid med vaevsplasminogen-aktivator-virkning
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
AU7282687A (en) * 1986-03-28 1987-10-20 Gabriel Alvarado-Urbina Protein analogues of tissue plasminogen activator
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
AU1295088A (en) * 1987-01-30 1988-08-24 American Home Products Corporation Des-epidermal growth factor plasminogen activators
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
JPH01132377A (ja) * 1987-10-09 1989-05-24 Monsanto Co 修正型組織プラスミノーゲンアクチベーター
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
WO1989003874A1 (en) * 1987-10-29 1989-05-05 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
EP0398962A1 (en) * 1988-02-05 1990-11-28 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same
AU3064989A (en) * 1988-02-05 1989-08-25 Genzyme Corporation Modified gene sequences encoding modified tpa and products therefrom
AU619803B2 (en) * 1988-02-05 1992-02-06 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3823805A1 (de) * 1988-07-14 1990-01-18 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3836200A1 (de) * 1988-10-24 1990-04-26 Boehringer Mannheim Gmbh Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
EP0440709B1 (en) * 1988-10-27 1995-05-24 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Thrombolytic agents with modified kringle domains
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
DE3927865A1 (de) * 1989-08-23 1991-02-28 Boehringer Mannheim Gmbh T-pa-mutante gk1l
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
US5795975A (en) * 1993-01-10 1998-08-18 Yeda Research And Development Co. Ltd. TNF receptor promoter
IL104355A (en) * 1993-01-10 2006-08-20 Yeda Res & Dev Tnf receptor promoter
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
ZA837173B (en) 1982-11-08 1984-05-30 Univ Case Western Reserve Genomic bovine growth hormone
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0207589A1 (en) 1985-04-03 1987-01-07 Beecham Group Plc Fibrinolytic enzyme
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product

Also Published As

Publication number Publication date
ES2053449T3 (es) 1994-08-01
DK431887D0 (da) 1987-08-19
EP0289508A1 (en) 1988-11-09
FI97809B (fi) 1996-11-15
NO176921B (no) 1995-03-13
GR3007280T3 (fi) 1993-07-30
JPH05344892A (ja) 1993-12-27
FI97809C (fi) 1997-02-25
NO176921C (no) 1995-06-21
EP0231624B1 (en) 1993-01-27
DE3687651D1 (de) 1993-03-11
AU600463B2 (en) 1990-08-16
DK431887A (da) 1987-08-19
JPH0659223B2 (ja) 1994-08-10
AU6770187A (en) 1987-07-15
DE3687651T2 (de) 1993-06-24
KR880700856A (ko) 1988-04-12
EP0231624A1 (en) 1987-08-12
FI882922A (fi) 1988-06-17
ATE85081T1 (de) 1993-02-15
KR950000303B1 (ko) 1995-01-13
NO873517D0 (no) 1987-08-20
WO1987003906A1 (en) 1987-07-02
NO873517L (no) 1987-08-20

Similar Documents

Publication Publication Date Title
FI97809B (fi) Rekombinantti-DNA-molekyyli, joka koodaa kudosperäisen plasminogeenin aktivaattorin (TPA) analogia
DK288183D0 (da) Fremgangsmade til fremstilling af et oligonucleotidt terapeutisk middel
DK0409472T3 (da) Knoglemorfogenetisk protein
DE69332955D1 (de) Chimäre prokoagulierende Proteine
DK75694A (da) Tumornecrosefaktor og derivater og mutantformer deraf, fremgangsmåde til fremstilling deraf, DNA som koder derfor, replicerbar udtrykkelsesvektor indeholdende DNA'en og celle transformeret dermed samt præparater omfattende tumornecrosefaktoren
DE3682891D1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
DK453782A (da) Dna-sekvenser, rekombinant plasmid samt anvendelser deraf
CA2091102A1 (en) Microsomal triglyceride transfer protein
FI863891A0 (fi) Menetelmiä sekropiinin ja muiden heterologisten polypeptidien tuottamiseksi bakteeri-isännässä araB-promoottoria käyttäen sekä menetelmissä käyttökelpoisia replikoituvia ekspressiovälineitä, geneettisiä muodostelmia ja bakteereja
DE3688324D1 (de) Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel.
NO179754C (no) Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekveks som koder for t-PA-analogen, ekspresjonsvektor omfattende DNA-sekvensen samt vertscelle omfattende denne
ES2240971T3 (es) Genes supresores de tumores, proteinas codificadas por ellos y uso de dichos genes y proteinas.
IL80562A0 (en) Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
NZ234453A (en) Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
NO179874C (no) Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekvens som koder for t-PA-analogen, samt ekspresjonsvektor omfattende DNA-sekvensen og vertcelle omfattende denne
NZ242124A (en) Dna encoding an enzyme having arabinan-degrading activity
ES2114555T3 (es) Nuevo interferon gamma humano recombinado.
DE69534596D1 (de) Epil/plazentin
AU4628289A (en) Wound-induced dna sequence from solanum tuberosum and its use
WO1990003394A3 (fr) Nouvelles lymphokines, sequences d'adn codant pour ces lymphokines et compositions pharmaceutiques contenant ces lymphokines
IT8521507A0 (it) Vettore di clonaggio, molecole di dna ricombinante, ceppi di bacillus subtilis trasformati con dette molecole e metodi per l'espressione di geni eterologhi e produzione e secrezione di proteine codificate da detti geni.
MX9601065A (es) Analogo de la proteina hin47 del haemophilus con actividad reducida de la proteasa.

Legal Events

Date Code Title Description
HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN COMPANY

BB Publication of examined application
MM Patent lapsed

Owner name: PHARMACIA & UPJOHN COMPANY