DK75694A - Tumornecrosefaktor og derivater og mutantformer deraf, fremgangsmåde til fremstilling deraf, DNA som koder derfor, replicerbar udtrykkelsesvektor indeholdende DNA'en og celle transformeret dermed samt præparater omfattende tumornecrosefaktoren - Google Patents

Tumornecrosefaktor og derivater og mutantformer deraf, fremgangsmåde til fremstilling deraf, DNA som koder derfor, replicerbar udtrykkelsesvektor indeholdende DNA'en og celle transformeret dermed samt præparater omfattende tumornecrosefaktoren

Info

Publication number
DK75694A
DK75694A DK075694A DK75694A DK75694A DK 75694 A DK75694 A DK 75694A DK 075694 A DK075694 A DK 075694A DK 75694 A DK75694 A DK 75694A DK 75694 A DK75694 A DK 75694A
Authority
DK
Denmark
Prior art keywords
necrosis factor
tumor necrosis
derivatives
mutant forms
recombinant
Prior art date
Application number
DK075694A
Other languages
English (en)
Other versions
DK171418B1 (da
Inventor
Bharat Bhushan Aggarwal
Davis Vannorman Goeddel
Sang He Lee
Glenn Evan Nedwin
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/677,257 external-priority patent/US4650674A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK75694A publication Critical patent/DK75694A/da
Application granted granted Critical
Publication of DK171418B1 publication Critical patent/DK171418B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C07K14/5255—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK075694A 1984-07-05 1994-06-24 Tumornecrosefaktorderivater, DNA som koder derfor, replikerbare udtrykkelsesvektorer indeholdende DNA'en, værtsceller transformeret dermed og en fremgangsmåde til fremstilling af tumornecrosefaktorderivaterne samt præparater omfattende tumornecrosefaktorderivaterne DK171418B1 (da)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US62806084A 1984-07-05 1984-07-05
US62805984A 1984-07-05 1984-07-05
US62795984A 1984-07-05 1984-07-05
US62806084 1984-07-05
US62805984 1984-07-05
US62795984 1984-07-05
US67715684A 1984-12-03 1984-12-03
US67745484A 1984-12-03 1984-12-03
US06/677,257 US4650674A (en) 1984-07-05 1984-12-03 Synergistic cytotoxic composition
US67715684 1984-12-03
US67725784 1984-12-03
US67745484 1984-12-03

Publications (2)

Publication Number Publication Date
DK75694A true DK75694A (da) 1994-06-24
DK171418B1 DK171418B1 (da) 1996-10-21

Family

ID=27560190

Family Applications (2)

Application Number Title Priority Date Filing Date
DK305885A DK169894B1 (da) 1984-07-05 1985-07-04 Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne
DK075694A DK171418B1 (da) 1984-07-05 1994-06-24 Tumornecrosefaktorderivater, DNA som koder derfor, replikerbare udtrykkelsesvektorer indeholdende DNA'en, værtsceller transformeret dermed og en fremgangsmåde til fremstilling af tumornecrosefaktorderivaterne samt præparater omfattende tumornecrosefaktorderivaterne

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK305885A DK169894B1 (da) 1984-07-05 1985-07-04 Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne

Country Status (20)

Country Link
EP (1) EP0168214B1 (da)
JP (4) JP2557341B2 (da)
AT (1) ATE113295T1 (da)
AU (1) AU599571B2 (da)
BG (1) BG60250B1 (da)
CZ (1) CZ283149B6 (da)
DE (2) DE19975064I2 (da)
DK (2) DK169894B1 (da)
FI (2) FI95472C (da)
GR (1) GR851626B (da)
HU (1) HU209153B (da)
IE (1) IE65426B1 (da)
IL (2) IL105271A (da)
LU (1) LU90456I2 (da)
NL (1) NL990033I2 (da)
NO (1) NO852673L (da)
NZ (1) NZ212632A (da)
PL (1) PL155778B1 (da)
SK (1) SK506785A3 (da)
YU (1) YU47968B (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
DE3582183D1 (de) * 1984-03-06 1991-04-25 Dainippon Pharmaceutical Co Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
EP0368367A1 (en) * 1984-12-21 1990-05-16 Biogen, Inc. Purification, production and use of tumor necrosis factors
JPS61155330A (ja) * 1984-12-28 1986-07-15 Denichi Mizuno 蛋白質標品
JPS6248634A (ja) * 1985-07-23 1987-03-03 Mochida Pharmaceut Co Ltd 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物
US4870163A (en) * 1985-08-29 1989-09-26 New York Blood Center, Inc. Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
NZ219027A (en) * 1986-01-24 1989-09-27 Genentech Inc Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin
DE3750915T2 (de) * 1986-02-04 1995-08-24 Den Ichi Mizuno Für Antitumor-Polypeptide kodierende DNS, die Polypeptide und diese Polypeptide enthaltenden Antitumor-Wirkstoffe.
US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
PT85076B (pt) * 1986-06-16 1990-07-31 Genentech Inc Metodo para o tratamento de doencas infecciosas pela administracao de factor de necrose tumoral-alfa
JPH0817712B2 (ja) * 1986-06-20 1996-02-28 大日本製薬株式会社 新規ヒトｔｎｆポリペプチド変異体
ATE107362T1 (de) * 1986-06-20 1994-07-15 Dainippon Pharmaceutical Co Polypeptid-mutanten des menschlichen tnf und für diese mutanten codierende dns.
US4857314A (en) * 1986-07-18 1989-08-15 Health Research , Inc. C-reactive proteins in treatment of animal and human cancers
CA1340698C (en) * 1986-07-25 1999-08-10 Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo Preparation and uses of interferon-gamma
KR880001300A (ko) * 1986-07-31 1988-04-22 맥스 디. 헨슬리 리트로바이러스 감염의 예방 및 치료를 위한 방법 및 조성물
US5002876A (en) * 1986-09-22 1991-03-26 Phillips Petroleum Company Yeast production of human tumor necrosis factor
US4777242A (en) * 1986-10-10 1988-10-11 Phillips Petroleum Company Purification of recombinant tumor necrosis factor
AU1346488A (en) * 1987-02-26 1988-09-26 Cetus Corporation Arginine-depleted human tumor necrosis factor
US4894225A (en) * 1987-03-02 1990-01-16 Cetus Corporation Combination therapy using antitumor immunotoxins with tumor necrosis factor
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217325B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene for tumour necrosis factor alpha.
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
DK0491878T3 (da) 1989-08-16 1997-06-23 Chiron Corp Præparater til inhibering af proteinhormondannelse og anvendelser deraf
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
AU642487B2 (en) * 1990-03-12 1993-10-21 Cephalon Australia Pty Ltd Neutrophil stimulating peptides
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
EP0682705A1 (en) * 1993-02-03 1995-11-22 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
WO1995024501A1 (en) 1994-03-07 1995-09-14 Cetus Oncology Corporation Compositions for the inhibition of tnf formation and uses thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
IL120979A0 (en) * 1997-06-02 1997-11-20 Interpharm Lab Ltd Glycosylated TNF
PT2953634T (pt) 2013-02-07 2021-09-02 Massachusetts Gen Hospital Métodos de expansão ou depleção das células t reguladoras

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH65623A (de) * 1913-08-02 1914-07-01 Siemens Ag Zeitrelais mit Wechselstrommotor und dessen Drehmoment entgegenwirkender Feder
NO163060C (no) * 1981-03-13 1990-03-28 Damon Biotech Inc Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer.
JPS5821621A (ja) * 1981-07-31 1983-02-08 Hayashibara Biochem Lab Inc ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤
CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
JPS60226816A (ja) * 1984-11-16 1985-11-12 Asahi Chem Ind Co Ltd 抗腫瘍活性をもつヒト由来蛋白質
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ
JPS60166696A (ja) * 1984-02-08 1985-08-29 Asahi Chem Ind Co Ltd 新規生理活性ポリペプチドのｄνａ
JPS60221092A (ja) * 1984-04-18 1985-11-05 Asahi Chem Ind Co Ltd 新規生理活性ポリペプチドのｄｎａ
JPS60137292A (ja) * 1983-12-26 1985-07-20 Asahi Chem Ind Co Ltd 新規生理活性ポリペプチドの遺伝情報を有するポリデオキシリボ核酸、該ポリデオキシリボ核酸を含む複製可能な組換ｄνａ、該複製可能な組換ｄνａで形質転換された微生物または細胞、新規生理活性ポリペプチド及びその製造方法
DE3472793D1 (en) * 1983-12-26 1988-08-25 Asahi Chemical Ind A novel physiologically active polypeptide
JPS60185799A (ja) * 1984-03-06 1985-09-21 Dainippon Pharmaceut Co Ltd ヒト癌壊死因子
JPS60232097A (ja) * 1984-04-23 1985-11-18 Dainippon Pharmaceut Co Ltd ヒト癌壊死因子ポリペプチドの製造法
DE3582183D1 (de) * 1984-03-06 1991-04-25 Dainippon Pharmaceutical Co Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
DE3421731A1 (de) * 1984-06-12 1985-12-12 Boehringer Ingelheim International GmbH, 6507 Ingelheim Humaner-tumor-nekrose-faktor
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
JP2515975B2 (ja) * 1985-02-26 1996-07-10 大日本製薬株式会社 抗腫瘍作用を有するポリペプチド

Also Published As

Publication number Publication date
JPH07291997A (ja) 1995-11-07
JP2614989B2 (ja) 1997-05-28
FI95472B (fi) 1995-10-31
SK279897B6 (sk) 1999-05-07
IE851691L (en) 1986-01-05
JPH0928387A (ja) 1997-02-04
GR851626B (da) 1985-11-26
FI98217B (fi) 1997-01-31
FI943750A0 (fi) 1994-08-15
NZ212632A (en) 1991-05-28
HUT38125A (en) 1986-04-28
FI98217C (fi) 1997-05-12
HU209153B (en) 1994-03-28
YU47968B (sh) 1996-08-13
CZ283149B6 (cs) 1998-01-14
DK169894B1 (da) 1995-03-27
PL254399A1 (en) 1986-06-17
DE3587939D1 (de) 1994-12-01
DE19975064I1 (de) 2005-09-29
EP0168214B1 (en) 1994-10-26
ATE113295T1 (de) 1994-11-15
YU113285A (en) 1991-04-30
BG60250B2 (bg) 1994-03-24
FI95472C (fi) 1996-02-12
NL990033I2 (nl) 2000-11-01
DK305885D0 (da) 1985-07-04
IE65426B1 (en) 1995-11-01
FI852626L (fi) 1986-01-06
DK305885A (da) 1986-03-14
NO852673L (no) 1986-01-06
JPS6140221A (ja) 1986-02-26
NL990033I1 (nl) 1999-12-01
JP2557341B2 (ja) 1996-11-27
IL75717A (en) 1994-11-28
JPH083061A (ja) 1996-01-09
FI943750A (fi) 1994-08-15
AU599571B2 (en) 1990-07-26
DE19975064I2 (de) 2005-11-03
IL75717A0 (en) 1985-11-29
FI852626A0 (fi) 1985-07-03
DE3587939T2 (de) 1995-04-27
EP0168214A3 (en) 1987-12-16
EP0168214A2 (en) 1986-01-15
DK171418B1 (da) 1996-10-21
CZ506785A3 (en) 1997-07-16
BG60250B1 (bg) 1994-03-24
PL155778B1 (pl) 1992-01-31
IL105271A (en) 1995-07-31
LU90456I2 (fr) 1999-12-06
SK506785A3 (en) 1999-05-07
AU4465285A (en) 1986-01-09

Similar Documents

Publication Publication Date Title
DK75694A (da) Tumornecrosefaktor og derivater og mutantformer deraf, fremgangsmåde til fremstilling deraf, DNA som koder derfor, replicerbar udtrykkelsesvektor indeholdende DNA'en og celle transformeret dermed samt præparater omfattende tumornecrosefaktoren
MY101852A (en) Tumor necrosis factor, methods for its preparation, containing it, dna encoding it and assay method using such dna.
PT1380587E (pt) Oxazolo, thiazolo e selenazolo -(4, 5-c )- naftiridina- 4- amina e analogos destes compostos
FI963630A0 (fi) IFN-beta:n uusia muteiineja
DK0961831T3 (da) Humant alfa-endokin
NZ227944A (en) Synergistic pharmaceutical composition of a hybrid interferon and a muramylpeptide
DK175837B1 (da) Interleukin I inhibitorer, fremgangsmåder til fremstilling deraf samt deres anvendelse til terapeutiske formål
DE68924464D1 (de) Interferon-gamma bindende Proteine.
AU7336687A (en) Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ES8800984A1 (es) Un metodo para obtener adn que codifica factor de necrosis de tumores mutante
IT1224385B (it) Cannula per prelievi, particolarmente di tipo endometriale e/o endocervicale

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired