GB2217325B - Synthetic gene for tumour necrosis factor alpha. - Google Patents

Synthetic gene for tumour necrosis factor alpha.

Info

Publication number
GB2217325B
GB2217325B GB8808205A GB8808205A GB2217325B GB 2217325 B GB2217325 B GB 2217325B GB 8808205 A GB8808205 A GB 8808205A GB 8808205 A GB8808205 A GB 8808205A GB 2217325 B GB2217325 B GB 2217325B
Authority
GB
United Kingdom
Prior art keywords
necrosis factor
factor alpha
synthetic gene
tumour necrosis
tumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8808205A
Other versions
GB8808205D0 (en
GB2217325A (en
Inventor
John Alun Davies
Ian David Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Bio Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology Ltd filed Critical British Bio Technology Ltd
Priority to GB8808205A priority Critical patent/GB2217325B/en
Publication of GB8808205D0 publication Critical patent/GB8808205D0/en
Publication of GB2217325A publication Critical patent/GB2217325A/en
Application granted granted Critical
Publication of GB2217325B publication Critical patent/GB2217325B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB8808205A 1988-04-08 1988-04-08 Synthetic gene for tumour necrosis factor alpha. Expired - Fee Related GB2217325B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8808205A GB2217325B (en) 1988-04-08 1988-04-08 Synthetic gene for tumour necrosis factor alpha.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8808205A GB2217325B (en) 1988-04-08 1988-04-08 Synthetic gene for tumour necrosis factor alpha.

Publications (3)

Publication Number Publication Date
GB8808205D0 GB8808205D0 (en) 1988-05-11
GB2217325A GB2217325A (en) 1989-10-25
GB2217325B true GB2217325B (en) 1991-11-20

Family

ID=10634774

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8808205A Expired - Fee Related GB2217325B (en) 1988-04-08 1988-04-08 Synthetic gene for tumour necrosis factor alpha.

Country Status (1)

Country Link
GB (1) GB2217325B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2055613A1 (en) * 1989-05-31 1990-12-01 Jeffrey W. Almond Poliovirus chimaeras

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155549A2 (en) * 1984-03-06 1985-09-25 Dainippon Pharmaceutical Co., Ltd. DNA encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
GB2158829A (en) * 1984-04-06 1985-11-20 Asahi Chemical Ind A novel human physiologically active polypeptide
EP0168214A2 (en) * 1984-07-05 1986-01-15 Genentech, Inc. Tumor necrosis factor, methods for its preparation, compositions containing it, DNA encoding it and assay method using such DNA
WO1986003751A2 (en) * 1984-12-21 1986-07-03 Biogen N.V. Purification, production and use of tumor necrosis factors
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
EP0263311A2 (en) * 1986-09-22 1988-04-13 Phillips Petroleum Company Yeast production of human tumor necrosis factor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155549A2 (en) * 1984-03-06 1985-09-25 Dainippon Pharmaceutical Co., Ltd. DNA encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
GB2158829A (en) * 1984-04-06 1985-11-20 Asahi Chemical Ind A novel human physiologically active polypeptide
EP0168214A2 (en) * 1984-07-05 1986-01-15 Genentech, Inc. Tumor necrosis factor, methods for its preparation, compositions containing it, DNA encoding it and assay method using such DNA
WO1986003751A2 (en) * 1984-12-21 1986-07-03 Biogen N.V. Purification, production and use of tumor necrosis factors
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
EP0263311A2 (en) * 1986-09-22 1988-04-13 Phillips Petroleum Company Yeast production of human tumor necrosis factor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Gene,Vol.32,1984,pages 67-74 *
J. Biotechnol. 1985, 3,141-153 *
NATURE,Vol.323,1986,page 187 *

Also Published As

Publication number Publication date
GB8808205D0 (en) 1988-05-11
GB2217325A (en) 1989-10-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930408