YU47968B - Postupak za dobivanje faktora nekroze tumora - Google Patents
Postupak za dobivanje faktora nekroze tumoraInfo
- Publication number
- YU47968B YU47968B YU113285A YU113285A YU47968B YU 47968 B YU47968 B YU 47968B YU 113285 A YU113285 A YU 113285A YU 113285 A YU113285 A YU 113285A YU 47968 B YU47968 B YU 47968B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- procedure
- necrosis factor
- tumor necrosis
- obtaining tumor
- necessity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C07K14/5255—Lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
POSTUPAK ZA DOBIVANJE FAKTORA NEKROZE TUMORA naznačen time, što obohvata adsorbovanje faktora nekroze tumora iz takve smeše na supstancu odabranu iz grupe koju čine silikat, staklo kontrolisanih pora, alkil sefaroza i čestice anjon izmen-ivačke smole koje imaju uglavnom uniformnu veličinu učestica, i zatim eluiranje faktora nekroze tumora. Prijava sadrži još 4 nezavisna i 27 zavisnih zahteva.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI8511132A SI8511132B (sl) | 1984-07-05 | 1985-07-08 | Faktor nekroze tumorja |
HRP-1132/85A HRP950156B1 (en) | 1984-07-05 | 1995-03-28 | Tumor necrosis factor |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62806084A | 1984-07-05 | 1984-07-05 | |
US62805984A | 1984-07-05 | 1984-07-05 | |
US62795984A | 1984-07-05 | 1984-07-05 | |
US67715684A | 1984-12-03 | 1984-12-03 | |
US67745484A | 1984-12-03 | 1984-12-03 | |
US06/677,257 US4650674A (en) | 1984-07-05 | 1984-12-03 | Synergistic cytotoxic composition |
Publications (2)
Publication Number | Publication Date |
---|---|
YU113285A YU113285A (en) | 1991-04-30 |
YU47968B true YU47968B (sh) | 1996-08-13 |
Family
ID=27560190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU113285A YU47968B (sh) | 1984-07-05 | 1985-07-08 | Postupak za dobivanje faktora nekroze tumora |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0168214B1 (sh) |
JP (4) | JP2557341B2 (sh) |
AT (1) | ATE113295T1 (sh) |
AU (1) | AU599571B2 (sh) |
BG (1) | BG60250B1 (sh) |
CZ (1) | CZ283149B6 (sh) |
DE (2) | DE3587939T2 (sh) |
DK (2) | DK169894B1 (sh) |
FI (2) | FI95472C (sh) |
GR (1) | GR851626B (sh) |
HU (1) | HU209153B (sh) |
IE (1) | IE65426B1 (sh) |
IL (2) | IL105271A (sh) |
LU (1) | LU90456I2 (sh) |
NL (1) | NL990033I2 (sh) |
NO (1) | NO852673L (sh) |
NZ (1) | NZ212632A (sh) |
PL (1) | PL155778B1 (sh) |
SK (1) | SK506785A3 (sh) |
YU (1) | YU47968B (sh) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1265444A (en) * | 1983-06-27 | 1990-02-06 | Lloyd J. Old | Effect of human tumor necrosis factor and human interferon on human cancer cells and methods |
US5288852A (en) * | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
DE19975063I2 (de) * | 1984-03-06 | 2005-08-18 | Dainippon Pharmaceutical Co | DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d. |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
JP2675294B2 (ja) * | 1984-10-15 | 1997-11-12 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
DE3585690D1 (de) * | 1984-12-21 | 1992-04-23 | Biogen Inc | Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren. |
JPS61155330A (ja) * | 1984-12-28 | 1986-07-15 | Denichi Mizuno | 蛋白質標品 |
JPS6248634A (ja) * | 1985-07-23 | 1987-03-03 | Mochida Pharmaceut Co Ltd | 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物 |
US4870163A (en) * | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
US4894439A (en) * | 1986-05-22 | 1990-01-16 | Cetus Corporation | N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes |
US4677197A (en) * | 1985-10-30 | 1987-06-30 | Cetus Corporation | Purification method for tumor necrosis factor |
US4828830A (en) * | 1986-01-24 | 1989-05-09 | Genentech, Inc. | Method and composition for prophylaxis and treatment of viral infections |
NZ219027A (en) * | 1986-01-24 | 1989-09-27 | Genentech Inc | Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin |
US5081021A (en) * | 1986-02-04 | 1992-01-14 | Mizuno Den Ichi | DNA encoding HTNF variants exhibiting enhanced activity |
US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
PT85076B (pt) * | 1986-06-16 | 1990-07-31 | Genentech Inc | Metodo para o tratamento de doencas infecciosas pela administracao de factor de necrose tumoral-alfa |
JPH0817712B2 (ja) * | 1986-06-20 | 1996-02-28 | 大日本製薬株式会社 | 新規ヒトtnfポリペプチド変異体 |
DE3750056T2 (de) * | 1986-06-20 | 1995-04-06 | Dainippon Pharmaceutical Co | Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS. |
US4857314A (en) * | 1986-07-18 | 1989-08-15 | Health Research , Inc. | C-reactive proteins in treatment of animal and human cancers |
CA1340698C (en) * | 1986-07-25 | 1999-08-10 | Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo | Preparation and uses of interferon-gamma |
DD263234A5 (de) * | 1986-07-31 | 1988-12-28 | Genentech,Inc.,Us | Verfahren zur herstellung von arzneimitteln zur behandlung oder vorbeugung von retroviralen infektionen |
US5002876A (en) * | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
US4777242A (en) * | 1986-10-10 | 1988-10-11 | Phillips Petroleum Company | Purification of recombinant tumor necrosis factor |
AU1346488A (en) * | 1987-02-26 | 1988-09-26 | Cetus Corporation | Arginine-depleted human tumor necrosis factor |
US4894225A (en) * | 1987-03-02 | 1990-01-16 | Cetus Corporation | Combination therapy using antitumor immunotoxins with tumor necrosis factor |
JPS6463395A (en) * | 1987-05-04 | 1989-03-09 | Oncogen | Oncostatin m and novel composition having antitumor activity |
DE3837012A1 (de) * | 1988-01-15 | 1989-07-27 | Knoll Ag | Verwendung von tnf und lt zur herstellung von arzneimitteln |
GB2217325B (en) * | 1988-04-08 | 1991-11-20 | British Bio Technology | Synthetic gene for tumour necrosis factor alpha. |
DE3843534A1 (de) * | 1988-12-23 | 1990-07-12 | Basf Ag | Neue tnf-polypeptide |
US6586222B1 (en) | 1989-08-16 | 2003-07-01 | Chiron Corporation | Recombinant PR-3 and compositions thereof |
ES2097766T3 (es) | 1989-08-16 | 1997-04-16 | Chiron Corp | Composiciones para la inhibicion de la formacion de hormonas proteicas y sus usos. |
US5998378A (en) * | 1989-08-16 | 1999-12-07 | Chiron Corporation | Compositions for the inhibition of TNF hormone formation and uses thereof |
US5843693A (en) * | 1989-08-16 | 1998-12-01 | Chiron Corporation | Assay method for screening for inhibitors of proTNF conversion |
US5200176A (en) * | 1989-10-06 | 1993-04-06 | Genentech, Inc. | Method for protection of ischemic tissues using tumor nerosis factor |
US5370870A (en) * | 1989-10-06 | 1994-12-06 | Genentech, Inc. | Method for protection against reactive oxygen species |
WO1991013908A1 (en) * | 1990-03-12 | 1991-09-19 | Peptide Technology Ltd. | Neutrophil stimulating peptides |
IL97779A (en) * | 1990-04-10 | 2000-01-31 | Genentech Inc | Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof |
CA2055168A1 (en) * | 1990-11-21 | 1992-05-22 | Walter Fiers | Tnf-muteins |
CA2155103A1 (en) * | 1993-02-03 | 1994-08-18 | Rudolph Lucas | Tnf-alpha muteins and a process for preparing them |
KR970005042B1 (ko) * | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
CA2119089A1 (en) * | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins |
EP0749494A1 (en) | 1994-03-07 | 1996-12-27 | Chiron Corporation | Compositions for the inhibition of tnf formation and uses thereof |
US5747023A (en) * | 1994-07-01 | 1998-05-05 | Genentech, Inc. | Cancer therapy using lymphotoxin |
IL120979A0 (en) * | 1997-06-02 | 1997-11-20 | Interpharm Lab Ltd | Glycosylated TNF |
JP6367836B2 (ja) | 2013-02-07 | 2018-08-01 | ザ ジェネラル ホスピタル コーポレイション | T制御性細胞の増殖または枯渇方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH65623A (de) * | 1913-08-02 | 1914-07-01 | Siemens Ag | Zeitrelais mit Wechselstrommotor und dessen Drehmoment entgegenwirkender Feder |
NO163060C (no) * | 1981-03-13 | 1990-03-28 | Damon Biotech Inc | Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer. |
JPS5821621A (ja) * | 1981-07-31 | 1983-02-08 | Hayashibara Biochem Lab Inc | ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤 |
CA1265444A (en) * | 1983-06-27 | 1990-02-06 | Lloyd J. Old | Effect of human tumor necrosis factor and human interferon on human cancer cells and methods |
JPS60226816A (ja) * | 1984-11-16 | 1985-11-12 | Asahi Chem Ind Co Ltd | 抗腫瘍活性をもつヒト由来蛋白質 |
JPH0695939B2 (ja) * | 1983-12-02 | 1994-11-30 | 大日本製薬株式会社 | ウサギ癌壊死因子をコ−ドするクロ−ン化dνa |
JPS60221092A (ja) * | 1984-04-18 | 1985-11-05 | Asahi Chem Ind Co Ltd | 新規生理活性ポリペプチドのdna |
DE3472793D1 (en) * | 1983-12-26 | 1988-08-25 | Asahi Chemical Ind | A novel physiologically active polypeptide |
JPS60166696A (ja) * | 1984-02-08 | 1985-08-29 | Asahi Chem Ind Co Ltd | 新規生理活性ポリペプチドのdνa |
JPS60137292A (ja) * | 1983-12-26 | 1985-07-20 | Asahi Chem Ind Co Ltd | 新規生理活性ポリペプチドの遺伝情報を有するポリデオキシリボ核酸、該ポリデオキシリボ核酸を含む複製可能な組換dνa、該複製可能な組換dνaで形質転換された微生物または細胞、新規生理活性ポリペプチド及びその製造方法 |
JPS60185799A (ja) * | 1984-03-06 | 1985-09-21 | Dainippon Pharmaceut Co Ltd | ヒト癌壊死因子 |
JPS60232097A (ja) * | 1984-04-23 | 1985-11-18 | Dainippon Pharmaceut Co Ltd | ヒト癌壊死因子ポリペプチドの製造法 |
DE19975063I2 (de) * | 1984-03-06 | 2005-08-18 | Dainippon Pharmaceutical Co | DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d. |
US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
DE3421731A1 (de) * | 1984-06-12 | 1985-12-12 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Humaner-tumor-nekrose-faktor |
JP2675294B2 (ja) * | 1984-10-15 | 1997-11-12 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
JP2515975B2 (ja) * | 1985-02-26 | 1996-07-10 | 大日本製薬株式会社 | 抗腫瘍作用を有するポリペプチド |
-
1985
- 1985-07-02 GR GR851626A patent/GR851626B/el unknown
- 1985-07-03 DE DE3587939T patent/DE3587939T2/de not_active Expired - Lifetime
- 1985-07-03 FI FI852626A patent/FI95472C/fi not_active IP Right Cessation
- 1985-07-03 IL IL10527185A patent/IL105271A/en not_active IP Right Cessation
- 1985-07-03 NZ NZ212632A patent/NZ212632A/xx unknown
- 1985-07-03 EP EP85304758A patent/EP0168214B1/en not_active Expired - Lifetime
- 1985-07-03 AT AT85304758T patent/ATE113295T1/de not_active IP Right Cessation
- 1985-07-03 NO NO852673A patent/NO852673L/no unknown
- 1985-07-03 DE DE1999175064 patent/DE19975064I2/de active Active
- 1985-07-03 IL IL7571785A patent/IL75717A/en not_active IP Right Cessation
- 1985-07-04 AU AU44652/85A patent/AU599571B2/en not_active Expired
- 1985-07-04 HU HU852602A patent/HU209153B/hu unknown
- 1985-07-04 BG BG070958A patent/BG60250B1/bg unknown
- 1985-07-04 IE IE169185A patent/IE65426B1/en not_active IP Right Cessation
- 1985-07-04 DK DK305885A patent/DK169894B1/da not_active IP Right Cessation
- 1985-07-05 SK SK5067-85A patent/SK506785A3/sk not_active IP Right Cessation
- 1985-07-05 CZ CS855067A patent/CZ283149B6/cs not_active IP Right Cessation
- 1985-07-05 JP JP60149075A patent/JP2557341B2/ja not_active Expired - Lifetime
- 1985-07-05 PL PL85254399A patent/PL155778B1/pl unknown
- 1985-07-08 YU YU113285A patent/YU47968B/sh unknown
-
1994
- 1994-06-24 DK DK075694A patent/DK171418B1/da not_active IP Right Cessation
- 1994-08-15 FI FI943750A patent/FI98217C/fi not_active IP Right Cessation
-
1995
- 1995-01-19 JP JP7006437A patent/JPH07291997A/ja active Pending
- 1995-01-19 JP JP7006453A patent/JP2614989B2/ja not_active Expired - Lifetime
-
1996
- 1996-07-23 JP JP8193520A patent/JPH0928387A/ja active Pending
-
1999
- 1999-10-06 LU LU90456C patent/LU90456I2/fr unknown
- 1999-10-12 NL NL990033C patent/NL990033I2/nl unknown
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