DE69332955D1 - Chimäre prokoagulierende Proteine - Google Patents
Chimäre prokoagulierende ProteineInfo
- Publication number
- DE69332955D1 DE69332955D1 DE69332955T DE69332955T DE69332955D1 DE 69332955 D1 DE69332955 D1 DE 69332955D1 DE 69332955 T DE69332955 T DE 69332955T DE 69332955 T DE69332955 T DE 69332955T DE 69332955 D1 DE69332955 D1 DE 69332955D1
- Authority
- DE
- Germany
- Prior art keywords
- factor viii
- procoagulant proteins
- chimeric
- chimeric factor
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003805 procoagulant Substances 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000001690 Factor VIII Human genes 0.000 abstract 1
- 108010054218 Factor VIII Proteins 0.000 abstract 1
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 229960000301 factor viii Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97608692A | 1992-11-13 | 1992-11-13 | |
US08/121,202 US5563045A (en) | 1992-11-13 | 1993-09-14 | Chimeric procoagulant proteins |
PCT/US1993/009438 WO1994011503A2 (en) | 1992-11-13 | 1993-10-01 | Chimeric factor viii |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69332955D1 true DE69332955D1 (de) | 2003-06-12 |
DE69332955T2 DE69332955T2 (de) | 2004-01-29 |
Family
ID=26819212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69332955T Expired - Lifetime DE69332955T2 (de) | 1992-11-13 | 1993-10-01 | Chimäre prokoagulierende Proteine |
Country Status (9)
Country | Link |
---|---|
US (1) | US5563045A (de) |
EP (2) | EP1308515A3 (de) |
AT (1) | ATE239789T1 (de) |
AU (1) | AU5298293A (de) |
DE (1) | DE69332955T2 (de) |
DK (1) | DK0672138T3 (de) |
ES (1) | ES2193145T3 (de) |
PT (1) | PT672138E (de) |
WO (1) | WO1994011503A2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180371B1 (en) * | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US6376463B1 (en) * | 1992-04-07 | 2002-04-23 | Emory University | Modified factor VIII |
US5744446A (en) * | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
US5663060A (en) * | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
US5888974A (en) * | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
DE19613620C2 (de) * | 1996-04-04 | 1998-04-16 | Steag Micro Tech Gmbh | Verfahren und Vorrichtung zum Trocknen von Substraten |
US8183344B2 (en) * | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
US20040092442A1 (en) * | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
CA2252896C (en) * | 1996-04-24 | 2009-03-10 | The Regents Of The University Of Michigan | Inactivation resistant factor viii |
US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
US7560107B2 (en) * | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US6200560B1 (en) * | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
CA2351671A1 (en) * | 1998-11-24 | 2000-06-08 | Regents Of The University Of Minnesota | Transgenic circulating endothelial cells |
US7615622B2 (en) | 2001-01-12 | 2009-11-10 | University Of Maryland, Baltimore | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII |
US20040143104A1 (en) * | 2001-08-08 | 2004-07-22 | Wadsworth Samuel C. | Methods of treating diabetes and other blood sugar disorders |
JP2005509409A (ja) * | 2001-08-08 | 2005-04-14 | ジェンザイム・コーポレーション | 糖尿病および他の血糖疾患の治療方法 |
EP3552627A1 (de) * | 2003-05-06 | 2019-10-16 | Bioverativ Therapeutics Inc. | Chimäre proteine mit gerinnungsfaktor fc zur behandlung von hämophilie |
WO2005033321A2 (en) | 2003-09-30 | 2005-04-14 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor |
WO2005046583A2 (en) * | 2003-10-30 | 2005-05-26 | Emory University | Modified fviii having reduced immunogenicity through mutagenesis of a2 and c2 epitopes |
US7211559B2 (en) | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
US20050107318A1 (en) * | 2003-11-17 | 2005-05-19 | Samuel Wadsworth | Methods of treating diabetes and other blood sugar disorders |
SI1750733T1 (sl) * | 2004-05-03 | 2014-03-31 | Emory University | POSTOPEK DAJANJA PRAĹ IÄŚJEGA fVIII BREZ DOMENE B |
EP2359865B1 (de) | 2005-04-07 | 2013-10-02 | The Trustees of The University of Pennsylvania | Verfahren zur Erhöhung der Funktion eines AAV-Vektors |
US20080070251A1 (en) * | 2006-06-30 | 2008-03-20 | Kaufman Randal J | Method of Producing Factor VIII Proteins by Recombinant Methods |
KR20110022604A (ko) * | 2008-05-16 | 2011-03-07 | 바이엘 헬스케어 엘엘씨 | 표적화 응고 인자 및 그의 사용 방법 |
WO2011028228A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
NZ600709A (en) | 2009-12-06 | 2015-01-30 | Biogen Idec Hemophilia Inc | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
US20130023033A1 (en) | 2010-03-29 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
US9611310B2 (en) | 2010-07-09 | 2017-04-04 | Bioverativ Therapeutics Inc. | Systems for factor VIII processing and methods thereof |
AU2011323236B2 (en) | 2010-11-05 | 2017-03-30 | Takeda Pharmaceutical Company Limited | A new variant of antihemophilic factor VIII having increased specific activity |
MX353930B (es) | 2011-02-17 | 2018-02-02 | Univ Pennsylvania | Composiciones y metodos para alterar la especificidad tisular y mejorar la transferencia de genes mediada por vector viral adeno-asociado 9. |
AU2012267484B2 (en) | 2011-06-10 | 2017-03-23 | Bioverativ Therapeutics Inc. | Pro-coagulant compounds and methods of use thereof |
AU2012282875B2 (en) * | 2011-07-08 | 2016-04-21 | Bioverativ Therapeutics Inc. | Factor VIII chimeric and hybrid polypeptides, and methods of use thereof |
WO2013016454A1 (en) | 2011-07-25 | 2013-01-31 | Biogen Idec Hemophilia Inc. | Assays to monitor bleeding disorders |
WO2013106787A1 (en) | 2012-01-12 | 2013-07-18 | Biogen Idec Ma Inc. | Chimeric factor viii polypeptides and uses thereof |
LT2802668T (lt) | 2012-01-12 | 2018-11-26 | Bioverativ Therapeutics Inc. | Imunogeninio atsako prieš faktorių viii individuose, kuriems skiriama faktoriaus viii terapija, sumažinimas |
RS59833B1 (sr) | 2012-02-15 | 2020-02-28 | Bioverativ Therapeutics Inc | Sastavi faktora viii i postupci za pravljenje i upotrebu istih |
CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
WO2014011819A2 (en) | 2012-07-11 | 2014-01-16 | Amunix Operating Inc. | Factor viii complex with xten and von willebrand factor protein, and uses thereof |
EP3970738A1 (de) | 2012-07-25 | 2022-03-23 | Bioverativ Therapeutics Inc. | Blutfaktorüberwachungstest und verwendungen davon |
WO2014063108A1 (en) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Methods of using a fixed dose of a clotting factor |
EP2914293A4 (de) | 2012-10-30 | 2016-04-20 | Biogen Ma Inc | Verfahren zur verwendung von fviii-polypeptid |
PL3666283T3 (pl) | 2013-03-15 | 2022-10-03 | Bioverativ Therapeutics Inc. | Formulacje polipeptydu czynnika viii |
WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
KR102666819B1 (ko) | 2013-06-28 | 2024-05-23 | 바이오버라티브 테라퓨틱스 인크. | Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도 |
WO2015021423A2 (en) | 2013-08-08 | 2015-02-12 | Biogen Idec Ma Inc. | Purification of chimeric fviii molecules |
EP3033097B1 (de) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Faktor viii-xten fusionen sowie ihre verwendungen. |
EP3065769A4 (de) | 2013-11-08 | 2017-05-31 | Biogen MA Inc. | Prokoagulatorische fusionsverbindung |
ES2967617T3 (es) | 2013-12-06 | 2024-05-03 | Bioverativ Therapeutics Inc | Herramientas de farmacocinética poblacional y sus usos |
AU2015204646B2 (en) | 2014-01-10 | 2020-08-27 | Bioverativ Therapeutics Inc. | Factor VIII chimeric proteins and uses thereof |
EP3626274A3 (de) | 2015-04-16 | 2020-06-17 | Emory University | Rekombinante promotoren und vektoren zur proteinexpression in leber und verwendung davon |
UA126016C2 (uk) | 2015-08-03 | 2022-08-03 | Біовератів Терапеутікс Інк. | Злитий білок фактора іх |
EP3390641B1 (de) | 2015-12-16 | 2023-08-09 | The New Zealand Institute for Plant and Food Research Limited | Zusammensetzungen und verfahren zur manipulation der entwicklung von pflanzen |
KR20210020030A (ko) | 2018-05-18 | 2021-02-23 | 바이오버라티브 테라퓨틱스 인크. | A형 혈우병의 치료 방법 |
JP2022512787A (ja) * | 2018-10-23 | 2022-02-07 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | 第viii因子機能を調節するための組成物および方法 |
WO2022032140A2 (en) | 2020-08-07 | 2022-02-10 | Amicus Therapeutics, Inc. | Vesicle targeting proteins and uses of same |
WO2024077110A2 (en) | 2022-10-05 | 2024-04-11 | Roger Paul Hellens | Uorf::reporter gene fusions to select sequence changes to gene edit into uorfs to regulate ascorbate genes |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
JPH07106156B2 (ja) * | 1983-10-28 | 1995-11-15 | ジェネティックス、インスティチュ−ト | ファクタ−▲viii▼および関連生産物の製造 |
AU5772886A (en) | 1985-04-12 | 1986-11-05 | Genetics Institute Inc. | Novel procoagulant proteins |
EP0253870B1 (de) | 1986-01-03 | 1993-03-31 | Genetics Institute, Inc. | Verfahren zur herstellung von faktor-viii:c-typ-proteinen |
US5451521A (en) | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
CA1331157C (en) | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
US5004803A (en) * | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
-
1993
- 1993-09-14 US US08/121,202 patent/US5563045A/en not_active Expired - Lifetime
- 1993-10-01 ES ES93923220T patent/ES2193145T3/es not_active Expired - Lifetime
- 1993-10-01 WO PCT/US1993/009438 patent/WO1994011503A2/en active IP Right Grant
- 1993-10-01 EP EP02025048A patent/EP1308515A3/de not_active Withdrawn
- 1993-10-01 PT PT93923220T patent/PT672138E/pt unknown
- 1993-10-01 AT AT93923220T patent/ATE239789T1/de not_active IP Right Cessation
- 1993-10-01 EP EP93923220A patent/EP0672138B1/de not_active Revoked
- 1993-10-01 DE DE69332955T patent/DE69332955T2/de not_active Expired - Lifetime
- 1993-10-01 AU AU52982/93A patent/AU5298293A/en not_active Abandoned
- 1993-10-01 DK DK93923220T patent/DK0672138T3/da active
Also Published As
Publication number | Publication date |
---|---|
AU5298293A (en) | 1994-06-08 |
DK0672138T3 (da) | 2003-08-11 |
ATE239789T1 (de) | 2003-05-15 |
PT672138E (pt) | 2003-09-30 |
EP1308515A2 (de) | 2003-05-07 |
US5563045A (en) | 1996-10-08 |
WO1994011503A2 (en) | 1994-05-26 |
DE69332955T2 (de) | 2004-01-29 |
WO1994011503A3 (en) | 1994-07-07 |
EP1308515A3 (de) | 2003-05-28 |
ES2193145T3 (es) | 2003-11-01 |
EP0672138A1 (de) | 1995-09-20 |
EP0672138B1 (de) | 2003-05-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |