AU5298293A - Chimeric factor viii - Google Patents
Chimeric factor viiiInfo
- Publication number
- AU5298293A AU5298293A AU52982/93A AU5298293A AU5298293A AU 5298293 A AU5298293 A AU 5298293A AU 52982/93 A AU52982/93 A AU 52982/93A AU 5298293 A AU5298293 A AU 5298293A AU 5298293 A AU5298293 A AU 5298293A
- Authority
- AU
- Australia
- Prior art keywords
- factor viii
- chimeric factor
- procoagulant proteins
- chimeric
- type procoagulant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229960000301 factor viii Drugs 0.000 title abstract 2
- 239000003805 procoagulant Substances 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000001690 Factor VIII Human genes 0.000 abstract 1
- 108010054218 Factor VIII Proteins 0.000 abstract 1
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97608692A | 1992-11-13 | 1992-11-13 | |
US976086 | 1992-11-13 | ||
US08/121,202 US5563045A (en) | 1992-11-13 | 1993-09-14 | Chimeric procoagulant proteins |
US121202 | 1993-09-14 | ||
PCT/US1993/009438 WO1994011503A2 (en) | 1992-11-13 | 1993-10-01 | Chimeric factor viii |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5298293A true AU5298293A (en) | 1994-06-08 |
Family
ID=26819212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU52982/93A Abandoned AU5298293A (en) | 1992-11-13 | 1993-10-01 | Chimeric factor viii |
Country Status (9)
Country | Link |
---|---|
US (1) | US5563045A (de) |
EP (2) | EP1308515A3 (de) |
AT (1) | ATE239789T1 (de) |
AU (1) | AU5298293A (de) |
DE (1) | DE69332955T2 (de) |
DK (1) | DK0672138T3 (de) |
ES (1) | ES2193145T3 (de) |
PT (1) | PT672138E (de) |
WO (1) | WO1994011503A2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180371B1 (en) * | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US5744446A (en) * | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
US5663060A (en) * | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
US5888974A (en) * | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
US6376463B1 (en) | 1992-04-07 | 2002-04-23 | Emory University | Modified factor VIII |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
DE19613620C2 (de) * | 1996-04-04 | 1998-04-16 | Steag Micro Tech Gmbh | Verfahren und Vorrichtung zum Trocknen von Substraten |
US20040092442A1 (en) * | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
US8183344B2 (en) * | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
DE69740154D1 (de) * | 1996-04-24 | 2011-05-05 | Univ Michigan | Gegen Inaktivierung resistenter Faktor VIII |
US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US6458563B1 (en) * | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
US6200560B1 (en) * | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
JP2002537761A (ja) * | 1998-11-24 | 2002-11-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | トランスジェニック循環内皮細胞 |
CA2434097A1 (en) | 2001-01-12 | 2002-08-08 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii |
US20040143104A1 (en) * | 2001-08-08 | 2004-07-22 | Wadsworth Samuel C. | Methods of treating diabetes and other blood sugar disorders |
JP2005509409A (ja) * | 2001-08-08 | 2005-04-14 | ジェンザイム・コーポレーション | 糖尿病および他の血糖疾患の治療方法 |
SI1624891T2 (sl) * | 2003-05-06 | 2013-09-30 | Biogen Idec Hemophilia Inc. | Strjevalni faktor-FC himerni proteini za zdravljenje hemofilije |
JP5054975B2 (ja) | 2003-09-30 | 2012-10-24 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
EP1682106A4 (de) * | 2003-10-30 | 2008-06-11 | Univ Emory | Modifiziertes fviii mit verringerter immunogenität durch mutagenese von a2- und c2-epitopen |
US7211559B2 (en) | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
US20050107318A1 (en) * | 2003-11-17 | 2005-05-19 | Samuel Wadsworth | Methods of treating diabetes and other blood sugar disorders |
ES2449044T3 (es) | 2004-05-03 | 2014-03-18 | Emory University | Procedimiento de administración de fVIII sin dominio B porcino |
JP5702519B2 (ja) | 2005-04-07 | 2015-04-15 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Aavベクターの機能を上げる方法 |
EP2035572A4 (de) * | 2006-06-30 | 2010-01-06 | Univ Michigan | Verfahren zur herstellung von faktor-viii-proteinen durch rekombinationsverfahren |
CN102112144A (zh) * | 2008-05-16 | 2011-06-29 | 拜耳医药保健有限公司 | 靶向性凝固因子及其使用方法 |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
LT2506868T (lt) | 2009-12-06 | 2018-02-26 | Bioverativ Therapeutics Inc. | Faktoriaus viii-fc chimeriniai ir hibridiniai polipeptidai ir jų panaudojimo būdai |
US20130023033A1 (en) | 2010-03-29 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
EP2591101B1 (de) | 2010-07-09 | 2018-11-07 | Bioverativ Therapeutics Inc. | Systeme für faktor viii-verarbeitung und verfahren davon |
SG190136A1 (en) | 2010-11-05 | 2013-07-31 | Baxter Int | A new variant of antihemophilic factor viii having increased specific activity |
ES2724800T3 (es) | 2011-02-17 | 2019-09-16 | Univ Pennsylvania | Composiciones y métodos para alterar la especificidad de tejido y mejorar la transferencia génica mediada por AAV9 |
EP2717898B1 (de) | 2011-06-10 | 2018-12-19 | Bioverativ Therapeutics Inc. | Gerinnungsfördernde verbindungen und anwendungsverfahren dafür |
CA2841066C (en) * | 2011-07-08 | 2023-09-26 | Biogen Idec Hemophilia Inc. | Factor viii chimeric and hybrid polypeptides, and methods of use thereof |
US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
WO2013106787A1 (en) | 2012-01-12 | 2013-07-18 | Biogen Idec Ma Inc. | Chimeric factor viii polypeptides and uses thereof |
ES2700583T3 (es) | 2012-01-12 | 2019-02-18 | Bioverativ Therapeutics Inc | Procedimientos para reducir la inmunogenicidad contra el Factor VIII en individuos sometidos a terapia con Factor VIII |
PL3564260T3 (pl) | 2012-02-15 | 2023-03-06 | Bioverativ Therapeutics Inc. | Kompozycje czynnika viii oraz sposoby ich wytwarzania i stosowania |
AU2013204636B2 (en) | 2012-02-15 | 2016-04-14 | Bioverativ Therapeutics Inc. | Recombinant Factor VIII proteins |
PL2882450T3 (pl) | 2012-07-11 | 2020-06-29 | Bioverativ Therapeutics Inc. | Kompleks czynnika viii z xten i białkiem czynnika von willebranda oraz jego zastosowania |
US10001495B2 (en) | 2012-07-25 | 2018-06-19 | Bioverativ Therapeutics Inc. | Blood factor monitoring assay and uses thereof |
US10391152B2 (en) | 2012-10-18 | 2019-08-27 | Bioverativ Therapeutics Inc. | Methods of using a fixed dose of a clotting factor |
EP3943102A1 (de) | 2012-10-30 | 2022-01-26 | Bioverativ Therapeutics Inc. | Verfahren zur verwendung von fviii-polypeptid |
EP4122487A1 (de) | 2013-03-15 | 2023-01-25 | Bioverativ Therapeutics Inc. | Faktor-viii-polypeptidformulierungen |
US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
CN113817069A (zh) | 2013-06-28 | 2021-12-21 | 比奥贝拉蒂治疗公司 | 具有xten的凝血酶可裂解连接子和其用途 |
US10947269B2 (en) | 2013-08-08 | 2021-03-16 | Bioverativ Therapeutics Inc. | Purification of chimeric FVIII molecules |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
US10584147B2 (en) | 2013-11-08 | 2020-03-10 | Biovertiv Therapeutics Inc. | Procoagulant fusion compound |
ES2967617T3 (es) | 2013-12-06 | 2024-05-03 | Bioverativ Therapeutics Inc | Herramientas de farmacocinética poblacional y sus usos |
IL282168B2 (en) | 2014-01-10 | 2023-03-01 | Bioverativ Therapeutics Inc | Factor viii chimeric proteins and their uses |
ES2763551T3 (es) | 2015-04-16 | 2020-05-29 | Univ Emory | Promotores y vectores recombinantes para la expresión de proteínas en el hígado y uso de los mismos |
CN108472337B (zh) | 2015-08-03 | 2022-11-25 | 比奥贝拉蒂治疗公司 | 因子ix融合蛋白以及其制备和使用方法 |
US20180371481A1 (en) | 2015-12-16 | 2018-12-27 | The New Zealand Institute For Plant And Food Research Limited | Compositions and Methods for Manipulating the Development of Plants |
SG11202010767SA (en) | 2018-05-18 | 2020-11-27 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
AU2019366942A1 (en) * | 2018-10-23 | 2021-06-10 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor VIII function |
US20240043494A1 (en) | 2020-08-07 | 2024-02-08 | Amicus Therapeutics, Inc. | Vesicle Targeting Proteins And Uses Of Same |
WO2024077110A2 (en) | 2022-10-05 | 2024-04-11 | Roger Paul Hellens | Uorf::reporter gene fusions to select sequence changes to gene edit into uorfs to regulate ascorbate genes |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985001961A1 (en) * | 1983-10-28 | 1985-05-09 | Genetics Institute | Production of factor viii and related products |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
JPH0788399B2 (ja) | 1985-04-12 | 1995-09-27 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | 新規プロコアギュラント蛋白質 |
DE3785102T2 (de) | 1986-01-03 | 1993-07-22 | Genetics Inst | Verfahren zur herstellung von faktor-viii:c-typ-proteinen. |
US5451521A (en) | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
CA1331157C (en) | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
US5004803A (en) * | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
-
1993
- 1993-09-14 US US08/121,202 patent/US5563045A/en not_active Expired - Lifetime
- 1993-10-01 WO PCT/US1993/009438 patent/WO1994011503A2/en active IP Right Grant
- 1993-10-01 EP EP02025048A patent/EP1308515A3/de not_active Withdrawn
- 1993-10-01 DE DE69332955T patent/DE69332955T2/de not_active Expired - Lifetime
- 1993-10-01 AU AU52982/93A patent/AU5298293A/en not_active Abandoned
- 1993-10-01 AT AT93923220T patent/ATE239789T1/de not_active IP Right Cessation
- 1993-10-01 ES ES93923220T patent/ES2193145T3/es not_active Expired - Lifetime
- 1993-10-01 PT PT93923220T patent/PT672138E/pt unknown
- 1993-10-01 EP EP93923220A patent/EP0672138B1/de not_active Revoked
- 1993-10-01 DK DK93923220T patent/DK0672138T3/da active
Also Published As
Publication number | Publication date |
---|---|
ES2193145T3 (es) | 2003-11-01 |
EP1308515A3 (de) | 2003-05-28 |
EP1308515A2 (de) | 2003-05-07 |
ATE239789T1 (de) | 2003-05-15 |
US5563045A (en) | 1996-10-08 |
DE69332955T2 (de) | 2004-01-29 |
EP0672138A1 (de) | 1995-09-20 |
WO1994011503A3 (en) | 1994-07-07 |
DK0672138T3 (da) | 2003-08-11 |
PT672138E (pt) | 2003-09-30 |
WO1994011503A2 (en) | 1994-05-26 |
DE69332955D1 (de) | 2003-06-12 |
EP0672138B1 (de) | 2003-05-07 |
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