US8597910B1
(en)
|
1985-04-11 |
2013-12-03 |
Children's Medical Center Corporation |
DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells
|
US5198349A
(en)
*
|
1986-01-03 |
1993-03-30 |
Genetics Institute, Inc. |
Method for producing factor VIII:C and analogs
|
US5451521A
(en)
*
|
1986-05-29 |
1995-09-19 |
Genetics Institute, Inc. |
Procoagulant proteins
|
US5576194A
(en)
*
|
1986-07-11 |
1996-11-19 |
Bayer Corporation |
Recombinant protein production
|
GR871029B
(en)
|
1986-07-14 |
1987-11-02 |
Genetics Inst |
Novel osteoinductive factors
|
AU606925B2
(en)
*
|
1987-01-30 |
1991-02-21 |
Biogen, Inc. |
A method for producing factor viii in high yield
|
CA1331157C
(en)
*
|
1987-04-06 |
1994-08-02 |
Randal J. Kaufman |
Method for producing factor viii:c-type proteins
|
US5043429B1
(en)
*
|
1987-05-01 |
1997-10-14 |
Scripps Research Inst |
Protein fragments containing factor VIII binding domain of von willebrand factor
|
JPH0387173A
(ja)
*
|
1987-09-10 |
1991-04-11 |
Teijin Ltd |
ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体
|
CA1340740C
(en)
*
|
1987-12-08 |
1999-09-14 |
Eileen R. Mulvihill |
Co-expression in eukaryotic cells
|
US5648254A
(en)
*
|
1988-01-15 |
1997-07-15 |
Zymogenetics, Inc. |
Co-expression in eukaryotic cells
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
DE69012601T2
(de)
*
|
1989-02-02 |
1995-01-19 |
Joel S Greenberger |
Gentherapie durch stützgewebebezügliche Zellen.
|
US7247475B2
(en)
|
1989-07-28 |
2007-07-24 |
Wyeth |
Method for producing monoclonal antibodies
|
US6475787B1
(en)
|
1989-07-28 |
2002-11-05 |
Wyeth |
Method for producing monoclonal antibodies
|
SE465222C5
(sv)
*
|
1989-12-15 |
1998-02-10 |
Pharmacia & Upjohn Ab |
Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
|
FR2657884B1
(fr)
|
1990-02-05 |
1994-09-02 |
Tm Innovation |
Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
|
US5661008A
(en)
*
|
1991-03-15 |
1997-08-26 |
Kabi Pharmacia Ab |
Recombinant human factor VIII derivatives
|
US5371198A
(en)
*
|
1991-12-16 |
1994-12-06 |
Novo Nordisk A/S |
Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
|
DK53792D0
(da)
*
|
1992-04-24 |
1992-04-24 |
Novo Nordisk As |
Fremgangsmaade til fremstilling af proteiner
|
US5563045A
(en)
|
1992-11-13 |
1996-10-08 |
Genetics Institute, Inc. |
Chimeric procoagulant proteins
|
US5952198A
(en)
*
|
1995-05-04 |
1999-09-14 |
Bayer Corporation |
Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition
|
US5744326A
(en)
*
|
1996-03-11 |
1998-04-28 |
The Immune Response Corporation |
Use of viral CIS-acting post-transcriptional regulatory sequences to increase expression of intronless genes containing near-consensus splice sites
|
US8183344B2
(en)
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
ATE319817T1
(de)
|
1996-04-24 |
2006-03-15 |
Univ Michigan |
Gegen inaktivierung resistenter faktor viii
|
DE69722639T2
(de)
|
1996-09-24 |
2004-04-29 |
The Procter & Gamble Company, Cincinnati |
Stabilisierte proteine mit protease-inhibitorfunktion und varianten davon
|
EP1062244B1
(de)
|
1998-03-12 |
2002-08-28 |
Genetics Institute, LLC |
Verbessertes verfahren zur herstellung von faktor viii
|
US7820796B2
(en)
|
1998-03-12 |
2010-10-26 |
Genetics Institute, Llc. |
Methods for producing Factor VIII proteins
|
EP1038959A1
(de)
|
1999-03-17 |
2000-09-27 |
Aventis Behring Gesellschaft mit beschränkter Haftung |
Faktor VIII ohne B-Domän, der ein oder mehrere Insertionsstücke von verkürztem Intron I des Faktors IX enthält
|
CZ303929B6
(cs)
|
2000-03-22 |
2013-07-03 |
Octapharma Biopharmaceuticals Gmbh |
Mutein faktoru VIII, odpovídající DNA sekvence, vektor a hostitelská bunka, farmaceutická kompozice, zpusob produkce muteinu a imortalizovaná lidská bunecná linie
|
US7615622B2
(en)
|
2001-01-12 |
2009-11-10 |
University Of Maryland, Baltimore |
Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII
|
EP1233064A1
(de)
|
2001-02-09 |
2002-08-21 |
Aventis Behring Gesellschaft mit beschränkter Haftung |
Modifizierte Faktor VIII cDNA und deren Verwendung bei der Produktion von Faktor VIII
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
US7211559B2
(en)
|
2003-10-31 |
2007-05-01 |
University Of Maryland, Baltimore |
Factor VIII compositions and methods
|
EP1707634A1
(de)
|
2005-03-29 |
2006-10-04 |
Octapharma AG |
Verfahren zur Isolierung von rekombinant hergestellten Proteinen
|
EP1739179A1
(de)
|
2005-06-30 |
2007-01-03 |
Octapharma AG |
Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
EP2520586A1
(de)
|
2006-06-30 |
2012-11-07 |
The Regents of the University of Michigan |
Verfahren zur Herstellung von Faktor-VIII-Proteinen durch Rekombinationsverfahren
|
EP1988101A1
(de)
|
2007-05-04 |
2008-11-05 |
Novo Nordisk A/S |
Verbesserung von Faktor-VIII-Polypeptid-Titern in Zellkulturen
|
PT2393828T
(pt)
|
2009-02-03 |
2017-01-18 |
Amunix Operating Inc |
Polipéptidos recombinantes estendidos e composições que compreendem os mesmos
|
JP5813641B2
(ja)
|
2009-08-24 |
2015-11-17 |
アムニクス オペレーティング インコーポレイテッド |
凝固第ix因子組成物ならびにそれを製造および使用する方法
|
PL3326643T3
(pl)
|
2009-12-06 |
2021-10-25 |
Bioverativ Therapeutics Inc. |
Chimeryczne i hybrydowe polipeptydy czynnika VIII-FC oraz sposoby ich zastosowania
|
WO2011095604A1
(en)
|
2010-02-04 |
2011-08-11 |
Octapharma Biopharmaceuticals Gmbh |
Half-life prolongation of proteins
|
EP3508573A1
(de)
|
2010-07-09 |
2019-07-10 |
Bioverativ Therapeutics Inc. |
Systeme für faktor viii-verarbeitung und verfahren davon
|
NZ605400A
(en)
|
2010-07-09 |
2015-05-29 |
Biogen Idec Hemophilia Inc |
Chimeric clotting factors
|
EP2957628A1
(de)
|
2010-10-05 |
2015-12-23 |
Novo Nordisk Health Care AG |
Verfahren zur proteinherstellung
|
SI2717898T1
(sl)
|
2011-06-10 |
2019-07-31 |
Bioverativ Therapeutics Inc. |
Spojine prokoagulantov in metode za njihovo uporabo
|
DK3513804T3
(da)
|
2011-07-08 |
2022-06-20 |
Bioverativ Therapeutics Inc |
Kimære og hybride faktor viii-polypeptider og fremgangsmåder til anvendelse deraf
|
EP2737311B1
(de)
|
2011-07-25 |
2020-12-02 |
Bioverativ Therapeutics Inc. |
Tests zur überwachung von blutungsstörungen
|
SG11201403764XA
(en)
|
2012-01-12 |
2014-07-30 |
Biogen Idec Inc |
Chimeric factor viii polypeptides and uses thereof
|
SI2802668T1
(sl)
|
2012-01-12 |
2019-01-31 |
Bioverativ Therapeutics Inc. |
Zmanjšanje imunogeničnosti proti faktorju VIII pri posameznikih, ki se zdravijo zaradi faktorja VIII
|
HUE043537T2
(hu)
|
2012-02-15 |
2019-08-28 |
Bioverativ Therapeutics Inc |
Rekombináns VIII faktor fehérjék
|
PL3564260T3
(pl)
|
2012-02-15 |
2023-03-06 |
Bioverativ Therapeutics Inc. |
Kompozycje czynnika viii oraz sposoby ich wytwarzania i stosowania
|
EP3693000B1
(de)
|
2012-06-08 |
2022-03-02 |
Bioverativ Therapeutics Inc. |
Prokoagulatorische verbindungen
|
CA2875247A1
(en)
|
2012-06-08 |
2013-12-12 |
Biogen Idec Ma Inc. |
Chimeric clotting factors
|
WO2014008480A2
(en)
|
2012-07-06 |
2014-01-09 |
Biogen Idec Ma Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
NZ703366A
(en)
|
2012-07-11 |
2018-03-23 |
Amunix Operating Inc |
Factor viii complex with xten and von willebrand factor protein, and uses thereof
|
EP3970738A1
(de)
|
2012-07-25 |
2022-03-23 |
Bioverativ Therapeutics Inc. |
Blutfaktorüberwachungstest und verwendungen davon
|
WO2014063108A1
(en)
|
2012-10-18 |
2014-04-24 |
Biogen Idec Ma Inc. |
Methods of using a fixed dose of a clotting factor
|
EP3446700A1
(de)
|
2012-10-30 |
2019-02-27 |
Bioverativ Therapeutics Inc. |
Verfahren zur verwendung von fviii-polypeptid
|
PL2956477T3
(pl)
|
2013-02-15 |
2021-06-14 |
Bioverativ Therapeutics Inc. |
Zoptymalizowany gen czynnika viii
|
WO2014144795A1
(en)
|
2013-03-15 |
2014-09-18 |
Biogen Idec Ma Inc. |
Factor viii polypeptide formulations
|
SG10201913874TA
(en)
|
2013-03-15 |
2020-03-30 |
Biogen Ma Inc |
Factor ix polypeptide formulations
|
EP3875106A1
(de)
|
2013-08-08 |
2021-09-08 |
Bioverativ Therapeutics Inc. |
Reinigung von chimären fviii-molekülen
|
TW202003554A
(zh)
|
2013-08-14 |
2020-01-16 |
美商百歐維拉提夫治療公司 |
因子viii-xten融合物及其用途
|
EP3065769A4
(de)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Prokoagulatorische fusionsverbindung
|
EP4332839A2
(de)
|
2013-12-06 |
2024-03-06 |
Bioverativ Therapeutics Inc. |
Pharmakokinetische werkzeuge für populationen und verwendungen davon
|
CN117106095A
(zh)
|
2014-01-10 |
2023-11-24 |
比奥贝拉蒂治疗公司 |
因子viii嵌合蛋白及其用途
|
JP6609561B2
(ja)
|
2014-02-04 |
2019-11-20 |
バイオジェン・エムエイ・インコーポレイテッド |
翻訳後修飾を濃縮するための、フロースルーモードにおける陽イオン交換クロマトグラフィーの使用
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
CN104630131B
(zh)
*
|
2015-01-15 |
2017-08-15 |
上海交通大学 |
一种稳定表达人凝血八因子的cho细胞株及其应用
|
BR112018002150A2
(pt)
|
2015-08-03 |
2018-09-18 |
Bioverativ Therapeutics Inc |
proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
|
US11753461B2
(en)
|
2016-02-01 |
2023-09-12 |
Bioverativ Therapeutics Inc. |
Optimized factor VIII genes
|
AU2017368328A1
(en)
|
2016-12-02 |
2019-07-18 |
Bioverativ Therapeutics Inc. |
Methods of inducing immune tolerance to clotting factors
|
CN110520150A
(zh)
|
2016-12-02 |
2019-11-29 |
比奥维拉迪维治疗股份有限公司 |
使用嵌合凝血因子治疗血友病性关节病的方法
|
CA3072334A1
(en)
|
2017-08-09 |
2019-02-14 |
Bioverativ Therapeutics Inc. |
Nucleic acid molecules and uses thereof
|
RU2020114616A
(ru)
|
2017-09-27 |
2021-10-28 |
Сайджилон Терапьютикс, Инк. |
Способы, композиции и имплантируемые элементы, содержащие активные клетки
|
JP2021512126A
(ja)
|
2018-02-01 |
2021-05-13 |
バイオベラティブ セラピューティクス インコーポレイテッド |
第viii因子を発現するレンチウイルスベクターの使用
|
US20210145889A1
(en)
|
2018-04-04 |
2021-05-20 |
Sigilon Therapeutics, Inc. |
Methods, compositions, and implantable elements comprising stem cells
|
KR20210005608A
(ko)
|
2018-04-04 |
2021-01-14 |
시질론 테라퓨틱스, 인크. |
이식 가능한 입자 및 관련 방법
|
US20190375822A1
(en)
|
2018-05-18 |
2019-12-12 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilia a
|
CN113227385A
(zh)
|
2018-08-09 |
2021-08-06 |
比奥维拉迪维治疗股份有限公司 |
核酸分子及其用于非病毒基因疗法的用途
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
US10654911B1
(en)
*
|
2019-04-02 |
2020-05-19 |
Beijing Neoletix Biological Technology Co., Ltd. |
Vector co-expressing truncated von Willebrand factor and factor VIII
|
CN114007637A
(zh)
|
2019-06-19 |
2022-02-01 |
比奥维拉迪维治疗股份有限公司 |
用于治疗血友病和低骨矿物质密度的重组因子viii-fc
|
IL310997A
(en)
|
2021-08-23 |
2024-04-01 |
Bioverativ Therapeutics Inc |
Factor VIII gene optimization
|
WO2023056331A1
(en)
|
2021-09-30 |
2023-04-06 |
Bioverativ Therapeutics Inc. |
Nucleic acids encoding factor viii polypeptides with reduced immunogenicity
|