ES2053449T3 - Analogos (tpa) de activadores de plasminogeno de tejido. - Google Patents
Analogos (tpa) de activadores de plasminogeno de tejido.Info
- Publication number
- ES2053449T3 ES2053449T3 ES86309704T ES86309704T ES2053449T3 ES 2053449 T3 ES2053449 T3 ES 2053449T3 ES 86309704 T ES86309704 T ES 86309704T ES 86309704 T ES86309704 T ES 86309704T ES 2053449 T3 ES2053449 T3 ES 2053449T3
- Authority
- ES
- Spain
- Prior art keywords
- tpa
- analogs
- tissue plasminogen
- plasminogen activators
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
ESTA INVENCION PRESENTA ANALOGOS DE ACTIVADOR TISULAR DE PLASMINOGENO (TPA). LOS ANALOGOS SON MOLECULAS SIMILARES AL TPA EN LAS QUE LAS REGIONES DE DOMINIO NATIVO HAN SIDO REORDENADAS, SUPRIMIDAS O AÑADIDAS O HAN SUFRIDO UNA COMBINACION DE ESTAS ACCIONES. LOS ANALOGOS SON EL PRODUCTO DE LA EXPRESION DEL ADN RECOMBINANTE QUE TAMBIEN SE DESCRIBE. ADICIONALMENTE, LA PRESENTE INVENCION DESCRIBE PLASMIDOS DE REPLICACION Y EXPRESION QUE CONTIENEN LAS SECUENCIAS DE ADN CODIFICADOR DE TPA DESCRITAS ARRIBA Y MICROORGANISMOS HUESPEDES ADECUADOS QUE SON CAPACES DE EXPRESAR LOS ANALOGOS DE TPA DESPUES DE SER TRANSFORMADOS CON UN PLASMIDO APROPIADO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81160785A | 1985-12-20 | 1985-12-20 | |
US90948286A | 1986-09-19 | 1986-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2053449T3 true ES2053449T3 (es) | 1994-08-01 |
Family
ID=27123502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES86309704T Expired - Lifetime ES2053449T3 (es) | 1985-12-20 | 1986-12-12 | Analogos (tpa) de activadores de plasminogeno de tejido. |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP0231624B1 (es) |
JP (1) | JPH0659223B2 (es) |
KR (2) | KR880700856A (es) |
AT (1) | ATE85081T1 (es) |
AU (1) | AU600463B2 (es) |
DE (1) | DE3687651T2 (es) |
DK (1) | DK431887D0 (es) |
ES (1) | ES2053449T3 (es) |
FI (1) | FI97809C (es) |
GR (1) | GR3007280T3 (es) |
NO (1) | NO176921C (es) |
WO (1) | WO1987003906A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK623186A (da) * | 1985-12-23 | 1987-08-26 | Chiron Corp | Polypeptid med vaevsplasminogen-aktivator-virkning |
ATE70301T1 (de) * | 1986-02-17 | 1991-12-15 | Stichting Centraal Lab | Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. |
WO1987005934A1 (en) * | 1986-03-28 | 1987-10-08 | Roberto Crea | Protein analogues of tissue plasminogen activator |
US5047241A (en) * | 1986-07-11 | 1991-09-10 | American Home Products Corporation | Tris-Kringle plasminogen activator with novel K2 insert |
US5580559A (en) * | 1986-12-05 | 1996-12-03 | Ciba-Geigy Corporation | Hybrid plasminogen activator |
US5242819A (en) * | 1986-12-05 | 1993-09-07 | Ciba-Geigy Corporation | DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase |
US5376547A (en) * | 1987-01-30 | 1994-12-27 | American Home Products Corporation | Des-epidermal growth factor plasminogen activators |
US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
SE8702562L (sv) * | 1987-06-18 | 1988-12-19 | Kabigen Ab | Nya fibrinolytiska enzymer |
US5244676A (en) * | 1987-10-09 | 1993-09-14 | Monsanto Company | Modified tissue plasminogen activator with modified glycosylation site |
JPH01132377A (ja) * | 1987-10-09 | 1989-05-24 | Monsanto Co | 修正型組織プラスミノーゲンアクチベーター |
US4963357A (en) * | 1987-10-09 | 1990-10-16 | Monsanto Company | Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor |
US5100666A (en) * | 1987-10-09 | 1992-03-31 | Monsanto Company | Modified tissue plasminogen activator K2K2SP |
US5037752A (en) * | 1987-10-09 | 1991-08-06 | Monsanto Company | Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277 |
DE3854195T2 (de) * | 1987-10-29 | 1995-12-21 | Yamanouchi Pharma Co Ltd | Polypeptid-verbindungen. |
US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
AU619803B2 (en) * | 1988-02-05 | 1992-02-06 | Genzyme Corporation | Rearranged tissue plasminogen activators and method for producing same |
EP0398962A1 (en) * | 1988-02-05 | 1990-11-28 | Genzyme Corporation | Rearranged tissue plasminogen activators and method for producing same |
AU3064989A (en) * | 1988-02-05 | 1989-08-25 | Genzyme Corporation | Modified gene sequences encoding modified tpa and products therefrom |
US5346824A (en) * | 1988-05-20 | 1994-09-13 | Genentech, Inc. | DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
DE3823805A1 (de) * | 1988-07-14 | 1990-01-18 | Basf Ag | Neue polypeptide, ihre herstellung und verwendung |
DE3825253A1 (de) * | 1988-07-25 | 1990-02-01 | Boehringer Mannheim Gmbh | T-pa-derivat und seine herstellung |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
DE3836200A1 (de) * | 1988-10-24 | 1990-04-26 | Boehringer Mannheim Gmbh | Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa) |
DE68922859T2 (de) * | 1988-10-27 | 1995-09-21 | Tno | Trombolytischer wirkstoff mit modifikation der domäne der kringle. |
CA2007364A1 (en) * | 1989-01-17 | 1990-07-17 | David J. Livingston | Gene sequences encoding modified residues situated in the protease domain of tpa |
DE3927865A1 (de) * | 1989-08-23 | 1991-02-28 | Boehringer Mannheim Gmbh | T-pa-mutante gk1l |
AU664469B2 (en) * | 1992-06-03 | 1995-11-16 | Genentech Inc. | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
US5795975A (en) * | 1993-01-10 | 1998-08-18 | Yeda Research And Development Co. Ltd. | TNF receptor promoter |
IL104355A (en) * | 1993-01-10 | 2006-08-20 | Yeda Res & Dev | Tnf receptor promoter |
US6706504B1 (en) | 1996-11-12 | 2004-03-16 | The Scripps Research Institute | Tissue type plasminogen activator (t-PA) variants: compositions and methods of use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL68561A (en) | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
ZA837173B (en) | 1982-11-08 | 1984-05-30 | Univ Case Western Reserve | Genomic bovine growth hormone |
US4511503A (en) | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
PT82326B (pt) * | 1985-04-04 | 1988-10-14 | Beecham Group Plc | Processo para a preparacao de activador de plasminogenio de tipo tissular fibrinoliticamente activo |
US4916071A (en) * | 1985-08-14 | 1990-04-10 | American Home Products Corporation | Poly-kringle plasminogen activator |
NZ217331A (en) * | 1985-08-26 | 1989-05-29 | Lilly Co Eli | Tissue plasminogen activator derivatives and genetically engineered product |
-
1986
- 1986-12-12 WO PCT/US1986/002684 patent/WO1987003906A1/en active IP Right Grant
- 1986-12-12 EP EP86309704A patent/EP0231624B1/en not_active Expired - Lifetime
- 1986-12-12 DE DE8686309704T patent/DE3687651T2/de not_active Expired - Fee Related
- 1986-12-12 EP EP87900529A patent/EP0289508A1/en active Pending
- 1986-12-12 ES ES86309704T patent/ES2053449T3/es not_active Expired - Lifetime
- 1986-12-12 AT AT86309704T patent/ATE85081T1/de active
- 1986-12-12 KR KR870700754A patent/KR880700856A/ko not_active IP Right Cessation
- 1986-12-12 KR KR1019870700754A patent/KR950000303B1/ko active
- 1986-12-12 AU AU67701/87A patent/AU600463B2/en not_active Ceased
-
1987
- 1987-08-19 DK DK431887A patent/DK431887D0/da not_active Application Discontinuation
- 1987-08-20 NO NO873517A patent/NO176921C/no not_active IP Right Cessation
-
1988
- 1988-06-17 FI FI882922A patent/FI97809C/fi not_active IP Right Cessation
-
1993
- 1993-02-15 JP JP5025188A patent/JPH0659223B2/ja not_active Expired - Lifetime
- 1993-03-09 GR GR930400502T patent/GR3007280T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI97809C (fi) | 1997-02-25 |
GR3007280T3 (es) | 1993-07-30 |
FI97809B (fi) | 1996-11-15 |
AU6770187A (en) | 1987-07-15 |
FI882922A0 (fi) | 1988-06-17 |
ATE85081T1 (de) | 1993-02-15 |
DE3687651T2 (de) | 1993-06-24 |
NO176921B (no) | 1995-03-13 |
FI882922A (fi) | 1988-06-17 |
EP0289508A1 (en) | 1988-11-09 |
NO873517L (no) | 1987-08-20 |
EP0231624A1 (en) | 1987-08-12 |
DK431887A (da) | 1987-08-19 |
DE3687651D1 (de) | 1993-03-11 |
KR950000303B1 (ko) | 1995-01-13 |
NO873517D0 (no) | 1987-08-20 |
JPH0659223B2 (ja) | 1994-08-10 |
WO1987003906A1 (en) | 1987-07-02 |
NO176921C (no) | 1995-06-21 |
KR880700856A (ko) | 1988-04-12 |
AU600463B2 (en) | 1990-08-16 |
DK431887D0 (da) | 1987-08-19 |
EP0231624B1 (en) | 1993-01-27 |
JPH05344892A (ja) | 1993-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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