ATE70301T1 - Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. - Google Patents

Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.

Info

Publication number
ATE70301T1
ATE70301T1 AT86200223T AT86200223T ATE70301T1 AT E70301 T1 ATE70301 T1 AT E70301T1 AT 86200223 T AT86200223 T AT 86200223T AT 86200223 T AT86200223 T AT 86200223T AT E70301 T1 ATE70301 T1 AT E70301T1
Authority
AT
Austria
Prior art keywords
mutants
pharmaceutical compositions
plasminogen activator
genetic information
production
Prior art date
Application number
AT86200223T
Other languages
English (en)
Inventor
Hans Pannekoek
Arnoldus Johannes G Veerman
Anton Jan Van Zonneveld
Original Assignee
Stichting Centraal Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8195701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE70301(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Stichting Centraal Lab filed Critical Stichting Centraal Lab
Application granted granted Critical
Publication of ATE70301T1 publication Critical patent/ATE70301T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
AT86200223T 1986-02-17 1986-02-17 Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. ATE70301T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP86200223A EP0234051B1 (de) 1986-02-17 1986-02-17 Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE70301T1 true ATE70301T1 (de) 1991-12-15

Family

ID=8195701

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86200223T ATE70301T1 (de) 1986-02-17 1986-02-17 Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.

Country Status (4)

Country Link
EP (1) EP0234051B1 (de)
JP (1) JPS62192323A (de)
AT (1) ATE70301T1 (de)
DE (1) DE3682891D1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
US5234686A (en) * 1985-04-03 1993-08-10 Beecham Group P.L.C. Human tissue plasminogen activator consisting essentially of t-PA residues to 160 to 527, pharmaceutical compositions and methods of treatment
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
DK623186A (da) * 1985-12-23 1987-08-26 Chiron Corp Polypeptid med vaevsplasminogen-aktivator-virkning
WO1987005934A1 (en) * 1986-03-28 1987-10-08 Roberto Crea Protein analogues of tissue plasminogen activator
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
JPH01132377A (ja) * 1987-10-09 1989-05-24 Monsanto Co 修正型組織プラスミノーゲンアクチベーター
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
WO1989012680A1 (en) * 1988-06-20 1989-12-28 Washington University USE OF MODIFIED tPA TO DETECT BLOOD CLOTS
DE3836200A1 (de) * 1988-10-24 1990-04-26 Boehringer Mannheim Gmbh Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
DE68922859T2 (de) * 1988-10-27 1995-09-21 Tno Trombolytischer wirkstoff mit modifikation der domäne der kringle.
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
CA2047063A1 (en) * 1991-07-15 1993-01-16 Warren C. Mackellar Method for folding tissue plasminogen activators and erivatives thereof
EP1380290A1 (de) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-Beta-Strukturweg und seine therapeutische Relevanz
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
AU2006267176A1 (en) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Cross-beta structure binding compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
PT82326B (pt) * 1985-04-04 1988-10-14 Beecham Group Plc Processo para a preparacao de activador de plasminogenio de tipo tissular fibrinoliticamente activo
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
WO1987003906A1 (en) * 1985-12-20 1987-07-02 The Upjohn Company Tissue plasminogen activator (tpa) analogs
DK623186A (da) * 1985-12-23 1987-08-26 Chiron Corp Polypeptid med vaevsplasminogen-aktivator-virkning
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins

Also Published As

Publication number Publication date
EP0234051B1 (de) 1991-12-11
JPS62192323A (ja) 1987-08-22
EP0234051A1 (de) 1987-09-02
DE3682891D1 (de) 1992-01-23

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UEP Publication of translation of european patent specification
RZN Patent revoked