ATE70301T1 - Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. - Google Patents
Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.Info
- Publication number
- ATE70301T1 ATE70301T1 AT86200223T AT86200223T ATE70301T1 AT E70301 T1 ATE70301 T1 AT E70301T1 AT 86200223 T AT86200223 T AT 86200223T AT 86200223 T AT86200223 T AT 86200223T AT E70301 T1 ATE70301 T1 AT E70301T1
- Authority
- AT
- Austria
- Prior art keywords
- mutants
- pharmaceutical compositions
- plasminogen activator
- genetic information
- production
- Prior art date
Links
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 title abstract 2
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 title abstract 2
- 230000002068 genetic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229960000187 tissue plasminogen activator Drugs 0.000 title 1
- 102000009123 Fibrin Human genes 0.000 abstract 3
- 108010073385 Fibrin Proteins 0.000 abstract 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 3
- 102100033571 Tissue-type plasminogen activator Human genes 0.000 abstract 3
- 108050006955 Tissue-type plasminogen activator Proteins 0.000 abstract 3
- 229950003499 fibrin Drugs 0.000 abstract 3
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP86200223A EP0234051B1 (de) | 1986-02-17 | 1986-02-17 | Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE70301T1 true ATE70301T1 (de) | 1991-12-15 |
Family
ID=8195701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT86200223T ATE70301T1 (de) | 1986-02-17 | 1986-02-17 | Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0234051B1 (de) |
JP (1) | JPS62192323A (de) |
AT (1) | ATE70301T1 (de) |
DE (1) | DE3682891D1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5108909A (en) * | 1985-03-22 | 1992-04-28 | Chiron Corporation | Expression of TPA in mammalian cells |
US5234686A (en) * | 1985-04-03 | 1993-08-10 | Beecham Group P.L.C. | Human tissue plasminogen activator consisting essentially of t-PA residues to 160 to 527, pharmaceutical compositions and methods of treatment |
GB8508717D0 (en) * | 1985-04-03 | 1985-05-09 | Beecham Group Plc | Composition |
ATE74379T1 (de) * | 1985-12-23 | 1992-04-15 | Chiron Corp | Peptidplasminogenaktivatoren. |
WO1987005934A1 (en) * | 1986-03-28 | 1987-10-08 | Roberto Crea | Protein analogues of tissue plasminogen activator |
US5047241A (en) * | 1986-07-11 | 1991-09-10 | American Home Products Corporation | Tris-Kringle plasminogen activator with novel K2 insert |
US5580559A (en) * | 1986-12-05 | 1996-12-03 | Ciba-Geigy Corporation | Hybrid plasminogen activator |
US5242819A (en) * | 1986-12-05 | 1993-09-07 | Ciba-Geigy Corporation | DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase |
SE8702562L (sv) * | 1987-06-18 | 1988-12-19 | Kabigen Ab | Nya fibrinolytiska enzymer |
US4963357A (en) * | 1987-10-09 | 1990-10-16 | Monsanto Company | Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor |
US5100666A (en) * | 1987-10-09 | 1992-03-31 | Monsanto Company | Modified tissue plasminogen activator K2K2SP |
ZA887556B (en) * | 1987-10-09 | 1989-07-26 | Monsanto Co | Modified tissue plasminogen activator |
US5037752A (en) * | 1987-10-09 | 1991-08-06 | Monsanto Company | Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277 |
US5244676A (en) * | 1987-10-09 | 1993-09-14 | Monsanto Company | Modified tissue plasminogen activator with modified glycosylation site |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
AU3876789A (en) * | 1988-06-20 | 1990-01-12 | Washington University | Use of modified tpa to detect blood clots |
DE3836200A1 (de) * | 1988-10-24 | 1990-04-26 | Boehringer Mannheim Gmbh | Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa) |
JPH04506897A (ja) * | 1988-10-27 | 1992-12-03 | ネーデルランセ オルハニサチエ フォール トゥーヘパスト―ナツールウェーテンシャッペ ルック オンデルズク テーエヌオー | 修飾されたクリングルドメインを有する血栓溶解剤 |
US5242688A (en) * | 1990-12-24 | 1993-09-07 | Eli Lilly And Company | Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants |
CA2047063A1 (en) * | 1991-07-15 | 1993-01-16 | Warren C. Mackellar | Method for folding tissue plasminogen activators and erivatives thereof |
EP1380290A1 (de) | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-Beta-Strukturweg und seine therapeutische Relevanz |
CA2615028A1 (en) | 2005-07-13 | 2007-01-18 | Crossbeta Biosciences B.V. | Cross-.beta. structure binding compounds |
US8114832B2 (en) | 2005-07-13 | 2012-02-14 | Crossbeta Biosciences B.V. | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR79202B (de) * | 1982-05-05 | 1984-10-22 | Genentech Inc | |
GR860875B (en) * | 1985-04-04 | 1986-07-29 | Beecham Group Plc | Novel compounds |
US4916071A (en) * | 1985-08-14 | 1990-04-10 | American Home Products Corporation | Poly-kringle plasminogen activator |
EP0289508A1 (de) * | 1985-12-20 | 1988-11-09 | The Upjohn Company | Analoge des gewebespezifischen plasminogenaktivators |
ATE74379T1 (de) * | 1985-12-23 | 1992-04-15 | Chiron Corp | Peptidplasminogenaktivatoren. |
EP0293394B2 (de) * | 1986-01-31 | 2003-10-29 | Genetics Institute, LLC | Neue thrombolytische proteine |
-
1986
- 1986-02-17 EP EP86200223A patent/EP0234051B1/de not_active Expired - Lifetime
- 1986-02-17 AT AT86200223T patent/ATE70301T1/de not_active IP Right Cessation
- 1986-02-17 DE DE8686200223T patent/DE3682891D1/de not_active Revoked
- 1986-04-01 JP JP61072630A patent/JPS62192323A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0234051A1 (de) | 1987-09-02 |
JPS62192323A (ja) | 1987-08-22 |
EP0234051B1 (de) | 1991-12-11 |
DE3682891D1 (de) | 1992-01-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
RZN | Patent revoked |