ATE93273T1 - Neue fibrinolytische enzyme. - Google Patents

Neue fibrinolytische enzyme.

Info

Publication number
ATE93273T1
ATE93273T1 AT88850207T AT88850207T ATE93273T1 AT E93273 T1 ATE93273 T1 AT E93273T1 AT 88850207 T AT88850207 T AT 88850207T AT 88850207 T AT88850207 T AT 88850207T AT E93273 T1 ATE93273 T1 AT E93273T1
Authority
AT
Austria
Prior art keywords
plasminogen activator
domain
fibrinolytically active
deleted
dna
Prior art date
Application number
AT88850207T
Other languages
English (en)
Inventor
Gunnar Pohl
Lennart Hansson
Bjoern Loewenadler
Original Assignee
Kabigen Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabigen Ab filed Critical Kabigen Ab
Application granted granted Critical
Publication of ATE93273T1 publication Critical patent/ATE93273T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT88850207T 1987-06-18 1988-06-14 Neue fibrinolytische enzyme. ATE93273T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8702562A SE8702562L (sv) 1987-06-18 1987-06-18 Nya fibrinolytiska enzymer
EP88850207A EP0297066B1 (de) 1987-06-18 1988-06-14 Neue fibrinolytische Enzyme

Publications (1)

Publication Number Publication Date
ATE93273T1 true ATE93273T1 (de) 1993-09-15

Family

ID=20368916

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88850207T ATE93273T1 (de) 1987-06-18 1988-06-14 Neue fibrinolytische enzyme.

Country Status (8)

Country Link
EP (1) EP0297066B1 (de)
JP (1) JP2628345B2 (de)
AT (1) ATE93273T1 (de)
AU (1) AU615450B2 (de)
CA (1) CA1341459C (de)
DE (1) DE3883315D1 (de)
DK (1) DK335488A (de)
SE (1) SE8702562L (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) * 1991-04-22 1997-01-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
KR100728916B1 (ko) * 2005-11-15 2007-06-14 권영두 타이밍벨트 및 그 결합구조

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61247384A (ja) * 1984-10-18 1986-11-04 チモ−ジエネテイツクス　インコ−ポレ−テツド 酵母中でプラスミノ−ゲン活性化因子を発現する方法
EP0207589A1 (de) * 1985-04-03 1987-01-07 Beecham Group Plc Modifiziertes fibrinolytisches Enzym
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
WO1987003906A1 (en) * 1985-12-20 1987-07-02 The Upjohn Company Tissue plasminogen activator (tpa) analogs
DK623186A (da) * 1985-12-23 1987-08-26 Chiron Corp Polypeptid med vaevsplasminogen-aktivator-virkning
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
NZ219829A (en) * 1986-04-02 1990-05-28 Beecham Group Plc Tissue-type plasminogen activator modified in the region of amino acids 67-69 and pharmaceutical compositions thereof
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
GB8701811D0 (en) * 1987-01-28 1987-03-04 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
JPH02436A (ja) 1990-01-05
AU1778988A (en) 1988-12-22
CA1341459C (en) 2004-10-19
JP2628345B2 (ja) 1997-07-09
DK335488D0 (da) 1988-06-17
SE8702562D0 (sv) 1987-06-18
AU615450B2 (en) 1991-10-03
EP0297066A1 (de) 1988-12-28
EP0297066B1 (de) 1993-08-18
SE8702562L (sv) 1988-12-19
DE3883315D1 (de) 1993-09-23
DK335488A (da) 1988-12-19

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties