ATE107960T1 - Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung. - Google Patents

Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung.

Info

Publication number
ATE107960T1
ATE107960T1 AT89904712T AT89904712T ATE107960T1 AT E107960 T1 ATE107960 T1 AT E107960T1 AT 89904712 T AT89904712 T AT 89904712T AT 89904712 T AT89904712 T AT 89904712T AT E107960 T1 ATE107960 T1 AT E107960T1
Authority
AT
Austria
Prior art keywords
variants
methods
plasminogen activator
tissue plasminogen
production
Prior art date
Application number
AT89904712T
Other languages
English (en)
Inventor
Stephen P Anderson
Deborah L Higgins
Adair J Hotchkiss
Cara B Marks
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22620139&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE107960(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE107960T1 publication Critical patent/ATE107960T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
AT89904712T 1988-03-21 1989-03-06 Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung. ATE107960T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/170,510 US5094953A (en) 1988-03-21 1988-03-21 Human tissue plasminogen activator variants

Publications (1)

Publication Number Publication Date
ATE107960T1 true ATE107960T1 (de) 1994-07-15

Family

ID=22620139

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89904712T ATE107960T1 (de) 1988-03-21 1989-03-06 Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung.

Country Status (13)

Country Link
US (4) US5094953A (de)
EP (1) EP0401303B2 (de)
JP (2) JP2605155B2 (de)
AT (1) ATE107960T1 (de)
AU (1) AU635892B2 (de)
CA (1) CA1341612C (de)
DE (1) DE68916532T3 (de)
DK (1) DK175776B1 (de)
ES (1) ES2018367A6 (de)
GR (1) GR1000387B (de)
IL (1) IL89500A (de)
NZ (1) NZ228401A (de)
WO (1) WO1989009266A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
GT198302091A (es) * 1982-05-05 1984-10-25 Activador de plasminogeno de tejido humano a),b),c).
US5714372A (en) * 1985-04-22 1998-02-03 Genentech, Inc. Tissue plasminogen activator variants
DE3854195T2 (de) * 1987-10-29 1995-12-21 Yamanouchi Pharma Co Ltd Polypeptid-verbindungen.
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) * 1991-04-22 1997-01-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
ATE226642T1 (de) * 1994-07-07 2002-11-15 Tno Modifizierte proenzyme als substrate für proteolische enzyme
US6136548A (en) * 1994-11-22 2000-10-24 Rutgers, The State University Of New Jersey Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
US6461640B1 (en) 1995-12-08 2002-10-08 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
ES2255177T5 (es) * 1997-07-23 2011-07-12 Roche Diagnostics Gmbh Fabricación de proteínas mutadas humanas en células humanas por medio de la recombinación homóloga.
US6136536A (en) * 1997-10-29 2000-10-24 Genetics Institute, Inc. Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
US6283300B1 (en) 1998-08-21 2001-09-04 Joseph B. Bielagus Feed distribution for low velocity air density separation
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
JP3880036B2 (ja) * 2001-05-11 2007-02-14 全国酪農業協同組合連合会 タンパク質の濃縮方法
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
CN1578650A (zh) * 2001-11-06 2005-02-09 马克西姆医药公司 治疗感染性疾病的组合物
US20080057050A1 (en) * 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581652B1 (fr) * 1985-04-22 1989-12-22 Genentech Inc Nouveaux mutants de l'activateur tissulaire du plasminogene humain
DK623186A (da) * 1985-12-23 1987-08-26 Chiron Corp Polypeptid med vaevsplasminogen-aktivator-virkning
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
EP0386240B1 (de) * 1987-10-29 1995-07-19 Yamanouchi Pharmaceutical Co. Ltd. Polypeptid-verbindungen
DE3937589C2 (de) * 1989-11-10 2001-12-13 Laing Oliver Zirkulationsgerät mit Widerstandsheizung

Also Published As

Publication number Publication date
AU635892B2 (en) 1993-04-08
AU3414889A (en) 1989-10-16
US5770425A (en) 1998-06-23
GR1000387B (el) 1992-06-30
JPH03503363A (ja) 1991-08-01
DE68916532T2 (de) 1995-01-12
EP0401303B2 (de) 1999-11-03
GR890100164A (en) 1990-01-19
IL89500A (en) 1998-09-24
US5366886A (en) 1994-11-22
JPH09168387A (ja) 1997-06-30
DK227390D0 (da) 1990-09-20
EP0401303A1 (de) 1990-12-12
NZ228401A (en) 1991-09-25
ES2018367A6 (es) 1991-04-01
DK175776B1 (da) 2005-02-14
DE68916532T3 (de) 2000-02-03
DK227390A (da) 1990-09-20
EP0401303B1 (de) 1994-06-29
DE68916532D1 (de) 1994-08-04
JP2605155B2 (ja) 1997-04-30
CA1341612C (en) 2011-04-12
IL89500A0 (en) 1989-09-10
US5094953A (en) 1992-03-10
WO1989009266A1 (en) 1989-10-05
US5314818A (en) 1994-05-24

Similar Documents

Publication Publication Date Title
ATE107960T1 (de) Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung.
DE69921102D1 (de) Verfahren zur verbesserung der serum halbwertszeit von biologisch aktiven molekülen
FI943632A (fi) Kudosplasminogeeniaktivaattorin glykosylaatiomuunnelmat terapeuttisten ominaisuuksien parantamiseksi
DK0600866T3 (da) Præparater og fremgangsmåder til identifikation af biologisk aktive molekyler
DE68929551D1 (de) Menschliche DNase
AU6701890A (en) Process for the production of biologically active protein
DK0751959T3 (da) Modificerede polypeptider med forøget biologisk aktivitet
DE69435096D1 (de) Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
SE8501050D0 (sv) Biologically active fragments of human antihemophilic factor and method for preparation thereof
DK0430200T3 (da) Polypeptidholdigt lægemiddel til subkutan eller intramuskulær applikation
DK431988D0 (da) Protein og dna til kodning deraf
DE3682891D1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
IS2819B (is) Viðloðunarsameindir í æðum og mótun á starfsemi@þeirra
DE69120287D1 (en) Aminosulfonylharnstoff-acat-inhibitoren
DE68918279D1 (de) Plasminogenaktivator-varianten und verfahren zu ihrer herstellung.
PT86771A (pt) Process for preparing 4-substituted benzamide derivatives with anticonvulsant activity
DK0542869T3 (da) Vævsplasminogenaktivatorvarianter med nedsat udskillelse
HU912740D0 (en) Solubilisation of tissue plasminogene activator (t-pa)
UA23903A (uk) Механізоване кріплення сполучення

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time