IL89500A - Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing them - Google Patents
Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing themInfo
- Publication number
- IL89500A IL89500A IL8950089A IL8950089A IL89500A IL 89500 A IL89500 A IL 89500A IL 8950089 A IL8950089 A IL 8950089A IL 8950089 A IL8950089 A IL 8950089A IL 89500 A IL89500 A IL 89500A
- Authority
- IL
- Israel
- Prior art keywords
- variant
- des
- native
- site
- amino acid
- Prior art date
Links
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Artificial Filaments (AREA)
- Inorganic Fibers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/170,510 US5094953A (en) | 1988-03-21 | 1988-03-21 | Human tissue plasminogen activator variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL89500A0 IL89500A0 (en) | 1989-09-10 |
| IL89500A true IL89500A (en) | 1998-09-24 |
Family
ID=22620139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8950089A IL89500A (en) | 1988-03-21 | 1989-03-06 | Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing them |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US5094953A (de) |
| EP (1) | EP0401303B2 (de) |
| JP (2) | JP2605155B2 (de) |
| AT (1) | ATE107960T1 (de) |
| AU (1) | AU635892B2 (de) |
| CA (1) | CA1341612C (de) |
| DE (1) | DE68916532T3 (de) |
| DK (1) | DK175776B1 (de) |
| ES (1) | ES2018367A6 (de) |
| GR (1) | GR1000387B (de) |
| IL (1) | IL89500A (de) |
| NZ (1) | NZ228401A (de) |
| WO (1) | WO1989009266A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI831484A7 (fi) * | 1982-05-05 | 1983-11-06 | Genentech Inc | Ihmiskudoksen plasminogeenien aktivaattori. |
| SU1662352A3 (ru) * | 1982-05-05 | 1991-07-07 | Генентек, Инк (Фирма) | Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа |
| US5714372A (en) * | 1985-04-22 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator variants |
| DE3854195T2 (de) * | 1987-10-29 | 1995-12-21 | Yamanouchi Pharma Co Ltd | Polypeptid-verbindungen. |
| DE3923339A1 (de) * | 1989-05-31 | 1990-12-06 | Boehringer Mannheim Gmbh | Gewebs-plasminogen-aktivator-derivat |
| US5242688A (en) * | 1990-12-24 | 1993-09-07 | Eli Lilly And Company | Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants |
| US5595736A (en) * | 1991-04-22 | 1997-01-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders |
| US5468505A (en) * | 1992-02-28 | 1995-11-21 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
| ATE226642T1 (de) * | 1994-07-07 | 2002-11-15 | Tno | Modifizierte proenzyme als substrate für proteolische enzyme |
| US6136548A (en) * | 1994-11-22 | 2000-10-24 | Rutgers, The State University Of New Jersey | Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging |
| US6461640B1 (en) | 1995-12-08 | 2002-10-08 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
| US20030113271A1 (en) * | 1997-01-29 | 2003-06-19 | University Technology Corporation | Formulations for pulmonary delivery |
| PT1000167E (pt) * | 1997-07-23 | 2006-05-31 | Roche Diagnostics Gmbh | Producao de proteinas mutantes humanas em celulas humanas por recombinacao homologa |
| US6136536A (en) * | 1997-10-29 | 2000-10-24 | Genetics Institute, Inc. | Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins |
| US6283300B1 (en) | 1998-08-21 | 2001-09-04 | Joseph B. Bielagus | Feed distribution for low velocity air density separation |
| US6242473B1 (en) | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
| JP3880036B2 (ja) * | 2001-05-11 | 2007-02-14 | 全国酪農業協同組合連合会 | タンパク質の濃縮方法 |
| DE10153601A1 (de) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA zur Behandlung von Schlaganfall |
| JP2005508366A (ja) * | 2001-11-06 | 2005-03-31 | マキシム ファーマシューティカルス，インコーポレイテッド | 感染性疾患の治療用組成物 |
| US20080057050A1 (en) * | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
| DE10342518A1 (de) * | 2003-09-12 | 2005-05-12 | Paion Gmbh | Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität |
| AR068914A1 (es) * | 2007-10-18 | 2009-12-16 | Paion Deutschland Gmbh | Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia |
| WO2015023830A1 (en) | 2013-08-14 | 2015-02-19 | Stc.Unm | Treatment and prevention of stroke and other neurological disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU596356B2 (en) * | 1985-04-22 | 1990-05-03 | Genentech Inc. | Novel human tissue plasminogen activator mutants |
| DK623186A (da) * | 1985-12-23 | 1987-08-26 | Chiron Corp | Polypeptid med vaevsplasminogen-aktivator-virkning |
| JP2527454B2 (ja) * | 1986-01-31 | 1996-08-21 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | 新しい血栓溶解タンパク質 |
| ATE70301T1 (de) * | 1986-02-17 | 1991-12-15 | Stichting Centraal Lab | Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. |
| AU7090887A (en) * | 1986-04-02 | 1987-10-08 | Beecham Group Plc | Plasminogen activators modified in first kringle domain |
| SE8702562L (sv) * | 1987-06-18 | 1988-12-19 | Kabigen Ab | Nya fibrinolytiska enzymer |
| US4935237A (en) * | 1988-03-21 | 1990-06-19 | Genentech, Inc. | Processes for the preparation of t-PA mutants |
| IL87276A (en) * | 1987-08-03 | 1995-07-31 | Fujisawa Pharmaceutical Co | Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same |
| EP0386240B1 (de) * | 1987-10-29 | 1995-07-19 | Yamanouchi Pharmaceutical Co. Ltd. | Polypeptid-verbindungen |
| DE3937589C2 (de) * | 1989-11-10 | 2001-12-13 | Laing Oliver | Zirkulationsgerät mit Widerstandsheizung |
-
1988
- 1988-03-21 US US07/170,510 patent/US5094953A/en not_active Expired - Lifetime
-
1989
- 1989-03-06 DE DE68916532T patent/DE68916532T3/de not_active Expired - Lifetime
- 1989-03-06 JP JP1504276A patent/JP2605155B2/ja not_active Expired - Lifetime
- 1989-03-06 WO PCT/US1989/000896 patent/WO1989009266A1/en not_active Ceased
- 1989-03-06 EP EP89904712A patent/EP0401303B2/de not_active Expired - Lifetime
- 1989-03-06 AT AT89904712T patent/ATE107960T1/de not_active IP Right Cessation
- 1989-03-06 IL IL8950089A patent/IL89500A/en active IP Right Grant
- 1989-03-06 AU AU34148/89A patent/AU635892B2/en not_active Expired
- 1989-03-17 GR GR890100164A patent/GR1000387B/el not_active IP Right Cessation
- 1989-03-20 NZ NZ228401A patent/NZ228401A/xx unknown
- 1989-03-21 ES ES8901017A patent/ES2018367A6/es not_active Expired - Lifetime
- 1989-03-21 CA CA594301A patent/CA1341612C/en not_active Expired - Fee Related
-
1990
- 1990-09-20 DK DK199002273A patent/DK175776B1/da not_active IP Right Cessation
-
1992
- 1992-02-19 US US07/846,245 patent/US5314818A/en not_active Expired - Lifetime
-
1993
- 1993-02-11 US US08/016,815 patent/US5366886A/en not_active Expired - Lifetime
-
1994
- 1994-07-18 US US08/276,862 patent/US5770425A/en not_active Expired - Fee Related
-
1996
- 1996-08-30 JP JP8229871A patent/JPH09168387A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2018367A6 (es) | 1991-04-01 |
| EP0401303A1 (de) | 1990-12-12 |
| GR1000387B (el) | 1992-06-30 |
| JPH03503363A (ja) | 1991-08-01 |
| DK175776B1 (da) | 2005-02-14 |
| US5366886A (en) | 1994-11-22 |
| US5770425A (en) | 1998-06-23 |
| NZ228401A (en) | 1991-09-25 |
| ATE107960T1 (de) | 1994-07-15 |
| DK227390D0 (da) | 1990-09-20 |
| WO1989009266A1 (en) | 1989-10-05 |
| GR890100164A (en) | 1990-01-19 |
| JP2605155B2 (ja) | 1997-04-30 |
| US5094953A (en) | 1992-03-10 |
| DK227390A (da) | 1990-09-20 |
| AU635892B2 (en) | 1993-04-08 |
| AU3414889A (en) | 1989-10-16 |
| EP0401303B1 (de) | 1994-06-29 |
| CA1341612C (en) | 2011-04-12 |
| US5314818A (en) | 1994-05-24 |
| JPH09168387A (ja) | 1997-06-30 |
| EP0401303B2 (de) | 1999-11-03 |
| IL89500A0 (en) | 1989-09-10 |
| DE68916532T3 (de) | 2000-02-03 |
| DE68916532D1 (de) | 1994-08-04 |
| DE68916532T2 (de) | 1995-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |