DE68916532D1 - Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung. - Google Patents

Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung.

Info

Publication number
DE68916532D1
DE68916532D1 DE68916532T DE68916532T DE68916532D1 DE 68916532 D1 DE68916532 D1 DE 68916532D1 DE 68916532 T DE68916532 T DE 68916532T DE 68916532 T DE68916532 T DE 68916532T DE 68916532 D1 DE68916532 D1 DE 68916532D1
Authority
DE
Germany
Prior art keywords
variants
plasminogen activator
tissue plasminogen
production
human tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68916532T
Other languages
English (en)
Other versions
DE68916532T3 (de
DE68916532T2 (de
Inventor
Stephen Anderson
Deborah Higgins
Adair Hotchkiss
Cara Marks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22620139&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68916532(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE68916532D1 publication Critical patent/DE68916532D1/de
Application granted granted Critical
Publication of DE68916532T2 publication Critical patent/DE68916532T2/de
Publication of DE68916532T3 publication Critical patent/DE68916532T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
DE68916532T 1988-03-21 1989-03-06 Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung. Expired - Lifetime DE68916532T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/170,510 US5094953A (en) 1988-03-21 1988-03-21 Human tissue plasminogen activator variants
PCT/US1989/000896 WO1989009266A1 (en) 1988-03-21 1989-03-06 Novel human tissue plasminogen activator variants and processes

Publications (3)

Publication Number Publication Date
DE68916532D1 true DE68916532D1 (de) 1994-08-04
DE68916532T2 DE68916532T2 (de) 1995-01-12
DE68916532T3 DE68916532T3 (de) 2000-02-03

Family

ID=22620139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916532T Expired - Lifetime DE68916532T3 (de) 1988-03-21 1989-03-06 Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung.

Country Status (13)

Country Link
US (4) US5094953A (de)
EP (1) EP0401303B2 (de)
JP (2) JP2605155B2 (de)
AT (1) ATE107960T1 (de)
AU (1) AU635892B2 (de)
CA (1) CA1341612C (de)
DE (1) DE68916532T3 (de)
DK (1) DK175776B1 (de)
ES (1) ES2018367A6 (de)
GR (1) GR1000387B (de)
IL (1) IL89500A (de)
NZ (1) NZ228401A (de)
WO (1) WO1989009266A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
MX197183A (es) * 1982-05-05 1994-02-28 Genentech Inc Activador de plasminogeno de tejido humano
US5714372A (en) * 1985-04-22 1998-02-03 Genentech, Inc. Tissue plasminogen activator variants
KR970005046B1 (ko) * 1987-10-29 1997-04-11 야마노우찌 세이야꾸 가부시끼가이샤 개량형 조직 플라스미노겐 활성화 인자
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) * 1991-04-22 1997-01-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
ATE226642T1 (de) * 1994-07-07 2002-11-15 Tno Modifizierte proenzyme als substrate für proteolische enzyme
US6136548A (en) * 1994-11-22 2000-10-24 Rutgers, The State University Of New Jersey Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
US6461640B1 (en) 1995-12-08 2002-10-08 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
ATE313643T1 (de) * 1997-07-23 2006-01-15 Roche Diagnostics Gmbh Herstellung humaner mutierter proteine in humanen zellen mittels homologer rekombination
US6136536A (en) * 1997-10-29 2000-10-24 Genetics Institute, Inc. Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
US6283300B1 (en) 1998-08-21 2001-09-04 Joseph B. Bielagus Feed distribution for low velocity air density separation
US6242473B1 (en) 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
JP3880036B2 (ja) * 2001-05-11 2007-02-14 全国酪農業協同組合連合会 タンパク質の濃縮方法
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
EP1448127A1 (de) * 2001-11-06 2004-08-25 Maxim Pharmaceuticals, Inc. Zusammensetzungen für die behandlung von infektionskrankheiten
US20080057050A1 (en) * 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581652B1 (fr) * 1985-04-22 1989-12-22 Genentech Inc Nouveaux mutants de l'activateur tissulaire du plasminogene humain
EP0227462B1 (de) * 1985-12-23 1992-04-01 Chiron Corporation Peptidplasminogenaktivatoren
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
EP0386240B1 (de) * 1987-10-29 1995-07-19 Yamanouchi Pharmaceutical Co. Ltd. Polypeptid-verbindungen
DE3937589C2 (de) * 1989-11-10 2001-12-13 Laing Oliver Zirkulationsgerät mit Widerstandsheizung

Also Published As

Publication number Publication date
NZ228401A (en) 1991-09-25
US5366886A (en) 1994-11-22
US5314818A (en) 1994-05-24
DK227390D0 (da) 1990-09-20
AU635892B2 (en) 1993-04-08
EP0401303B2 (de) 1999-11-03
JP2605155B2 (ja) 1997-04-30
DE68916532T3 (de) 2000-02-03
EP0401303B1 (de) 1994-06-29
IL89500A0 (en) 1989-09-10
ES2018367A6 (es) 1991-04-01
JPH03503363A (ja) 1991-08-01
AU3414889A (en) 1989-10-16
DK227390A (da) 1990-09-20
US5770425A (en) 1998-06-23
JPH09168387A (ja) 1997-06-30
US5094953A (en) 1992-03-10
GR890100164A (en) 1990-01-19
DK175776B1 (da) 2005-02-14
EP0401303A1 (de) 1990-12-12
DE68916532T2 (de) 1995-01-12
CA1341612C (en) 2011-04-12
GR1000387B (el) 1992-06-30
ATE107960T1 (de) 1994-07-15
WO1989009266A1 (en) 1989-10-05
IL89500A (en) 1998-09-24

Similar Documents

Publication Publication Date Title
DE68916532D1 (de) Varianten von menschlichem gewebeplasminogenaktivator sowie verfahren zu deren herstellung.
ATE279430T1 (de) Verfahren zur verbesserung der serum halbwertszeit von biologisch aktiven molekülen
DK85786D0 (da) Biologisk aktive fragmenter af human antihaemofilisk faktor og fremgangsmaade til fremstilling deraf
DE69127829T2 (de) Expression von pace in wirtszellen und verfahren zu dessen verwendung
FI103278B1 (fi) Menetelmä biologisesti aktiivisen TGF- :n kaltaisen proteiinin tuottamiseksi
DE69836491D1 (de) Fibrinmikrokugeln und deren verwendungen
DK0600866T3 (da) Præparater og fremgangsmåder til identifikation af biologisk aktive molekyler
DE3784064D1 (de) Einheitlicher, steriler fluessigkeitsverabreichungszusammenbau und herstellungsverfahren.
DK0430200T3 (da) Polypeptidholdigt lægemiddel til subkutan eller intramuskulær applikation
DK662288A (da) Vasculaere antikoagulerende proteiner, dna som koder for disse og fremgangsmaade til fremstilling deraf
DK431988D0 (da) Protein og dna til kodning deraf
DE3682891D1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
DE69120287D1 (en) Aminosulfonylharnstoff-acat-inhibitoren
DE68918279D1 (de) Plasminogenaktivator-varianten und verfahren zu ihrer herstellung.
DK315387D0 (da) Androst-4-en-3,17-dioner og fremgangsmaade til fremstilling deraf
DE3788592T2 (de) Plasmidvektor zur Expression im Bazillus, dessen Umwendung für die Klonierung des menschlichen Wachstumshormongens und Verfahren zur Produktion des Hormons.
ES2033295T3 (es) Un metodo para preparar un activador de plasminogeno.
HU912740D0 (en) Solubilisation of tissue plasminogene activator (t-pa)
DK0542869T3 (da) Vævsplasminogenaktivatorvarianter med nedsat udskillelse
ATE49964T1 (de) Benzodioxepane, verfahren zur herstellung und verwendung als heilmittel.
UA23903A (uk) Механізоване кріплення сполучення

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings