ES2018367A6 - Un metodo para proporcionar variantes de t-pa humano. - Google Patents
Un metodo para proporcionar variantes de t-pa humano.Info
- Publication number
- ES2018367A6 ES2018367A6 ES8901017A ES8901017A ES2018367A6 ES 2018367 A6 ES2018367 A6 ES 2018367A6 ES 8901017 A ES8901017 A ES 8901017A ES 8901017 A ES8901017 A ES 8901017A ES 2018367 A6 ES2018367 A6 ES 2018367A6
- Authority
- ES
- Spain
- Prior art keywords
- variants
- plasminogen activator
- tissue plasminogen
- processes
- human tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 title abstract 4
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 title abstract 4
- 229960000187 tissue plasminogen activator Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 102000009123 Fibrin Human genes 0.000 abstract 2
- 108010073385 Fibrin Proteins 0.000 abstract 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 2
- 229950003499 fibrin Drugs 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Abstract
UN METODO PARA PROPORCIONAR VARIANTES DE T-PA HUMANO. EL METODO OBJETO DEL INVENTO SE CARACTERIZA PORQUE SE OBTIENE UNA VARIANTE DE T-PA QUE COMPRENDE T-PA MODIFICADO POR RETIRADA FUNCIONAL DE POR LOS MENOS UNA PORCION DE UN DOMINIO RESPONSABLE DE FIJACION A FIBRINA; SE MODIFICA ADICIONALMENTE LA VARIANTE DE T-PA DE ACUERDO CON LA OPERACION ANTERIOR PARA PRODUCIR UNA SEGUNDA VARIANTE DE T-PA; SE COMPARA LAS CARACTERISTICAS DE FIJACION A FIBRINA DE DICHA SEGUNDA VARIANTE DE T-PA A LA DE T-PA NATURAL; Y SE SELECCIONA UNA SEGUNDA VARIANTE DE T-PA ASI OBTENIDA, QUE EXHIBE FIJACION RESTAURADA A FIBRINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/170,510 US5094953A (en) | 1988-03-21 | 1988-03-21 | Human tissue plasminogen activator variants |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2018367A6 true ES2018367A6 (es) | 1991-04-01 |
Family
ID=22620139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8901017A Expired - Lifetime ES2018367A6 (es) | 1988-03-21 | 1989-03-21 | Un metodo para proporcionar variantes de t-pa humano. |
Country Status (13)
Country | Link |
---|---|
US (4) | US5094953A (es) |
EP (1) | EP0401303B2 (es) |
JP (2) | JP2605155B2 (es) |
AT (1) | ATE107960T1 (es) |
AU (1) | AU635892B2 (es) |
CA (1) | CA1341612C (es) |
DE (1) | DE68916532T3 (es) |
DK (1) | DK175776B1 (es) |
ES (1) | ES2018367A6 (es) |
GR (1) | GR1000387B (es) |
IL (1) | IL89500A (es) |
NZ (1) | NZ228401A (es) |
WO (1) | WO1989009266A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI831484L (fi) * | 1982-05-05 | 1983-11-06 | Genentech Inc | Plasminogen aktivator foer maenskovaevnad |
MX197183A (es) * | 1982-05-05 | 1994-02-28 | Genentech Inc | Activador de plasminogeno de tejido humano |
US5714372A (en) * | 1985-04-22 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator variants |
KR970005046B1 (ko) * | 1987-10-29 | 1997-04-11 | 야마노우찌 세이야꾸 가부시끼가이샤 | 개량형 조직 플라스미노겐 활성화 인자 |
DE3923339A1 (de) * | 1989-05-31 | 1990-12-06 | Boehringer Mannheim Gmbh | Gewebs-plasminogen-aktivator-derivat |
US5242688A (en) * | 1990-12-24 | 1993-09-07 | Eli Lilly And Company | Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants |
US5595736A (en) * | 1991-04-22 | 1997-01-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders |
US5468505A (en) * | 1992-02-28 | 1995-11-21 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
ATE226642T1 (de) * | 1994-07-07 | 2002-11-15 | Tno | Modifizierte proenzyme als substrate für proteolische enzyme |
US6136548A (en) * | 1994-11-22 | 2000-10-24 | Rutgers, The State University Of New Jersey | Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging |
US6461640B1 (en) | 1995-12-08 | 2002-10-08 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
US20030113271A1 (en) * | 1997-01-29 | 2003-06-19 | University Technology Corporation | Formulations for pulmonary delivery |
ATE313643T1 (de) * | 1997-07-23 | 2006-01-15 | Roche Diagnostics Gmbh | Herstellung humaner mutierter proteine in humanen zellen mittels homologer rekombination |
US6136536A (en) * | 1997-10-29 | 2000-10-24 | Genetics Institute, Inc. | Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins |
US6283300B1 (en) | 1998-08-21 | 2001-09-04 | Joseph B. Bielagus | Feed distribution for low velocity air density separation |
US6242473B1 (en) | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
JP3880036B2 (ja) * | 2001-05-11 | 2007-02-14 | 全国酪農業協同組合連合会 | タンパク質の濃縮方法 |
DE10153601A1 (de) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA zur Behandlung von Schlaganfall |
EP1448127A1 (en) * | 2001-11-06 | 2004-08-25 | Maxim Pharmaceuticals, Inc. | Compositions for the treatment of infectious diseases |
US20080057050A1 (en) * | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
DE10342518A1 (de) * | 2003-09-12 | 2005-05-12 | Paion Gmbh | Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität |
AR068914A1 (es) * | 2007-10-18 | 2009-12-16 | Paion Deutschland Gmbh | Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia |
US10220008B2 (en) | 2013-08-14 | 2019-03-05 | Stc.Unm | Treatment and prevention of stroke and other neurological disorders |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2581652B1 (fr) * | 1985-04-22 | 1989-12-22 | Genentech Inc | Nouveaux mutants de l'activateur tissulaire du plasminogene humain |
EP0227462B1 (en) * | 1985-12-23 | 1992-04-01 | Chiron Corporation | Novel peptide plasminogen activators |
JP2527454B2 (ja) * | 1986-01-31 | 1996-08-21 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | 新しい血栓溶解タンパク質 |
ATE70301T1 (de) * | 1986-02-17 | 1991-12-15 | Stichting Centraal Lab | Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. |
PT84588B (en) * | 1986-04-02 | 1989-05-09 | Beecham Group Plc | Process for preparing a fibrinolytic enzyme |
SE8702562L (sv) * | 1987-06-18 | 1988-12-19 | Kabigen Ab | Nya fibrinolytiska enzymer |
US4935237A (en) * | 1988-03-21 | 1990-06-19 | Genentech, Inc. | Processes for the preparation of t-PA mutants |
IL87276A (en) * | 1987-08-03 | 1995-07-31 | Fujisawa Pharmaceutical Co | Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it |
EP0386240B1 (en) * | 1987-10-29 | 1995-07-19 | Yamanouchi Pharmaceutical Co. Ltd. | Novel polypeptide compounds |
DE3937589C2 (de) * | 1989-11-10 | 2001-12-13 | Laing Oliver | Zirkulationsgerät mit Widerstandsheizung |
-
1988
- 1988-03-21 US US07/170,510 patent/US5094953A/en not_active Expired - Lifetime
-
1989
- 1989-03-06 IL IL8950089A patent/IL89500A/en active IP Right Grant
- 1989-03-06 DE DE68916532T patent/DE68916532T3/de not_active Expired - Lifetime
- 1989-03-06 JP JP1504276A patent/JP2605155B2/ja not_active Expired - Lifetime
- 1989-03-06 AU AU34148/89A patent/AU635892B2/en not_active Expired
- 1989-03-06 AT AT89904712T patent/ATE107960T1/de not_active IP Right Cessation
- 1989-03-06 WO PCT/US1989/000896 patent/WO1989009266A1/en active IP Right Grant
- 1989-03-06 EP EP89904712A patent/EP0401303B2/en not_active Expired - Lifetime
- 1989-03-17 GR GR890100164A patent/GR1000387B/el not_active IP Right Cessation
- 1989-03-20 NZ NZ228401A patent/NZ228401A/xx unknown
- 1989-03-21 CA CA594301A patent/CA1341612C/en not_active Expired - Fee Related
- 1989-03-21 ES ES8901017A patent/ES2018367A6/es not_active Expired - Lifetime
-
1990
- 1990-09-20 DK DK199002273A patent/DK175776B1/da not_active IP Right Cessation
-
1992
- 1992-02-19 US US07/846,245 patent/US5314818A/en not_active Expired - Lifetime
-
1993
- 1993-02-11 US US08/016,815 patent/US5366886A/en not_active Expired - Lifetime
-
1994
- 1994-07-18 US US08/276,862 patent/US5770425A/en not_active Expired - Fee Related
-
1996
- 1996-08-30 JP JP8229871A patent/JPH09168387A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NZ228401A (en) | 1991-09-25 |
US5366886A (en) | 1994-11-22 |
US5314818A (en) | 1994-05-24 |
DK227390D0 (da) | 1990-09-20 |
AU635892B2 (en) | 1993-04-08 |
EP0401303B2 (en) | 1999-11-03 |
JP2605155B2 (ja) | 1997-04-30 |
DE68916532T3 (de) | 2000-02-03 |
EP0401303B1 (en) | 1994-06-29 |
IL89500A0 (en) | 1989-09-10 |
JPH03503363A (ja) | 1991-08-01 |
AU3414889A (en) | 1989-10-16 |
DK227390A (da) | 1990-09-20 |
US5770425A (en) | 1998-06-23 |
JPH09168387A (ja) | 1997-06-30 |
US5094953A (en) | 1992-03-10 |
GR890100164A (en) | 1990-01-19 |
DK175776B1 (da) | 2005-02-14 |
DE68916532D1 (de) | 1994-08-04 |
EP0401303A1 (en) | 1990-12-12 |
DE68916532T2 (de) | 1995-01-12 |
CA1341612C (en) | 2011-04-12 |
GR1000387B (el) | 1992-06-30 |
ATE107960T1 (de) | 1994-07-15 |
WO1989009266A1 (en) | 1989-10-05 |
IL89500A (en) | 1998-09-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL89500A0 (en) | Human tissue plasminogen activator variants and processes | |
FI943632A (fi) | Kudosplasminogeeniaktivaattorin glykosylaatiomuunnelmat terapeuttisten ominaisuuksien parantamiseksi | |
DE69921102D1 (de) | Verfahren zur verbesserung der serum halbwertszeit von biologisch aktiven molekülen | |
GR3033146T3 (en) | Modified polypeptides with increased biological activity | |
IE831024L (en) | Human tissue plasminogen activator | |
MY102472A (en) | Preparation of funtional human urokinase proteins. | |
IL80659A (en) | Modified tissue plasminogen activators,their preparation and pharmaceutical compositions containing them | |
ES8602118A1 (es) | Un procedimiento para preparar un conjugado de proteina fibrinoliticamente activa | |
AU2036188A (en) | New tissue plasminogen activator | |
Sumi et al. | Higher fibrin-binding and thrombolytic properties of single polypeptide chain-high molecular weight urokinase | |
DE69120287D1 (en) | Aminosulfonylharnstoff-acat-inhibitoren | |
AU1778988A (en) | Novel fibrinolytic enzymes | |
EP0339505A3 (en) | Monoclonal antibodies to tissue plasminogen activator (t-pa) which prolong its functional half-life | |
ZA868813B (en) | Dna sequence,recombinant dna and process for producing human tissue plasminogen activator |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20090323 |