FI831484A7 - Ihmiskudoksen plasminogeenien aktivaattori. - Google Patents

Ihmiskudoksen plasminogeenien aktivaattori. Download PDF

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Publication number
FI831484A7
FI831484A7 FI831484A FI831484A FI831484A7 FI 831484 A7 FI831484 A7 FI 831484A7 FI 831484 A FI831484 A FI 831484A FI 831484 A FI831484 A FI 831484A FI 831484 A7 FI831484 A7 FI 831484A7
Authority
FI
Finland
Prior art keywords
plasminogen activator
human tissue
tissue plasminogen
human
activator
Prior art date
Application number
FI831484A
Other languages
English (en)
Swedish (sv)
Other versions
FI831484L (fi
FI831484A0 (fi
Inventor
William Jack Kohr
Diane Pennica
David Vannorman Goeddel
Gordon Allen Vehar
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI831484A0 publication Critical patent/FI831484A0/fi
Publication of FI831484A7 publication Critical patent/FI831484A7/fi
Publication of FI831484L publication Critical patent/FI831484L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI831484A 1982-05-05 1983-05-02 Plasminogen aktivator foer maenskovaevnad FI831484L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14

Publications (3)

Publication Number Publication Date
FI831484A0 FI831484A0 (fi) 1983-05-02
FI831484A7 true FI831484A7 (fi) 1983-11-06
FI831484L FI831484L (fi) 1983-11-06

Family

ID=27006805

Family Applications (1)

Application Number Title Priority Date Filing Date
FI831484A FI831484L (fi) 1982-05-05 1983-05-02 Plasminogen aktivator foer maenskovaevnad

Country Status (2)

Country Link
US (8) US5728565A (fi)
FI (1) FI831484L (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
WO1998028422A1 (en) * 1996-12-20 1998-07-02 Human Genome Sciences, Inc. Raidd, a novel cell death adaptor molecule
JP2002511264A (ja) * 1998-04-16 2002-04-16 ジェネンテック・インコーポレーテッド 組織プラスミノーゲン活性化因子プロ配列を使用するグリコシル化タンパク質の分泌
PL204011B1 (pl) 1999-11-04 2009-12-31 Genentech Inc Sposób monitorowania sposobu oczyszczania przez usuwanie aktywatora plazminogenu z próbki
IL159015A0 (en) * 2001-05-25 2004-05-12 Genset Sa Polypeptides, their preparation and use
AU2002365408B2 (en) * 2001-11-26 2008-04-24 Genentech, Inc. Catheter composition and uses thereof
US20040152170A1 (en) * 2001-12-14 2004-08-05 Lee Chichang Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media
CA2470026A1 (en) * 2001-12-14 2003-06-26 Centocor, Inc. Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media
US20030166147A1 (en) * 2001-12-14 2003-09-04 Lee Chichang Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media
US20040142495A1 (en) * 2002-12-16 2004-07-22 Hartman William G. Analyte detecting article and method
US20060104969A1 (en) * 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
US20060246975A1 (en) * 2005-04-07 2006-11-02 Frank J. Pellegrini Character matching game
EP2010117A4 (en) * 2006-04-12 2010-12-01 Massachusetts Inst Technology COMPOSITIONS AND METHODS FOR INHIBITING ADHESIONS
CA2650140A1 (en) * 2006-04-14 2007-10-25 Mriganka Sur Identifying and modulating molecular pathways that mediate nervous system plasticity
US8916148B2 (en) 2006-11-07 2014-12-23 Genentech, Inc. Tissue plasminogen activator variant uses
US8542900B2 (en) * 2007-03-08 2013-09-24 Sync-Rx Ltd. Automatic reduction of interfering elements from an image stream of a moving organ
US20120058537A1 (en) * 2011-07-27 2012-03-08 Fereidoun Mahboudi Chimeric truncated and mutant variant of tissue plasminogen activator (t-pa) resistant to plasminogen activator inhibitor-1
KR102277471B1 (ko) 2019-10-22 2021-07-14 주식회사 지니스 '혈관내 혈전' 용해제

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427470A (en) * 1965-08-11 1969-02-11 Mohawk Data Sciences Corp Multiple level logic circuits
US3904460A (en) * 1971-01-04 1975-09-09 Ppg Industries Inc Treating glass sheets
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
IL43343A (en) * 1972-10-24 1976-03-31 Lilly Co Eli Production of plasminogen activator
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (fi) * 1973-12-03 1977-11-04 Fabre Sa Pierre
US4177262A (en) * 1974-12-17 1979-12-04 Choay S.A. Plasminogen compositions containing preactivated plasminogens with or without native plasminogens, process for making same, pharmaceutical compositions and control of blood clots
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
US4245051A (en) * 1978-03-30 1981-01-13 Rockefeller University Human serum plasminogen activator
US4190708A (en) * 1978-05-24 1980-02-26 Monsanto Company Production of urokinase
CH643297A5 (de) * 1978-06-30 1984-05-30 Alpha Patent Ltd Verfahren zur reindarstellung von urokinase.
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
CA1154671A (fr) * 1979-07-27 1983-10-04 Lucien D. D'hinterland Separation d'un activateur tissulaire du plasminogene
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US5011795A (en) * 1983-01-19 1991-04-30 Genentech, Inc. Human tPA production using vectors coding for DHFR protein
EP0174835A1 (en) * 1984-09-11 1986-03-19 The Upjohn Company Human tissue plasminogen activator and recombinant DNA compounds
GR861365B (en) * 1985-05-28 1986-09-29 Wellcome Found Novel formulation
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants

Also Published As

Publication number Publication date
US5702938A (en) 1997-12-30
US5728565A (en) 1998-03-17
US6284247B1 (en) 2001-09-04
US6274335B1 (en) 2001-08-14
US5728566A (en) 1998-03-17
US5753486A (en) 1998-05-19
US5869314A (en) 1999-02-09
US5587159A (en) 1996-12-24
FI831484L (fi) 1983-11-06
FI831484A0 (fi) 1983-05-02

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Legal Events

Date Code Title Description
FC Application refused
FC Application refused
MM Patent lapsed

Owner name: GENENTECH, INC.