DK227390D0 - Vaevsplasminogenaktivatorvarianter - Google Patents

Vaevsplasminogenaktivatorvarianter

Info

Publication number
DK227390D0
DK227390D0 DK227390A DK227390A DK227390D0 DK 227390 D0 DK227390 D0 DK 227390D0 DK 227390 A DK227390 A DK 227390A DK 227390 A DK227390 A DK 227390A DK 227390 D0 DK227390 D0 DK 227390D0
Authority
DK
Denmark
Prior art keywords
variants
plasminogen activator
tissue plasminogen
disclosed
fibrin binding
Prior art date
Application number
DK227390A
Other languages
English (en)
Other versions
DK175776B1 (da
DK227390A (da
Inventor
Stephen P Anderson
Deborah L Higgins
Adair J Hotchkiss
Cara B Marks
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22620139&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK227390(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK227390D0 publication Critical patent/DK227390D0/da
Publication of DK227390A publication Critical patent/DK227390A/da
Application granted granted Critical
Publication of DK175776B1 publication Critical patent/DK175776B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Artificial Filaments (AREA)
  • Inorganic Fibers (AREA)
DK199002273A 1988-03-21 1990-09-20 Varianter af human vævsplasminogenaktivator og fremgangsmåde til fremstilling deraf DK175776B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/170,510 US5094953A (en) 1988-03-21 1988-03-21 Human tissue plasminogen activator variants
US17051088 1988-03-21
US8900896 1989-03-06
PCT/US1989/000896 WO1989009266A1 (en) 1988-03-21 1989-03-06 Novel human tissue plasminogen activator variants and processes

Publications (3)

Publication Number Publication Date
DK227390D0 true DK227390D0 (da) 1990-09-20
DK227390A DK227390A (da) 1990-09-20
DK175776B1 DK175776B1 (da) 2005-02-14

Family

ID=22620139

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199002273A DK175776B1 (da) 1988-03-21 1990-09-20 Varianter af human vævsplasminogenaktivator og fremgangsmåde til fremstilling deraf

Country Status (13)

Country Link
US (4) US5094953A (da)
EP (1) EP0401303B2 (da)
JP (2) JP2605155B2 (da)
AT (1) ATE107960T1 (da)
AU (1) AU635892B2 (da)
CA (1) CA1341612C (da)
DE (1) DE68916532T3 (da)
DK (1) DK175776B1 (da)
ES (1) ES2018367A6 (da)
GR (1) GR1000387B (da)
IL (1) IL89500A (da)
NZ (1) NZ228401A (da)
WO (1) WO1989009266A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
US5714372A (en) * 1985-04-22 1998-02-03 Genentech, Inc. Tissue plasminogen activator variants
WO1989003874A1 (en) * 1987-10-29 1989-05-05 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) * 1991-04-22 1997-01-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
JPH0856665A (ja) * 1994-07-07 1996-03-05 Nederland Centr Org Toegepast Natuur Onder タンパク質分解酵素用の基質としての修飾された酵素前駆体
US6136548A (en) * 1994-11-22 2000-10-24 Rutgers, The State University Of New Jersey Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
US6461640B1 (en) 1995-12-08 2002-10-08 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
JP2001511341A (ja) * 1997-07-23 2001-08-14 ロシュ ダイアグノスティックス ゲーエムベーハー ヒト細胞におけるヒト変異型タンパク質の相同的組換えによる生産
US6136536A (en) * 1997-10-29 2000-10-24 Genetics Institute, Inc. Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
US6283300B1 (en) 1998-08-21 2001-09-04 Joseph B. Bielagus Feed distribution for low velocity air density separation
US6242473B1 (en) 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
JP3880036B2 (ja) * 2001-05-11 2007-02-14 全国酪農業協同組合連合会 タンパク質の濃縮方法
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
NZ532074A (en) * 2001-11-06 2006-02-24 Maxim Pharm Inc Compositions for the treatment of infectious diseases
US20080057050A1 (en) * 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3682104D1 (de) * 1985-04-22 1991-11-28 Genentech Inc Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen.
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins
EP0234051B1 (en) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
EP0386240B1 (en) * 1987-10-29 1995-07-19 Yamanouchi Pharmaceutical Co. Ltd. Novel polypeptide compounds
DE3937589C2 (de) * 1989-11-10 2001-12-13 Laing Oliver Zirkulationsgerät mit Widerstandsheizung

Also Published As

Publication number Publication date
US5366886A (en) 1994-11-22
EP0401303B1 (en) 1994-06-29
EP0401303B2 (en) 1999-11-03
CA1341612C (en) 2011-04-12
WO1989009266A1 (en) 1989-10-05
JPH09168387A (ja) 1997-06-30
NZ228401A (en) 1991-09-25
ES2018367A6 (es) 1991-04-01
JPH03503363A (ja) 1991-08-01
DK175776B1 (da) 2005-02-14
AU635892B2 (en) 1993-04-08
GR890100164A (en) 1990-01-19
DK227390A (da) 1990-09-20
IL89500A (en) 1998-09-24
EP0401303A1 (en) 1990-12-12
GR1000387B (el) 1992-06-30
US5094953A (en) 1992-03-10
IL89500A0 (en) 1989-09-10
US5314818A (en) 1994-05-24
JP2605155B2 (ja) 1997-04-30
ATE107960T1 (de) 1994-07-15
AU3414889A (en) 1989-10-16
US5770425A (en) 1998-06-23
DE68916532D1 (de) 1994-08-04
DE68916532T3 (de) 2000-02-03
DE68916532T2 (de) 1995-01-12

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