DE69514342T2 - Modifizierte polypeptide mit erhoehter biologischer aktivitaet - Google Patents
Modifizierte polypeptide mit erhoehter biologischer aktivitaetInfo
- Publication number
- DE69514342T2 DE69514342T2 DE69514342T DE69514342T DE69514342T2 DE 69514342 T2 DE69514342 T2 DE 69514342T2 DE 69514342 T DE69514342 T DE 69514342T DE 69514342 T DE69514342 T DE 69514342T DE 69514342 T2 DE69514342 T2 DE 69514342T2
- Authority
- DE
- Germany
- Prior art keywords
- modified polypeptides
- biological activity
- increased biological
- increased
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/216,259 US5580853A (en) | 1994-03-22 | 1994-03-22 | Modified polypeptides with increased biological activity |
PCT/US1995/003242 WO1995025746A1 (en) | 1994-03-22 | 1995-03-15 | Modified polypeptides with increased biological activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69514342D1 DE69514342D1 (de) | 2000-02-10 |
DE69514342T2 true DE69514342T2 (de) | 2000-11-30 |
Family
ID=22806382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69514342T Expired - Fee Related DE69514342T2 (de) | 1994-03-22 | 1995-03-15 | Modifizierte polypeptide mit erhoehter biologischer aktivitaet |
Country Status (9)
Country | Link |
---|---|
US (1) | US5580853A (de) |
EP (1) | EP0751959B1 (de) |
AT (1) | ATE188486T1 (de) |
DE (1) | DE69514342T2 (de) |
DK (1) | DK0751959T3 (de) |
ES (1) | ES2143620T3 (de) |
GR (1) | GR3033146T3 (de) |
PT (1) | PT751959E (de) |
WO (1) | WO1995025746A1 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6153407A (en) * | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
US5614184A (en) | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
US5747446A (en) * | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
US5919758A (en) * | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
US5767078A (en) * | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
AU733212B2 (en) | 1996-03-28 | 2001-05-10 | Board Of Trustees Of The University Of Illinois, The | Material and methods for making improved liposome compositions |
US6242570B1 (en) | 1997-07-10 | 2001-06-05 | Beth Israel Deaconess Medical Center | Production and use of recombinant protein multimers with increased biological activity |
US6187564B1 (en) | 1997-07-10 | 2001-02-13 | Beth Israel Deaconess Medical Center | DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
WO1999002709A1 (en) * | 1997-07-10 | 1999-01-21 | Beth Israel Deaconess Medical Center | Recombinant erythropoietin / immunoglobulin fusion proteins |
US6217886B1 (en) | 1997-07-14 | 2001-04-17 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved micelle compositions |
US6605648B1 (en) * | 1999-04-06 | 2003-08-12 | Phillips Plastics Corporation | Sinterable structures and method |
CA2499211A1 (en) * | 1999-05-17 | 2000-11-23 | Conjuchem Inc. | Modified peptides yy and conjugates thereof |
US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
US6849714B1 (en) * | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
AU754770B2 (en) * | 1999-05-17 | 2002-11-21 | Conjuchem Biotechnologies Inc. | Long lasting insulinotropic peptides |
US7601691B2 (en) * | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
JP4944324B2 (ja) * | 1999-07-13 | 2012-05-30 | ボルダー バイオテクノロジー, インコーポレイテッド | 免疫グロブリン融合タンパク質 |
US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
US6703480B1 (en) | 1999-11-24 | 2004-03-09 | Palani Balu | Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use |
ATE428790T1 (de) | 2000-09-25 | 2009-05-15 | Genetronics Inc | Verbessertes system zur regulation der transgenexpression |
AU2002233082B2 (en) * | 2001-02-02 | 2005-11-10 | Conjuchem Biotechnologies Inc. | Long lasting growth hormone releasing factor derivatives |
WO2002066511A2 (en) * | 2001-02-16 | 2002-08-29 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
ITMI20011986A1 (it) * | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
GB0209893D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
GB0209896D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
ATE466085T1 (de) * | 2002-09-09 | 2010-05-15 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
EP1613274B1 (de) | 2003-04-15 | 2010-03-03 | GlaxoSmithKline LLC | Humane il-18 substitutionsmutanten und deren konjugate |
EP1625156B1 (de) * | 2003-05-12 | 2012-09-19 | Affymax, Inc. | An den erythropoietinrezeptor bindenden peptiden |
JP4266028B2 (ja) * | 2003-05-12 | 2009-05-20 | アフィーマックス・インコーポレイテッド | エリスロポエチン受容体に結合する新規ペプチド |
EP2204193A3 (de) * | 2003-05-12 | 2010-08-18 | Affymax, Inc. | Spacer-Bestandteile für Poly(ethylenglykol)-modifizierte Verbindungen auf Peptidbasis |
WO2004101600A2 (en) * | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Novel poly(ethylene glycol) modified compounds and uses thereof |
EP2230257A1 (de) | 2004-04-23 | 2010-09-22 | ConjuChem Biotechnologies Inc. | Verfahren zur Reinigung von Albuminkonjugaten |
KR20070108140A (ko) * | 2004-11-11 | 2007-11-08 | 아피맥스, 인크. | 에리트로포이에틴 수용체에 결합하는 신규한 펩타이드 |
WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
WO2006063055A2 (en) * | 2004-12-06 | 2006-06-15 | Bolder Biotechnology, Inc. | Enzyme conjugates for use as detoxifying agents |
CN101124243A (zh) * | 2004-12-23 | 2008-02-13 | 莫尔梅德股份有限公司 | 缀合产物 |
WO2006086733A2 (en) * | 2005-02-11 | 2006-08-17 | Immunogen, Inc. | Process for preparing maytansinoid antibody conjugates |
US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7550433B2 (en) * | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
ES2390826T3 (es) * | 2005-08-24 | 2012-11-16 | Immunogen Inc | Procedimiento para preparar conjugados de fármaco purificados |
US8039432B2 (en) | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
CN101678079B (zh) | 2006-11-28 | 2013-12-25 | 韩诺生物制约株式会社 | 修饰的促红细胞生成素多肽及其治疗用途 |
US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
HUE043645T2 (hu) | 2009-06-03 | 2019-08-28 | Immunogen Inc | Konjugációs módszerek |
PL2691155T3 (pl) | 2011-03-29 | 2019-06-28 | Immunogen, Inc. | Otrzymywanie koniugatu majtansynoidu przeciwciała jednoetapowym sposobem |
US9243049B2 (en) | 2011-08-09 | 2016-01-26 | Uab Profarma | Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof |
US10035817B2 (en) | 2012-10-04 | 2018-07-31 | Immunogen, Inc. | Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4258193A (en) * | 1978-07-13 | 1981-03-24 | Toyo Jozo Kabushiki Kaisha | Disulfide derivatives having S--S exchange reactivity |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4677195A (en) * | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
US4797491A (en) * | 1986-03-17 | 1989-01-10 | Cetus Corporation | Compound 1-(3-(2-pyridyldithio)propionamido)-12-(5-hydrazidoglutaramido)-4,9-dioxadodecane |
US5260421A (en) * | 1987-12-21 | 1993-11-09 | Applied Research Systems Ars Holding N.V. | Site-directed mutagenesis modified glycoprotein hormones |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5066490A (en) * | 1988-06-01 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Protein crosslinking reagents cleavable within acidified intracellular vesicles |
US5241078A (en) * | 1988-06-14 | 1993-08-31 | Cetus Oncology | Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom |
US5024834A (en) * | 1988-07-12 | 1991-06-18 | Cetus Corporation | Thioether linked immunotoxin conjugates |
US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
US5134071A (en) * | 1989-02-06 | 1992-07-28 | State University Of New York | Polymerization and copolymerization of proteins |
US5157123A (en) * | 1989-03-13 | 1992-10-20 | Georgetown University | S-(2-thiopyridyl)-l-cysteine, a heterobifunctional crosslinking reagent |
US5116944A (en) * | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
-
1994
- 1994-03-22 US US08/216,259 patent/US5580853A/en not_active Expired - Lifetime
-
1995
- 1995-03-15 DE DE69514342T patent/DE69514342T2/de not_active Expired - Fee Related
- 1995-03-15 ES ES95912917T patent/ES2143620T3/es not_active Expired - Lifetime
- 1995-03-15 PT PT95912917T patent/PT751959E/pt unknown
- 1995-03-15 DK DK95912917T patent/DK0751959T3/da active
- 1995-03-15 WO PCT/US1995/003242 patent/WO1995025746A1/en active Search and Examination
- 1995-03-15 EP EP95912917A patent/EP0751959B1/de not_active Expired - Lifetime
- 1995-03-15 AT AT95912917T patent/ATE188486T1/de not_active IP Right Cessation
-
2000
- 2000-04-04 GR GR20000400839T patent/GR3033146T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0751959A1 (de) | 1997-01-08 |
US5580853A (en) | 1996-12-03 |
ATE188486T1 (de) | 2000-01-15 |
DK0751959T3 (da) | 2000-06-26 |
DE69514342D1 (de) | 2000-02-10 |
ES2143620T3 (es) | 2000-05-16 |
GR3033146T3 (en) | 2000-08-31 |
EP0751959B1 (de) | 2000-01-05 |
WO1995025746A1 (en) | 1995-09-28 |
PT751959E (pt) | 2000-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: BETH ISRAEL DEACONESS MEDICAL CENTER, INC., BOSTON |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |