DE69514342D1 - Modifizierte polypeptide mit erhoehter biologischer aktivitaet - Google Patents
Modifizierte polypeptide mit erhoehter biologischer aktivitaetInfo
- Publication number
- DE69514342D1 DE69514342D1 DE69514342T DE69514342T DE69514342D1 DE 69514342 D1 DE69514342 D1 DE 69514342D1 DE 69514342 T DE69514342 T DE 69514342T DE 69514342 T DE69514342 T DE 69514342T DE 69514342 D1 DE69514342 D1 DE 69514342D1
- Authority
- DE
- Germany
- Prior art keywords
- modified polypeptides
- biological activity
- increased biological
- increased
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/216,259 US5580853A (en) | 1994-03-22 | 1994-03-22 | Modified polypeptides with increased biological activity |
PCT/US1995/003242 WO1995025746A1 (en) | 1994-03-22 | 1995-03-15 | Modified polypeptides with increased biological activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69514342D1 true DE69514342D1 (de) | 2000-02-10 |
DE69514342T2 DE69514342T2 (de) | 2000-11-30 |
Family
ID=22806382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69514342T Expired - Fee Related DE69514342T2 (de) | 1994-03-22 | 1995-03-15 | Modifizierte polypeptide mit erhoehter biologischer aktivitaet |
Country Status (9)
Country | Link |
---|---|
US (1) | US5580853A (de) |
EP (1) | EP0751959B1 (de) |
AT (1) | ATE188486T1 (de) |
DE (1) | DE69514342T2 (de) |
DK (1) | DK0751959T3 (de) |
ES (1) | ES2143620T3 (de) |
GR (1) | GR3033146T3 (de) |
PT (1) | PT751959E (de) |
WO (1) | WO1995025746A1 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6153407A (en) * | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
US5614184A (en) | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
US5919758A (en) * | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
US5747446A (en) * | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
US5767078A (en) * | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
EP0914094A4 (de) | 1996-03-28 | 2000-03-01 | Univ Illinois | Materialen und verfahren zur herstellung verbesserter liposomaler mittel |
US6242570B1 (en) | 1997-07-10 | 2001-06-05 | Beth Israel Deaconess Medical Center | Production and use of recombinant protein multimers with increased biological activity |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
AU8182298A (en) * | 1997-07-10 | 1999-02-08 | Beth Israel Deaconess Medical Center | Recombinant erythropoietin / immunoglobulin fusion proteins |
US6187564B1 (en) * | 1997-07-10 | 2001-02-13 | Beth Israel Deaconess Medical Center | DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics |
US6217886B1 (en) | 1997-07-14 | 2001-04-17 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved micelle compositions |
US6605648B1 (en) * | 1999-04-06 | 2003-08-12 | Phillips Plastics Corporation | Sinterable structures and method |
US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
ES2257298T3 (es) * | 1999-05-17 | 2006-08-01 | Conjuchem, Inc. | Proteccion de peptidos terapeuticos endogenos contra la actividad de la peptidasa a traves de la conjugacion con componentes sanguineos. |
PT1180121E (pt) * | 1999-05-17 | 2004-03-31 | Conjuchem Inc | Peptidos insulinotropicos de longa duracao |
US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US6849714B1 (en) * | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US7601691B2 (en) * | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
WO2001003737A1 (en) * | 1999-07-13 | 2001-01-18 | Bolder Biotechnology Inc. | Immunoglobulin fusion proteins |
US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
US6703480B1 (en) | 1999-11-24 | 2004-03-09 | Palani Balu | Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use |
CA2423093C (en) | 2000-09-25 | 2013-09-17 | Valentis, Inc. | Improved system for regulation of transgene expression |
EA006484B1 (ru) * | 2001-02-02 | 2005-12-29 | Конджачем, Инк. | Долгоживущие производные рилизинг-фактора гормона роста |
JP4280070B2 (ja) * | 2001-02-16 | 2009-06-17 | コンジュケム バイオテクノロジーズ インコーポレイテッド | 胃腸疾患および胃腸障害の処置のための長期持続性グルカゴン様ペプチド2(glp−2) |
ITMI20011986A1 (it) * | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
GB0209896D0 (en) | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
GB0209893D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
AU2003263552A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
TW200510454A (en) | 2003-04-15 | 2005-03-16 | Smithkline Beecham Corp | Conjugates comprising human IL-18 and substitution mutants thereof |
MXPA05012316A (es) * | 2003-05-12 | 2006-04-18 | Affymax Inc | Peptidos novedosos que se unen al receptor de la eritropoyetina. |
WO2004101611A2 (en) * | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Peptides that bind to the erythropoietin receptor |
CA2525399A1 (en) * | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Novel spacer moiety for poly(ethylene glycol)-modified peptide-based co mpounds |
JP2007530440A (ja) * | 2003-05-12 | 2007-11-01 | アフィーマックス・インコーポレイテッド | 新規ポリ(エチレングリコール)修飾化合物およびその用途 |
DE602005022239D1 (de) | 2004-04-23 | 2010-08-19 | Conjuchem Biotechnologies Inc | Festphase zur Verwendung in einem Verfahren zur Reinigung von Albuminkonjugaten |
MX2007005777A (es) * | 2004-11-11 | 2007-07-20 | Affymax Inc | Peptidos novedosos que se unen al receptor de eritropoietina. |
WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
US20090249503A1 (en) * | 2004-12-06 | 2009-10-01 | Bolder Biotechnology, Inc. | Enzyme conjugates for use as detoxifying agents |
WO2006067633A2 (en) * | 2004-12-23 | 2006-06-29 | Molmed Spa | Conjugation product |
CA2597407C (en) * | 2005-02-11 | 2013-09-10 | Immunogen, Inc. | Process for preparing stable drug conjugates |
US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7550433B2 (en) * | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
AU2006283726C1 (en) | 2005-08-24 | 2015-05-07 | Immunogen, Inc. | Process for preparing maytansinoid antibody conjugates |
US8039432B2 (en) | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
CN101678079B (zh) | 2006-11-28 | 2013-12-25 | 韩诺生物制约株式会社 | 修饰的促红细胞生成素多肽及其治疗用途 |
US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
MX349210B (es) | 2009-06-03 | 2017-07-18 | Immunogen Inc | Métodos de conjugación. |
KR20220009505A (ko) | 2011-03-29 | 2022-01-24 | 이뮤노젠 아이엔씨 | 일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조 |
EP2742064B1 (de) | 2011-08-09 | 2016-07-27 | UAB Profarma | Derivate aus rekombinanten proteinen, homo-multimere des granulozyten-kolonie-stimulierenden faktors und verfahren zu ihrer herstellung |
US10035817B2 (en) | 2012-10-04 | 2018-07-31 | Immunogen, Inc. | Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4258193A (en) * | 1978-07-13 | 1981-03-24 | Toyo Jozo Kabushiki Kaisha | Disulfide derivatives having S--S exchange reactivity |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4677195A (en) * | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
US4797491A (en) * | 1986-03-17 | 1989-01-10 | Cetus Corporation | Compound 1-(3-(2-pyridyldithio)propionamido)-12-(5-hydrazidoglutaramido)-4,9-dioxadodecane |
US5260421A (en) * | 1987-12-21 | 1993-11-09 | Applied Research Systems Ars Holding N.V. | Site-directed mutagenesis modified glycoprotein hormones |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5066490A (en) * | 1988-06-01 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Protein crosslinking reagents cleavable within acidified intracellular vesicles |
US5241078A (en) * | 1988-06-14 | 1993-08-31 | Cetus Oncology | Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom |
US5024834A (en) * | 1988-07-12 | 1991-06-18 | Cetus Corporation | Thioether linked immunotoxin conjugates |
US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
US5134071A (en) * | 1989-02-06 | 1992-07-28 | State University Of New York | Polymerization and copolymerization of proteins |
US5157123A (en) * | 1989-03-13 | 1992-10-20 | Georgetown University | S-(2-thiopyridyl)-l-cysteine, a heterobifunctional crosslinking reagent |
US5116944A (en) * | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
-
1994
- 1994-03-22 US US08/216,259 patent/US5580853A/en not_active Expired - Lifetime
-
1995
- 1995-03-15 ES ES95912917T patent/ES2143620T3/es not_active Expired - Lifetime
- 1995-03-15 EP EP95912917A patent/EP0751959B1/de not_active Expired - Lifetime
- 1995-03-15 DK DK95912917T patent/DK0751959T3/da active
- 1995-03-15 AT AT95912917T patent/ATE188486T1/de not_active IP Right Cessation
- 1995-03-15 PT PT95912917T patent/PT751959E/pt unknown
- 1995-03-15 DE DE69514342T patent/DE69514342T2/de not_active Expired - Fee Related
- 1995-03-15 WO PCT/US1995/003242 patent/WO1995025746A1/en active Search and Examination
-
2000
- 2000-04-04 GR GR20000400839T patent/GR3033146T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69514342T2 (de) | 2000-11-30 |
EP0751959B1 (de) | 2000-01-05 |
GR3033146T3 (en) | 2000-08-31 |
WO1995025746A1 (en) | 1995-09-28 |
ATE188486T1 (de) | 2000-01-15 |
EP0751959A1 (de) | 1997-01-08 |
DK0751959T3 (da) | 2000-06-26 |
ES2143620T3 (es) | 2000-05-16 |
US5580853A (en) | 1996-12-03 |
PT751959E (pt) | 2000-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: BETH ISRAEL DEACONESS MEDICAL CENTER, INC., BOSTON |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |