DK175776B1 - Varianter af human vævsplasminogenaktivator og fremgangsmåde til fremstilling deraf - Google Patents

Varianter af human vævsplasminogenaktivator og fremgangsmåde til fremstilling deraf Download PDF

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Publication number
DK175776B1
DK175776B1 DK199002273A DK227390A DK175776B1 DK 175776 B1 DK175776 B1 DK 175776B1 DK 199002273 A DK199002273 A DK 199002273A DK 227390 A DK227390 A DK 227390A DK 175776 B1 DK175776 B1 DK 175776B1
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DK
Denmark
Prior art keywords
des
plasmid
site
variants
fragment
Prior art date
Application number
DK199002273A
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Danish (da)
English (en)
Other versions
DK227390D0 (da
DK227390A (da
Inventor
Stephen Anderson
Deborah L Higgins
Adair J Hotchkiss
Cara B Marks
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22620139&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK175776(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK227390D0 publication Critical patent/DK227390D0/da
Publication of DK227390A publication Critical patent/DK227390A/da
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
DK199002273A 1988-03-21 1990-09-20 Varianter af human vævsplasminogenaktivator og fremgangsmåde til fremstilling deraf DK175776B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/170,510 US5094953A (en) 1988-03-21 1988-03-21 Human tissue plasminogen activator variants
US17051088 1988-03-21
PCT/US1989/000896 WO1989009266A1 (en) 1988-03-21 1989-03-06 Novel human tissue plasminogen activator variants and processes
US8900896 1989-03-06

Publications (3)

Publication Number Publication Date
DK227390D0 DK227390D0 (da) 1990-09-20
DK227390A DK227390A (da) 1990-09-20
DK175776B1 true DK175776B1 (da) 2005-02-14

Family

ID=22620139

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199002273A DK175776B1 (da) 1988-03-21 1990-09-20 Varianter af human vævsplasminogenaktivator og fremgangsmåde til fremstilling deraf

Country Status (13)

Country Link
US (4) US5094953A (de)
EP (1) EP0401303B2 (de)
JP (2) JP2605155B2 (de)
AT (1) ATE107960T1 (de)
AU (1) AU635892B2 (de)
CA (1) CA1341612C (de)
DE (1) DE68916532T3 (de)
DK (1) DK175776B1 (de)
ES (1) ES2018367A6 (de)
GR (1) GR1000387B (de)
IL (1) IL89500A (de)
NZ (1) NZ228401A (de)
WO (1) WO1989009266A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
MX197183A (es) * 1982-05-05 1994-02-28 Genentech Inc Activador de plasminogeno de tejido humano
US5714372A (en) * 1985-04-22 1998-02-03 Genentech, Inc. Tissue plasminogen activator variants
KR970005046B1 (ko) * 1987-10-29 1997-04-11 야마노우찌 세이야꾸 가부시끼가이샤 개량형 조직 플라스미노겐 활성화 인자
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) * 1991-04-22 1997-01-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
ATE226642T1 (de) * 1994-07-07 2002-11-15 Tno Modifizierte proenzyme als substrate für proteolische enzyme
US6136548A (en) * 1994-11-22 2000-10-24 Rutgers, The State University Of New Jersey Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
US6461640B1 (en) 1995-12-08 2002-10-08 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
ATE313643T1 (de) * 1997-07-23 2006-01-15 Roche Diagnostics Gmbh Herstellung humaner mutierter proteine in humanen zellen mittels homologer rekombination
US6136536A (en) * 1997-10-29 2000-10-24 Genetics Institute, Inc. Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
US6283300B1 (en) 1998-08-21 2001-09-04 Joseph B. Bielagus Feed distribution for low velocity air density separation
US6242473B1 (en) 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
JP3880036B2 (ja) * 2001-05-11 2007-02-14 全国酪農業協同組合連合会 タンパク質の濃縮方法
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
EP1448127A1 (de) * 2001-11-06 2004-08-25 Maxim Pharmaceuticals, Inc. Zusammensetzungen für die behandlung von infektionskrankheiten
US20080057050A1 (en) * 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581652B1 (fr) * 1985-04-22 1989-12-22 Genentech Inc Nouveaux mutants de l'activateur tissulaire du plasminogene humain
EP0227462B1 (de) * 1985-12-23 1992-04-01 Chiron Corporation Peptidplasminogenaktivatoren
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
EP0386240B1 (de) * 1987-10-29 1995-07-19 Yamanouchi Pharmaceutical Co. Ltd. Polypeptid-verbindungen
DE3937589C2 (de) * 1989-11-10 2001-12-13 Laing Oliver Zirkulationsgerät mit Widerstandsheizung

Also Published As

Publication number Publication date
NZ228401A (en) 1991-09-25
US5366886A (en) 1994-11-22
US5314818A (en) 1994-05-24
DK227390D0 (da) 1990-09-20
AU635892B2 (en) 1993-04-08
EP0401303B2 (de) 1999-11-03
JP2605155B2 (ja) 1997-04-30
DE68916532T3 (de) 2000-02-03
EP0401303B1 (de) 1994-06-29
IL89500A0 (en) 1989-09-10
ES2018367A6 (es) 1991-04-01
JPH03503363A (ja) 1991-08-01
AU3414889A (en) 1989-10-16
DK227390A (da) 1990-09-20
US5770425A (en) 1998-06-23
JPH09168387A (ja) 1997-06-30
US5094953A (en) 1992-03-10
GR890100164A (en) 1990-01-19
DE68916532D1 (de) 1994-08-04
EP0401303A1 (de) 1990-12-12
DE68916532T2 (de) 1995-01-12
CA1341612C (en) 2011-04-12
GR1000387B (el) 1992-06-30
ATE107960T1 (de) 1994-07-15
WO1989009266A1 (en) 1989-10-05
IL89500A (en) 1998-09-24

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