ES2033295T3 - Un metodo para preparar un activador de plasminogeno. - Google Patents

Un metodo para preparar un activador de plasminogeno.

Info

Publication number
ES2033295T3
ES2033295T3 ES198787200909T ES87200909T ES2033295T3 ES 2033295 T3 ES2033295 T3 ES 2033295T3 ES 198787200909 T ES198787200909 T ES 198787200909T ES 87200909 T ES87200909 T ES 87200909T ES 2033295 T3 ES2033295 T3 ES 2033295T3
Authority
ES
Spain
Prior art keywords
plasminogen activator
gln
lys
preparing
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787200909T
Other languages
English (en)
Inventor
Desire Jose Collen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Application granted granted Critical
Publication of ES2033295T3 publication Critical patent/ES2033295T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

ACTIVADOR DEL PLASMINOGENO RECIENTEMENTE ENCONTRADO, DENOMINADO SCU-PA-32K Y COMPUESTO POR UNA SOLA CADENA PEPTIDICA QUE TIENE UN PESO MOLECULAR DE APROXIMADAMENTE 32.000 Y UNA SECUENCIA DE AMINOACIDO AMINOTERMINAL DE LEU-LYS-PHE-GIN-GLY-GIN-LYS, RESULTA TENER LA CAPACIDAD DE PRODUCIR LA LISIS DE LOS COAGULOS DE SANGRE QUE CONTIENEN FIBRINA, EN EL TORRENTE SANGUINEO, SIN LA ACTIVACION DEL SISTEMA SANGUINEO FIBRINILITICO. ESTE ACTIVADOR DEL PLASMINOGENO PUEDE UTILIZARSE, POR LO TANTO, EN COMPOSICIONES MEDICINALES TROMBOLITICAS.
ES198787200909T 1986-05-15 1987-05-15 Un metodo para preparar un activador de plasminogeno. Expired - Lifetime ES2033295T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8601240A NL8601240A (nl) 1986-05-15 1986-05-15 Plasminogeenactivator en trombolytisch geneesmiddel.

Publications (1)

Publication Number Publication Date
ES2033295T3 true ES2033295T3 (es) 1993-03-16

Family

ID=19848019

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787200909T Expired - Lifetime ES2033295T3 (es) 1986-05-15 1987-05-15 Un metodo para preparar un activador de plasminogeno.

Country Status (7)

Country Link
EP (1) EP0247674B1 (es)
JP (1) JPS62285784A (es)
AT (1) ATE78292T1 (es)
DE (1) DE3780357T2 (es)
ES (1) ES2033295T3 (es)
GR (1) GR3005408T3 (es)
NL (1) NL8601240A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法
DE3735917A1 (de) * 1987-10-23 1989-05-03 Basf Ag Neue polypeptide, ihre herstellung und verwendung
GB8809093D0 (en) * 1988-04-18 1988-05-18 Erba Carlo Spa Low molecular weight derivatives of prourokinase
GB8919803D0 (en) * 1989-09-01 1989-10-18 Ciba Geigy Pharmaceutical compositions
DE4101736A1 (de) 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI88932C (fi) * 1982-04-15 1993-07-26 Genentech Inc Framstaellning av funktionellt maenskligt urokinasprotein
EP0139447B1 (en) * 1983-09-13 1992-12-30 The Green Cross Corporation A process for preparing urokinase zymogen

Also Published As

Publication number Publication date
EP0247674B1 (en) 1992-07-15
EP0247674A1 (en) 1987-12-02
ATE78292T1 (de) 1992-08-15
JPS62285784A (ja) 1987-12-11
DE3780357T2 (de) 1992-12-17
GR3005408T3 (es) 1993-05-24
NL8601240A (nl) 1987-12-01
DE3780357D1 (de) 1992-08-20

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