ES2037669T3 - Un procedimiento para preparar una sustancia que se une a la trombina. - Google Patents

Un procedimiento para preparar una sustancia que se une a la trombina.

Info

Publication number
ES2037669T3
ES2037669T3 ES198787100603T ES87100603T ES2037669T3 ES 2037669 T3 ES2037669 T3 ES 2037669T3 ES 198787100603 T ES198787100603 T ES 198787100603T ES 87100603 T ES87100603 T ES 87100603T ES 2037669 T3 ES2037669 T3 ES 2037669T3
Authority
ES
Spain
Prior art keywords
thrombin
substance
affinity
joins
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787100603T
Other languages
English (en)
Inventor
Nobuo Aoki
Masami Shiratsuchi
Shigeru Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of ES2037669T3 publication Critical patent/ES2037669T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

UNA SUSTANCIA ENLAZANTE DE TROMBINA NUEVA QUE TIENE LAS CARACTERISTICAS DE (A) PESO MOLECULAR 47000 (MAS MENOS) 600 EN CONDICION REDUCIDA Y 38000 (MAS MENOS) 600 EN CONDICION NO REDUCIDA, (B) PUNTO ISOELECTRICO PH 4,9-5,7, (C) AFINIDAD FUERTE A LA TROMBINA, (D) ACTIVIDAD, (1) CAPAZ DE PROMOVER LA ACTIVACION DE PROTEINA C CATALIZADA POR TROMBINA, (2) PROLONGA EL TIEMPO DE COAGULACION, Y (E) ESTABLE A LOS AGENTES DESNATURALIZANTES (UREA SODIO Y DODECILSULFATO), SE PUEDE OBTENER A PARTIR DE PLACENTA HUMANA POR MEDIO DE EXTRACCION, FRACCIONAMIENTO UTILIZANDO CROMATOGRAFIA DE CAMBIO IONICO Y CROMATOGRAFIA DE AFINIDAD, Y/O FILTRACION SOBRE GEL, SEGUIDA DE ELCTROFORESIS. LA SUSTANCIA ES UTIL COMO MEDICAMENTO PARA EL TRATAMIENTO DE LA TROMBOSIS.
ES198787100603T 1986-01-21 1987-01-19 Un procedimiento para preparar una sustancia que se une a la trombina. Expired - Lifetime ES2037669T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61010620A JPH0689014B2 (ja) 1986-01-21 1986-01-21 トロンビン結合性物質およびその製法

Publications (1)

Publication Number Publication Date
ES2037669T3 true ES2037669T3 (es) 1993-07-01

Family

ID=11755265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787100603T Expired - Lifetime ES2037669T3 (es) 1986-01-21 1987-01-19 Un procedimiento para preparar una sustancia que se une a la trombina.

Country Status (6)

Country Link
US (1) US4748156A (es)
EP (1) EP0230945B1 (es)
JP (1) JPH0689014B2 (es)
AT (1) ATE59962T1 (es)
DE (1) DE3767311D1 (es)
ES (1) ES2037669T3 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066788A (en) * 1984-09-21 1991-11-19 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
NZ213563A (en) * 1984-09-21 1991-08-27 Boehringer Ingelheim Int Anticoagulant proteins and pharmaceutical compositions
JPS63146898A (ja) * 1986-07-15 1988-06-18 Kowa Co トロンビン結合性物質およびその製法
DE3750664T2 (de) * 1986-07-15 1995-06-22 Kowa Co Throminbindende Substanz und Verfahren zu ihrer Herstellung.
JPS6330423A (ja) * 1986-07-22 1988-02-09 Kowa Co トロンビン結合性物質およびその製法
DE3639561A1 (de) * 1986-11-20 1988-06-01 Baumann Hanno Verfahren zur herstellung von nicht-thrombogenen substraten
DE3856335T2 (de) * 1987-01-08 2000-01-27 Asahi Chemical Ind Peptid zur beschleunigung der wirkung des proteins-c mit thrombin
JP2766473B2 (ja) * 1987-01-08 1998-06-18 旭化成工業株式会社 トロンビンによるプロテインｃの活性化を促進するペプチド
JPH0720997B2 (ja) * 1988-08-29 1995-03-08 興和株式会社 新規なトロンビン結合性物質及びその製法
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
EP0458903A4 (en) * 1989-02-17 1992-06-17 Codon Soluble analogs of thrombomodulin
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5574134A (en) * 1989-07-11 1996-11-12 University Of Delaware Polypeptide monomers, linearly extended and/or crosslinked forms thereof, and applications thereof
US5320945A (en) * 1989-07-14 1994-06-14 Boehringer Mannheim Gmbh Method and reagent for the determination of antithrombin III
DE59001418D1 (de) * 1989-07-15 1993-06-17 Boehringer Ingelheim Int Antikoagulanz enthaltendes mittel.
EP0489180A4 (en) * 1990-06-27 1993-03-31 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
WO1992014842A1 (en) * 1991-02-21 1992-09-03 Gilead Sciences, Inc. Aptamers specific for thrombin and methods of use
IE920562A1 (en) * 1991-02-21 1992-08-26 Gilead Sciences Aptamer specific for biomolecules and method of making
US5840867A (en) * 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
WO1993007491A1 (en) * 1991-10-04 1993-04-15 Board Of Regents Of The University Of Nebraska A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
US5716795A (en) * 1991-10-04 1998-02-10 Matschiner; John T. Thrombomodulin-based coagulometric assay of the protein C system
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
US20070215548A1 (en) * 2006-01-05 2007-09-20 Zhou Joe Xin H Systems and methods for packing chromatography columns

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297212A (es) * 1962-08-31
BE787961A (fr) * 1971-08-24 1973-02-26 Behringwerke Ag Procede d'isolement d'une matiere thromboplastique et medicament contenant ladite matiere
DE2640387C3 (de) * 1976-09-08 1981-01-22 Behringwerke Ag, 3550 Marburg Gewebespezifisches Protein und Verfahren zu dessen Herstellung
DE2720704C2 (de) * 1977-05-07 1986-09-25 Behringwerke Ag, 3550 Marburg Neues Glycoprotein, Verfahren zu seiner Herstellung und seine Verwendung
DE2842467A1 (de) * 1978-09-29 1980-04-10 Behringwerke Ag Neues ubiquitaeres gewebsprotein pp tief 8
DE2854759A1 (de) * 1978-12-19 1980-07-10 Behringwerke Ag Neues plazentaspezifisches gewebsprotein pp tief 10
DE3013724A1 (de) * 1980-04-10 1981-10-15 Behringwerke Ag, 3550 Marburg Neues protein pp (pfeil abwaerts)9(pfeil abwaerts), verfahren zu seiner anreicherung und gewinnung sowieseine verwendung
DE3109629A1 (de) * 1981-03-13 1982-09-23 Behringwerke Ag, 3550 Marburg "neues protein (pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)), verfahren zu seiner anreicherung und gewinnung sowie seine verwendung"
DE3228503A1 (de) * 1982-07-30 1984-02-02 Behringwerke Ag, 3550 Marburg Neues protein (pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)7(pfeil abwaerts)), verfahren zu seiner anreicherung und gewinnung sowie seine verwendung
DE3230996A1 (de) * 1982-08-20 1984-02-23 Behringwerke Ag, 3550 Marburg Neues protein (pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)3(pfeil abwaerts)), verfahren zu seiner anreicherung und gewinnung sowie seine verwendung
DE3315000A1 (de) * 1983-04-26 1984-10-31 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
JPS60152421A (ja) * 1984-01-23 1985-08-10 Sanwa Kagaku Kenkyusho:Kk ヒト胎盤性プラスミノ−ゲン活性化因子、及びそれとヒトプラスミノ−ゲン活性化阻害因子との結合物、及びそれらの製法
DE3404563A1 (de) * 1984-02-09 1985-08-14 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)9(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
DE3410694A1 (de) * 1984-03-23 1985-10-03 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)2(pfeil abwaerts)(pfeil abwaerts)1(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung

Also Published As

Publication number Publication date
US4748156A (en) 1988-05-31
EP0230945A3 (en) 1988-03-23
ATE59962T1 (de) 1991-02-15
JPH0689014B2 (ja) 1994-11-09
DE3767311D1 (de) 1991-02-21
JPS62169728A (ja) 1987-07-25
EP0230945B1 (en) 1991-01-16
EP0230945A2 (en) 1987-08-05

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