HUP9901161A2 - Módosított aktivitású hibrid VIII. faktor - Google Patents

Módosított aktivitású hibrid VIII. faktor

Info

Publication number
HUP9901161A2
HUP9901161A2 HU9901161A HUP9901161A HUP9901161A2 HU P9901161 A2 HUP9901161 A2 HU P9901161A2 HU 9901161 A HU9901161 A HU 9901161A HU P9901161 A HUP9901161 A HU P9901161A HU P9901161 A2 HUP9901161 A2 HU P9901161A2
Authority
HU
Hungary
Prior art keywords
hybrid proteins
blood coagulation
factor viii
modified activity
hybrid factor
Prior art date
Application number
HU9901161A
Other languages
English (en)
Inventor
Johannes J. Voorberg
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Publication of HUP9901161A2 publication Critical patent/HUP9901161A2/hu
Publication of HUP9901161A3 publication Critical patent/HUP9901161A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/10—Factor VIII, AHF; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgyát véralvadásban szerepet játszó, módősítőttaktivitású, többek között főkőzőtt véralvadást kiváltó aktivitásúhibrid fehérjék, hibrid fehérjék, a hibrid fehérjék előállításáraszőlgáló eljárásők és a hibrid fehérjéket tartalmazó gyógyászatikészítmények képezik. A találmány tárgyát képezik tővábbá a hibridfehérjéket kódőló pőlinűkleőtidők és azőkat tartalmazó transzfőrmáltsejtek is. A találmány szerinti hibrid fehérjékhez úgy jűtnak, hőgy avéralvadásban szerepet játszó fehérje legalább egy régióját kicserélikalvadásgátló vagy antitrőmbikűs fehérjéből származó legalább egyrégióval. A találmány szerinti hibrid fehérjék megnövelt mértékbenképesek véralvadást kiváltani. ŕ
HU9901161A 1995-11-13 1996-11-13 Hybrid factor viii with modified activity HUP9901161A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/558,107 US5910481A (en) 1995-11-13 1995-11-13 Hybrid proteins with modified activity

Publications (2)

Publication Number Publication Date
HUP9901161A2 true HUP9901161A2 (hu) 1999-07-28
HUP9901161A3 HUP9901161A3 (en) 2001-10-29

Family

ID=24228239

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901161A HUP9901161A3 (en) 1995-11-13 1996-11-13 Hybrid factor viii with modified activity

Country Status (10)

Country Link
US (5) US5910481A (hu)
EP (1) EP0861326A1 (hu)
JP (1) JP2001501803A (hu)
AU (1) AU707410B2 (hu)
CA (1) CA2235628A1 (hu)
CZ (1) CZ140298A3 (hu)
HU (1) HUP9901161A3 (hu)
NO (1) NO982154L (hu)
PL (1) PL326673A1 (hu)
WO (1) WO1997018315A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US7560107B2 (en) * 1996-06-26 2009-07-14 Emory University Modified factor VIII
US20020019036A1 (en) * 1996-12-13 2002-02-14 Hans-Peter Schwarz Von willebrand factor derivatives and methods of isolating proteins that bind to von willebrand factor
EP1074842A1 (en) * 1999-07-21 2001-02-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Catalytic anti-factor VIII allo-antibodies
JP4361786B2 (ja) * 2001-06-14 2009-11-11 ザ スクリプス リサーチ インスティチュート 操作されたジスルフィド結合を有する安定化蛋白質
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
US8101379B2 (en) * 2006-12-15 2012-01-24 Institute of Radiation Medicine Academy of Military Medical Science Preparation of low bleeding anticoagulant fusion protein and its use
WO2009088876A2 (en) 2007-12-31 2009-07-16 Baxter International Inc. Transgenic non-human animals expressing human blood clotting factors and uses thereof
WO2011017414A2 (en) 2009-08-04 2011-02-10 Baxter International Inc. Transgenic mouse lacking endogenous fviii and vwf - a model of hemophilia a
JP6174367B2 (ja) * 2013-04-26 2017-08-02 株式会社Ｌｓｉメディエンス トロンビン含有試薬及び測定方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0162067B1 (en) * 1983-10-28 1992-07-15 Genetics Institute, Inc. Production of factor viii and related products
EP0146903A3 (en) * 1983-12-19 1987-07-22 Schering Corporation Production of a vector encoding a novel hybrid interferon species
EP0150735B2 (en) * 1984-01-12 2004-01-07 Chiron Corporation Protein composition exhibiting coagulation activity and method for the preparation thereof
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
AU5772886A (en) * 1985-04-12 1986-11-05 Genetics Institute Inc. Novel procoagulant proteins
NO872932L (no) * 1986-07-18 1988-01-19 Gist Brocades Nv Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
JPH01502080A (ja) * 1986-11-17 1989-07-27 ニュー・イングランド・メディカル・センター 組み換えビタミンｋ依存性蛋白質のガンマカルボキシル化の増強
NL8701021A (nl) * 1987-04-29 1988-11-16 Stichting Centraal Lab Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten.
JP2799316B2 (ja) * 1987-06-12 1998-09-17 ヘキスト・マリオン・ルセル株式会社 雑種ヒトプロテインｃおよびその遺伝子工学的製法
EP0690126B1 (en) * 1987-06-12 2001-11-28 Baxter Aktiengesellschaft Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
PT88641B (pt) * 1987-10-02 1993-04-30 Genentech Inc Metodo para a preparacao de uma variante de adesao
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
DK0465529T3 (da) * 1989-03-21 1998-10-05 Vical Inc Ekspression af exogene polynukleotidsekvenser i et hvirveldyr
NL8902454A (nl) * 1989-10-03 1991-05-01 Stichting Centraal Lab Mutanten van de humane plasminogeen activator inhibitor 1 (pai-1), hun bereiding en toepassing, en recombinante polynucleotiden die voor deze mutanten coderende genetische informatie omvatten.
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
EP0439442B1 (en) * 1990-01-25 1996-03-06 Washington University Factor x-laci hybrid protein
IL96519A0 (en) * 1990-02-15 1991-08-16 Harvard College Covalent angiogenin/rnase hybrids
US5298422A (en) * 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
AU5602394A (en) * 1992-11-13 1994-06-08 Duke University Chimeric blood coagulation proteins
US5563045A (en) * 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
WO1995018827A1 (en) * 1994-01-07 1995-07-13 Novo Nordisk A/S Factor viii derivatives
WO1995018829A1 (en) * 1994-01-07 1995-07-13 Novo Nordisk A/S Factor viii derivatives
AU1382695A (en) * 1994-01-07 1995-08-01 Novo Nordisk A/S Factor viii derivatives
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity

Also Published As

Publication number Publication date
US5910481A (en) 1999-06-08
US5869292A (en) 1999-02-09
CZ140298A3 (cs) 1998-08-12
EP0861326A1 (en) 1998-09-02
HUP9901161A3 (en) 2001-10-29
NO982154L (no) 1998-07-13
WO1997018315A1 (en) 1997-05-22
AU707410B2 (en) 1999-07-08
US6130203A (en) 2000-10-10
CA2235628A1 (en) 1997-05-22
NO982154D0 (no) 1998-05-12
US6156888A (en) 2000-12-05
PL326673A1 (en) 1998-10-12
US6051418A (en) 2000-04-18
AU7624296A (en) 1997-06-05
JP2001501803A (ja) 2001-02-13

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