ES2073425T3 - Una nueva glicoproteina de tipo trombomodulina susceptible de ser obtenida a partir de la orina. - Google Patents

Una nueva glicoproteina de tipo trombomodulina susceptible de ser obtenida a partir de la orina.

Info

Publication number
ES2073425T3
ES2073425T3 ES89123963T ES89123963T ES2073425T3 ES 2073425 T3 ES2073425 T3 ES 2073425T3 ES 89123963 T ES89123963 T ES 89123963T ES 89123963 T ES89123963 T ES 89123963T ES 2073425 T3 ES2073425 T3 ES 2073425T3
Authority
ES
Spain
Prior art keywords
urine
thrombomodulin
type susceptible
new glycoprotein
glycoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89123963T
Other languages
English (en)
Inventor
Yasuyuki Kunihiro
Ryo Tanaka
Michio Ichimura
Akio Uemura
Nobuo Ohzawa
Ei Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2073425T3 publication Critical patent/ES2073425T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

ESTE INVENTO SE REFIERE A UNA NUEVA SUSTANCIA ANTICOAGULANTE PRESENTE EN LA ORINA HUMANA, UN PROCESO PARA SU PREPARACION Y UNA COMPOSICION FARMACEUTICA COMPRENDIENDO DICHA SUSTANCIA PARA LA PREVENCION Y/O TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON DESORDENES EN EL SISTEMA DE COAGULACION DE LA SANGRE
ES89123963T 1988-12-27 1989-12-27 Una nueva glicoproteina de tipo trombomodulina susceptible de ser obtenida a partir de la orina. Expired - Lifetime ES2073425T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33041388 1988-12-27
JP28524089 1989-11-01

Publications (1)

Publication Number Publication Date
ES2073425T3 true ES2073425T3 (es) 1995-08-16

Family

ID=26555801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89123963T Expired - Lifetime ES2073425T3 (es) 1988-12-27 1989-12-27 Una nueva glicoproteina de tipo trombomodulina susceptible de ser obtenida a partir de la orina.

Country Status (8)

Country Link
US (2) US5202421A (es)
EP (2) EP0376251B1 (es)
AT (2) ATE215967T1 (es)
AU (2) AU626365B2 (es)
CA (1) CA2006658C (es)
DE (2) DE68929388T2 (es)
ES (1) ES2073425T3 (es)
GR (1) GR3015765T3 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
EP0489180A4 (en) * 1990-06-27 1993-03-31 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
US5834028A (en) * 1993-12-17 1998-11-10 Mochida Pharmaceutical Co., Ltd. Soluble thrombomodulin-containing composition
US5981716A (en) * 1995-06-07 1999-11-09 Gruppo Lepettit, S.P.A. Process for the purification of proteins
JP4067117B2 (ja) * 1995-06-09 2008-03-26 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 選択性スロンビン抑制剤としてのブラジキニン同族体
JP3745805B2 (ja) * 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 トロンボモジュリンの精製方法
US6982249B1 (en) 1997-04-23 2006-01-03 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
CN1275916A (zh) * 1997-10-15 2000-12-06 旭化成工业株式会社 用于在贮藏/运输中保持血栓调节素含水注射剂质量的方法
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
DE19945351C2 (de) * 1999-09-22 2002-04-18 Lohmann Therapie Syst Lts Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen
CN1352087A (zh) * 2000-11-02 2002-06-05 上海博德基因开发有限公司 一种新的多肽——人糖蛋白42和编码这种多肽的多核苷酸
BR0310087A (pt) * 2002-05-17 2005-08-16 Wyeth Corp Veìculos sólidos injetáveis para ácido hialurÈnico para aplicação de proteìnas osteogênicas
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
WO2008044631A1 (fr) * 2006-10-06 2008-04-17 Asahi Kasei Pharma Corporation Agent thérapeutique et/ou améliorant pour la coagulation intravasculaire disséminée
SG184699A1 (en) 2007-03-23 2012-10-30 Asahi Kasei Pharma Corp Method for producing high-purity soluble thrombomodulin
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
EP2565269B1 (en) 2010-04-30 2016-11-16 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
CN103974710B (zh) 2011-11-15 2016-07-06 旭化成制药株式会社 用于败血症的治疗和/或改善的药物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4810232B1 (es) * 1970-09-04 1973-04-02
BE791783A (fr) * 1972-11-23 1973-05-23 Lilly Co Eli Polypeptides et procede pour les preparer
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
JPH0753667B2 (ja) * 1985-08-09 1995-06-07 新技術開発事業団 骨髄移植療法補助剤
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法
JPS6330423A (ja) * 1986-07-22 1988-02-09 Kowa Co トロンビン結合性物質およびその製法
DE3750664T2 (de) * 1986-07-15 1995-06-22 Kowa Co Throminbindende Substanz und Verfahren zu ihrer Herstellung.
JPH0764878B2 (ja) * 1986-10-14 1995-07-12 興和株式会社 抗血液凝固物質及びその製法
DE3856335T2 (de) * 1987-01-08 2000-01-27 Asahi Chemical Ind Peptid zur beschleunigung der wirkung des proteins-c mit thrombin
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
JPH0219399A (ja) * 1988-07-05 1990-01-23 Oklahoma Medical Res Found トロンビン結合ポリピペプチド
JPH0720997B2 (ja) * 1988-08-29 1995-03-08 興和株式会社 新規なトロンビン結合性物質及びその製法
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof

Also Published As

Publication number Publication date
AU626365B2 (en) 1992-07-30
CA2006658A1 (en) 1990-06-27
AU4727889A (en) 1990-08-16
US5202421A (en) 1993-04-13
DE68922202T2 (de) 1995-09-21
AU2742892A (en) 1993-01-07
EP0376251B1 (en) 1995-04-12
ATE215967T1 (de) 2002-04-15
CA2006658C (en) 2000-03-28
AU653269B2 (en) 1994-09-22
EP0376251A2 (en) 1990-07-04
GR3015765T3 (en) 1995-07-31
US5300490A (en) 1994-04-05
EP0376251A3 (en) 1990-12-19
EP0632055A1 (en) 1995-01-04
DE68929388D1 (de) 2002-05-16
EP0632055B1 (en) 2002-04-10
ATE121100T1 (de) 1995-04-15
DE68929388T2 (de) 2002-11-14
DE68922202D1 (de) 1995-05-18

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